MX2016014404A - Preparacion liquida acuosa que contiene acido 2-amino-3-(bromobenzoil) fenilacetico. - Google Patents
Preparacion liquida acuosa que contiene acido 2-amino-3-(bromobenzoil) fenilacetico.Info
- Publication number
- MX2016014404A MX2016014404A MX2016014404A MX2016014404A MX2016014404A MX 2016014404 A MX2016014404 A MX 2016014404A MX 2016014404 A MX2016014404 A MX 2016014404A MX 2016014404 A MX2016014404 A MX 2016014404A MX 2016014404 A MX2016014404 A MX 2016014404A
- Authority
- MX
- Mexico
- Prior art keywords
- liquid preparation
- aqueous liquid
- rhinitis
- bromobenzoyl
- amino
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title 1
- 206010039083 rhinitis Diseases 0.000 abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 206010010741 Conjunctivitis Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000000592 Nasal Polyps Diseases 0.000 abstract 1
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010039705 Scleritis Diseases 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000010217 blepharitis Diseases 0.000 abstract 1
- ZBPLOVFIXSTCRZ-UHFFFAOYSA-N bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 abstract 1
- 201000009151 chronic rhinitis Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- -1 fatty acid ester Chemical class 0.000 abstract 1
- 230000001969 hypertrophic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000016366 nasal cavity polyp Diseases 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920001664 tyloxapol Polymers 0.000 abstract 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 abstract 1
- 229960004224 tyloxapol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una preparación líquida acuosa de la presente invención que contiene ácido 2-amino-3-(4-bromobenzoil)fenilacético o su sal farmacológicamente aceptable o un hidrato del mismo, un polímero de tipo alcohol de poliéter de alquilarilo tal como Tiloxapol o un éster de ácido graso de polietilenglicol tal como un monoestearato de polietilenglicol es estable. Una modalidad de dicha preparación líquida no incluye conservante alguno. Dicha preparación líquida acuosa en forma de gotas oculares es útil para el tratamiento de blefaritis, conjuntivitis, escleritis e inflamación post-operatoria. Asimismo, la preparación líquida acuosa de la presente invención en forma de una gota nasal es útil para el tratamiento de la rinitis alérgica y rinitis alérgica (por ejemplo, rinitis crónica, rinitis hipertrófica, pólipo nasal, etc.).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003012427 | 2003-01-21 | ||
| US14/269,692 US9144609B2 (en) | 2003-01-21 | 2014-05-05 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid |
| PCT/IB2015/000887 WO2015170177A1 (en) | 2003-01-21 | 2015-05-05 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016014404A true MX2016014404A (es) | 2017-10-27 |
Family
ID=32767329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014404A MX2016014404A (es) | 2003-01-21 | 2015-05-05 | Preparacion liquida acuosa que contiene acido 2-amino-3-(bromobenzoil) fenilacetico. |
Country Status (15)
| Country | Link |
|---|---|
| US (9) | US8129431B2 (es) |
| EP (1) | EP1586316B1 (es) |
| JP (1) | JP4500261B2 (es) |
| KR (1) | KR101059711B1 (es) |
| CN (1) | CN100341498C (es) |
| AT (1) | ATE393627T1 (es) |
| BE (1) | BE2011C027I2 (es) |
| CA (2) | CA2944832C (es) |
| DE (2) | DE122011100019I1 (es) |
| ES (1) | ES2301964T3 (es) |
| FR (1) | FR11C0031I2 (es) |
| HU (1) | HUS1100022I1 (es) |
| MX (1) | MX2016014404A (es) |
| PT (1) | PT1586316E (es) |
| WO (2) | WO2004064828A1 (es) |
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| CA2560559C (en) | 2004-11-05 | 2013-07-02 | Senju Pharmaceutical Co., Ltd. | Aqueous intraocular penetration-promoting eye drop |
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| BRPI0808410A2 (pt) * | 2007-02-28 | 2015-06-23 | Aciex Therapeutics Inc | Métodos e composições para normalizar secreções da glândula meibomiana |
| CN101754748A (zh) * | 2007-05-24 | 2010-06-23 | 阿西克斯医疗公司 | 治疗干眼症的制剂和方法 |
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| EP2420223B1 (en) * | 2008-03-17 | 2017-07-19 | Novartis Ag | Aqueous pharmaceutical compositions containing borate-polyol complexes |
| US8778999B2 (en) | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
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| MX348418B (es) | 2011-10-12 | 2017-06-12 | Bausch & Lomb | Composicion ocular que contiene bromfenaco con biodisponibilidad incrementada. |
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| JP6353365B2 (ja) * | 2012-09-27 | 2018-07-04 | 千寿製薬株式会社 | 水性液剤 |
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| MX348418B (es) * | 2011-10-12 | 2017-06-12 | Bausch & Lomb | Composicion ocular que contiene bromfenaco con biodisponibilidad incrementada. |
| CA2890182C (en) * | 2012-11-19 | 2020-10-06 | Bausch & Lomb Incorporated | Aqueous liquid composition containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid |
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2004
- 2004-01-16 DE DE201112100019 patent/DE122011100019I1/de active Pending
- 2004-01-16 ES ES04702854T patent/ES2301964T3/es not_active Expired - Lifetime
- 2004-01-16 AT AT04702854T patent/ATE393627T1/de active
- 2004-01-16 EP EP04702854A patent/EP1586316B1/en not_active Expired - Lifetime
- 2004-01-16 CN CNB2004800009763A patent/CN100341498C/zh not_active Expired - Lifetime
- 2004-01-16 WO PCT/JP2004/000350 patent/WO2004064828A1/ja not_active Ceased
- 2004-01-16 US US10/525,006 patent/US8129431B2/en not_active Expired - Lifetime
- 2004-01-16 PT PT04702854T patent/PT1586316E/pt unknown
- 2004-01-16 DE DE602004013420T patent/DE602004013420T2/de not_active Expired - Lifetime
- 2004-01-16 JP JP2005508062A patent/JP4500261B2/ja not_active Expired - Fee Related
- 2004-01-16 KR KR1020057004667A patent/KR101059711B1/ko not_active Expired - Fee Related
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2007
- 2007-05-30 US US11/755,662 patent/US20070287749A1/en not_active Abandoned
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2011
- 2011-08-17 FR FR11C0031C patent/FR11C0031I2/fr active Active
- 2011-08-30 BE BE2011C027C patent/BE2011C027I2/fr unknown
- 2011-11-04 HU HUS1100022C patent/HUS1100022I1/hu unknown
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2012
- 2012-01-19 US US13/353,653 patent/US8497304B2/en not_active Expired - Fee Related
- 2012-11-28 US US13/687,242 patent/US8669290B2/en not_active Expired - Lifetime
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2014
- 2014-01-28 US US14/165,976 patent/US8754131B2/en not_active Expired - Lifetime
- 2014-04-25 US US14/261,720 patent/US8871813B2/en not_active Expired - Lifetime
- 2014-05-05 US US14/269,692 patent/US9144609B2/en not_active Expired - Lifetime
- 2014-09-23 US US14/493,903 patent/US8927606B1/en not_active Expired - Lifetime
- 2014-09-30 US US14/502,014 patent/US9561277B2/en not_active Expired - Fee Related
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2015
- 2015-05-05 MX MX2016014404A patent/MX2016014404A/es unknown
- 2015-05-05 WO PCT/IB2015/000887 patent/WO2015170177A1/en not_active Ceased
- 2015-05-05 CA CA2944832A patent/CA2944832C/en not_active Expired - Fee Related
- 2015-05-05 CA CA3043910A patent/CA3043910A1/en not_active Abandoned
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