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MX2014000964A - Derivados aza heterociclicos sustituidos. - Google Patents

Derivados aza heterociclicos sustituidos.

Info

Publication number
MX2014000964A
MX2014000964A MX2014000964A MX2014000964A MX2014000964A MX 2014000964 A MX2014000964 A MX 2014000964A MX 2014000964 A MX2014000964 A MX 2014000964A MX 2014000964 A MX2014000964 A MX 2014000964A MX 2014000964 A MX2014000964 A MX 2014000964A
Authority
MX
Mexico
Prior art keywords
substituted heterocyclic
aza derivatives
heterocyclic aza
compounds
derivatives
Prior art date
Application number
MX2014000964A
Other languages
English (en)
Inventor
Thomas Christoph
Jeewoo Lee
Bernhard Lesch
Robert Frank-Foltyn
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014000964A publication Critical patent/MX2014000964A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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Abstract

La invención se relaciona con derivados aza heterocíclicos como ligandos de receptor vainilloide, con composiciones farmacéuticas que contienen estos compuestos y también estos compuestos para uso en el tratamiento y/o profilaxis de dolor y enfermedades y/o trastornos adicionales.
MX2014000964A 2011-07-26 2012-07-25 Derivados aza heterociclicos sustituidos. MX2014000964A (es)

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PCT/EP2012/003138 WO2013013817A1 (en) 2011-07-26 2012-07-25 Substituted heterocyclic aza derivatives

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AU (1) AU2012289255A1 (es)
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WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
JP6936796B2 (ja) 2015-07-06 2021-09-22 ロダン・セラピューティクス，インコーポレーテッド ヒストンデアセチラーゼのヘテロハロ阻害剤
EP3130589A1 (en) 2015-08-13 2017-02-15 Grünenthal GmbH Heterocyclic aza compounds
EP3130590A1 (en) 2015-08-13 2017-02-15 Grünenthal GmbH Aromatic aza compounds as vr1/trpv1 ligands
US10604487B2 (en) 2016-01-14 2020-03-31 Research Cooperation Foundation Of Yeungnam University Pyridinol derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
AU2018207402B2 (en) 2017-01-11 2023-09-28 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
WO2019032528A1 (en) 2017-08-07 2019-02-14 Rodin Therapeutics, Inc BICYCLIC HISTONE DEACETYLASE INHIBITORS
CN108997202A (zh) * 2018-07-10 2018-12-14 湖南华腾制药有限公司 一种（5-三氟甲基-吡啶-2-基）-乙酸盐的制备方法
US20220340546A1 (en) * 2019-06-14 2022-10-27 Disarm Therapeutics, Inc. Inhibitors of sarm1
EP4052706A4 (en) * 2019-10-31 2023-11-08 Checkmate Therapeutics Inc. COMPOSITION FOR THE PREVENTION OR INHIBITION OF AXONAL DEGENERATION
WO2022030589A1 (ja) * 2020-08-05 2022-02-10 国立大学法人北海道大学 単座配位尿素化合物を含む配位子とそれを含むホウ素化触媒

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AU2008238250B2 (en) 2007-04-16 2013-01-24 Grunenthal Gmbh Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
DE102007018151A1 (de) * 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
CA2842916A1 (en) * 2011-07-26 2013-01-31 Grunenthal Gmbh Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

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CA2842983A1 (en) 2013-01-31
KR20140049027A (ko) 2014-04-24
AR087302A1 (es) 2014-03-12
JP2014521618A (ja) 2014-08-28
AU2012289255A1 (en) 2014-01-30
EP2736882A1 (en) 2014-06-04
BR112014001908A2 (pt) 2017-02-21
WO2013013817A1 (en) 2013-01-31

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