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MX2019011148A - Metodos de tratamiento. - Google Patents

Metodos de tratamiento.

Info

Publication number
MX2019011148A
MX2019011148A MX2019011148A MX2019011148A MX2019011148A MX 2019011148 A MX2019011148 A MX 2019011148A MX 2019011148 A MX2019011148 A MX 2019011148A MX 2019011148 A MX2019011148 A MX 2019011148A MX 2019011148 A MX2019011148 A MX 2019011148A
Authority
MX
Mexico
Prior art keywords
treatment methods
identifying
methods
compositions
cancer therapy
Prior art date
Application number
MX2019011148A
Other languages
English (en)
Inventor
Baker Flechtner Jessica
LOSSKY-ELIAS Marie
M Carroll Pamela
Lam Hubert
K Mcneil Lisa
Jane Broom Wendy
Original Assignee
Genocea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genocea Biosciences Inc filed Critical Genocea Biosciences Inc
Publication of MX2019011148A publication Critical patent/MX2019011148A/es

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Abstract

En el presente documento se proporcionan métodos y composiciones para identificar antígenos tumorales de linfocitos humanos, y para identificar sujetos para terapia contra el cáncer.
MX2019011148A 2017-03-20 2018-03-20 Metodos de tratamiento. MX2019011148A (es)

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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201908530QA (en) 2017-03-20 2019-10-30 Genocea Biosciences Inc Treatment methods
EP3873614A4 (en) * 2018-10-29 2022-09-07 Genocea Biosciences, Inc. TREATMENT PROCEDURES
CN109957549A (zh) * 2018-12-03 2019-07-02 胜武（北京）生物科技有限公司 一种双功能溶瘤病毒及其应用
US20200179500A1 (en) * 2018-12-05 2020-06-11 Wayne State University Methods and immunogenic compositions relating to her2 with selective sequence modifications
CN110016082B (zh) * 2018-12-25 2021-03-23 海南医学院第一附属医院 MIP3α-FGFR1-PD1/Fc融合蛋白及其核酸分子和应用
WO2020232408A1 (en) * 2019-05-15 2020-11-19 Genocea Biosciences, Inc. Treatment methods
US20230031980A1 (en) * 2019-12-13 2023-02-02 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Methods and compositions for treating and diagnosing a sage1-related condition
US20210338725A1 (en) * 2020-04-02 2021-11-04 Genocea Biosciences, Inc. Treatment methods
WO2021231436A1 (en) * 2020-05-11 2021-11-18 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic methods for treating covid-19 infections
WO2021232200A1 (en) * 2020-05-18 2021-11-25 Guangdong Tcrcure Biopharma Technology Co., Ltd. Il-12 armored immune cell therapy and uses thereof
US20230243849A1 (en) * 2020-05-26 2023-08-03 University Of Kentucky Research Foundation Identifying Risk of Cerebra Edema
EP4192942A1 (en) * 2020-08-07 2023-06-14 Genentech, Inc. T cell-based methods for predicting polypeptide immunogenicity
WO2022056491A1 (en) * 2020-09-14 2022-03-17 Genocea Biosciences, Inc. Treatment methods
CA3210289A1 (en) 2021-03-09 2022-09-15 Anna Maria SOBIERAJ Mage-a4 peptide-mhc antigen binding proteins
WO2022190007A1 (en) 2021-03-09 2022-09-15 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries
WO2022236069A1 (en) * 2021-05-07 2022-11-10 University Of North Texas Health Science Center At Fort Worth Blood test to screen out parkinson's disease
WO2023086969A2 (en) 2021-11-12 2023-05-19 Ichor Medical Systems Inc. Treatment methods
US20260016474A1 (en) * 2022-07-14 2026-01-15 University Of South Australia Methods and products for determining responsiveness to anti-pd1 immune checkpoint inhibitor immunotherapy
AU2023342450A1 (en) 2022-09-14 2025-03-13 Cdr-Life Ag Mage-a4 peptide dual t cell engagers
CN118955735A (zh) * 2024-08-02 2024-11-15 中国药科大学 一种融合蛋白及基于其的mRNA递送系统和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925661A (en) 1984-04-19 1990-05-15 Leaf Huang Target-specific cytotoxic liposomes
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4863874A (en) 1986-07-11 1989-09-05 The United States Of America As Represented By The Secretary Of The Army Method for detecting phosphatidylinositol through binding to Concanavalin A
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5989565A (en) 1993-01-29 1999-11-23 University Of Pittsburgh Elution and identification of T cell epitopes from viable cells
US5643599A (en) 1995-06-07 1997-07-01 President And Fellows Of Harvard College Intracellular delivery of macromolecules
US6872518B2 (en) 1997-09-22 2005-03-29 University Of Rochester Methods for selecting polynucleotides encoding T cell epitopes
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
CA2333750A1 (en) 1998-06-23 1999-12-29 Dale T. Umetsu Adjuvant therapy
US6004815A (en) 1998-08-13 1999-12-21 The Regents Of The University Of California Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells
US6407063B1 (en) 1998-10-02 2002-06-18 Ludwig Institute For Cancer Research Tumor antigens and CTL clones isolated by a novel procedure
DE60041183D1 (de) 1999-05-06 2009-02-05 Univ Wake Forest Zusammensetzungen und methoden zur identifikation von antigenen, die eine immunantwort hervorrufen
US20030077263A1 (en) 1999-10-29 2003-04-24 Immunex Corporation Method of activating dendritic cells
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US20030003485A1 (en) 2001-05-15 2003-01-02 Ludwig Institute For Cancer Research Methods for identifying antigens
US7262269B2 (en) 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
DE10164819A1 (de) 2001-11-20 2005-05-19 Deml, Ludwig, Dr. Verfahren zur Identifizierung von Zielepitopen der T-Zell-vermittelten Immunantwort und zum Nachweis Epitop-spezifischer T-Zellen
US7413868B2 (en) 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
EP1715346A1 (en) 2005-04-22 2006-10-25 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Method of identifying CD4+ T cell antigens
WO2006138449A2 (en) 2005-06-16 2006-12-28 The Wistar Institute Method for identifying a mhc class ii-dependent tumor-associated t helper cell antigen
AU2007217515B2 (en) 2006-02-21 2014-02-06 President And Fellows Of Harvard College Compositions for and methods of identifying antigens
WO2009020553A2 (en) 2007-08-03 2009-02-12 President And Fellows Of Harvard College Chlamydia antigens
AU2009266924B2 (en) * 2008-07-01 2015-12-10 Genocea Biosciences, Inc. Antigen screening system
WO2011143656A2 (en) 2010-05-14 2011-11-17 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
CN105377867B (zh) 2013-05-03 2019-11-12 加利福尼亚大学董事会 I型干扰素的环状二核苷酸诱导
JP6453855B2 (ja) 2013-05-18 2019-01-16 アドゥロ バイオテック，インク． 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を活性化するための組成物及び方法
MA40737A (fr) * 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
ES2764178T3 (es) 2014-12-16 2020-06-02 Kayla Therapeutics Dinucleótidos cíclicos fluorados para inducción de citocinas
SG11201908530QA (en) 2017-03-20 2019-10-30 Genocea Biosciences Inc Treatment methods

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