MX2007001188A - 1,1,2,2-tetra (hetero)ariletanos o 1,1,2-tri (hetero)aril-2-heterocicliletanos como inhibidores del canal de potasio. - Google Patents

1,1,2,2-tetra (hetero)ariletanos o 1,1,2-tri (hetero)aril-2-heterocicliletanos como inhibidores del canal de potasio.

Info

Publication number: MX2007001188A
Authority: MX; Mexico
Prior art keywords: ring; heteroaryl ring; group; independently selected; unsubstituted
Prior art date: 2004-07-29

Application number

MX2007001188A

Other languages

English (en)

Spanish (es)

Inventor

Mark T Bilodeau

Zhicai Wu

John Hartnett

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-29

Filing date

2005-07-25

Publication date

2007-03-21

2005-07-25 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2007-03-21 Publication of MX2007001188A publication Critical patent/MX2007001188A/es

Links

239000003112 inhibitor Substances 0.000 title abstract description 6
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108020001213 potassium channel Proteins 0.000 title abstract description 5
125000005842 heteroatom Chemical group 0.000 title description 11
150000001875 compounds Chemical class 0.000 claims abstract description 80
206010003119 arrhythmia Diseases 0.000 claims abstract description 12
125000001072 heteroaryl group Chemical group 0.000 claims description 92
125000000623 heterocyclic group Chemical group 0.000 claims description 30
125000002950 monocyclic group Chemical group 0.000 claims description 25
125000004432 carbon atom Chemical group C* 0.000 claims description 24
125000003118 aryl group Chemical group 0.000 claims description 23
229910052717 sulfur Inorganic materials 0.000 claims description 23
229910052799 carbon Inorganic materials 0.000 claims description 21
150000001721 carbon Chemical group 0.000 claims description 19
239000003814 drug Substances 0.000 claims description 19
229910052760 oxygen Inorganic materials 0.000 claims description 16
238000006467 substitution reaction Methods 0.000 claims description 15
125000004433 nitrogen atom Chemical group N* 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 14
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125000001424 substituent group Chemical group 0.000 claims description 11
239000001257 hydrogen Substances 0.000 claims description 10
229910052739 hydrogen Inorganic materials 0.000 claims description 10
150000002367 halogens Chemical class 0.000 claims description 8
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 7
125000000753 cycloalkyl group Chemical group 0.000 claims description 7
229910052736 halogen Inorganic materials 0.000 claims description 6
150000002431 hydrogen Chemical class 0.000 claims description 6
230000005764 inhibitory process Effects 0.000 claims description 6
ICZMUQRLGYREPQ-UHFFFAOYSA-N n-[6-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC(C(C(C=2C=NC=CC=2)C=2C=NC=CC=2)C=2C=C(C=CC=2)C#N)=N1 ICZMUQRLGYREPQ-UHFFFAOYSA-N 0.000 claims description 6
QPWKXYZJANVPLF-UHFFFAOYSA-N n-[6-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC(C(C(C=2C=NC=CC=2)C=2C=NC=CC=2)C=2C=CC(F)=CC=2)=N1 QPWKXYZJANVPLF-UHFFFAOYSA-N 0.000 claims description 6
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LHFAZNXOLPUMGO-QFIPXVFZSA-N 3-[(1s)-1-(2-aminopyrimidin-4-yl)-2,2-dipyridin-3-ylethyl]benzonitrile Chemical compound NC1=NC=CC([C@@H](C(C=2C=NC=CC=2)C=2C=NC=CC=2)C=2C=C(C=CC=2)C#N)=N1 LHFAZNXOLPUMGO-QFIPXVFZSA-N 0.000 claims description 2
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
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CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
229960002009 naproxen Drugs 0.000 description 1
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
229960001597 nifedipine Drugs 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
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229960005117 olmesartan Drugs 0.000 description 1
VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 description 1
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239000002997 ophthalmic solution Substances 0.000 description 1
229940100654 ophthalmic suspension Drugs 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
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150000007524 organic acids Chemical class 0.000 description 1
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239000001301 oxygen Substances 0.000 description 1
235000019629 palatability Nutrition 0.000 description 1
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IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 description 1
229960003929 perindopril erbumine Drugs 0.000 description 1
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239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
125000004193 piperazinyl group Chemical group 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000036278 prepulse Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
229960000244 procainamide Drugs 0.000 description 1
REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
239000000047 product Substances 0.000 description 1
239000003380 propellant Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
125000003373 pyrazinyl group Chemical group 0.000 description 1
125000003072 pyrazolidinyl group Chemical group 0.000 description 1
125000003226 pyrazolyl group Chemical group 0.000 description 1
125000002098 pyridazinyl group Chemical group 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
229960001455 quinapril Drugs 0.000 description 1
JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
229960003401 ramipril Drugs 0.000 description 1
HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000013577 regulation of ventricular cardiomyocyte membrane repolarization Effects 0.000 description 1
230000003252 repetitive effect Effects 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
238000012216 screening Methods 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
230000035939 shock Effects 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
229960002370 sotalol Drugs 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229930002534 steroid glycoside Natural products 0.000 description 1
150000008143 steroidal glycosides Chemical class 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
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239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
230000006794 tachycardia Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000003419 tautomerization reaction Methods 0.000 description 1
229960005187 telmisartan Drugs 0.000 description 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
125000001113 thiadiazolyl group Chemical group 0.000 description 1
125000001984 thiazolidinyl group Chemical group 0.000 description 1
125000004568 thiomorpholinyl group Chemical group 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
239000003868 thrombin inhibitor Substances 0.000 description 1
PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
229960005001 ticlopidine Drugs 0.000 description 1
COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 description 1
229960003425 tirofiban Drugs 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229960002051 trandolapril Drugs 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
235000019798 tripotassium phosphate Nutrition 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
208000003663 ventricular fibrillation Diseases 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
229950003419 zatebradine Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MX2007001188A 2004-07-29 2005-07-25 1,1,2,2-tetra (hetero)ariletanos o 1,1,2-tri (hetero)aril-2-heterocicliletanos como inhibidores del canal de potasio. MX2007001188A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US59218104P	2004-07-29	2004-07-29
PCT/US2005/026334 WO2006028590A1 (en)	2004-07-29	2005-07-25	1,1,2,2-tetra (hetero) arylethanes or 1,1,2-tri (hetero) aryl-2-heterocyclylethanes as potassium channel inhibitors

Publications (1)

Publication Number	Publication Date
MX2007001188A true MX2007001188A (es)	2007-03-21

Family

ID=35613661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX2007001188A MX2007001188A (es)	2004-07-29	2005-07-25	1,1,2,2-tetra (hetero)ariletanos o 1,1,2-tri (hetero)aril-2-heterocicliletanos como inhibidores del canal de potasio.

Country Status (15)

Country	Link
KR (1)	KR20070043985A (uk)
AR (1)	AR049847A1 (uk)
BR (1)	BRPI0513793A (uk)
CR (1)	CR8876A (uk)
EC (1)	ECSP077208A (uk)
IL (1)	IL180846A0 (uk)
MA (1)	MA28980B1 (uk)
MX (1)	MX2007001188A (uk)
NO (1)	NO20071107L (uk)
PE (1)	PE20060382A1 (uk)
RU (1)	RU2344134C2 (uk)
TW (1)	TW200607493A (uk)
UA (1)	UA88018C2 (uk)
WO (1)	WO2006028590A1 (uk)
ZA (1)	ZA200700477B (uk)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105311003A (zh) *	2009-03-18	2016-02-10	麦迪库瑞国际公司	替罗非班的透皮药物制剂和给药
SI2858987T1 (en)	2012-06-11	2018-06-29	Bristol-Myers Squibb Company	PREPARATION OF 5-PHENYL-4- (PYRIDIN-2-ILLETHYLAMINO) -CHUINAZOLIN-2-YL) -PIRIDIN-3-SULPHONAMIDE PHOSPHORAMIDIC ACID

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2140865B2 (de) *	1971-08-14	1979-10-11	Bayer Ag, 5090 Leverkusen	1 -Imidazolyl-methanphosphonsäureester, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE19951701A1 (de) *	1999-10-27	2001-05-03	Aventis Pharma Gmbh	Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten
DE60322019D1 (de) *	2002-01-04	2008-08-21	Neurosearch As	Kaliumkanal-modulatoren

2005
- 2005-07-19 AR ARP050102975A patent/AR049847A1/es unknown
- 2005-07-22 TW TW094125011A patent/TW200607493A/zh unknown
- 2005-07-22 PE PE2005000858A patent/PE20060382A1/es not_active Application Discontinuation
- 2005-07-25 BR BRPI0513793-4A patent/BRPI0513793A/pt not_active IP Right Cessation
- 2005-07-25 MX MX2007001188A patent/MX2007001188A/es unknown
- 2005-07-25 UA UAA200702125A patent/UA88018C2/uk unknown
- 2005-07-25 WO PCT/US2005/026334 patent/WO2006028590A1/en not_active Ceased
- 2005-07-25 KR KR1020077002228A patent/KR20070043985A/ko not_active Withdrawn
- 2005-07-25 RU RU2007107408/04A patent/RU2344134C2/ru not_active IP Right Cessation
2007
- 2007-01-16 ZA ZA200700477A patent/ZA200700477B/xx unknown
- 2007-01-21 IL IL180846A patent/IL180846A0/en unknown
- 2007-01-25 CR CR8876A patent/CR8876A/es not_active Application Discontinuation
- 2007-01-26 EC EC2007007208A patent/ECSP077208A/es unknown
- 2007-02-21 MA MA29689A patent/MA28980B1/fr unknown
- 2007-02-27 NO NO20071107A patent/NO20071107L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ECSP077208A (es)	2007-02-28
MA28980B1 (fr)	2007-11-01
AR049847A1 (es)	2006-09-06
RU2007107408A (ru)	2008-09-10
KR20070043985A (ko)	2007-04-26
BRPI0513793A (pt)	2008-05-13
WO2006028590A1 (en)	2006-03-16
ZA200700477B (en)	2009-08-26
IL180846A0 (en)	2007-06-03
CR8876A (es)	2007-08-28
PE20060382A1 (es)	2006-05-15
TW200607493A (en)	2006-03-01
UA88018C2 (uk)	2009-09-10
NO20071107L (no)	2007-04-19
RU2344134C2 (ru)	2009-01-20

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US8067607B2 (en)	2011-11-29	Potassium channel inhibitors
MX2007001188A (es)	2007-03-21	1,1,2,2-tetra (hetero)ariletanos o 1,1,2-tri (hetero)aril-2-heterocicliletanos como inhibidores del canal de potasio.
JP5190381B2 (ja)	2013-04-24	カリウムチャネル阻害剤
EP1981508A2 (en)	2008-10-22	Potassium channel inhibitors
US8278317B2 (en)	2012-10-02	Potassium channel inhibitors
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