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MX2016006177A - Método para diseñar células t resistentes a fármacos de quimioterapia para inmunoterapia. - Google Patents

Método para diseñar células t resistentes a fármacos de quimioterapia para inmunoterapia.

Info

Publication number
MX2016006177A
MX2016006177A MX2016006177A MX2016006177A MX2016006177A MX 2016006177 A MX2016006177 A MX 2016006177A MX 2016006177 A MX2016006177 A MX 2016006177A MX 2016006177 A MX2016006177 A MX 2016006177A MX 2016006177 A MX2016006177 A MX 2016006177A
Authority
MX
Mexico
Prior art keywords
cells
immunotherapy
chemotherapy
engineering
drug resistant
Prior art date
Application number
MX2016006177A
Other languages
English (en)
Other versions
MX378635B (es
Inventor
Valton Julien
Duchateau Philippe
Sourdive David
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of MX2016006177A publication Critical patent/MX2016006177A/es
Publication of MX378635B publication Critical patent/MX378635B/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01074—Deoxycytidine kinase (2.7.1.74)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2510/00—Genetically modified cells

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  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con el uso de células terapéuticas alogénicas listas para utilizarse en inmunoterapia junto con quimioterapia para tratar pacientes con cáncer. En particular, la invención desarrolló un método para diseñar células T alogénicas resistentes a agentes terapéuticos. Los beneficios terapéuticos proporcionados por esta estrategia deberán intensificarse por los efectos sinergísticos entre quimioterapia e inmunoterapia. En particular, la presente invención se relaciona con un método para modificar células T al inactivar al menos un componente receptor de células T que codifica un gen y al modificar las células T para conferir resistencia al fármaco. La invención abre el camino a estrategias de inmunoterapia estándar y de adopción razonable para tratar cáncer.
MX2016006177A 2013-11-22 2014-11-21 Método para diseñar células t resistentes a fármacos de quimioterapia para inmunoterapia. MX378635B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907874P 2013-11-22 2013-11-22
DKPA201470362 2014-06-17
PCT/EP2014/075317 WO2015075195A1 (en) 2013-11-22 2014-11-21 Method of engineering chemotherapy drug resistant t-cells for immunotherapy

Publications (2)

Publication Number Publication Date
MX2016006177A true MX2016006177A (es) 2016-08-19
MX378635B MX378635B (es) 2025-03-10

Family

ID=51059229

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006177A MX378635B (es) 2013-11-22 2014-11-21 Método para diseñar células t resistentes a fármacos de quimioterapia para inmunoterapia.

Country Status (11)

Country Link
US (1) US10813951B2 (es)
EP (1) EP3071687B1 (es)
JP (1) JP6976058B2 (es)
KR (1) KR102348577B1 (es)
CN (1) CN105765061A (es)
AU (1) AU2014351797B2 (es)
BR (1) BR112016011169A2 (es)
CA (1) CA2931267C (es)
IL (1) IL245725B (es)
MX (1) MX378635B (es)
WO (1) WO2015075195A1 (es)

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Publication number Publication date
US20160361359A1 (en) 2016-12-15
AU2014351797B2 (en) 2021-03-11
BR112016011169A2 (pt) 2017-09-19
MX378635B (es) 2025-03-10
JP2016538861A (ja) 2016-12-15
WO2015075195A1 (en) 2015-05-28
KR102348577B1 (ko) 2022-01-06
US10813951B2 (en) 2020-10-27
CA2931267C (en) 2023-08-15
IL245725B (en) 2021-04-29
IL245725A0 (en) 2016-07-31
EP3071687B1 (en) 2019-07-31
CA2931267A1 (en) 2015-05-28
EP3071687A1 (en) 2016-09-28
AU2014351797A1 (en) 2016-06-09
CN105765061A (zh) 2016-07-13
JP6976058B2 (ja) 2021-12-01
KR20160103002A (ko) 2016-08-31

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