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CO2018005640A2 - Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria - Google Patents

Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria

Info

Publication number
CO2018005640A2
CO2018005640A2 CONC2018/0005640A CO2018005640A CO2018005640A2 CO 2018005640 A2 CO2018005640 A2 CO 2018005640A2 CO 2018005640 A CO2018005640 A CO 2018005640A CO 2018005640 A2 CO2018005640 A2 CO 2018005640A2
Authority
CO
Colombia
Prior art keywords
treatment
jak kinase
compounds
kinase inhibitor
respiratory disease
Prior art date
Application number
CONC2018/0005640A
Other languages
English (en)
Inventor
Melissa Fleury
Venkat R Thalladi
Miroslav Rapta
Paul R Fatheree
Gary E L Brandt
John R Jacobsen
Anne-Marie Beausoleil
Lan Jiang
Cameron Smith
Steven D E Sullivan
Orden Lori Jean Van
Pierre-Jean Colson
Gene Timothy Fass
Noah Benjamin
Marta Dabros
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of CO2018005640A2 publication Critical patent/CO2018005640A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención provee compuestos de fórmula (I): en donde X es (I) y las variables se definen en la memoria descriptiva, o una sal farmacéuticamente aceptable de los mismos, que son útiles como inhibidores de JAK quinasa. La invención también provee composiciones farmacéuticas que comprenden dichos compuestos, métodos para usar dichos compuestos para tratar enfermedades respiratorias, y procesos e intermediarios útiles para preparar dichos compuestos
CONC2018/0005640A 2015-11-03 2018-05-29 Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria CO2018005640A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (1)

Publication Number Publication Date
CO2018005640A2 true CO2018005640A2 (es) 2018-05-31

Family

ID=57442794

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0005640A CO2018005640A2 (es) 2015-11-03 2018-05-29 Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria

Country Status (22)

Country Link
US (6) US10100049B2 (es)
EP (1) EP3371186A1 (es)
JP (1) JP6800969B2 (es)
KR (1) KR20180073687A (es)
CN (1) CN108349972B (es)
AU (1) AU2016350816B2 (es)
BR (1) BR112018008966B1 (es)
CA (1) CA3001542C (es)
CL (1) CL2018001145A1 (es)
CO (1) CO2018005640A2 (es)
EA (1) EA034914B1 (es)
HK (1) HK1252685A1 (es)
IL (1) IL258772B (es)
MX (1) MX374605B (es)
MY (1) MY195427A (es)
NZ (1) NZ741737A (es)
PH (1) PH12018500828B1 (es)
SA (1) SA518391470B1 (es)
TW (1) TWI710560B (es)
UA (1) UA123633C2 (es)
WO (1) WO2017079205A1 (es)
ZA (1) ZA201802496B (es)

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US10556901B2 (en) 2015-11-03 2020-02-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors
TWI754019B (zh) 2017-03-09 2022-02-01 美商施萬生物製藥研發 Ip有限責任公司 含有4員雜環醯胺之jak抑制劑
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
CA3059785A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
SG11201909376TA (en) 2017-05-01 2019-11-28 Theravance Biopharma R&D Ip Llc Crystalline forms of a jak inhibitor compound
BR112021004052A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc amidas de dimetil-amino azetidina como inibidores de jak
WO2020051135A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
JP7383696B2 (ja) 2018-09-04 2023-11-20 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤としての５員～７員の複素環アミド
CA3113667A1 (en) 2018-10-29 2020-05-07 Theravance Biopharma R&D Ip, Llc 2-azabicyclo hexane compound as jak inhibitor
CN117083273A (zh) 2021-03-26 2023-11-17 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的二盐酸盐的晶型

Also Published As

Publication number Publication date
JP2018531982A (ja) 2018-11-01
MX374605B (es) 2025-03-06
US20190106420A1 (en) 2019-04-11
ZA201802496B (en) 2025-01-29
US20180319796A1 (en) 2018-11-08
EA201891091A1 (ru) 2018-12-28
EA034914B1 (ru) 2020-04-06
US11718616B2 (en) 2023-08-08
WO2017079205A1 (en) 2017-05-11
IL258772A (en) 2018-06-28
HK1252685A1 (zh) 2019-05-31
CN108349972A (zh) 2018-07-31
UA123633C2 (uk) 2021-05-05
MY195427A (en) 2023-01-20
NZ741737A (en) 2023-11-24
CA3001542C (en) 2021-02-16
US20170121327A1 (en) 2017-05-04
US20200087303A1 (en) 2020-03-19
US20210130351A1 (en) 2021-05-06
IL258772B (en) 2021-01-31
TWI710560B (zh) 2020-11-21
KR20180073687A (ko) 2018-07-02
AU2016350816B2 (en) 2020-06-25
US11299492B2 (en) 2022-04-12
US20220306624A1 (en) 2022-09-29
CL2018001145A1 (es) 2018-07-06
AU2016350816A1 (en) 2018-05-17
BR112018008966B1 (pt) 2023-05-02
SA518391470B1 (ar) 2021-03-31
BR112018008966A2 (pt) 2018-11-27
JP6800969B2 (ja) 2020-12-16
PH12018500828A1 (en) 2018-10-29
PH12018500828B1 (en) 2023-06-30
CA3001542A1 (en) 2017-05-11
US10526330B2 (en) 2020-01-07
TW201726673A (zh) 2017-08-01
CN108349972B (zh) 2021-06-08
EP3371186A1 (en) 2018-09-12
MX2018005446A (es) 2018-08-01
US10100049B2 (en) 2018-10-16
US10913740B2 (en) 2021-02-09
US10183942B2 (en) 2019-01-22

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