MX2015000064A - Compuestos de acrilamida como ligandos receptores de histamina h3. - Google Patents
Compuestos de acrilamida como ligandos receptores de histamina h3.Info
- Publication number
- MX2015000064A MX2015000064A MX2015000064A MX2015000064A MX2015000064A MX 2015000064 A MX2015000064 A MX 2015000064A MX 2015000064 A MX2015000064 A MX 2015000064A MX 2015000064 A MX2015000064 A MX 2015000064A MX 2015000064 A MX2015000064 A MX 2015000064A
- Authority
- MX
- Mexico
- Prior art keywords
- histamine
- receptor ligands
- acrylamide compounds
- compounds
- formula
- Prior art date
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 title abstract 2
- 150000003926 acrylamides Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se relaciona con compuestos novedosos de acrilamida de fórmula (I), y sus sales farmacéuticamente aceptables y el proceso para su preparación. (ver Fórmula) Los compuestos de fórmula (I) son útiles en el tratamiento de varios trastornos que se relacionan con receptores de histamina H3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3464CH2012 | 2012-08-23 | ||
| PCT/IN2012/000796 WO2014030170A1 (en) | 2012-08-23 | 2012-12-05 | Acrylamide compounds as histamine h3 receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015000064A true MX2015000064A (es) | 2015-04-08 |
| MX360001B MX360001B (es) | 2018-10-18 |
Family
ID=54187093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015000064A MX360001B (es) | 2012-08-23 | 2012-12-05 | Compuestos de acrilamida como ligandos receptores de histamina h3. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9328092B2 (es) |
| EP (1) | EP2888243B1 (es) |
| JP (1) | JP5981654B2 (es) |
| KR (1) | KR101707343B1 (es) |
| CN (1) | CN104540812B (es) |
| AP (1) | AP2014008139A0 (es) |
| AU (1) | AU2012388383C1 (es) |
| BR (1) | BR112015001524B1 (es) |
| CA (1) | CA2878217C (es) |
| CY (1) | CY1118035T1 (es) |
| DK (1) | DK2888243T3 (es) |
| EA (1) | EA025136B1 (es) |
| ES (1) | ES2592819T3 (es) |
| HR (1) | HRP20161167T1 (es) |
| HU (1) | HUE030901T2 (es) |
| IL (1) | IL236437A (es) |
| LT (1) | LT2888243T (es) |
| ME (1) | ME02519B (es) |
| MX (1) | MX360001B (es) |
| PL (1) | PL2888243T3 (es) |
| PT (1) | PT2888243T (es) |
| RS (1) | RS55158B1 (es) |
| SG (1) | SG11201408423XA (es) |
| SI (1) | SI2888243T1 (es) |
| SM (1) | SMT201600336B (es) |
| WO (1) | WO2014030170A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11313246B2 (en) * | 2016-11-30 | 2022-04-26 | General Electric Company | Gas turbine engine wash system |
| WO2022113008A1 (en) | 2020-11-27 | 2022-06-02 | Richter Gedeon Nyrt. | Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder |
| EP4488263A2 (en) | 2022-03-02 | 2025-01-08 | Hangzhou Bio-Sincerity Pharma-tech Co., Ltd. | Phenylurea derivative and pharmaceutical use thereof |
| KR20250016079A (ko) | 2022-03-02 | 2025-02-03 | 항저우 바이오-신세리티 파마-테크 컴퍼니 리미티드 | 히스타민 h3 수용체 길항제 및 이의 약학적 용도 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1798735A (zh) * | 2003-06-12 | 2006-07-05 | 诺沃挪第克公司 | 用作激素敏感性脂肪酶的抑制剂的1－芳基－4－(芳氧基羰基)－哌嗪衍生物 |
| US8008301B2 (en) | 2004-04-01 | 2011-08-30 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| BRPI0511778A (pt) * | 2004-06-02 | 2008-01-15 | Hoffmann La Roche | derivados da naftalina úteis como ligantes do receptor 3 da histamina |
