[go: up one dir, main page]

MX2009004103A - Derivados de ftalazinona. - Google Patents

Derivados de ftalazinona.

Info

Publication number
MX2009004103A
MX2009004103A MX2009004103A MX2009004103A MX2009004103A MX 2009004103 A MX2009004103 A MX 2009004103A MX 2009004103 A MX2009004103 A MX 2009004103A MX 2009004103 A MX2009004103 A MX 2009004103A MX 2009004103 A MX2009004103 A MX 2009004103A
Authority
MX
Mexico
Prior art keywords
phthalazinone derivative
phthalazinone
derivative
phthalazin
cyclopropanecarbonyl
Prior art date
Application number
MX2009004103A
Other languages
English (en)
Inventor
Keith Allan Menear
Anthony Peter Ottridge
Derek John Londesbrough
Michael Raymond Hallett
Keith Raymond Mullholland
John David Pittam
David Dermot Patrick Laffan
Ian Woodward Ashworth
Martin Francis Jones
Janette Helen Cherryman
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38952365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009004103(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of MX2009004103A publication Critical patent/MX2009004103A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

El compuesto 4-[3-(4-ciclopropancarbonil-piperazin-1-carbonil)-4-f luoro-bencil]-2H-ftalazin-1-ona como la forma cristalina A.
MX2009004103A 2006-10-17 2007-10-15 Derivados de ftalazinona. MX2009004103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82969406P 2006-10-17 2006-10-17
PCT/GB2007/003888 WO2008047082A2 (en) 2006-10-17 2007-10-15 Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one

Publications (1)

Publication Number Publication Date
MX2009004103A true MX2009004103A (es) 2009-05-05

Family

ID=38952365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004103A MX2009004103A (es) 2006-10-17 2007-10-15 Derivados de ftalazinona.

Country Status (34)

