DE122011100019I1 - Wassrige flussige zubereitung mit 2-amino-3-(4-bromobenzoyl) phenylessigsaure. - Google Patents
Wassrige flussige zubereitung mit 2-amino-3-(4-bromobenzoyl) phenylessigsaure.Info
- Publication number
- DE122011100019I1 DE122011100019I1 DE201112100019 DE122011100019C DE122011100019I1 DE 122011100019 I1 DE122011100019 I1 DE 122011100019I1 DE 201112100019 DE201112100019 DE 201112100019 DE 122011100019 C DE122011100019 C DE 122011100019C DE 122011100019 I1 DE122011100019 I1 DE 122011100019I1
- Authority
- DE
- Germany
- Prior art keywords
- liquid preparation
- aqueous liquid
- rhinitis
- bromobenzoyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title abstract 5
- ZBPLOVFIXSTCRZ-UHFFFAOYSA-N bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002335 preservative effect Effects 0.000 abstract 3
- 206010039083 rhinitis Diseases 0.000 abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 abstract 1
- 206010010741 Conjunctivitis Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000000592 Nasal Polyps Diseases 0.000 abstract 1
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010039705 Scleritis Diseases 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000010217 blepharitis Diseases 0.000 abstract 1
- 201000009151 chronic rhinitis Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- -1 fatty acid ester Chemical class 0.000 abstract 1
- 230000001969 hypertrophic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000016366 nasal cavity polyp Diseases 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920001664 tyloxapol Polymers 0.000 abstract 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 abstract 1
- 229960004224 tyloxapol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003012427 | 2003-01-21 | ||
| PCT/JP2004/000350 WO2004064828A1 (ja) | 2003-01-21 | 2004-01-16 | 2−アミノ−3−(4−ブロモベンゾイル)フェニル酢酸含有水性液剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE122011100019I1 true DE122011100019I1 (de) | 2011-11-03 |
Family
ID=32767329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE201112100019 Pending DE122011100019I1 (de) | 2003-01-21 | 2004-01-16 | Wassrige flussige zubereitung mit 2-amino-3-(4-bromobenzoyl) phenylessigsaure. |
| DE602004013420T Expired - Lifetime DE602004013420T2 (de) | 2003-01-21 | 2004-01-16 | Wässrige flüssige zubereitung mit 2-amino-3-(4-bromobenzoyl)phenylessigsäure |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004013420T Expired - Lifetime DE602004013420T2 (de) | 2003-01-21 | 2004-01-16 | Wässrige flüssige zubereitung mit 2-amino-3-(4-bromobenzoyl)phenylessigsäure |
Country Status (15)
| Country | Link |
|---|---|
| US (9) | US8129431B2 (de) |
| EP (1) | EP1586316B1 (de) |
| JP (1) | JP4500261B2 (de) |
| KR (1) | KR101059711B1 (de) |
| CN (1) | CN100341498C (de) |
| AT (1) | ATE393627T1 (de) |
| BE (1) | BE2011C027I2 (de) |
| CA (2) | CA2944832C (de) |
| DE (2) | DE122011100019I1 (de) |
| ES (1) | ES2301964T3 (de) |
| FR (1) | FR11C0031I2 (de) |
| HU (1) | HUS1100022I1 (de) |
| MX (1) | MX2016014404A (de) |
| PT (1) | PT1586316E (de) |
| WO (2) | WO2004064828A1 (de) |
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| KR101059711B1 (ko) * | 2003-01-21 | 2011-08-29 | 센주 세이야꾸 가부시키가이샤 | 2-아미노-3-(4-브로모벤조일)페닐아세트산 함유 수성액제 |
| JP4933897B2 (ja) * | 2004-11-05 | 2012-05-16 | 千寿製薬株式会社 | 眼内移行性促進水性点眼剤 |
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| US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
| EP1981491A4 (de) * | 2006-01-25 | 2009-09-23 | Aciex Inc | Formulierungen und verfahren zur behandlung von keratoconjunctivitis sicca |
| AU2008219600A1 (en) * | 2007-02-28 | 2008-09-04 | Aciex Therapeutics, Inc. | Methods and compositions for normalizing meibomian gland secretions |
| EP2160182A1 (de) * | 2007-05-24 | 2010-03-10 | Aciex Therapeutics, Inc. | Formulierungen und verfahren zur behandlung von keratoconjunctivitis sicca |
| CN101313899B (zh) * | 2007-06-01 | 2012-02-29 | 北京德众万全药物技术开发有限公司 | 一种含有溴芬酸钠的眼用药物组合物 |
| WO2009105534A2 (en) * | 2008-02-21 | 2009-08-27 | Ista Pharmaceuticals | Ophthalmic nsaids as adjuvants |
| DK2420223T3 (da) * | 2008-03-17 | 2017-11-06 | Novartis Ag | Vandige farmaceutiske sammensætninger med borat-polyol-komplekser |
| US8778999B2 (en) * | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
| GB2484843A (en) * | 2009-10-15 | 2012-04-25 | Johnson Matthey Plc | Polymorphs of Bromfenac sodium |
| US8299295B2 (en) | 2009-10-15 | 2012-10-30 | Johnson Matthey Public Limited Company | Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs |
| GB0919757D0 (en) * | 2009-11-12 | 2009-12-30 | Johnson Matthey Plc | Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs |
| EP2498768A1 (de) * | 2009-11-11 | 2012-09-19 | Micro Labs Limited | Pharmazeutische kombination aus einer prostaglandinverbindung und nsaid zur behandlung von glaukom und augenhochdruck |
| CN103379904A (zh) * | 2011-01-18 | 2013-10-30 | 千寿制药株式会社 | 具有保存效能的溴芬酸水性液剂组合物 |
| JP6012231B2 (ja) * | 2011-04-08 | 2016-10-25 | ロート製薬株式会社 | ブロムフェナク含有組成物 |
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| US20130023575A1 (en) * | 2011-07-22 | 2013-01-24 | Kamran Hosseini | Compositions and methods for the treatment of ocular surface allergies |
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| US20130217657A1 (en) * | 2011-12-21 | 2013-08-22 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| US20130165419A1 (en) * | 2011-12-21 | 2013-06-27 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| CN104661682B (zh) * | 2012-09-27 | 2018-05-11 | 千寿制药株式会社 | 水性液剂 |
| JP6161500B2 (ja) * | 2012-10-05 | 2017-07-12 | ロート製薬株式会社 | ブロムフェナク含有組成物 |
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| WO2014120293A1 (en) * | 2013-01-31 | 2014-08-07 | Sentiss Pharma Pvt.Ltd. | Ophthalmic formulations |
| BR112015017919A8 (pt) | 2013-01-31 | 2019-11-05 | Senju Pharma Co | preparação líquida aquosa e método para clarificar uma preparação líquida aquosa |
| KR20150110775A (ko) * | 2013-01-31 | 2015-10-02 | 센주 세이야꾸 가부시키가이샤 | 안정한 수성액제 |
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| KR101059711B1 (ko) * | 2003-01-21 | 2011-08-29 | 센주 세이야꾸 가부시키가이샤 | 2-아미노-3-(4-브로모벤조일)페닐아세트산 함유 수성액제 |
| ATE552838T1 (de) * | 2003-11-14 | 2012-04-15 | Senju Pharma Co | Wässrige lösung mit aminoglykosid-antibiotikum und bromfenac |
| JP5223052B2 (ja) | 2010-05-21 | 2013-06-26 | 春誠 鈴木 | コーキングガン |
| ES2992712T3 (en) * | 2011-10-12 | 2024-12-17 | Bausch & Lomb | Ocular composition containing bromfenac with increased bioavailability |
| WO2014078766A1 (en) * | 2012-11-19 | 2014-05-22 | Bausch & Lomb Incorporated | Aqueous liquid composition containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid |
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2004
- 2004-01-16 KR KR1020057004667A patent/KR101059711B1/ko not_active Expired - Fee Related
- 2004-01-16 WO PCT/JP2004/000350 patent/WO2004064828A1/ja not_active Ceased
- 2004-01-16 US US10/525,006 patent/US8129431B2/en not_active Expired - Lifetime
- 2004-01-16 PT PT04702854T patent/PT1586316E/pt unknown
- 2004-01-16 JP JP2005508062A patent/JP4500261B2/ja not_active Expired - Fee Related
- 2004-01-16 ES ES04702854T patent/ES2301964T3/es not_active Expired - Lifetime
- 2004-01-16 DE DE201112100019 patent/DE122011100019I1/de active Pending
- 2004-01-16 AT AT04702854T patent/ATE393627T1/de active
- 2004-01-16 EP EP04702854A patent/EP1586316B1/de not_active Expired - Lifetime
- 2004-01-16 CN CNB2004800009763A patent/CN100341498C/zh not_active Expired - Lifetime
- 2004-01-16 DE DE602004013420T patent/DE602004013420T2/de not_active Expired - Lifetime
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2007
- 2007-05-30 US US11/755,662 patent/US20070287749A1/en not_active Abandoned
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2011
- 2011-08-17 FR FR11C0031C patent/FR11C0031I2/fr active Active
- 2011-08-30 BE BE2011C027C patent/BE2011C027I2/fr unknown
- 2011-11-04 HU HUS1100022C patent/HUS1100022I1/hu unknown
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2012
- 2012-01-19 US US13/353,653 patent/US8497304B2/en not_active Expired - Fee Related
- 2012-11-28 US US13/687,242 patent/US8669290B2/en not_active Expired - Lifetime
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2014
- 2014-01-28 US US14/165,976 patent/US8754131B2/en not_active Expired - Lifetime
- 2014-04-25 US US14/261,720 patent/US8871813B2/en not_active Expired - Lifetime
- 2014-05-05 US US14/269,692 patent/US9144609B2/en not_active Expired - Lifetime
- 2014-09-23 US US14/493,903 patent/US8927606B1/en not_active Expired - Lifetime
- 2014-09-30 US US14/502,014 patent/US9561277B2/en not_active Expired - Fee Related
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2015
- 2015-05-05 CA CA2944832A patent/CA2944832C/en not_active Expired - Fee Related
- 2015-05-05 MX MX2016014404A patent/MX2016014404A/es unknown
- 2015-05-05 WO PCT/IB2015/000887 patent/WO2015170177A1/en not_active Ceased
- 2015-05-05 CA CA3043910A patent/CA3043910A1/en not_active Abandoned
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