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MX2010003720A - Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer. - Google Patents

Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.

Info

Publication number
MX2010003720A
MX2010003720A MX2010003720A MX2010003720A MX2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A
Authority
MX
Mexico
Prior art keywords
dendritic cells
genetic engineering
cancer treatment
cells created
provides
Prior art date
Application number
MX2010003720A
Other languages
English (en)
Inventor
J Mark Braughler
Prasanna Kumar
Walter J Storkus
Hideho Okada
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of MX2010003720A publication Critical patent/MX2010003720A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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    • G01N2333/52—Assays involving cytokines
    • G01N2333/555—Interferons [IFN]
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    • G01N2800/00—Detection or diagnosis of diseases
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Engineering & Computer Science (AREA)
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Abstract

Esta invención proporciona el campo de productos terapéuticos. De manera más específica, la presente invención proporciona métodos para generar in vitro células dendríticas creadas por ingeniería genética que expresan de manera condicional interleucina-12 (IL-12) bajo el control de un sistema de modulación de expresión génica en la presencia del ligando activador y usos para propósitos terapéuticos en animales incluyendo humanos.
MX2010003720A 2007-10-08 2008-10-08 Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer. MX2010003720A (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US97839407P 2007-10-08 2007-10-08
US97822407P 2007-10-08 2007-10-08
US97850907P 2007-10-09 2007-10-09
US97948007P 2007-10-12 2007-10-12
US97948507P 2007-10-12 2007-10-12
US99016707P 2007-11-26 2007-11-26
US99068907P 2007-11-28 2007-11-28
US99180707P 2007-12-03 2007-12-03
US1908908P 2008-01-04 2008-01-04
PCT/US2008/011563 WO2009048560A1 (en) 2007-10-08 2008-10-08 Engineered dendritic cells and uses for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2010003720A true MX2010003720A (es) 2010-10-20

Family

ID=40549463

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003720A MX2010003720A (es) 2007-10-08 2008-10-08 Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.

Country Status (16)

Country Link
US (4) US20090123441A1 (es)
EP (2) EP2207874B1 (es)
JP (3) JP2010539993A (es)
KR (3) KR101740205B1 (es)
CN (1) CN101883845B (es)
AU (1) AU2008311292B9 (es)
BR (1) BRPI0818287A2 (es)
CA (1) CA2702058A1 (es)
ES (2) ES2531522T3 (es)
HU (2) HUE035406T2 (es)
IL (1) IL204841A (es)
MX (1) MX2010003720A (es)
NZ (1) NZ585190A (es)
RU (3) RU2484132C2 (es)
WO (1) WO2009048560A1 (es)
ZA (1) ZA201003163B (es)

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HUE035406T2 (en) * 2007-10-08 2018-05-02 Intrexon Corp Engineered dendritic cells and uses for the treatment of cancer
RU2573912C2 (ru) 2008-10-08 2016-01-27 Интрексон Корпорейшн Сконструированные клетки, экспрессирующие множественные иммуномодуляторы, и их применения
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CN102174479B (zh) * 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
CN103534355A (zh) * 2011-03-04 2014-01-22 英特瑞克斯顿股份有限公司 条件性表达蛋白质的载体
JP6347745B2 (ja) 2011-09-08 2018-06-27 イントレキソン コーポレーション 結晶性ジアシルヒドラジンおよびその使用
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RU2722212C9 (ru) * 2014-08-05 2020-07-23 СиБи ТЕРЕПЬЮТИКС, ИНК. Анти-pd-l1 антитела
ES2853823T3 (es) * 2014-09-30 2021-09-17 Intervet Int Bv Anticuerpos de PD-L1 que se unen a PD-L1 canino
WO2017062953A1 (en) 2015-10-10 2017-04-13 Intrexon Corporation Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
CN108713025A (zh) 2015-11-11 2018-10-26 英特拉克森公司 用于治疗心脏病况和其他病理的从单个载体表达多种生物活性多肽的组合物和方法
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