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MX2018004546A - Composiciones y métodos para la inhibicion de antígenos específicos de linaje. - Google Patents

Composiciones y métodos para la inhibicion de antígenos específicos de linaje.

Info

Publication number
MX2018004546A
MX2018004546A MX2018004546A MX2018004546A MX2018004546A MX 2018004546 A MX2018004546 A MX 2018004546A MX 2018004546 A MX2018004546 A MX 2018004546A MX 2018004546 A MX2018004546 A MX 2018004546A MX 2018004546 A MX2018004546 A MX 2018004546A
Authority
MX
Mexico
Prior art keywords
methods
inhibition
compositions
specific antigens
lineage specific
Prior art date
Application number
MX2018004546A
Other languages
English (en)
Inventor
Mahmood Ali Abdullah
BOROT Florence
Mukherjee Siddhartha
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of MX2018004546A publication Critical patent/MX2018004546A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A—HUMAN NECESSITIES
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    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/565—Complementarity determining region [CDR]
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  • Health & Medical Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract

En la presente se describen métodos para administrar un agente que se dirige a un antígeno de superficie celular específico de linaje y una población de células hematopoyéticas que son deficientes en el antígeno de superficie celular para la inmunoterapia de neoplasias malignas hematológicas.
MX2018004546A 2015-10-16 2016-10-17 Composiciones y métodos para la inhibicion de antígenos específicos de linaje. MX2018004546A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562242685P 2015-10-16 2015-10-16
PCT/US2016/057339 WO2017066760A1 (en) 2015-10-16 2016-10-17 Compositions and methods for inhibition of lineage specific antigens

Publications (1)

Publication Number Publication Date
MX2018004546A true MX2018004546A (es) 2019-04-15

Family

ID=58518249

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018004546A MX2018004546A (es) 2015-10-16 2016-10-17 Composiciones y métodos para la inhibicion de antígenos específicos de linaje.
MX2024000739A MX2024000739A (es) 2015-10-16 2018-04-12 Composiciones y metodos para la inhibicion de antigenos especificos de linaje.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024000739A MX2024000739A (es) 2015-10-16 2018-04-12 Composiciones y metodos para la inhibicion de antigenos especificos de linaje.

Country Status (10)

Country Link
US (7) US10137155B2 (es)
EP (2) EP4265633A3 (es)
JP (3) JP7017506B2 (es)
CN (2) CN108290939B (es)
AU (2) AU2016337525B2 (es)
CA (1) CA3001859A1 (es)
ES (1) ES2962651T3 (es)
IL (3) IL300420B2 (es)
MX (2) MX2018004546A (es)
WO (1) WO2017066760A1 (es)

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US12251403B2 (en) 2018-08-28 2025-03-18 Vor Biopharma Inc. Genetically engineered hematopoietic stem cells and uses thereof

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CN108290939B (zh) 2015-10-16 2023-01-13 纽约市哥伦比亚大学理事会 用于抑制谱系特异性抗原的组合物和方法
BR112018009098A8 (pt) * 2015-11-04 2019-02-26 Univ Pennsylvania métodos e composições para edição genética em células-tronco hematopoiéticas
EP3448987A4 (en) 2016-04-29 2020-05-27 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
KR102709603B1 (ko) * 2017-02-28 2024-09-27 보르 바이오파마 인크. 계통 특이적 단백질의 억제를 위한 조성물 및 방법
JP2020531535A (ja) * 2017-08-28 2020-11-05 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Ｃｄ３３標的剤と共に使用するためのｃｄ３３エクソン２欠損型ドナー幹細胞
KR102320280B1 (ko) * 2018-05-31 2021-11-29 주식회사 센트릭스바이오 CD300c의 발현 억제제 또는 활성 억제제를 포함하는 암 예방 또는 치료용 약학적 조성물
KR20210046001A (ko) * 2018-08-21 2021-04-27 시그마-알드리치 컴퍼니., 엘엘씨 시토졸 dna 센서 경로의 하향-조절
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AU2019355115A1 (en) * 2018-10-03 2021-03-04 Nepenthe Bioscience LLC Anti-CD79 antibodies and their uses
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020088631A1 (en) 2018-11-01 2020-05-07 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
MX2021005398A (es) * 2018-11-07 2021-07-06 Crispr Therapeutics Ag Terapia del cancer con celulas inmunitarias anti-cd33.
CA3126677A1 (en) * 2019-01-16 2020-07-23 The Trustees Of Columbia University In The City Of New York Compositions and methods for inhibition of lineage specific antigens
JP7656330B2 (ja) * 2019-01-28 2025-04-03 マルチチュード インコーポレーテッド Ｃｄ４４に特異的な抗体
CN109777784B (zh) * 2019-02-22 2021-12-31 上海尚泰生物技术有限公司 一种增强向肿瘤部位迁移的嵌合抗原受体载体构建方法与应用
CA3141732A1 (en) * 2019-05-23 2020-11-26 Vor Biopharma Inc Compositions and methods for cd33 modification
US20220251192A1 (en) * 2019-06-26 2022-08-11 Memorial Sloan Kettering Cancer Center Anti-cd33 antibodies for treating cancer
WO2021041971A1 (en) 2019-08-28 2021-03-04 Vor Biopharma, Inc. Compositions and methods for cll1 modification
AU2020336211A1 (en) * 2019-08-28 2022-03-10 Vor Biopharma Inc. Compositions and methods for CD123 modification
US20220380776A1 (en) * 2019-10-22 2022-12-01 Fred Hutchinson Cancer Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells
WO2022250433A1 (ko) * 2021-05-24 2022-12-01 주식회사 센트릭스바이오 Cd300c 항원 또는 그의 수용체에 특이적으로 결합하는 키메라 항원 수용체
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