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MX2019004181A - Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano. - Google Patents

Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano.

Info

Publication number
MX2019004181A
MX2019004181A MX2019004181A MX2019004181A MX2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A
Authority
MX
Mexico
Prior art keywords
cells
methods
modified
tryptophan
pathway
Prior art date
Application number
MX2019004181A
Other languages
English (en)
Inventor
I Levitsky Hyam
Ports Michael
Paul Thomas Evan
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2019004181A publication Critical patent/MX2019004181A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
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Abstract

Se proporcionan métodos de tratamiento que implica inmunoterapia, tal como terapia de células T, y administración de un modulador del metabolismo de triptófano y/o la ruta de quinurenina. En algunas modalidades, el método incluye una terapia de combinación que implica la administración de células T modificadas, tal como células que expresan el receptor de antígeno quimérico (CAR), y un modulador del metabolismo de triptófano y/o la ruta de quinurenina, tal como un inhibidor de una enzima. También se proporciona células modificadas en las cuales la expresión de una molécula implicada en la ruta de quinurenina se modifica. También se proporcionan métodos para fabricar células modificadas, células, composiciones, métodos de administración a sujetos, ácidos nucleicos, y kits para el uso en los métodos. En algunos aspectos, las características de los métodos y células proporcionan actividad incrementada y mejorada, actividad, resultado, función, respuesta, persistencia, expansión, y/o proliferación de células para terapia de células adoptivas.
MX2019004181A 2016-10-13 2017-10-13 Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano. MX2019004181A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662407776P 2016-10-13 2016-10-13
US201762514767P 2017-06-02 2017-06-02
PCT/US2017/056680 WO2018071873A2 (en) 2016-10-13 2017-10-13 Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators

Publications (1)

Publication Number Publication Date
MX2019004181A true MX2019004181A (es) 2019-10-30

Family

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Application Number Title Priority Date Filing Date
MX2019004181A MX2019004181A (es) 2016-10-13 2017-10-13 Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano.

Country Status (15)

Country Link
US (1) US11896615B2 (es)
EP (2) EP3525803B1 (es)
JP (2) JP7623784B2 (es)
KR (1) KR20190084053A (es)
CN (1) CN110381963A (es)
AU (1) AU2017343780B2 (es)
BR (1) BR112019006652A2 (es)
CA (1) CA3037387A1 (es)
ES (1) ES2939646T3 (es)
IL (1) IL265848A (es)
MA (2) MA46649A (es)
MX (1) MX2019004181A (es)
PH (1) PH12019500803A1 (es)
SG (1) SG11201903282TA (es)
WO (1) WO2018071873A2 (es)

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AU2017343780B2 (en) 2023-08-31
KR20190084053A (ko) 2019-07-15
US11896615B2 (en) 2024-02-13
JP2019533676A (ja) 2019-11-21

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