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MX2012001463A - Proceso para la fabricacion de compuestos. - Google Patents

Proceso para la fabricacion de compuestos.

Info

Publication number
MX2012001463A
MX2012001463A MX2012001463A MX2012001463A MX2012001463A MX 2012001463 A MX2012001463 A MX 2012001463A MX 2012001463 A MX2012001463 A MX 2012001463A MX 2012001463 A MX2012001463 A MX 2012001463A MX 2012001463 A MX2012001463 A MX 2012001463A
Authority
MX
Mexico
Prior art keywords
manufacture
active compounds
pharmaceutically active
processes
novel
Prior art date
Application number
MX2012001463A
Other languages
English (en)
Inventor
Stefan Hildbrand
Hans-Juergen Mair
Roumen Nikolaev Radinov
Yi Ren
James Anderson Wright
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2012001463A publication Critical patent/MX2012001463A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

De acuerdo con la presente invención se proporcionan procesos novedosos para la fabricación del compuesto de la fórmula 1 (ver fórmula (1)) así como novedosas rutas de síntesis para intermediarios clase empleados en estos procesos.
MX2012001463A 2009-08-03 2010-07-30 Proceso para la fabricacion de compuestos. MX2012001463A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09167054 2009-08-03
EP09175101 2009-11-05
PCT/EP2010/061079 WO2011015522A2 (en) 2009-08-03 2010-07-30 Process for the manufacture of pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
MX2012001463A true MX2012001463A (es) 2012-02-22

Family

ID=42938195

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2013004041A MX340573B (es) 2009-08-03 2010-07-30 Proceso para la fabricacion de compuestos farmaceuticamente activos.
MX2013004036A MX340572B (es) 2009-08-03 2010-07-30 Proceso para la fabricacion de compuestos farmaceuticamente activos.
MX2012001463A MX2012001463A (es) 2009-08-03 2010-07-30 Proceso para la fabricacion de compuestos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2013004041A MX340573B (es) 2009-08-03 2010-07-30 Proceso para la fabricacion de compuestos farmaceuticamente activos.
MX2013004036A MX340572B (es) 2009-08-03 2010-07-30 Proceso para la fabricacion de compuestos farmaceuticamente activos.

Country Status (16)

Country Link
US (3) US8329724B2 (es)
EP (1) EP2462116B1 (es)
JP (2) JP5784602B2 (es)
KR (2) KR101461291B1 (es)
CN (3) CN103601725B (es)
AU (1) AU2010280848B2 (es)
BR (1) BR112012002251B1 (es)
CA (1) CA2768632C (es)
DK (1) DK2462116T3 (es)
ES (1) ES2513441T3 (es)
IL (2) IL217755A (es)
MX (3) MX340573B (es)
PL (1) PL2462116T3 (es)
SG (3) SG195594A1 (es)
SI (1) SI2462116T1 (es)
WO (1) WO2011015522A2 (es)

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US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US8779150B2 (en) 2010-07-21 2014-07-15 Hoffmann-La Roche Inc. Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
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WO2017066193A1 (en) 2015-10-15 2017-04-20 Princeton Drug Discovery, Llc Novel inhibitors of protein kinases
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ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
US20180334457A1 (en) * 2017-05-18 2018-11-22 Shilpa Medicare Limited Substantially pure vemurafenib and its salts
CN110903254B (zh) * 2018-09-17 2022-11-25 苏州鹏旭医药科技有限公司 一种应用于jak抑制剂类药物杂环中间体的合成方法
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MX340572B (es) 2016-07-13
US8741920B2 (en) 2014-06-03
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