Country Link
US (2) US7692006B2 (es)
EP (3) EP2374800A3 (es)
JP (3) JP5248513B2 (es)
KR (2) KR20140011425A (es)
CN (3) CN101528714B (es)
AR (1) AR063320A1 (es)
AT (1) ATE528296T1 (es)
AU (1) AU2007311766B2 (es)
BR (1) BRPI0717125B8 (es)
CA (2) CA2664275C (es)
CL (1) CL2007002967A1 (es)
CO (1) CO6210728A2 (es)
CY (1) CY1112345T1 (es)
DK (1) DK2064189T3 (es)
ES (2) ES2372630T3 (es)
HR (1) HRP20120007T1 (es)
IL (2) IL197420A (es)
ME (1) ME01987B (es)
MX (1) MX2009004103A (es)
MY (2) MY147389A (es)
NO (2) NO341963B1 (es)
NZ (1) NZ575627A (es)
PE (1) PE20081175A1 (es)
PL (1) PL2064189T3 (es)
PT (1) PT2064189E (es)
RS (1) RS52112B (es)
RU (1) RU2465270C3 (es)
SA (2) SA07280551B1 (es)
SG (2) SG10201408404XA (es)
SI (1) SI2064189T1 (es)
TW (1) TWI404716B (es)
UA (1) UA97494C2 (es)
UY (1) UY30639A1 (es)
WO (1) WO2008047082A2 (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
GB0521373D0 (en) * 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
WO2007144637A1 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited 2 -oxyheteroarylamide derivatives as parp inhibitors
EP2035380A2 (en) * 2006-06-15 2009-03-18 Kudos Pharmaceuticals Limited Parp inhibitors
CN101484421A (zh) * 2006-06-15 2009-07-15 库多斯药物有限公司 作为parp抑制剂的2-氧基苯甲酰胺衍生物
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
PL2698062T3 (pl) * 2006-12-28 2015-12-31 Abbvie Inc Inhibitory polimerazy poli(adp-rybozy)
US8466150B2 (en) 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
KR101598231B1 (ko) * 2007-10-17 2016-02-26 쿠도스 파마슈티칼스 리미티드 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온
DK2346495T4 (da) 2008-10-07 2023-08-28 Kudos Pharm Ltd Farmaceutisk formulering 514
UY32790A (es) * 2009-07-15 2011-02-28 Astrazeneca Ab Compuesto de ftalazinona
EP2598491B1 (en) 2010-07-27 2015-09-02 Cadila Healthcare Limited Substituted 4-(4-fluoro-3-(piperazine-1- carbonyl)benzyl)phthalazin-1(2h)-one derivatives as poly (adp-ribose) polymerase- 1 inhibitors
CN102485721B (zh) * 2010-12-03 2015-12-09 曹亚 取代的2,3-二氮杂萘酮化合物及其用途
MX367614B (es) 2012-01-20 2019-08-28 Del Mar Pharmaceuticals Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.
SG11201503670YA (en) 2012-12-31 2015-07-30 Cadila Healthcare Ltd Substituted phthalazin-1 (2h)-one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1
EP2983674A4 (en) 2013-04-08 2017-05-10 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
CA2946538A1 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
EP3157566B1 (en) 2014-06-17 2019-05-01 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of chk1 and atr inhibitors
CN105777651A (zh) * 2015-01-13 2016-07-20 江苏豪森药业集团有限公司 聚腺苷酸二磷酸核糖转移酶抑制剂的晶型及其制备方法和医药用途
CN105985294B (zh) * 2015-02-11 2020-12-25 四川科伦药物研究院有限公司 一种奥拉帕尼的制备方法
WO2016165650A1 (zh) * 2015-04-17 2016-10-20 苏州晶云药物科技有限公司 奥拉帕尼与尿素的共晶及其制备方法