| CN1972926B (zh) | 2004-06-21 | 2011-02-16 | 霍夫曼-拉罗奇有限公司 | 作为组胺受体拮抗剂的吲哚衍生物 |
| CA2577061C (en) | 2004-08-23 | 2014-02-18 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| CN101316838B (zh) * | 2005-11-30 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物 |
| WO2007137955A1 (en) | 2006-05-30 | 2007-12-06 | F. Hoffmann-La Roche Ag | Piperidinyl pyrimidine derivatives |
| US7534788B2 (en) * | 2007-07-25 | 2009-05-19 | Hoffmann-La Roche Inc. | Benzofuran and benzothiophene-2-carboxylic acid amide derivatives |
| CL2008002622A1 (es) | 2007-09-06 | 2009-11-27 | Glaxo Group Ltd | 1-(1-metiletil)-4-{[4-(tetrahidro-2h-piran-4-iloxi)fenil]carbonil}piperazina y su sal hidrocloruro; formas cristalinas de la sal; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento o profilaxis de deterioro cognitivo, fatiga o trastorno del sueno. |
| US7799816B2 (en) | 2008-02-04 | 2010-09-21 | Roche Palo Alto Llc | Imidazolinylmethyl aryl sulfonamide |
| US20110046130A1 (en) | 2008-03-31 | 2011-02-24 | Evotec Ag | Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists |
| CA2721303C (en) | 2008-05-08 | 2016-06-28 | Evotec Ag | Azetidines and cyclobutanes as histamine h3 receptor antagonists |
| ES2558531T3 (es) * | 2010-09-02 | 2016-02-05 | Suven Life Sciences Limited | Compuestos de heterociclilo como ligandos de receptores de histamina H3 |
-
2012
- 2012-12-05 AU AU2012388383A patent/AU2012388383C1/en active Active
- 2012-12-05 HR HRP20161167TT patent/HRP20161167T1/hr unknown
- 2012-12-05 RS RS20160783A patent/RS55158B1/sr unknown
- 2012-12-05 SI SI201230707A patent/SI2888243T1/sl unknown
- 2012-12-05 LT LTEP12844650.7T patent/LT2888243T/lt unknown
- 2012-12-05 CN CN201280075253.4A patent/CN104540812B/zh active Active
- 2012-12-05 EA EA201590413A patent/EA025136B1/ru unknown
- 2012-12-05 US US14/419,474 patent/US9328092B2/en active Active
- 2012-12-05 SG SG11201408423XA patent/SG11201408423XA/en unknown
- 2012-12-05 ES ES12844650.7T patent/ES2592819T3/es active Active
- 2012-12-05 AP AP2014008139A patent/AP2014008139A0/xx unknown
- 2012-12-05 PL PL12844650T patent/PL2888243T3/pl unknown
- 2012-12-05 CA CA2878217A patent/CA2878217C/en active Active
- 2012-12-05 MX MX2015000064A patent/MX360001B/es active IP Right Grant
- 2012-12-05 EP EP12844650.7A patent/EP2888243B1/en active Active
- 2012-12-05 PT PT128446507T patent/PT2888243T/pt unknown
- 2012-12-05 KR KR1020157001952A patent/KR101707343B1/ko active Active
- 2012-12-05 BR BR112015001524-7A patent/BR112015001524B1/pt active IP Right Grant
- 2012-12-05 ME MEP-2016-190A patent/ME02519B/me unknown
- 2012-12-05 HU HUE12844650A patent/HUE030901T2/en unknown
- 2012-12-05 WO PCT/IN2012/000796 patent/WO2014030170A1/en not_active Ceased
- 2012-12-05 JP JP2015528009A patent/JP5981654B2/ja active Active
- 2012-12-05 DK DK12844650.7T patent/DK2888243T3/en active
-
2014
- 2014-12-24 IL IL236437A patent/IL236437A/en active IP Right Grant
-
2016
- 2016-09-22 CY CY20161100943T patent/CY1118035T1/el unknown
- 2016-09-23 SM SM201600336T patent/SMT201600336B/it unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |