[go: up one dir, main page]

MX2020009790A - Proceso para fabricar compuestos de quinolona. - Google Patents

Proceso para fabricar compuestos de quinolona.

Info

Publication number
MX2020009790A
MX2020009790A MX2020009790A MX2020009790A MX2020009790A MX 2020009790 A MX2020009790 A MX 2020009790A MX 2020009790 A MX2020009790 A MX 2020009790A MX 2020009790 A MX2020009790 A MX 2020009790A MX 2020009790 A MX2020009790 A MX 2020009790A
Authority
MX
Mexico
Prior art keywords
quinolone compounds
quinolone
compounds
making
synthesizing
Prior art date
Application number
MX2020009790A
Other languages
English (en)
Inventor
Maxwell M Reeve
Graham Johnson
Roger Hanselmann
Original Assignee
Melinta Subsidiary Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Subsidiary Corp filed Critical Melinta Subsidiary Corp
Publication of MX2020009790A publication Critical patent/MX2020009790A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H57/00—General details of gearing
    • F16H57/02—Gearboxes; Mounting gearing therein
    • F16H57/027—Gearboxes; Mounting gearing therein characterised by means for venting gearboxes, e.g. air breathers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H57/00—General details of gearing
    • F16H57/02—Gearboxes; Mounting gearing therein
    • F16H57/037—Gearboxes for accommodating differential gearings
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H48/00—Differential gearings
    • F16H48/06—Differential gearings with gears having orbital motion
    • F16H48/08—Differential gearings with gears having orbital motion comprising bevel gears
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H57/00—General details of gearing
    • F16H57/04—Features relating to lubrication or cooling or heating
    • F16H57/0457—Splash lubrication
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H57/00—General details of gearing
    • F16H57/04—Features relating to lubrication or cooling or heating
    • F16H57/048—Type of gearings to be lubricated, cooled or heated
    • F16H57/0482—Gearings with gears having orbital motion
    • F16H57/0483—Axle or inter-axle differentials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T74/00—Machine element or mechanism
    • Y10T74/19—Gearing
    • Y10T74/19642—Directly cooperating gears
    • Y10T74/19688—Bevel
    • Y10T74/19693—Motor vehicle drive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T74/00—Machine element or mechanism
    • Y10T74/21—Elements
    • Y10T74/2186—Gear casings
    • Y10T74/2188—Axle and torque tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere al campo de la sintetización de compuestos antiinfecciosos. Más particularmente, la invención se refiere a la sintetización de una familia de compuestos de quinolona útiles como agentes antiinfecciosos. La invención incluye un proceso para preparar un compuesto de quinolona en donde menos de aproximadamente 0.40 % de la impureza dimérica de la quinolona es producida.
MX2020009790A 2008-09-24 2011-03-23 Proceso para fabricar compuestos de quinolona. MX2020009790A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19408308P 2008-09-24 2008-09-24

Publications (1)

Publication Number Publication Date
MX2020009790A true MX2020009790A (es) 2020-10-12

Family

ID=42060333

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2011003122A MX2011003122A (es) 2008-09-24 2009-09-23 Proceso para fabricar compuestos de quinolona.
MX2015000081A MX377930B (es) 2008-09-24 2009-09-23 Proceso para fabricar compuestos de quinolona.
MX2020009790A MX2020009790A (es) 2008-09-24 2011-03-23 Proceso para fabricar compuestos de quinolona.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2011003122A MX2011003122A (es) 2008-09-24 2009-09-23 Proceso para fabricar compuestos de quinolona.
MX2015000081A MX377930B (es) 2008-09-24 2009-09-23 Proceso para fabricar compuestos de quinolona.

