MX2014015556A - Analogos de glucagon que exhiben actividad del receptor gip. - Google Patents
Analogos de glucagon que exhiben actividad del receptor gip.Info
- Publication number
- MX2014015556A MX2014015556A MX2014015556A MX2014015556A MX2014015556A MX 2014015556 A MX2014015556 A MX 2014015556A MX 2014015556 A MX2014015556 A MX 2014015556A MX 2014015556 A MX2014015556 A MX 2014015556A MX 2014015556 A MX2014015556 A MX 2014015556A
- Authority
- MX
- Mexico
- Prior art keywords
- gip receptor
- analogs
- receptor activity
- glucagon
- exhibiting gip
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 102000051325 Glucagon Human genes 0.000 title 1
- 108060003199 Glucagon Proteins 0.000 title 1
- 230000001747 exhibiting effect Effects 0.000 title 1
- 229960004666 glucagon Drugs 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
Se proporcionan en la presente análogos de glucagón que exhiben potente actividad en el receptor GIP, y, como tales se contemplan para el uso en el tratamiento de diabetes y obesidad. En modalidades ejemplares, el análogo de glucagón de las presentes descripciones exhibe una EC50 en el receptor GIP que está dentro del intervalo nanomolar o picomolar.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662874P | 2012-06-21 | 2012-06-21 | |
| US201361787973P | 2013-03-15 | 2013-03-15 | |
| PCT/US2013/046229 WO2013192130A1 (en) | 2012-06-21 | 2013-06-18 | Analogs of glucagon exhibiting gip receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014015556A true MX2014015556A (es) | 2015-03-05 |
| MX356000B MX356000B (es) | 2018-05-08 |
Family
ID=48692696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014015556A MX356000B (es) | 2012-06-21 | 2013-06-18 | Analogos de glucagon que exhiben actividad del receptor gip. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9868772B2 (es) |
| EP (1) | EP2864350B1 (es) |
| JP (1) | JP6300239B2 (es) |
| KR (1) | KR20150039748A (es) |
| CN (1) | CN104583233B (es) |
| AR (1) | AR091478A1 (es) |
| AU (1) | AU2013277372B2 (es) |
| BR (1) | BR112014031671A2 (es) |
| CA (1) | CA2877127A1 (es) |
| CL (1) | CL2014003421A1 (es) |
| CO (1) | CO7170125A2 (es) |
| CR (1) | CR20150015A (es) |
| DK (1) | DK2864350T3 (es) |
| EA (1) | EA029025B1 (es) |
| ES (1) | ES2674946T3 (es) |
| HR (1) | HRP20180936T1 (es) |
| HU (1) | HUE039267T2 (es) |
| IL (1) | IL236386B (es) |
| MX (1) | MX356000B (es) |
| MY (1) | MY185217A (es) |
| PE (1) | PE20150863A1 (es) |
| PH (1) | PH12014502857A1 (es) |
| PL (1) | PL2864350T3 (es) |
| PT (1) | PT2864350T (es) |
| RS (1) | RS57347B1 (es) |
| SG (1) | SG11201408491SA (es) |
| SI (1) | SI2864350T1 (es) |
| TR (1) | TR201808818T4 (es) |
| TW (1) | TWI644920B (es) |
| WO (1) | WO2013192130A1 (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3632919T (lt) | 2012-04-26 | 2023-02-27 | Bristol-Myers Squibb Company | Imidazotiadiazolo ir imidazopirazino dariniai, kaip proteazės aktyvuoto receptoriaus 4 (par4) inhibitoriai, skirti trombocitų agregacijos gydymui |
| DK2864350T3 (en) * | 2012-06-21 | 2018-05-28 | Univ Indiana Res & Tech Corp | ANALOGUE OF GLUCAGON EXPRESSING GIP RECEPTOR ACTIVITY |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| SG11201503526UA (en) | 2012-12-21 | 2015-06-29 | Sanofi Sa | Dual glp1/gip or trigonal glp1/gip/glucagon agonists |
| PE20151770A1 (es) | 2013-05-28 | 2015-12-11 | Takeda Pharmaceutical | Compuesto peptidico |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3082847A1 (en) * | 2013-12-20 | 2016-10-26 | Indiana University Research and Technology Corporation | Lipidated incretin receptor ligand human immunoglobulin fc-region fusion polypeptides |
| TW201625670A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| MX382408B (es) | 2014-10-24 | 2025-03-13 | Merck Sharp & Dohme Llc | Coagonistas de los receptores de glucagón y de glp-1. |
| AR103322A1 (es) | 2014-12-30 | 2017-05-03 | Hanmi Pharm Ind Co Ltd | Derivados de glucagón con estabilidad mejorada |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| PT3322437T (pt) | 2015-06-30 | 2024-03-20 | Hanmi Pharmaceutical Co Ltd | Derivado de glucagon e composição que compreende um conjugado de ação prolongada do mesmo |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| ES2968038T3 (es) | 2015-12-23 | 2024-05-06 | Univ Johns Hopkins | Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas |
| EA038544B1 (ru) * | 2015-12-31 | 2021-09-13 | Ханми Фарм. Ко., Лтд. | Тройной агонист рецепторов глюкагона/glp-1/gip |
| US10501516B2 (en) | 2016-05-24 | 2019-12-10 | Takeda Pharmaceutical Company Limited | Peptide compound |
| UA126662C2 (uk) | 2016-06-29 | 2023-01-11 | Ханмі Фарм. Ко., Лтд. | Похідна глюкагону, її кон'югат, композиція, яка її містить, та її терапевтичне застосування |
| TW201833131A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 作為胜肽類ｇｌｐ１／升糖素／ｇｉｐ受體促效劑之新化合物 |
| TW201833132A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 作為肽類ｇｌｐ１／升糖素／ｇｉｐ三重受體激動劑之新穎化合物 |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| CN120887972A (zh) * | 2017-11-24 | 2025-11-04 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的胰高血糖素类似物 |
| AU2019250362B2 (en) | 2018-04-10 | 2025-11-06 | Sanofi-Aventis Deutschland Gmbh | Lixisenatide synthesis with capping |
| JP7434169B2 (ja) | 2018-04-10 | 2024-02-20 | サノフィ－アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 固相からの固相結合ペプチドの切断方法 |
| TWI707865B (zh) | 2018-05-04 | 2020-10-21 | 丹麥商諾佛 儂迪克股份有限公司 | Gip衍生物及其用途 |
| TW202015735A (zh) | 2018-05-30 | 2020-05-01 | 法商賽諾菲公司 | 包含ｇｌｐ－１／升糖素／ｇｉｐ三重受體促效劑、連接子及透明質酸之接合物 |
| TW202523681A (zh) * | 2018-07-23 | 2025-06-16 | 美商美國禮來大藥廠 | Gip/glp1共促效劑化合物 |
| US11166910B2 (en) | 2019-01-25 | 2021-11-09 | Nordiccan A/S | Cannabinoid chewing gum with sugar alcohols |
| WO2021169512A1 (zh) * | 2020-02-24 | 2021-09-02 | 中山大学 | 多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用 |
| AR121650A1 (es) * | 2020-03-25 | 2022-06-22 | Takeda Pharmaceuticals Co | Dosificación qd de compuestos peptídicos agonistas del receptor de gip y sus usos |
| CN113493503B (zh) * | 2020-04-08 | 2022-08-05 | 浙江道尔生物科技有限公司 | 一种肠促胰岛素类似物及其制备方法和用途 |
| MX2023000303A (es) | 2020-07-22 | 2023-02-09 | Novo Nordisk As | Coagonistas de los receptores del peptido 1 similar al glucagon (glp-1) y del polipeptido insulinotropico dependiente de glucosa (gip) adecuados para el suministro oral. |
| CN114621327B (zh) * | 2020-12-10 | 2023-08-18 | 江苏中新医药有限公司 | GLP-1、GIP和Gcg多重受体激动蛋白质 |
| WO2022133797A1 (zh) | 2020-12-23 | 2022-06-30 | 浙江道尔生物科技有限公司 | 一种长效胰高血糖素衍生物 |
| CN117120462A (zh) * | 2021-01-22 | 2023-11-24 | 深圳市图微安创科技开发有限公司 | 多肽化合物在预防或治疗炎症性肠病及其相关的肠纤维化中的应用 |
| WO2023288313A1 (en) * | 2021-07-16 | 2023-01-19 | Pep2Tango Therapeutics Inc. | Compositions including multi-agonist peptides and methods of manufacture and use |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| CN115490760B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物 |