CN106146492A (zh) * 2015-04-17 2016-11-23 上海汇伦生命科技有限公司 杂环并咪唑类化合物、其药物组合物及其制备方法和用途
US10562886B2 (en) 2015-05-21 2020-02-18 The Regents Of The University Of California Anti-cancer compounds
CN112010809A (zh) * 2015-06-12 2020-12-01 苏州科睿思制药有限公司 奥拉帕尼的晶型i及其制备方法
CN105175370A (zh) * 2015-07-27 2015-12-23 安徽万邦医药科技有限公司 一种2-氟-5-[(3-氧代-1(3h)-异苯并呋喃亚基)甲基]苯腈的合成方法
HK1258570A1 (zh) 2015-09-30 2019-11-15 Vertex Pharmaceuticals Inc. 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法
CN105254572A (zh) * 2015-11-09 2016-01-20 北京科莱博医药开发有限责任公司 一种奥拉帕尼的晶型及其制备方法和应用
CN106699672B (zh) * 2015-11-16 2019-10-29 上海博邦医药科技有限公司 一种奥拉帕尼无定型物及其制备方法
ITUB20159206A1 (it) * 2015-12-22 2017-06-22 Olon Spa Forme cristalline e amorfe di olaparib
US20170204067A1 (en) * 2016-01-14 2017-07-20 Scinopharm Taiwan, Ltd. Crystalline forms of olaparib and manufacturing processes therefor
CZ201682A3 (cs) 2016-02-15 2017-08-23 Zentiva, K.S. Solvatované krystalické formy olaparibu, jejich příprava a použití
CN105503739B (zh) * 2016-02-24 2018-09-11 合肥启旸生物科技有限公司 一种奥拉帕尼的制备方法
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2017153958A1 (en) * 2016-03-11 2017-09-14 Lupin Limited Novel polymorphic forms and amorphous form of olaparib
CN107304186B (zh) * 2016-04-25 2021-08-27 杭州容立医药科技有限公司 一种奥拉帕尼的精制方法
CN107304187B (zh) * 2016-04-25 2021-07-09 杭州容立医药科技有限公司 一种奥拉帕尼的重结晶方法
WO2017191562A1 (en) * 2016-05-04 2017-11-09 Alembic Pharmaceuticals Limited Process for the preparation of olaparib and polymorphs thereof
WO2017223516A1 (en) 2016-06-24 2017-12-28 The Regents Of The University Of California Phthalazine derivatives as inhibitors of parp1, parp2 and/or tubulin useful for the treatment of cancer
EP3263529B1 (en) 2016-06-27 2019-11-06 Xylem Europe GmbH Quartz sleeve support for an uv-lamp
CZ2016391A3 (cs) 2016-06-29 2018-01-10 Zentiva, K.S. Farmaceutická formulace olaparibu
EP3504196A4 (en) * 2016-08-24 2020-01-22 Scinopharm Taiwan, Ltd. METHOD FOR PRODUCING OLAPARIB
WO2018122168A1 (en) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinations of bub1 kinase and parp inhibitors
CN107098862A (zh) * 2017-06-05 2017-08-29 山东裕欣药业有限公司 一种奥拉帕尼二水合物及其制备方法
CN107325055A (zh) * 2017-08-14 2017-11-07 山东裕欣药业有限公司 一种奥拉帕尼化合物的合成方法
TWI765086B (zh) * 2017-08-24 2022-05-21 大陸商江蘇恒瑞醫藥股份有限公司 Parp-1抑制劑的晶型及其製備方法
CN108101852A (zh) * 2017-12-27 2018-06-01 山东裕欣药业有限公司 一种奥拉帕尼的制备方法
WO2019133864A1 (en) 2017-12-29 2019-07-04 Accutar Biotechnology DUAL INHIBITORS OF PARP1 and CDK
BR112020013672A2 (pt) 2018-01-05 2020-12-01 Cybrexa 1, Inc. compostos, composições, e métodos para tratamento de doenças que envolvem tecidos afetados por ácidos ou hipoxia
CA3031777A1 (en) 2018-01-31 2019-07-31 Apotex Inc. Crystalline form of olaparib
CN110204530B (zh) * 2018-02-28 2020-05-08 新发药业有限公司 一种瓦他拉尼的制备方法
CN108558773A (zh) * 2018-05-17 2018-09-21 苏州莱克施德药业有限公司 一种奥拉帕尼药物中间体的制备方法
CN109535082A (zh) * 2018-12-24 2019-03-29 合肥创新医药技术有限公司 一种奥拉帕尼的制备方法
US10703728B1 (en) * 2019-06-18 2020-07-07 Scinopharm Taiwan, Ltd. Crystalline form of olaparib and a process for preparing the same
CA3146560A1 (en) 2019-07-10 2021-01-14 Cybrexa 2, Inc. Peptide conjugates of cytotoxins as therapeutics
JP7675060B2 (ja) 2019-07-10 2025-05-12 サイブレクサ ３，インコーポレイテッド 治療薬としての微小管標的化剤のペプチドコンジュゲート
WO2021044437A1 (en) * 2019-09-04 2021-03-11 Cipla Limited Olaparib co-crystals and process of preparation thereof
CN110563703B (zh) * 2019-09-18 2021-04-09 浙江省医学科学院 基于crbn配体诱导parp-1降解的化合物及制备方法和应用
EP4081518A4 (en) 2019-12-23 2023-12-27 Accutar Biotechnology, Inc. COMBINATIONS OF ESTROGEN RECEPTOR DEGRADERS AND CYCLIN-DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER
CN111116514B (zh) * 2020-01-10 2024-03-19 广州科锐特生物科技有限公司 一种1-环丙甲酰基哌嗪盐酸盐的制备方法
AU2021262569A1 (en) 2020-04-28 2022-11-24 Rhizen Pharmaceuticals Ag Novel compounds useful as poly(ADP-ribose) polymerase (PARP) inhibitors
CN111995582B (zh) * 2020-07-09 2021-12-03 天津理工大学 一种奥拉帕尼与尿素的共晶及其制备方法
CN111689905B (zh) * 2020-07-22 2021-12-03 天津理工大学 一种奥拉帕尼与马来酸的共晶及其制备方法
JP7453475B2 (ja) * 2020-09-16 2024-03-19 ナフォーミックス テクノロジーズ リミテッド オラパリブシュウ酸共結晶及びその医薬的使用
CN114249695A (zh) * 2020-09-21 2022-03-29 齐鲁制药有限公司 一种奥拉帕利的新晶型、制备方法及用途
CN114276301B (zh) * 2020-09-27 2025-04-01 江西科睿药业有限公司 Parp抑制剂的中间体化合物及其制备方法和应用
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
CN114539161B (zh) * 2020-11-11 2024-03-29 成都硕德药业有限公司 一种奥拉帕尼-尿素共晶及其制备方法
CN112661733A (zh) * 2020-12-23 2021-04-16 南京方生和医药科技有限公司 奥拉帕利杂质中间体、奥拉帕利杂质及其制备方法
CN112500379B (zh) * 2020-12-23 2024-01-23 南京方生和医药科技有限公司 一种奥拉帕利中间体及奥拉帕利的制备方法
PE20240119A1 (es) 2021-01-08 2024-01-22 Cybrexa 2 Inc Proceso para preparar un resto enlazador de conjugados
WO2022155172A1 (en) 2021-01-13 2022-07-21 Cybrexa 3, Inc. Peptide conjugates of therapeutics
US20240092768A1 (en) * 2021-01-22 2024-03-21 Xizang Haisco Pharmaceutical Co., Ltd. Crystal form of anti-influenza virus compound, preparation method for crystal form, and use of crystal form
IL307339A (en) 2021-04-08 2023-11-01 Rhizen Pharmaceuticals Ag Poly(ADP-ribose) polymerase inhibitors
WO2023017393A1 (en) * 2021-08-09 2023-02-16 Glenmark Life Sciences Limited Process for the preparation of olaparib, and crystalline form thereof
CN113636979B (zh) * 2021-08-12 2023-06-13 天津理工大学 一种奥拉帕尼与富马酸共晶晶型α及其制备方法与应用
KR102645122B1 (ko) * 2021-08-25 2024-03-07 주식회사 보령 올라파립의 제조방법
CN120309514A (zh) * 2021-09-15 2025-07-15 上海博邦医药科技有限公司 一种奥拉帕尼中间体的制备方法
CN115448886A (zh) * 2022-10-11 2022-12-09 福建福瑞明德药业有限公司 一种奥拉帕利的制备方法
WO2026013152A1 (en) 2024-07-09 2026-01-15 Stada Arzneimittel Ag Pharmaceutical composition comprising olaparib
EP4682140A1 (en) 2024-07-17 2026-01-21 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of olaparib

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
US4665181A (en) * 1984-05-17 1987-05-12 Pennwalt Corporation Anti-inflammatory phthalazinones
US5041653A (en) 1985-05-03 1991-08-20 Sri International Substituted benzamide radiosensitizers
US5032617A (en) 1985-05-03 1991-07-16 Sri International Substituted benzamide radiosensitizers
US5215738A (en) 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
ATE60598T1 (de) * 1985-11-11 1991-02-15 Asta Pharma Ag 4-benzyl-1-(2h)-phthalazinon-derivate.
DE68920798T2 (de) 1988-08-19 1995-05-18 Warner Lambert Co Substituierte Dihydroisochinolinone und verwandte Verbindungen als Verstärker der letalen Effekte von Bestrahlung und bestimmten Chemotherapeutika; ausgewählte Verbindungen, Analoga und Verfahren.
EP0389995B1 (en) 1989-03-28 1995-05-31 Nisshin Flour Milling Co., Ltd. Isoquinoline derivatives for the treatment of glaucoma or ocular hypertension
GB9011833D0 (en) 1990-05-25 1990-07-18 Collins Mary K L Inhibition of viral infection
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
US6004979A (en) * 1991-02-07 1999-12-21 Hoechst Marion Roussel Nitrogenous bicycles
EP0502575A1 (en) 1991-03-06 1992-09-09 Merck & Co. Inc. Substituted 1-(2H)-isoquinolinones
CZ199593A3 (en) 1992-10-02 1994-04-13 Asta Medica Ag Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
WO1994010151A1 (en) 1992-11-02 1994-05-11 Merck & Co., Inc. Substituted phthalazinones as nerotensin antagonists
EP0634404A1 (en) 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
US5587384A (en) * 1994-02-04 1996-12-24 The Johns Hopkins University Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
US5648355A (en) * 1994-02-09 1997-07-15 Kos Pharmaceutical, Inc. Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
AU691331B2 (en) 1994-08-12 1998-05-14 Myriad Genetics, Inc. Method for diagnosing a predisposition for breast and ovarian cancer
DK0705903T3 (da) 1994-08-12 2001-08-27 Myriad Genetics Inc Mutationer i det 17q-koblede bryst- og ovariecancerprædisponeringen
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
US5834466A (en) 1994-12-22 1998-11-10 The Regents Of The University Of California Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
IL117805A0 (en) * 1995-04-07 1996-08-04 Schering Corp Carbonyl piperazinyl and piperidinyl compounds
IL120264A0 (en) 1996-02-29 1997-06-10 Pfizer Method of reducing tissue damage associated with non-cardiac ischemia
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5859035A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5874452A (en) * 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5854265A (en) * 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5939557A (en) * 1996-04-03 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036587A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. A method of treating cancer
CA2251955A1 (en) * 1996-04-18 1997-10-23 Nancy E. Kohl A method of treating cancer
US5880128A (en) * 1996-05-08 1999-03-09 Schering Corporation Carbonyl piperazinyl and piperidinyl compounds
WO1997045412A1 (en) * 1996-05-30 1997-12-04 Merck & Co., Inc. A method of treating cancer
US5854264A (en) * 1996-07-24 1998-12-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5888529A (en) 1997-03-28 1999-03-30 The Regents Of The University Of California Ileus treatment method
US6060038A (en) * 1997-05-15 2000-05-09 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
AU8784698A (en) 1997-08-15 1999-03-08 Johns Hopkins University, The Method of using selective parp inhibitors to prevent or treat neurotoxicity
US6426415B1 (en) * 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US20020022636A1 (en) 1997-09-03 2002-02-21 Jia-He Li Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6197785B1 (en) * 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6635642B1 (en) * 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
CA2310250A1 (en) * 1997-11-14 1999-05-27 August Masaru Watanabe Treatment for alzheimer's disease
JP2002505288A (ja) 1998-03-02 2002-02-19 コセンシス，インコーポレイテッド 置換キナゾリンおよびアナログならびにそれらの使用
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US6387897B1 (en) * 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US6492375B2 (en) * 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6310059B1 (en) * 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
EP1148053A4 (en) 1999-01-26 2002-03-06 Ono Pharmaceutical Co 2H-PHTHALAZIN-1-ON DERIVATIVES AND DRUG COMPOSITIONS THAT CONTAIN THESE DERIVATIVES AS ACTIVE INGREDIENTS
DE19921567A1 (de) 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
AU769858B2 (en) 1999-08-11 2004-02-05 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel C-4 methyl carbonate analog
US6465448B1 (en) 1999-08-13 2002-10-15 Case Western Reserve University Methoxyamine potentiation of temozolomide anti-cancer activity
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
WO2001021615A1 (fr) 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Dérivés de benzimidazole
WO2001023390A2 (de) 1999-09-28 2001-04-05 Basf Aktiengesellschaft Azepinoindol-derivate, deren herstellung und anwendung
US6552016B1 (en) * 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US6476048B1 (en) * 1999-12-07 2002-11-05 Inotek Pharamaceuticals Corporation Substituted phenanthridinones and methods of use thereof
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
ATE372337T1 (de) 2000-02-01 2007-09-15 Abbott Gmbh & Co Kg Heterozyklische verbindungen und deren anwendung als parp-inhibitoren
JPWO2001079184A1 (ja) 2000-04-18 2004-03-18 住友製薬株式会社 置換ピペラジン類
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
DE10022925A1 (de) 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
US20030022819A1 (en) * 2000-06-16 2003-01-30 Ling Leona E. Angiogenesis-modulating compositions and uses
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
NZ525138A (en) 2000-10-30 2004-03-26 Kudos Pharm Ltd Phthalazinone derivatives for use as PARP inhibitors
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
AU2002220241A1 (en) 2000-12-01 2002-06-11 Iconix Pharmaceuticals, Inc. Parb inhibitors
EP1217000A1 (en) * 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
WO2002068407A1 (en) 2001-02-28 2002-09-06 Yamanouchi Pharmaceutical Co., Ltd. Benzimidazole compound
DE60218458T2 (de) 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. Isochinolinon derivate als parp inhibitoren
EP1396488A1 (en) 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
US20030073692A1 (en) * 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
JP3843454B2 (ja) 2002-02-19 2006-11-08 小野薬品工業株式会社 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤
US20030195192A1 (en) * 2002-04-05 2003-10-16 Fortuna Haviv Nicotinamides having antiangiogenic activity
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
ES2357057T3 (es) * 2002-04-30 2011-04-15 Kudos Pharmaceuticals Limited Derivados de ftalazinona.
GB2415430B (en) * 2003-03-12 2006-07-12 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) * 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
NZ547984A (en) 2003-12-01 2009-03-31 Kudos Pharm Ltd DNA damage repair inhibitors for treatment of cancer
EP1744751A4 (en) * 2004-03-18 2010-03-10 Brigham & Womens Hospital METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
WO2006001463A1 (ja) * 2004-06-23 2006-01-05 Ono Pharmaceutical Co., Ltd. Ｓ１ｐ受容体結合能を有する化合物およびその用途
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
DE102005011822A1 (de) * 2005-03-15 2006-09-21 Merck Patent Gmbh Phthalazinone
GB0521373D0 (en) * 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
PL2698062T3 (pl) 2006-12-28 2015-12-31 Abbvie Inc Inhibitory polimerazy poli(adp-rybozy)
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
KR101598231B1 (ko) * 2007-10-17 2016-02-26 쿠도스 파마슈티칼스 리미티드 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온

