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MX2014000963A - Derivados de carboxamida y urea aromaticos biciclicos sustituidos como ligandos del receptor de vanilloide. - Google Patents

Derivados de carboxamida y urea aromaticos biciclicos sustituidos como ligandos del receptor de vanilloide.

Info

Publication number
MX2014000963A
MX2014000963A MX2014000963A MX2014000963A MX2014000963A MX 2014000963 A MX2014000963 A MX 2014000963A MX 2014000963 A MX2014000963 A MX 2014000963A MX 2014000963 A MX2014000963 A MX 2014000963A MX 2014000963 A MX2014000963 A MX 2014000963A
Authority
MX
Mexico
Prior art keywords
receptor ligands
bicyclic aromatic
urea derivatives
substituted bicyclic
vanilloid receptor
Prior art date
Application number
MX2014000963A
Other languages
English (en)
Inventor
Thomas Christoph
Jeewoo Lee
Bernhard Lesch
Robert Frank-Foltyn
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014000963A publication Critical patent/MX2014000963A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • General Health & Medical Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
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  • Diabetes (AREA)
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Abstract

La presente invención se refiere a carboxamida aromática bicíclica sustituida y derivados de urea como ligandos del receptor vanilloide, a composiciones farmacéuticas que contienen estos compuestos y también a estos compuestos para uso en el tratamiento y/o profilaxis de dolor y enfermedades y/o trastornos adicionales.
MX2014000963A 2011-07-26 2012-07-25 Derivados de carboxamida y urea aromaticos biciclicos sustituidos como ligandos del receptor de vanilloide. MX2014000963A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11006113 2011-07-26
PCT/EP2012/003136 WO2013013816A1 (en) 2011-07-26 2012-07-25 Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands

Publications (1)

Publication Number Publication Date
MX2014000963A true MX2014000963A (es) 2014-03-27

Family

ID=46639966

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000963A MX2014000963A (es) 2011-07-26 2012-07-25 Derivados de carboxamida y urea aromaticos biciclicos sustituidos como ligandos del receptor de vanilloide.

Country Status (9)

Country Link
US (1) US9029378B2 (es)
EP (1) EP2736899A1 (es)
JP (1) JP2014521617A (es)
KR (1) KR20140049028A (es)
AU (1) AU2012289254A1 (es)
BR (1) BR112014001714A2 (es)
CA (1) CA2842976A1 (es)
MX (1) MX2014000963A (es)
WO (1) WO2013013816A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10270003B2 (en) * 2012-12-04 2019-04-23 Taiwan Semiconductor Manufacturing Company, Ltd. Method and apparatus for CMOS sensor packaging
EP3130590A1 (en) * 2015-08-13 2017-02-15 Grünenthal GmbH Aromatic aza compounds as vr1/trpv1 ligands
CA3032334A1 (en) * 2016-07-29 2018-02-01 Lupin Limited Substituted thiazolo-pyridine compounds as malt1 inhibitors
CN108383782A (zh) * 2018-03-20 2018-08-10 北京凯恩梅格医药科技有限公司 4-氨基喹哪啶的合成方法
WO2022030589A1 (ja) * 2020-08-05 2022-02-10 国立大学法人北海道大学 単座配位尿素化合物を含む配位子とそれを含むホウ素化触媒
WO2025067473A1 (zh) * 2023-09-28 2025-04-03 四川大学华西医院 一种含苯环的具有镇痛功效的化合物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US20050113576A1 (en) * 2003-08-05 2005-05-26 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
CA2565211A1 (en) * 2004-04-29 2005-11-24 Abbott Laboratories Amino-tetrazoles analogues and methods of use
CA2592116A1 (en) 2004-12-23 2006-08-03 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
EP1940821B1 (de) 2005-10-19 2013-03-20 Grünenthal GmbH Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln
PE20070795A1 (es) 2005-10-28 2007-08-24 Lilly Co Eli Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa
WO2007113548A1 (en) 2006-04-06 2007-10-11 Astrazeneca Ab Naphthyridine derivatives
TW200824687A (en) * 2006-08-25 2008-06-16 Abbott Lab Compounds that inhibit TRPV1 and uses thereof
DE102007018151A1 (de) 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
CA2683461A1 (en) 2007-04-16 2008-10-23 Gruenenthal Gmbh Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
JP5478488B2 (ja) 2007-06-20 2014-04-23 メルク・シャープ・アンド・ドーム・コーポレーション Ｊａｎｕｓキナーゼの阻害剤
KR101171488B1 (ko) 2007-08-22 2012-08-07 아이알엠 엘엘씨 키나제 억제제로서의 2-헤테로아릴아미노-피리미딘 유도체
CN102395586A (zh) 2009-02-17 2012-03-28 奇斯药制品公司 作为p38map激酶抑制剂的三唑并吡啶衍生物
EP2241557A1 (de) 2009-04-02 2010-10-20 Æterna Zentaris GmbH Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen
ES2640257T3 (es) 2009-05-07 2017-11-02 Medifron Dbt Inc. Fenilureas y fenilamidas sustituidas como ligandos del receptor vanilloide
US8334315B2 (en) 2009-05-07 2012-12-18 Gruenenthal Gmbh Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands
SG178299A1 (en) 2009-08-28 2012-03-29 Daiichi Sankyo Co Ltd Novel tetrahydroisoquinoline compounds

Also Published As

Publication number Publication date
KR20140049028A (ko) 2014-04-24
CA2842976A1 (en) 2013-01-31
WO2013013816A1 (en) 2013-01-31
AU2012289254A1 (en) 2014-03-13
JP2014521617A (ja) 2014-08-28
EP2736899A1 (en) 2014-06-04
US20130029995A1 (en) 2013-01-31
US9029378B2 (en) 2015-05-12
BR112014001714A2 (pt) 2017-02-14

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