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MX2010004028A - 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona. - Google Patents

4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona.

Info

Publication number
MX2010004028A
MX2010004028A MX2010004028A MX2010004028A MX2010004028A MX 2010004028 A MX2010004028 A MX 2010004028A MX 2010004028 A MX2010004028 A MX 2010004028A MX 2010004028 A MX2010004028 A MX 2010004028A MX 2010004028 A MX2010004028 A MX 2010004028A
Authority
MX
Mexico
Prior art keywords
cyclopropanecarbonyl
piperazine
fluoro
carbonyl
phthalaz
Prior art date
Application number
MX2010004028A
Other languages
English (en)
Inventor
Kathryn Anne Quigley
Ezra John Still
Leonard Jesse Chyall
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of MX2010004028A publication Critical patent/MX2010004028A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2H-ftalacin-1-ona como Forma L cristalina, m?todos para obtener la Forma L, composiciones farmac?uticas que comprenden la Forma L y m?todos de uso de la Forma L y composiciones que comprenden la Forma L.
MX2010004028A 2007-10-17 2008-10-17 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona. MX2010004028A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98050807P 2007-10-17 2007-10-17
PCT/GB2008/003510 WO2009050469A1 (en) 2007-10-17 2008-10-17 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl] -2h-phthalaz in-1-one

Publications (1)

Publication Number Publication Date
MX2010004028A true MX2010004028A (es) 2010-04-30

Family

ID=40227654

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004028A MX2010004028A (es) 2007-10-17 2008-10-17 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona.

Country Status (12)

Country Link
US (1) US8183369B2 (es)
EP (1) EP2212296B1 (es)
JP (1) JP5593229B2 (es)
KR (1) KR101598231B1 (es)
CN (1) CN101821242B (es)
AU (1) AU2008313467B2 (es)
BR (1) BRPI0817537B1 (es)
CA (1) CA2702429A1 (es)
ES (1) ES2530695T3 (es)
MX (1) MX2010004028A (es)
RU (1) RU2487868C2 (es)
WO (1) WO2009050469A1 (es)

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CN105753789B (zh) * 2015-04-17 2018-09-25 苏州晶云药物科技有限公司 奥拉帕尼与尿素的共晶及其制备方法
CN105254572A (zh) * 2015-11-09 2016-01-20 北京科莱博医药开发有限责任公司 一种奥拉帕尼的晶型及其制备方法和应用
CN106699672B (zh) * 2015-11-16 2019-10-29 上海博邦医药科技有限公司 一种奥拉帕尼无定型物及其制备方法
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CN114249695A (zh) * 2020-09-21 2022-03-29 齐鲁制药有限公司 一种奥拉帕利的新晶型、制备方法及用途
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US20240199582A1 (en) 2021-04-08 2024-06-20 Rhizen Pharmaceuticals Ag Inhibitors of poly(adp-ribose) polymerase
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Also Published As

Publication number Publication date
EP2212296B1 (en) 2014-12-03
WO2009050469A1 (en) 2009-04-23
KR20100087153A (ko) 2010-08-03
ES2530695T3 (es) 2015-03-04
HK1142065A1 (en) 2010-11-26
RU2010111570A (ru) 2011-11-27
JP2011500655A (ja) 2011-01-06
AU2008313467A1 (en) 2009-04-23
CN101821242B (zh) 2013-07-24
CA2702429A1 (en) 2009-04-23
KR101598231B1 (ko) 2016-02-26
JP5593229B2 (ja) 2014-09-17
CN101821242A (zh) 2010-09-01
AU2008313467B2 (en) 2013-08-29
BRPI0817537A2 (pt) 2015-03-31
US8183369B2 (en) 2012-05-22
US20100286157A1 (en) 2010-11-11
BRPI0817537B1 (pt) 2022-04-05
RU2487868C2 (ru) 2013-07-20
EP2212296A1 (en) 2010-08-04

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