Country Status (28)

Country Link
US (3) USRE46617E1 (es)
EP (3) EP3214083B1 (es)
JP (2) JP6013734B2 (es)
KR (3) KR20110091504A (es)
CN (2) CN102164912B (es)
AU (1) AU2009297085B2 (es)
BR (1) BRPI0919241B8 (es)
CA (1) CA2738236C (es)
CY (2) CY1123658T1 (es)
DK (2) DK3214083T3 (es)
ES (3) ES2966093T3 (es)
FI (2) FI3766876T3 (es)
HK (1) HK1214243A1 (es)
HR (1) HRP20201879T1 (es)
HU (2) HUE052219T2 (es)
IL (1) IL211845A (es)
LT (3) LT3766876T (es)
MX (3) MX2011003122A (es)
NL (1) NL301091I2 (es)
NO (1) NO2021006I1 (es)
PL (2) PL3766876T3 (es)
PT (1) PT3214083T (es)
RS (1) RS61194B1 (es)
RU (1) RU2546667C2 (es)
SG (1) SG10201605492YA (es)
SI (1) SI3214083T1 (es)
SM (1) SMT202000690T1 (es)
WO (1) WO2010036329A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576216B2 (en) * 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
CN102164912B (zh) 2008-09-24 2015-08-19 麦林塔医疗有限公司 制备喹诺酮类化合物的工艺
TW201444558A (zh) * 2013-03-15 2014-12-01 Melinta Therapeutics Inc 使用喹諾酮類抗生素治療淋病感染的方法
CN104098548B (zh) * 2013-04-11 2017-07-18 上海医药工业研究院 一种Delafloxacin的精制方法
CN103709100A (zh) * 2013-12-31 2014-04-09 南京工业大学 一种8-氯代喹诺酮衍生物的制备方法
TW201605447A (zh) * 2014-06-20 2016-02-16 美林塔治療學有限公司 處理感染的方法
CN106256824B (zh) * 2015-06-18 2020-10-27 重庆医药工业研究院有限责任公司 一种高纯度德拉沙星葡甲胺盐的制备方法
CN105017224A (zh) * 2015-07-10 2015-11-04 扬子江药业集团有限公司 一种德拉沙星葡甲胺晶型的制备方法
CN107778293B (zh) * 2016-08-29 2023-06-16 鲁南制药集团股份有限公司 一种改进的德拉沙星的制备方法
ES2895023T3 (es) 2017-03-31 2022-02-17 Fujifilm Corp Compuesto de 4-piridona o sal del mismo y composición farmacéutica y formulación que los incluyen
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
CN113527262B (zh) * 2021-06-22 2022-07-15 安徽普利药业有限公司 一种德拉沙星及其葡甲胺盐的精制方法
CN114031607B (zh) * 2021-11-16 2023-01-10 海南普利制药股份有限公司 一种德拉沙星及其中间体的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE69623358T2 (de) * 1995-09-22 2003-05-08 Wakunaga Pharma Co Ltd Pyridoncarbonsäurederivate als antibakterielle Wirkstoffe
CA2376760C (en) * 1999-07-01 2008-11-25 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or salts thereof
JP2005097116A (ja) 1999-11-11 2005-04-14 Wakunaga Pharmaceut Co Ltd キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
EP2816033A1 (en) * 2004-07-30 2014-12-24 Abbvie Inc. Preparation of pyridonecarboxylic acid antibacterials
EP3056492B1 (en) 2004-10-08 2021-09-22 AbbVie Inc. Meglumine salt and crystalline forms thereof of a drug (delafloxacin)
WO2006110815A1 (en) * 2005-04-11 2006-10-19 Abbott Laboratories Pharmaceutical compositions having improved dissolution profiles for poorly soluble drugs
CN102164912B (zh) 2008-09-24 2015-08-19 麦林塔医疗有限公司 制备喹诺酮类化合物的工艺