Also Published As

Publication number Publication date
KR20140011425A (ko) 2014-01-28
CL2007002967A1 (es) 2008-04-18
TWI404716B (zh) 2013-08-11
IL216705A (en) 2014-02-27
HK1203959A1 (en) 2015-11-06
ME01987B (me) 2012-08-31
WO2008047082A2 (en) 2008-04-24
UA97494C2 (en) 2012-02-27
MY162829A (en) 2017-07-31
ES2372630T3 (es) 2012-01-24
CN104649979B (zh) 2017-04-12
RU2465270C2 (ru) 2012-10-27
SG10201408404XA (en) 2015-01-29
CA2664275C (en) 2015-03-17
CO6210728A2 (es) 2010-10-20
RU2465270C3 (ru) 2017-03-28
DK2064189T3 (da) 2012-01-02
CA2875147C (en) 2016-09-06
CN101528714B (zh) 2012-06-06
AU2007311766A1 (en) 2008-04-24
WO2008047082A3 (en) 2008-09-25
CY1112345T1 (el) 2015-12-09
IL216705A0 (en) 2012-01-31
NO343063B1 (no) 2018-10-22
MY147389A (en) 2012-11-30
HK1126483A1 (en) 2009-09-04
ATE528296T1 (de) 2011-10-15
EP2064189A2 (en) 2009-06-03
JP2015013879A (ja) 2015-01-22
US20080146575A1 (en) 2008-06-19
SI2064189T1 (sl) 2012-01-31
NO341963B1 (no) 2018-03-05
IL197420A (en) 2015-07-30
JP5719471B2 (ja) 2015-05-20
EP2824098A1 (en) 2015-01-14
PL2064189T3 (pl) 2012-03-30
JP2010506894A (ja) 2010-03-04
HRP20120007T1 (hr) 2012-01-31
CN104649979A (zh) 2015-05-27
US8247416B2 (en) 2012-08-21
EP2064189B1 (en) 2011-10-12
BRPI0717125B1 (pt) 2022-02-08
KR20090085033A (ko) 2009-08-06
SA110310666B1 (ar) 2013-10-09
PT2064189E (pt) 2012-01-05
SG168523A1 (en) 2011-02-28
AU2007311766B2 (en) 2013-02-21
BRPI0717125A2 (pt) 2013-12-17
US7692006B2 (en) 2010-04-06
UY30639A1 (es) 2008-05-31
ES2587129T3 (es) 2016-10-20
KR101494910B1 (ko) 2015-02-23
EP2374800A2 (en) 2011-10-12
US20090270617A1 (en) 2009-10-29
JP5607773B2 (ja) 2014-10-15
SA07280551B1 (ar) 2011-05-04
CA2875147A1 (en) 2008-04-24
CN101528714A (zh) 2009-09-09
JP2013136607A (ja) 2013-07-11
NZ575627A (en) 2011-09-30
EP2374800A3 (en) 2012-02-29
AR063320A1 (es) 2009-01-21
PE20081175A1 (es) 2008-11-06
TW200825066A (en) 2008-06-16
BRPI0717125B8 (pt) 2023-01-10
IL197420A0 (en) 2009-12-24
JP5248513B2 (ja) 2013-07-31
CN102627611A (zh) 2012-08-08
RS52112B (sr) 2012-08-31
NO20171775A1 (no) 2009-05-13
EP2824098B1 (en) 2016-06-22
RU2009109068A (ru) 2010-11-27
NO20091882L (no) 2009-05-13
CA2664275A1 (en) 2008-04-24

Similar Documents

Publication Publication Date Title
MX2009004103A (es) Derivados de ftalazinona.
MX2010004028A (es) 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona.
EA200801959A1 (ru) Высокоразветвленный полипропилен
ZA200809689B (en) 1, 3, 4 -Oxadiazole derivatives as DGAT1 inhibitors
IL187451A0 (en) Oxadiazole derivatives as dgat inhibitors
GB2461659A (en) Structured compositions comprising a clay
MX2009007336A (es) Indazoles substituidos con 5-furopiridinona.
SI2132204T1 (sl) Kristalinične oblike 8-azabiciklo(3.2.1) oktanske spojine
IL202093A0 (en) 4,4-disubstituted piperidine derivatives
EP2018792A4 (en) SUBSTITUTED PIPERIDINE PHENYLOXAZOLIDINONE
MX2010005795A (es) Usos terapeuticos de compuestos con afinidad con el transportador de serotonina, los receptores de serotonina y el transportador de noradrenalina.
MX2012007837A (es) Derivados de oxazolopirimidina 2, 5 - sustituidos.
NZ591045A (en) Polymeric benzyl carbonate-derivatives
WO2009111028A8 (en) Aurora kinase inhibitors
FR2918550B1 (fr) Sommier pour un lit.
HK1155153A (en) 1, 2 disubstituted heterocyclic compounds
HK1128688A (en) 1,3,4-oxadiazole derivatives as dgat1 inhibitors
HK1142314A (en) Spirocyclopropyl piperidine derivatives
HK1117837A (en) Oxadiazole derivatives as dgat inhibitors
HK1126207A (en) 2,5-disubstituted piperidines
AU2007902941A0 (en) Refuse receptable deoderizer sanitier & insectisiser
HK1122193A (en) Ready-to-eat feed for domestic pets
HK1144193A (en) Oxadiazole derivatives
HK1134891A (en) Novel oxadiazole compounds
HK1136290A (en) 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors

Legal Events

Date Code Title Description
FG Grant or registration