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HK1202117A1 - Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an so2-containing group as vanilloid receptor ligands - Google Patents

Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an so2-containing group as vanilloid receptor ligands Download PDF

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Publication number
HK1202117A1
HK1202117A1 HK15102581.4A HK15102581A HK1202117A1 HK 1202117 A1 HK1202117 A1 HK 1202117A1 HK 15102581 A HK15102581 A HK 15102581A HK 1202117 A1 HK1202117 A1 HK 1202117A1
Authority
HK
Hong Kong
Prior art keywords
substituted
containing group
receptor ligands
phenyl moiety
urea derivatives
Prior art date
Application number
HK15102581.4A
Other languages
Chinese (zh)
Inventor
Robert Frank-Foltyn
Thomas Christoph
Nils Damann
Bernhard Lesch
Gregor Bahrenberg
Derek John Saunders
Hannelore Stockhausen
Yong-Soo Kim
Myeong-Seop Kim
Jeewoo Lee
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of HK1202117A1 publication Critical patent/HK1202117A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
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  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
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  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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Abstract

The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with a S02-containing group as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
HK15102581.4A 2011-11-09 2012-11-08 Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an so2-containing group as vanilloid receptor ligands HK1202117A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11008927 2011-11-09
EP11008927.3 2011-11-09
PCT/EP2012/072143 WO2013068464A1 (en) 2011-11-09 2012-11-08 Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an so2-containing group as vanilloid receptor ligands

Publications (1)

Publication Number Publication Date
HK1202117A1 true HK1202117A1 (en) 2015-09-18

Family

ID=47143914

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102581.4A HK1202117A1 (en) 2011-11-09 2012-11-08 Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an so2-containing group as vanilloid receptor ligands

Country Status (13)

Country Link
EP (1) EP2776401A1 (en)
JP (1) JP2014532744A (en)
KR (1) KR20140091041A (en)
CN (1) CN104066720A (en)
AR (1) AR088799A1 (en)
AU (1) AU2012334068A1 (en)
BR (1) BR112014011108A2 (en)
CA (1) CA2854424A1 (en)
HK (1) HK1202117A1 (en)
IN (1) IN2014KN00865A (en)
MX (1) MX2014005233A (en)
TW (1) TW201326135A (en)
WO (1) WO2013068464A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20221373T1 (en) 2014-03-07 2023-01-06 Biocryst Pharmaceuticals, Inc. Substituted pyrazoles as human plasma kallikrein inhibitors
KR101909092B1 (en) 2014-11-24 2018-10-17 (주) 메디프론디비티 Substituted oxazole-and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands ii
CN114920697A (en) * 2022-05-16 2022-08-19 河南应用技术职业学院 Heterocyclic group substituted indan propionamide compound and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010244685B2 (en) 2009-05-07 2016-02-18 Medifron Dbt Inc. Substituted phenylureas and phenylamides as vanilloid receptor ligands
WO2010127855A1 (en) 2009-05-07 2010-11-11 Grünenthal GmbH Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands

Also Published As

Publication number Publication date
WO2013068464A1 (en) 2013-05-16
EP2776401A1 (en) 2014-09-17
BR112014011108A2 (en) 2017-05-16
AU2012334068A1 (en) 2014-05-22
CA2854424A1 (en) 2013-05-16
MX2014005233A (en) 2014-08-22
AR088799A1 (en) 2014-07-10
KR20140091041A (en) 2014-07-18
TW201326135A (en) 2013-07-01
IN2014KN00865A (en) 2015-10-02
JP2014532744A (en) 2014-12-08
CN104066720A (en) 2014-09-24

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