Also Published As

Publication number Publication date
US8871938B2 (en) 2014-10-28
DK2346855T3 (en) 2017-07-24
LT3766876T (lt) 2023-12-11
CN102164912A (zh) 2011-08-24
CA2738236A1 (en) 2010-04-01
EP2346855B1 (en) 2017-04-05
KR20110091504A (ko) 2011-08-11
RU2546667C2 (ru) 2015-04-10
EP2346855A4 (en) 2012-07-04
EP3214083B1 (en) 2020-09-16
HUS2100004I1 (hu) 2021-03-01
ES2966093T3 (es) 2024-04-18
NL301091I1 (nl) 2021-02-10
ES2629466T3 (es) 2017-08-09
BRPI0919241B1 (pt) 2020-05-12
PL3214083T3 (pl) 2021-04-06
HK1214243A1 (zh) 2016-07-22
WO2010036329A3 (en) 2010-07-01
FI3766876T3 (fi) 2023-12-05
BRPI0919241B8 (pt) 2021-05-25
KR101775304B1 (ko) 2017-09-05
SG10201605492YA (en) 2016-09-29
MX2011003122A (es) 2011-07-20
EP3766876A1 (en) 2021-01-20
AU2009297085A1 (en) 2010-04-01
US20120041208A1 (en) 2012-02-16
MX377930B (es) 2025-03-10
SI3214083T1 (sl) 2021-02-26
DK3214083T3 (da) 2020-12-07
LTPA2021002I1 (lt) 2021-03-10
IL211845A0 (en) 2011-06-30
CA2738236C (en) 2016-11-15
HRP20201879T1 (hr) 2021-01-22
IL211845A (en) 2017-03-30
JP2012508161A (ja) 2012-04-05
JP2015178515A (ja) 2015-10-08
HUE052219T2 (hu) 2021-04-28
EP2346855A2 (en) 2011-07-27
WO2010036329A2 (en) 2010-04-01
NL301091I2 (nl) 2021-08-03
LTC3214083I2 (lt) 2022-06-27
CY2021004I1 (el) 2021-05-05
SMT202000690T1 (it) 2021-01-05
ES2826273T3 (es) 2021-05-17
AU2009297085B2 (en) 2015-07-09
NO2021006I1 (no) 2021-02-15
PL3766876T3 (pl) 2024-04-02
CN105001207A (zh) 2015-10-28
CY2021004I2 (el) 2021-05-05
US8497378B2 (en) 2013-07-30
CY1123658T1 (el) 2021-05-05
PT3214083T (pt) 2020-12-04
JP6013734B2 (ja) 2016-10-25
FIC20210002I1 (fi) 2021-02-16
BRPI0919241A2 (pt) 2016-06-21
US20140171648A1 (en) 2014-06-19
EP3766876B1 (en) 2023-09-13
EP3214083A1 (en) 2017-09-06
EP3766876B8 (en) 2023-10-18
CN102164912B (zh) 2015-08-19
HK1244481A1 (en) 2018-08-10
KR20160116020A (ko) 2016-10-06
BRPI0919241A8 (pt) 2017-10-17
RU2011116052A (ru) 2012-10-27
USRE46617E1 (en) 2017-11-28
KR20170039758A (ko) 2017-04-11
RS61194B1 (sr) 2021-01-29
LT3214083T (lt) 2021-01-25

Similar Documents

Publication Publication Date Title
MX2020009790A (es) Proceso para fabricar compuestos de quinolona.
IN2012DN02751A (es)
NZ600119A (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
UY32142A (es) Preparación de una quinoliniloxidifenilciclopropanodicarboxamida
MX2009007695A (es) Compuestos complejos de carbohidrato de hierro.
TW201129555A (en) Process for the manufacture of dabigatrane etexilate
PH12012501918A1 (en) Process for preparation of dopo-derived compounds and compositions thereof
MY150596A (en) Hsp90 inhibitors
MX2012001463A (es) Proceso para la fabricacion de compuestos.
SG170729A1 (en) Processes and intermediates for preparing steric compounds
MY153622A (en) Processes and intermediates for making sweet taste enhancers
IN2014MN01521A (es)
MX2009008196A (es) Nuevo procedimiento de sintesis de la agomelatina.
MY150280A (en) Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
MX2010009860A (es) Sintesis total de salinosporamida a y sus analogos.
PH12013500541A1 (en) Monohydrate of an azaadamantane derivative
MX2012001411A (es) Proceso para la preparacion de derivados de acido 1-(2-halobifenil-4-il)-ciclopropanocarboxilico.
MX2011009898A (es) Proceso para la obtencion de derivados de acido propionico.
MY157423A (en) Production method of intermediate compound for synthesizing medicament
IN2015DN02424A (es)
MY157304A (en) Process for the preparation of a compound useful as an inhibator of tafia
MX2012007834A (es) Derivados de acido carboxilico que comprenden un anillo de oxazolopirimidina 2,5-sustituido.
MX2012007870A (es) Derivados de acido carboxilico que comprende un anillo de oxazolopirimidina 2, 5, 7-sustituido.
MY144746A (en) Process for the preparation of agomelatine
MX2010009926A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexancarboxilico.