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MX2014003584A - Derivados de metanosulfonamida sustituidos como ligandos de receptores vaniloides. - Google Patents

Derivados de metanosulfonamida sustituidos como ligandos de receptores vaniloides.

Info

Publication number
MX2014003584A
MX2014003584A MX2014003584A MX2014003584A MX2014003584A MX 2014003584 A MX2014003584 A MX 2014003584A MX 2014003584 A MX2014003584 A MX 2014003584A MX 2014003584 A MX2014003584 A MX 2014003584A MX 2014003584 A MX2014003584 A MX 2014003584A
Authority
MX
Mexico
Prior art keywords
receptor ligands
vanilloid receptor
methanesulfonamide derivatives
substituted
substituted methanesulfonamide
Prior art date
Application number
MX2014003584A
Other languages
English (en)
Inventor
Thomas Christoph
Gregor Bahrenberg
Jeewoo Lee
Bernhard Lesch
Robert Frank-Foltyn
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014003584A publication Critical patent/MX2014003584A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurosurgery (AREA)
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  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
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Abstract

La invención se refiere a derivados de metanosulfonamida sustituida como ligandos de receptores vaniloides, para composiciones farmacéuticas conteniendo estos compuestos y además a estos compuestos para el uso en el tratamiento y/o profilaxis de dolor y enfermedades adicionales y/o trastornos.
MX2014003584A 2011-09-26 2012-09-25 Derivados de metanosulfonamida sustituidos como ligandos de receptores vaniloides. MX2014003584A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11007806 2011-09-26
PCT/EP2012/068883 WO2013045452A1 (en) 2011-09-26 2012-09-25 Substituted methanesulfonamide derivatives as vanilloid receptor ligands

Publications (1)

Publication Number Publication Date
MX2014003584A true MX2014003584A (es) 2014-04-25

Family

ID=46924441

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003584A MX2014003584A (es) 2011-09-26 2012-09-25 Derivados de metanosulfonamida sustituidos como ligandos de receptores vaniloides.

Country Status (10)

Country Link
US (1) US20130079373A1 (es)
EP (1) EP2760837A1 (es)
JP (1) JP2014526547A (es)
KR (1) KR20140073539A (es)
CN (1) CN103906734A (es)
AU (1) AU2012314509A1 (es)
BR (1) BR112014006675A2 (es)
CA (1) CA2849933A1 (es)
MX (1) MX2014003584A (es)
WO (1) WO2013045452A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3224252B1 (en) 2014-11-24 2019-01-09 Medifron Dbt Inc. Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands ii
EP3130589A1 (en) 2015-08-13 2017-02-15 Grünenthal GmbH Heterocyclic aza compounds
CN108785676A (zh) * 2018-06-25 2018-11-13 青岛大学 Trpv1对map成瘾调控作用
CN111303023A (zh) * 2020-03-12 2020-06-19 湖南复瑞生物医药技术有限责任公司 一种2-氯-3-氰基-6-三氟甲基吡啶的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005314407A (ja) * 2004-03-31 2005-11-10 Nippon Nohyaku Co Ltd 新規なハロアルキルスルホンアニリド誘導体、除草剤及びその使用方法並びにその中間体
EP1940821B1 (de) * 2005-10-19 2013-03-20 Grünenthal GmbH Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln
BR112012021806A2 (pt) * 2010-03-01 2015-09-08 Myrexis Inc compostos e seus usos terapêusticos.

Also Published As

Publication number Publication date
BR112014006675A2 (pt) 2017-04-04
CA2849933A1 (en) 2013-04-04
EP2760837A1 (en) 2014-08-06
CN103906734A (zh) 2014-07-02
US20130079373A1 (en) 2013-03-28
KR20140073539A (ko) 2014-06-16
AU2012314509A1 (en) 2014-02-27
WO2013045452A1 (en) 2013-04-04
JP2014526547A (ja) 2014-10-06

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