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MX2013001988A - Compuestos de heterociclilo comoligandos del receptor h3 de la histamina - Google Patents

Compuestos de heterociclilo comoligandos del receptor h3 de la histamina

Info

Publication number
MX2013001988A
MX2013001988A MX2013001988A MX2013001988A MX2013001988A MX 2013001988 A MX2013001988 A MX 2013001988A MX 2013001988 A MX2013001988 A MX 2013001988A MX 2013001988 A MX2013001988 A MX 2013001988A MX 2013001988 A MX2013001988 A MX 2013001988A
Authority
MX
Mexico
Prior art keywords
histamine
compounds
receptor ligands
heterocyclyl compounds
formula
Prior art date
Application number
MX2013001988A
Other languages
English (en)
Other versions
MX354852B (es
Inventor
Venkateswarlu Jasti
Anil Karbhari Shinde
Adi Reddy Dwarampudi
Ramakrishna Nirogi
Pradeep Jayarajan
Ishtiyaque Ahmad
Rambabu Namala
Ramasastri Kambhampati
Laxman Kota
Murlimohan Gampa
Padmavathi Kodru
Taraka Naga Vinaykumar Tiriveedhi
Vishwottam Nagaraj Kandikere
Nageshwara Rao Muddana
Ramanatha Shrikantha Saralaya
Dhanalakshmi Shanmuganathan
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of MX2013001988A publication Critical patent/MX2013001988A/es
Publication of MX354852B publication Critical patent/MX354852B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona con compuestos de heterociclilo de fórmula (I), y sus sales farmaceúticamente aceptables y con las composiciones que los contienen. (ver Fórmula) La presente invención también se relaciona con un proceso para la preparación de los compuestos novedosos anteriores, y sus sales farmaceúticamente aceptables. Los compuestos de fórmula (I) son útiles en el tratamiento de varios trastornos que están relacionados con los receptores H3 de la Histamina.
MX2013001988A 2010-09-02 2010-11-15 Compuestos de heterociclilo comoligandos del receptor h3 de la histamina. MX354852B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2551CH2010 2010-09-02
PCT/IN2010/000740 WO2012029070A1 (en) 2010-09-02 2010-11-15 Heterocyclyl compounds as histamine h3 receptor ligands

Publications (2)

Publication Number Publication Date
MX2013001988A true MX2013001988A (es) 2013-05-09
MX354852B MX354852B (es) 2018-03-22

Family

ID=43608695

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001988A MX354852B (es) 2010-09-02 2010-11-15 Compuestos de heterociclilo comoligandos del receptor h3 de la histamina.

Country Status (26)

Country Link
US (1) US8912179B2 (es)
EP (1) EP2611444B1 (es)
JP (1) JP5650329B2 (es)
KR (1) KR101538239B1 (es)
CN (1) CN103079566B (es)
AU (1) AU2010360038B2 (es)
BR (1) BR112013005084A2 (es)
CA (1) CA2812970C (es)
CY (1) CY1117096T1 (es)
DK (1) DK2611444T3 (es)
EA (1) EA022746B1 (es)
ES (1) ES2558531T3 (es)
HR (1) HRP20151380T1 (es)
HU (1) HUE028435T2 (es)
IL (1) IL224652A (es)
ME (1) ME02320B (es)
MX (1) MX354852B (es)
NZ (1) NZ607658A (es)
PL (1) PL2611444T3 (es)
PT (1) PT2611444E (es)
RS (1) RS54514B1 (es)
SG (1) SG188212A1 (es)
SI (1) SI2611444T1 (es)
SM (1) SMT201600012B (es)
WO (1) WO2012029070A1 (es)
ZA (1) ZA201301143B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20161167T1 (hr) * 2012-08-23 2016-11-04 Suven Life Sciences Limited Spoj akrilamida kao ligandi histaminskog h3 receptora
CN104530088A (zh) * 2014-12-08 2015-04-22 苏州施亚生物科技有限公司 2-氨基-6,7-二氢-5H-噻唑并[5,4-b]吡啶-4-羧酸叔丁酯及其衍生物,以及它们的合成方法
EP3378477A1 (en) * 2017-03-21 2018-09-26 BIOPROJET Pharma New therapeutical use of h3-ligands
EA202091113A1 (ru) 2017-11-02 2020-08-28 Айкурис Гмбх Унд Ко. Кг Новые высокоактивные аминотиазолзамещенные индол-2-карбоксамиды, активные в отношении вируса гепатита b (hbv)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695575A (en) 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
PH23995A (en) 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
JP2005502623A (ja) 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
NZ538401A (en) 2002-09-06 2008-03-28 Janssen Pharmaceutica Nv (1H-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders
CA2572822A1 (en) * 2004-07-16 2006-01-26 Janssen Pharmaceutica N.V. Dimeric piperidine derivatives
EA200700254A1 (ru) * 2004-07-16 2007-06-29 Янссен Фармацевтика Н. В. Димерные производные пипередина
ATE420091T1 (de) * 2005-03-14 2009-01-15 Glaxo Group Ltd Kondensierte thiazolderivate mit affinität für den histamin-h3-rezeptor
AU2007229492B2 (en) * 2006-03-28 2011-11-03 High Point Pharmaceuticals, Llc Benzothiazoles having histamine H3 receptor activity
WO2008012010A1 (en) * 2006-07-27 2008-01-31 Ucb Pharma, S.A. Fused oxazoles & thiazoles as histamine h3- receptor ligands
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US7557101B2 (en) * 2006-12-08 2009-07-07 Hoffman-La Roche Inc. 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives
US20080146559A1 (en) * 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101925606A (zh) * 2008-01-24 2010-12-22 Ucb医药有限公司 包含环丁氧基的化合物
WO2010026113A1 (en) 2008-09-03 2010-03-11 Evotec Neurosciences Gmbh Acyl- and sufonyl tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists

Also Published As

Publication number Publication date
EP2611444B1 (en) 2015-10-14
AU2010360038A1 (en) 2013-04-04
CN103079566A (zh) 2013-05-01
WO2012029070A1 (en) 2012-03-08
HUE028435T2 (en) 2016-12-28
HRP20151380T1 (hr) 2016-01-15
CA2812970C (en) 2015-01-13
NZ607658A (en) 2014-02-28
RS54514B1 (sr) 2016-06-30
JP2013536834A (ja) 2013-09-26
EP2611444A1 (en) 2013-07-10
IL224652A (en) 2016-05-31
KR20130042605A (ko) 2013-04-26
DK2611444T3 (en) 2016-01-11
ES2558531T3 (es) 2016-02-05
CN103079566B (zh) 2015-06-17
SMT201600012B (it) 2016-02-25
US8912179B2 (en) 2014-12-16
SG188212A1 (en) 2013-04-30
US20140148440A1 (en) 2014-05-29
PL2611444T3 (pl) 2016-03-31
EA201390327A1 (ru) 2013-08-30
PT2611444E (pt) 2016-02-04
CY1117096T1 (el) 2017-04-05
JP5650329B2 (ja) 2015-01-07
HK1180955A1 (en) 2013-11-01
SI2611444T1 (sl) 2016-04-29
CA2812970A1 (en) 2012-03-08
EA022746B1 (ru) 2016-02-29
BR112013005084A2 (pt) 2020-08-25
ZA201301143B (en) 2013-10-30
ME02320B (me) 2016-06-20
AU2010360038B2 (en) 2014-05-15
MX354852B (es) 2018-03-22
KR101538239B1 (ko) 2015-07-20

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