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MXPA03000627A - Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c. - Google Patents

Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.

Info

Publication number
MXPA03000627A
MXPA03000627A MXPA03000627A MXPA03000627A MXPA03000627A MX PA03000627 A MXPA03000627 A MX PA03000627A MX PA03000627 A MXPA03000627 A MX PA03000627A MX PA03000627 A MXPA03000627 A MX PA03000627A MX PA03000627 A MXPA03000627 A MX PA03000627A
Authority
MX
Mexico
Prior art keywords
hepatitis
virus
protease inhibitors
serine protease
novel peptides
Prior art date
Application number
MXPA03000627A
Other languages
English (en)
Inventor
Yuhua Huang
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22822095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA03000627(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of MXPA03000627A publication Critical patent/MXPA03000627A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invencion describe nuevos compuestos que tienen actividad de inhibicion de la proteasa de VCH como tambien metodos para preparar dichos compuestos; en otra realizacion, la invencion describe composiciones farmaceuticas que comprenden dichos compuestos, como tambien metodos de uso para el tratamiento de trastornos asociados con la proteasa de VCH.
MXPA03000627A 2000-07-21 2001-07-19 Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c. MXPA03000627A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22010800P 2000-07-21 2000-07-21
PCT/US2001/022678 WO2002008244A2 (en) 2000-07-21 2001-07-19 Peptides as ns3-serine protease inhibitors of hepatitis c virus

Publications (1)

Publication Number Publication Date
MXPA03000627A true MXPA03000627A (es) 2004-07-30

Family

ID=22822095

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000627A MXPA03000627A (es) 2000-07-21 2001-07-19 Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.

Country Status (31)

Country Link
US (4) US7012066B2 (es)
EP (1) EP1385870B1 (es)
JP (3) JP4298289B2 (es)
KR (2) KR100939155B1 (es)
CN (3) CN102206247B (es)
AR (2) AR033985A1 (es)
AT (1) ATE461207T1 (es)
AU (2) AU2001276988B2 (es)
BR (1) BR0112540A (es)
CA (1) CA2410662C (es)
CY (2) CY1112267T1 (es)
CZ (1) CZ303213B6 (es)
DE (2) DE60141608D1 (es)
DK (1) DK1385870T3 (es)
EC (1) ECSP034438A (es)
ES (1) ES2341534T3 (es)
HU (1) HU229997B1 (es)
IL (2) IL153670A0 (es)
LU (1) LU91910I2 (es)
MX (1) MXPA03000627A (es)
MY (2) MY143322A (es)
NO (2) NO332329B1 (es)
NZ (1) NZ523782A (es)
PL (1) PL206255B1 (es)
PT (1) PT1385870E (es)
RU (2) RU2355700C9 (es)
SI (1) SI1385870T1 (es)
SK (1) SK288064B6 (es)
TW (1) TWI324611B (es)
WO (1) WO2002008244A2 (es)
ZA (1) ZA200210312B (es)

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* Cited by examiner, † Cited by third party
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