MX2018001193A - Compuestos de derivados de 1,3,4-oxadiazolsulfonamida como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos. - Google Patents
Compuestos de derivados de 1,3,4-oxadiazolsulfonamida como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos.Info
- Publication number
- MX2018001193A MX2018001193A MX2018001193A MX2018001193A MX2018001193A MX 2018001193 A MX2018001193 A MX 2018001193A MX 2018001193 A MX2018001193 A MX 2018001193A MX 2018001193 A MX2018001193 A MX 2018001193A MX 2018001193 A MX2018001193 A MX 2018001193A
- Authority
- MX
- Mexico
- Prior art keywords
- histone deacetylase
- same
- inhibitor
- pharmaceutical composition
- derivative compounds
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 1,3,4-oxadiazole sulfonamide derivative compounds Chemical class 0.000 title 1
- 229940122617 Histone deacetylase 6 inhibitor Drugs 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 5
- 108090000353 Histone deacetylase Proteins 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a compuestos novedosos representados por la fórmula I que tienen actividad inhibidora de histona desacetilasa (HDAC6), estereoisómeros de los mismos o sales farmacéuticamente aceptables de los mismos, el uso de los mismos para la preparación de medicamentos terapéuticos, composiciones farmacéuticas que contienen los mismos, un método de tratamiento de enfermedades usando la composición, y métodos de preparación de los compuestos novedosos (I). Los compuestos novedosos, estereoisómeros de los mismos o sales farmacéuticamente aceptables de los mismos según la presente invención tienen actividad inhibidora de histona desacetilasa (HDAC) y son eficaces para la prevención o el tratamiento de enfermedades mediadas por HDAC6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20150105976 | 2015-07-27 | ||
| PCT/KR2016/008214 WO2017018803A1 (en) | 2015-07-27 | 2016-07-27 | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018001193A true MX2018001193A (es) | 2018-05-22 |
| MX376584B MX376584B (es) | 2025-03-07 |
Family
ID=57886873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018001193A MX376584B (es) | 2015-07-27 | 2016-07-27 | Compuestos de derivados de 1,3,4-oxadiazolsulfonamida como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10538498B2 (es) |
| EP (1) | EP3328843B1 (es) |
| JP (1) | JP6560436B2 (es) |
| KR (1) | KR101799007B1 (es) |
| CN (1) | CN107922362B (es) |
| AU (1) | AU2016299484B2 (es) |
| CA (1) | CA2993929C (es) |
| DK (1) | DK3328843T3 (es) |
| ES (1) | ES2935932T3 (es) |
| FI (1) | FI3328843T3 (es) |
| HR (1) | HRP20230052T1 (es) |
| HU (1) | HUE061174T2 (es) |
| MX (1) | MX376584B (es) |
| MY (1) | MY197262A (es) |
| NZ (1) | NZ739026A (es) |
| PH (1) | PH12018500212A1 (es) |
| PL (1) | PL3328843T3 (es) |
| PT (1) | PT3328843T (es) |
| RU (1) | RU2697665C1 (es) |
| TW (1) | TWI639587B (es) |
| WO (1) | WO2017018803A1 (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2984618C (en) | 2015-05-07 | 2024-01-09 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| MX379817B (es) | 2015-05-07 | 2025-03-11 | Chdi Foundation Inc | Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos. |
| CA2987570C (en) | 2015-07-27 | 2021-06-15 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| MX377262B (es) | 2015-07-27 | 2025-03-07 | Chong Kun Dang Pharmaceutical Corp | Compuesto derivado de amida de 1,3,4-oxadiazol como inhibidor de histona desacetilasa 6 y composición farmacéutica que lo contiene. |
| FI3328843T3 (fi) | 2015-07-27 | 2023-01-31 | 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus | |
| PT3331864T (pt) * | 2015-08-04 | 2022-01-18 | Chong Kun Dang Pharmaceutical Corp | Compostos derivados de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica compreendendo os mesmos |
| KR101839137B1 (ko) | 2015-10-12 | 2018-03-26 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 옥사다이아졸 아민 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| WO2018153730A1 (en) * | 2017-02-21 | 2018-08-30 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| EP3606913B1 (en) * | 2017-04-03 | 2022-04-27 | Syngenta Participations AG | Microbiocidal oxadiazole derivatives |
| JP7135007B2 (ja) * | 2017-07-31 | 2022-09-12 | 武田薬品工業株式会社 | 複素環化合物 |
| US11261201B2 (en) | 2018-01-12 | 2022-03-01 | President And Fellows Of Harvard College | TRNA synthetase inhibitors |
| WO2019140254A1 (en) * | 2018-01-12 | 2019-07-18 | President And Fellows Of Harvard College | Multicyclic compounds and use of same for treating tuberculosis |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| KR20200061310A (ko) * | 2018-11-23 | 2020-06-02 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제를 포함하는 약학적 조성물 |
| WO2020158762A1 (ja) | 2019-01-30 | 2020-08-06 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3956324B1 (en) | 2019-04-17 | 2024-02-21 | Quimatryx, S.L. | 1,3,4-oxadiazole derivatives as histone deacetylase inhibitors |
| BR112021023640A2 (pt) | 2019-05-31 | 2022-01-04 | Chong Kun Dang Pharmaceutical Corp | Compostos de derivado de 1,3,4-oxadiazol homoftalimida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos |
| BR112021026334A2 (pt) | 2019-06-27 | 2022-05-10 | Medstar Health | Macrófagos ativados por hdac6, composições, e usos dos mesmos |
| CA3149096A1 (en) | 2019-07-30 | 2021-02-04 | Eikonizo Therapapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| WO2021060567A1 (en) | 2019-09-27 | 2021-04-01 | Takeda Pharmaceutical Company Limited | 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors |
| BR112022011917A2 (pt) | 2019-12-20 | 2022-09-06 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazois e seus usos |
| KR102537615B1 (ko) | 2020-02-25 | 2023-05-30 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| KR102537616B1 (ko) | 2020-02-25 | 2023-05-26 | 주식회사 종근당 | 히스톤 탈아세틸화 효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| KR102576148B1 (ko) * | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| CN116157398B (zh) | 2020-08-07 | 2025-03-11 | 意大发马克股份公司 | 噁二唑系选择性组蛋白去乙酰化酶6抑制剂 |
| WO2022173727A1 (en) * | 2021-02-09 | 2022-08-18 | Celgene Corporation | Sulfonamides and their use for treatment of helminthic infections and diseases |
| KR102905373B1 (ko) * | 2021-04-08 | 2025-12-29 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 싸이오카보닐 화합물 및 이를 포함하는 약제학적 조성물 |
| EP4326263A1 (en) | 2021-04-23 | 2024-02-28 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for use in the treatment of dilated cardiomyopathy |
| CA3216768A1 (en) | 2021-05-04 | 2022-11-10 | Jin Yang | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
| TW202337446A (zh) * | 2022-01-28 | 2023-10-01 | 韓商鐘根堂股份有限公司 | 用於預防或治療肺動脈高血壓之組合物 |
| CA3243781A1 (en) * | 2022-02-08 | 2023-08-17 | Georgetown University | A1H-BENZO[C][1,2]THIADIAZINE-2,2-DIOXIDES BEARING HETEROCYCLIC BONDS AS SELECTIVE HISTONE DEACETYLASE INHIBITORS 6 |
| KR102904231B1 (ko) * | 2022-04-07 | 2025-12-29 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
| KR20240035172A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
| PE20251844A1 (es) * | 2022-10-14 | 2025-07-17 | Chong Kun Dang Pharmaceutical Corp | Compuestos de sulfoximina como inhibidores de la histona desacetilasa 6, y composicion farmaceutica que comprende los mismos |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
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| FI3328843T3 (fi) | 2015-07-27 | 2023-01-31 | 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus | |
| PT3331864T (pt) | 2015-08-04 | 2022-01-18 | Chong Kun Dang Pharmaceutical Corp | Compostos derivados de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica compreendendo os mesmos |
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2016
- 2016-07-27 FI FIEP16830836.9T patent/FI3328843T3/fi active
- 2016-07-27 US US15/747,952 patent/US10538498B2/en active Active
- 2016-07-27 EP EP16830836.9A patent/EP3328843B1/en active Active
- 2016-07-27 MX MX2018001193A patent/MX376584B/es active IP Right Grant
- 2016-07-27 DK DK16830836.9T patent/DK3328843T3/da active
- 2016-07-27 PL PL16830836.9T patent/PL3328843T3/pl unknown
- 2016-07-27 CN CN201680044430.0A patent/CN107922362B/zh active Active
- 2016-07-27 NZ NZ739026A patent/NZ739026A/en unknown
- 2016-07-27 AU AU2016299484A patent/AU2016299484B2/en active Active
- 2016-07-27 ES ES16830836T patent/ES2935932T3/es active Active
- 2016-07-27 TW TW105123824A patent/TWI639587B/zh active
- 2016-07-27 KR KR1020160095332A patent/KR101799007B1/ko active Active
- 2016-07-27 HU HUE16830836A patent/HUE061174T2/hu unknown
- 2016-07-27 JP JP2018503804A patent/JP6560436B2/ja active Active
- 2016-07-27 PT PT168308369T patent/PT3328843T/pt unknown
- 2016-07-27 CA CA2993929A patent/CA2993929C/en active Active
- 2016-07-27 RU RU2018106877A patent/RU2697665C1/ru active
- 2016-07-27 WO PCT/KR2016/008214 patent/WO2017018803A1/en not_active Ceased
- 2016-07-27 HR HRP20230052TT patent/HRP20230052T1/hr unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3328843A1 (en) | 2018-06-06 |
| WO2017018803A1 (en) | 2017-02-02 |
| RU2697665C1 (ru) | 2019-08-16 |
| HK1251571A1 (zh) | 2019-02-01 |
| PT3328843T (pt) | 2023-01-24 |
| HRP20230052T1 (hr) | 2023-03-03 |
| CN107922362B (zh) | 2021-06-15 |
| CA2993929A1 (en) | 2017-02-02 |
| EP3328843A4 (en) | 2019-01-16 |
| CN107922362A (zh) | 2018-04-17 |
| PL3328843T3 (pl) | 2023-02-27 |
| KR20170013836A (ko) | 2017-02-07 |
| TW201712001A (zh) | 2017-04-01 |
| US10538498B2 (en) | 2020-01-21 |
| AU2016299484A1 (en) | 2018-02-01 |
| TWI639587B (zh) | 2018-11-01 |
| KR101799007B1 (ko) | 2017-11-17 |
| BR112018001720A2 (pt) | 2018-11-06 |
| MY197262A (en) | 2023-06-08 |
| DK3328843T3 (da) | 2023-01-09 |
| EP3328843B1 (en) | 2022-10-26 |
| ES2935932T3 (es) | 2023-03-13 |
| PH12018500212A1 (en) | 2018-08-13 |
| FI3328843T3 (fi) | 2023-01-31 |
| HUE061174T2 (hu) | 2023-05-28 |
| JP6560436B2 (ja) | 2019-08-14 |
| JP2018526343A (ja) | 2018-09-13 |
| MX376584B (es) | 2025-03-07 |
| NZ739026A (en) | 2019-03-29 |
| US20180251437A1 (en) | 2018-09-06 |
| CA2993929C (en) | 2020-10-20 |
| AU2016299484B2 (en) | 2019-08-01 |
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