| JP7402574B1 (ja) | 2023-03-15 | 2023-12-21 | 株式会社合同資源 | α－ヨード置換カルボン酸 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| IN165717B (es) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤 |
| US6303144B1 (en) | 1998-02-10 | 2001-10-16 | Welfide Corporation | Preparations with controlled release |
| GB2344287A (en) | 1998-12-03 | 2000-06-07 | Ferring Bv | Controlled release pharmaceutical formulation |
| EP1551505B1 (en) | 2002-10-04 | 2010-02-24 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
| SE0302312D0 (sv) * | 2002-10-04 | 2003-08-27 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| AU2004204494B2 (en) | 2003-01-09 | 2011-09-29 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| AU2007249736A1 (en) | 2006-05-15 | 2007-11-22 | Wisconsin Alumni Research Foundation | Pulmonary delivery of 1alpha,25-dihydroxyvitamin D3 and co-administration of parathyroid hormone or calcitonin |
| FR2902092B1 (fr) | 2006-06-07 | 2008-09-05 | Sapelem Soc Par Actions Simpli | Appareil de manutention de charge |
| AU2008216265B2 (en) * | 2007-02-15 | 2014-04-03 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| US8282990B2 (en) | 2007-04-19 | 2012-10-09 | Dong-A Pharmaceutical, Co., Ltd. | Method for preparing a biodegradable polymer microsphere containing a glucose-regulating peptide |
| CN103298935A (zh) | 2007-08-15 | 2013-09-11 | 阿穆尼克斯公司 | 用于改善生物活性多肽性能的组合物和方法 |
| MX337038B (es) * | 2008-06-17 | 2016-02-10 | Univ Indiana Res & Tech Corp | Co-antagonistas de receptor de glucagon/glp-1. |
| EP2300035B1 (en) | 2008-06-17 | 2015-08-12 | Indiana University Research and Technology Corporation | Gip-based mixed agonists for treatment of metabolic disorders and obesity |
| SG172291A1 (en) | 2008-12-19 | 2011-07-28 | Univ Indiana Res & Tech Corp | Amide based glucagon superfamily peptide prodrugs |
| MX2011013625A (es) | 2009-06-16 | 2012-01-20 | Univ Indiana Res & Tech Corp | Compuestos glucagon activo de receptor de gip. |
| JP2013518115A (ja) | 2010-01-27 | 2013-05-20 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐ｇｉｐアゴニスト複合体及び組成物 |
| ES2661228T3 (es) * | 2010-05-13 | 2018-03-28 | Indiana University Research And Technology Corporation | Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona |
| CA2796894A1 (en) * | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Amide based glucagon superfamily peptide prodrugs |
| MX2013015168A (es) * | 2011-06-22 | 2014-03-31 | Univ Indiana Res & Tech Corp | Co-agonista del receptor de glucagon/glp-1. |
| ME02816B (me) * | 2011-06-22 | 2018-01-20 | Univ Indiana Res & Tech Corp | Koagonisti receptora za glukagon/glp-1 receptora |
| DK2864350T3 (en) * | 2012-06-21 | 2018-05-28 | Univ Indiana Res & Tech Corp | ANALOGUE OF GLUCAGON EXPRESSING GIP RECEPTOR ACTIVITY |
| ES2822994T3 (es) * | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
-
2013
- 2013-06-18 DK DK13731246.8T patent/DK2864350T3/en active
- 2013-06-18 EA EA201590065A patent/EA029025B1/ru not_active IP Right Cessation
- 2013-06-18 CN CN201380043984.5A patent/CN104583233B/zh not_active Expired - Fee Related
- 2013-06-18 KR KR20157001447A patent/KR20150039748A/ko not_active Abandoned
- 2013-06-18 CA CA2877127A patent/CA2877127A1/en not_active Abandoned
- 2013-06-18 AR ARP130102143 patent/AR091478A1/es unknown
- 2013-06-18 US US14/408,813 patent/US9868772B2/en not_active Expired - Fee Related
- 2013-06-18 ES ES13731246.8T patent/ES2674946T3/es active Active
- 2013-06-18 JP JP2015518506A patent/JP6300239B2/ja not_active Expired - Fee Related
- 2013-06-18 MX MX2014015556A patent/MX356000B/es active IP Right Grant
- 2013-06-18 SG SG11201408491SA patent/SG11201408491SA/en unknown
- 2013-06-18 RS RS20180728A patent/RS57347B1/sr unknown
- 2013-06-18 HU HUE13731246A patent/HUE039267T2/hu unknown
- 2013-06-18 TR TR2018/08818T patent/TR201808818T4/tr unknown
- 2013-06-18 PE PE2014002465A patent/PE20150863A1/es not_active Application Discontinuation
- 2013-06-18 PL PL13731246T patent/PL2864350T3/pl unknown
- 2013-06-18 TW TW102121585A patent/TWI644920B/zh not_active IP Right Cessation
- 2013-06-18 MY MYPI2014003510A patent/MY185217A/en unknown
- 2013-06-18 SI SI201331079T patent/SI2864350T1/en unknown
- 2013-06-18 HR HRP20180936TT patent/HRP20180936T1/hr unknown
- 2013-06-18 BR BR112014031671A patent/BR112014031671A2/pt not_active Application Discontinuation
- 2013-06-18 WO PCT/US2013/046229 patent/WO2013192130A1/en not_active Ceased
- 2013-06-18 EP EP13731246.8A patent/EP2864350B1/en not_active Not-in-force
- 2013-06-18 PT PT137312468T patent/PT2864350T/pt unknown
- 2013-06-18 AU AU2013277372A patent/AU2013277372B2/en not_active Ceased
-
2014
- 2014-12-17 CL CL2014003421A patent/CL2014003421A1/es unknown
- 2014-12-21 IL IL236386A patent/IL236386B/en active IP Right Grant
- 2014-12-22 PH PH12014502857A patent/PH12014502857A1/en unknown
-
2015
- 2015-01-19 CR CR20150015A patent/CR20150015A/es not_active Application Discontinuation
- 2015-01-19 CO CO15009514A patent/CO7170125A2/es unknown
-
2017
- 2017-12-04 US US15/830,158 patent/US20180105569A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12014502857A1 (en) | Analogs of glucagon exhibiting gip receptor activity | |
| MX2014015558A (es) | Analogos de glucagon que exhiben actividad del receptor gip. | |
| PH12013501215A1 (en) | Glucagon analogs exhibiting gip receptor activity | |
| LT2916860T (lt) | Diabeto gydymui skirta kompozicija, apimanti oksintomodulino analogą | |
| GEP20176808B (en) | Fused heterocyclic compound | |
| MX2016005560A (es) | Compuestos agonistas triples de glucagon-glp-1-gip. | |
| SG11201503230XA (en) | Glucagon/glp-1 agonists for the treatment of obesity | |
| PH12016501192B1 (en) | Tetrahydropyridopyrazines modulators of gpr6 | |
| MX2016004325A (es) | Nuevo derivado de un analogo de insulina. | |
| IL235484A0 (en) | Glucokinase-activating preparations for the treatment of diabetes | |
| PH12016500978A1 (en) | Piperazine derivatives having multimodal activity against pain | |
| MX2019008643A (es) | Uso de serlopitant como antagonistas del receptor nk-1 en prurito. | |
| SG11201406447SA (en) | (r) -nifuratel, its use for the treatment of infections and synthesis of (r) and (s) -nifuratel | |
| MX2016006603A (es) | Compuestos piperidinicos con actividad multimodal contra el dolor. | |
| SG10201900954SA (en) | Heterocycles as Modulators of Kinase Activity | |
| MX2015014470A (es) | Analogos de combretastatina. | |
| MX348841B (es) | Derivados de pirimidooxazocina como inhibidores de mtor. | |
| MX2015005312A (es) | Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12. | |
| NZ719451A (en) | Glucagon analog for treatment of severe hypoglycemia | |
| NZ719463A (en) | Glucagon analog for treatment of severe hypoglycemia | |
| TW201241006A (en) | Glucagon analogs exhibiting GIP receptor activity | |
| UA109404C2 (ru) | 6-(2-r-метилселено)-2-оксо-4-фенил-3,5-дициано-1,2,3,4-тетрагидропиридины |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |