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MX2016011901A - Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2. - Google Patents

Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2.

Info

Publication number
MX2016011901A
MX2016011901A MX2016011901A MX2016011901A MX2016011901A MX 2016011901 A MX2016011901 A MX 2016011901A MX 2016011901 A MX2016011901 A MX 2016011901A MX 2016011901 A MX2016011901 A MX 2016011901A MX 2016011901 A MX2016011901 A MX 2016011901A
Authority
MX
Mexico
Prior art keywords
prostaglandin
receptor modulators
acetic acid
acid derivatives
azaindole acetic
Prior art date
Application number
MX2016011901A
Other languages
English (en)
Other versions
MX368179B (es
Inventor
Aissaoui Hamed
Boss Christoph
Siegrist Romain
Bouis Patrick
Hazemann Julien
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2016011901A publication Critical patent/MX2016011901A/es
Publication of MX368179B publication Critical patent/MX368179B/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
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  • Pain & Pain Management (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a derivados del ácido acético azaindol de fórmula (I), en donde R1 y R2 son tal como se describen en la descripción y su uso como moduladores del receptor de prostaglandina, más particularmente como moduladores del receptor de prostaglandina D2, en el tratamiento de diversas enfermedades y trastornos mediados por la prostaglandina, a composiciones farmacéuticas que contienen estos compuestos y a procesos para su preparación. (ver Fórmula).
MX2016011901A 2014-03-17 2015-03-16 Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2. MX368179B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2014059883 2014-03-17
PCT/IB2015/051895 WO2015140684A1 (en) 2014-03-17 2015-03-16 Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators

Publications (2)

Publication Number Publication Date
MX2016011901A true MX2016011901A (es) 2016-12-05
MX368179B MX368179B (es) 2019-09-23

Family

ID=52808086

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016011901A MX368179B (es) 2014-03-17 2015-03-16 Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2.
MX2019011265A MX384987B (es) 2014-03-17 2015-03-16 Derivados del ácido acético azaindol y su uso como moduladores de receptor de prostaglandina d2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019011265A MX384987B (es) 2014-03-17 2015-03-16 Derivados del ácido acético azaindol y su uso como moduladores de receptor de prostaglandina d2.

Country Status (31)

Country Link
US (2) US9879006B2 (es)
EP (1) EP3119779B1 (es)
JP (1) JP6152489B2 (es)
KR (1) KR101864060B1 (es)
CN (1) CN106103435B (es)
AR (1) AR099767A1 (es)
AU (1) AU2015233029B2 (es)
BR (1) BR112016021471B1 (es)
CA (1) CA2939892C (es)
CL (1) CL2016002321A1 (es)
CY (1) CY1120744T1 (es)
DK (1) DK3119779T3 (es)
EA (1) EA030159B1 (es)
ES (1) ES2687279T3 (es)
HR (1) HRP20181555T1 (es)
HU (1) HUE039614T2 (es)
IL (1) IL247705B (es)
LT (1) LT3119779T (es)
MA (1) MA39750B1 (es)
MX (2) MX368179B (es)
MY (1) MY179356A (es)
PE (1) PE20161177A1 (es)
PH (1) PH12016501764B1 (es)
PL (1) PL3119779T3 (es)
PT (1) PT3119779T (es)
RS (1) RS57867B1 (es)
SG (1) SG11201607708RA (es)
SI (1) SI3119779T1 (es)
TW (1) TWI649321B (es)
UA (1) UA117780C2 (es)
WO (1) WO2015140684A1 (es)

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EA030159B1 (ru) * 2014-03-17 2018-06-29 Идорсиа Фармасьютиклз Лтд Производные азаиндолуксусной кислоты и их применение в качестве модуляторов рецепторов простагландина d2
JP6484644B2 (ja) 2014-03-18 2019-03-13 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ アザインドール酢酸誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用
UA123156C2 (uk) * 2015-09-15 2021-02-24 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА ФОРМА (S)-2-(8-((5-ХЛОРПІРИМІДИН-2-ІЛ)(МЕТИЛ)АМІНО)-2-ФТОР-6,7,8,9-ТЕТРАГІДРО-5H-ПІРИДО[3,2-b]ІНДОЛ-5-ІЛ)ОЦТОВОЇ КИСЛОТИ, ЇЇ ЗАСТОСУВАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЇЇ МІСТИТЬ
KR102480088B1 (ko) * 2016-03-17 2022-12-23 삼성디스플레이 주식회사 양자점 발광 소자

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