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MX2013014846A - Benzoxazepinonas fusionadas como moduladoras de canales ionicos. - Google Patents

Benzoxazepinonas fusionadas como moduladoras de canales ionicos.

Info

Publication number
MX2013014846A
MX2013014846A MX2013014846A MX2013014846A MX2013014846A MX 2013014846 A MX2013014846 A MX 2013014846A MX 2013014846 A MX2013014846 A MX 2013014846A MX 2013014846 A MX2013014846 A MX 2013014846A MX 2013014846 A MX2013014846 A MX 2013014846A
Authority
MX
Mexico
Prior art keywords
benzoxazepinonas
fused
channel modulators
ionic channel
compounds
Prior art date
Application number
MX2013014846A
Other languages
English (en)
Other versions
MX336810B (es
Inventor
Britton Kenneth Corkey
Elfatih Elzein
Robert H Jiang
Rao V Kalla
Dmitry Koltun
Xiaofen Li
Ruben Martinez
Eric Q Parkhill
Thao Perry
Jeff Zablocki
Chandrasekar Venkataramani
Michael Graupe
Juan Guerrero
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46513866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013014846(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2013014846A publication Critical patent/MX2013014846A/es
Publication of MX336810B publication Critical patent/MX336810B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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  • Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Luminescent Compositions (AREA)
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Abstract

La presente invención se relaciona con compuestos que son inhibidores de los canales de sodio y a su uso en el tratamiento de diversos estados de enfermedad, que incluyen enfermedades cardiovasculares y diabetes. En formas de realización particulares, la estructura de los compuestos es dada por la Fórmula I: (ver Fórmula) en donde Z1, Z2, Z3, Z4, X, Y, R2, R3 y R4 son como se describen en el presente documento, con métodos para la preparación y uso de los compuestos y con composiciones farmacéuticas que contienen los mismos.
MX2013014846A 2011-07-01 2012-06-29 Benzoxazepinonas fusionadas como moduladoras de canales ionicos. MX336810B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161503980P 2011-07-01 2011-07-01
US201161582160P 2011-12-30 2011-12-30
PCT/US2012/045086 WO2013006485A1 (en) 2011-07-01 2012-06-29 Fused benzoxazepinones as ion channel modulators

Publications (2)

Publication Number Publication Date
MX2013014846A true MX2013014846A (es) 2014-03-31
MX336810B MX336810B (es) 2016-02-03

Family

ID=46513866

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014846A MX336810B (es) 2011-07-01 2012-06-29 Benzoxazepinonas fusionadas como moduladoras de canales ionicos.

Country Status (38)

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US (5) US8586732B2 (es)
EP (6) EP3101013B1 (es)
JP (2) JP5889407B2 (es)
KR (2) KR20160040734A (es)
CN (2) CN103857659B (es)
AP (1) AP2013007300A0 (es)
AR (1) AR086828A1 (es)
AU (1) AU2012279236B2 (es)
BR (1) BR112013032361A2 (es)
CA (1) CA2838223A1 (es)
CL (1) CL2013003598A1 (es)
CO (1) CO6821960A2 (es)
CR (1) CR20130658A (es)
CY (1) CY1117915T1 (es)
DK (1) DK2726466T3 (es)
EA (2) EA027356B1 (es)
EC (1) ECSP13013083A (es)
ES (6) ES2792864T3 (es)
HK (5) HK1225724A1 (es)
HR (1) HRP20160952T1 (es)
HU (1) HUE029398T2 (es)
IL (2) IL230022B (es)
MD (1) MD4371C1 (es)
ME (1) ME02546B (es)
MX (1) MX336810B (es)
NZ (2) NZ716245A (es)
PE (1) PE20140690A1 (es)
PH (1) PH12013502549B1 (es)
PL (1) PL2726466T3 (es)
PT (1) PT2726466T (es)
RS (1) RS55024B1 (es)
SI (1) SI2726466T1 (es)
SM (1) SMT201600271B (es)
TW (4) TW201837023A (es)
UA (1) UA115529C2 (es)
UY (1) UY34171A (es)
WO (1) WO2013006485A1 (es)
ZA (1) ZA201308981B (es)

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LT2464645T (lt) 2009-07-27 2017-10-25 Gilead Sciences, Inc. Kondensuoti heterocikliniai junginiai, kaip jonų kanalų moduliatoriai
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UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
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EA201690215A1 (ru) 2013-08-01 2016-07-29 Джилид Сайэнс, Инк. Соединение и способы для лечения синдрома удлиненного интервала qt
NZ715554A (en) * 2013-08-01 2017-01-27 Gilead Sciences Inc Method of treating hypertrophic cardiomyopathy
MY181928A (en) * 2013-09-10 2021-01-14 Chromocell Corp Sodium channel modulators for the treatment of pain and diabetes
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
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