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LTPA2021002I1 - Kvinolono junginių gamybos būdas - Google Patents

Kvinolono junginių gamybos būdas

Info

Publication number
LTPA2021002I1
LTPA2021002I1 LTPA2021002C LTPA2021002C LTPA2021002I1 LT PA2021002 I1 LTPA2021002 I1 LT PA2021002I1 LT PA2021002 C LTPA2021002 C LT PA2021002C LT PA2021002 C LTPA2021002 C LT PA2021002C LT PA2021002 I1 LTPA2021002 I1 LT PA2021002I1
Authority
LT
Lithuania
Prior art keywords
production
quinolone compounds
quinolone
compounds
Prior art date
Application number
LTPA2021002C
Other languages
English (en)
Original Assignee
Melinta Subsidiary Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Subsidiary Corp. filed Critical Melinta Subsidiary Corp.
Publication of LTPA2021002I1 publication Critical patent/LTPA2021002I1/lt
Publication of LTC3214083I2 publication Critical patent/LTC3214083I2/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H57/00General details of gearing
    • F16H57/02Gearboxes; Mounting gearing therein
    • F16H57/027Gearboxes; Mounting gearing therein characterised by means for venting gearboxes, e.g. air breathers
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H57/00General details of gearing
    • F16H57/02Gearboxes; Mounting gearing therein
    • F16H57/037Gearboxes for accommodating differential gearings
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H48/00Differential gearings
    • F16H48/06Differential gearings with gears having orbital motion
    • F16H48/08Differential gearings with gears having orbital motion comprising bevel gears
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H57/00General details of gearing
    • F16H57/04Features relating to lubrication or cooling or heating
    • F16H57/0457Splash lubrication
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H57/00General details of gearing
    • F16H57/04Features relating to lubrication or cooling or heating
    • F16H57/048Type of gearings to be lubricated, cooled or heated
    • F16H57/0482Gearings with gears having orbital motion
    • F16H57/0483Axle or inter-axle differentials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T74/00Machine element or mechanism
    • Y10T74/19Gearing
    • Y10T74/19642Directly cooperating gears
    • Y10T74/19688Bevel
    • Y10T74/19693Motor vehicle drive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T74/00Machine element or mechanism
    • Y10T74/21Elements
    • Y10T74/2186Gear casings
    • Y10T74/2188Axle and torque tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
LTPA2021002C 2008-09-24 2021-02-17 Kvinolono junginių gamybos būdas LTC3214083I2 (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19408308P 2008-09-24 2008-09-24
PCT/US2009/005276 WO2010036329A2 (en) 2008-09-24 2009-09-23 Process for making quinolone compounds
EP09816565.7A EP2346855B1 (en) 2008-09-24 2009-09-23 Process for making quinolone compounds

Publications (2)

Publication Number Publication Date
LTPA2021002I1 true LTPA2021002I1 (lt) 2021-03-10
LTC3214083I2 LTC3214083I2 (lt) 2022-06-27

Family

ID=42060333

Family Applications (3)

Application Number Title Priority Date Filing Date
LTEP20191961.0T LT3766876T (lt) 2008-09-24 2009-09-23 Farmacinė vaisto forma, turinti chinolono darinį
LTEP17163383.7T LT3214083T (lt) 2008-09-24 2009-09-23 Kvinolono junginių gamybos būdas
LTPA2021002C LTC3214083I2 (lt) 2008-09-24 2021-02-17 Kvinolono junginių gamybos būdas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
LTEP20191961.0T LT3766876T (lt) 2008-09-24 2009-09-23 Farmacinė vaisto forma, turinti chinolono darinį
LTEP17163383.7T LT3214083T (lt) 2008-09-24 2009-09-23 Kvinolono junginių gamybos būdas

Country Status (28)

Country Link
US (3) US8497378B2 (lt)
EP (3) EP3214083B1 (lt)
JP (2) JP6013734B2 (lt)
KR (3) KR101775304B1 (lt)
CN (2) CN102164912B (lt)
AU (1) AU2009297085B2 (lt)
BR (1) BRPI0919241B8 (lt)
CA (1) CA2738236C (lt)
CY (2) CY1123658T1 (lt)
DK (2) DK2346855T3 (lt)
ES (3) ES2629466T3 (lt)
FI (2) FI3766876T3 (lt)
HK (1) HK1214243A1 (lt)
HR (1) HRP20201879T1 (lt)
HU (2) HUE052219T2 (lt)
IL (1) IL211845A (lt)
LT (3) LT3766876T (lt)
MX (3) MX377930B (lt)
NL (1) NL301091I2 (lt)
NO (1) NO2021006I1 (lt)
PL (2) PL3214083T3 (lt)
PT (1) PT3214083T (lt)
RS (1) RS61194B1 (lt)
RU (1) RU2546667C2 (lt)
SG (1) SG10201605492YA (lt)
SI (1) SI3214083T1 (lt)
SM (1) SMT202000690T1 (lt)
WO (1) WO2010036329A2 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576216B2 (en) * 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
EP3214083B1 (en) * 2008-09-24 2020-09-16 Melinta Subsidiary Corp. Process for making quinolone compounds
WO2014152317A2 (en) * 2013-03-15 2014-09-25 Melinta Therapeutics, Inc. Methods of treating gonorrhea infections using quinolone antibiotics
CN104098548B (zh) * 2013-04-11 2017-07-18 上海医药工业研究院 一种Delafloxacin的精制方法
CN103709100A (zh) * 2013-12-31 2014-04-09 南京工业大学 一种8-氯代喹诺酮衍生物的制备方法
TW201605447A (zh) * 2014-06-20 2016-02-16 美林塔治療學有限公司 處理感染的方法
CN106256824B (zh) * 2015-06-18 2020-10-27 重庆医药工业研究院有限责任公司 一种高纯度德拉沙星葡甲胺盐的制备方法
CN105017224A (zh) * 2015-07-10 2015-11-04 扬子江药业集团有限公司 一种德拉沙星葡甲胺晶型的制备方法
CN107778293B (zh) * 2016-08-29 2023-06-16 鲁南制药集团股份有限公司 一种改进的德拉沙星的制备方法
CA3058111A1 (en) 2017-03-31 2018-10-04 Fujifilm Corporation 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
CN113527262B (zh) * 2021-06-22 2022-07-15 安徽普利药业有限公司 一种德拉沙星及其葡甲胺盐的精制方法
CN114031607B (zh) * 2021-11-16 2023-01-10 海南普利制药股份有限公司 一种德拉沙星及其中间体的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CN1105715C (zh) 1995-09-22 2003-04-16 涌永制药株式会社 新型吡啶酮羧酸衍生物或其盐以及以它们为有效成分的抗菌剂
IL147043A0 (en) * 1999-07-01 2002-08-14 Wakunaga Pharma Co Ltd Quinolinecarboxylic acid derivative or salts thereof
JP2005097116A (ja) 1999-11-11 2005-04-14 Wakunaga Pharmaceut Co Ltd キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
CA2575148C (en) * 2004-07-30 2012-07-17 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
SI3056492T1 (sl) 2004-10-08 2022-03-31 Abbvie Inc. Sol meglumina in njene kristalinične oblike zdravila (delafloksacin)
WO2006110815A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories Pharmaceutical compositions having improved dissolution profiles for poorly soluble drugs
EP3214083B1 (en) 2008-09-24 2020-09-16 Melinta Subsidiary Corp. Process for making quinolone compounds

Also Published As

Publication number Publication date
CN102164912B (zh) 2015-08-19
HUE052219T2 (hu) 2021-04-28
EP3214083A1 (en) 2017-09-06
LTC3214083I2 (lt) 2022-06-27
PT3214083T (pt) 2020-12-04
WO2010036329A2 (en) 2010-04-01
EP2346855A2 (en) 2011-07-27
KR20160116020A (ko) 2016-10-06
BRPI0919241A2 (pt) 2016-06-21
MX377930B (es) 2025-03-10
CY2021004I1 (el) 2021-05-05
LT3766876T (lt) 2023-12-11
BRPI0919241A8 (pt) 2017-10-17
RU2011116052A (ru) 2012-10-27
HK1244481A1 (en) 2018-08-10
KR20170039758A (ko) 2017-04-11
LT3214083T (lt) 2021-01-25
SMT202000690T1 (it) 2021-01-05
WO2010036329A3 (en) 2010-07-01
AU2009297085B2 (en) 2015-07-09
CY2021004I2 (el) 2021-05-05
ES2966093T3 (es) 2024-04-18
HK1214243A1 (zh) 2016-07-22
EP2346855A4 (en) 2012-07-04
JP2015178515A (ja) 2015-10-08
US20120041208A1 (en) 2012-02-16
SG10201605492YA (en) 2016-09-29
EP3766876B8 (en) 2023-10-18
IL211845A0 (en) 2011-06-30
CN105001207A (zh) 2015-10-28
SI3214083T1 (sl) 2021-02-26
EP3766876B1 (en) 2023-09-13
MX2011003122A (es) 2011-07-20
CY1123658T1 (el) 2021-05-05
NL301091I2 (nl) 2021-08-03
US20140171648A1 (en) 2014-06-19
ES2629466T3 (es) 2017-08-09
MX2020009790A (es) 2020-10-12
JP6013734B2 (ja) 2016-10-25
EP3766876A1 (en) 2021-01-20
FIC20210002I1 (fi) 2021-02-16
US8497378B2 (en) 2013-07-30
AU2009297085A1 (en) 2010-04-01
DK3214083T3 (da) 2020-12-07
ES2826273T3 (es) 2021-05-17
DK2346855T3 (en) 2017-07-24
KR20110091504A (ko) 2011-08-11
RU2546667C2 (ru) 2015-04-10
EP2346855B1 (en) 2017-04-05
PL3214083T3 (pl) 2021-04-06
JP2012508161A (ja) 2012-04-05
USRE46617E1 (en) 2017-11-28
KR101775304B1 (ko) 2017-09-05
BRPI0919241B1 (pt) 2020-05-12
HUS2100004I1 (hu) 2021-03-01
NO2021006I1 (no) 2021-02-15
CN102164912A (zh) 2011-08-24
CA2738236A1 (en) 2010-04-01
NL301091I1 (nl) 2021-02-10
US8871938B2 (en) 2014-10-28
CA2738236C (en) 2016-11-15
PL3766876T3 (pl) 2024-04-02
EP3214083B1 (en) 2020-09-16
RS61194B1 (sr) 2021-01-29
IL211845A (en) 2017-03-30
HRP20201879T1 (hr) 2021-01-22
FI3766876T3 (fi) 2023-12-05
BRPI0919241B8 (pt) 2021-05-25

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