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MA28980B1 - 1, 1, 2, 2-tetra (hetero) arylethanes ou 1, 1, 2-tri (hetero) aryle-2-heterocyclylethanes comme inhibiteurs des canaux potassiques - Google Patents

1, 1, 2, 2-tetra (hetero) arylethanes ou 1, 1, 2-tri (hetero) aryle-2-heterocyclylethanes comme inhibiteurs des canaux potassiques

Info

Publication number
MA28980B1
MA28980B1 MA29689A MA29689A MA28980B1 MA 28980 B1 MA28980 B1 MA 28980B1 MA 29689 A MA29689 A MA 29689A MA 29689 A MA29689 A MA 29689A MA 28980 B1 MA28980 B1 MA 28980B1
Authority
MA
Morocco
Prior art keywords
hetero
inhibitors
heterocyclylethanes
arylethanes
tetra
Prior art date
Application number
MA29689A
Other languages
English (en)
Inventor
Mark T Bilodeau
Zhicai Wu
John Hartnett
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA28980B1 publication Critical patent/MA28980B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cette invention porte sur des composés représentés par la structure (1) utiles en tant qu'inhibiteurs de canal potassique dans le traitement des arythmies cardiaques et autres maladies similaires.
MA29689A 2004-07-29 2007-02-21 1, 1, 2, 2-tetra (hetero) arylethanes ou 1, 1, 2-tri (hetero) aryle-2-heterocyclylethanes comme inhibiteurs des canaux potassiques MA28980B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59218104P 2004-07-29 2004-07-29

Publications (1)

Publication Number Publication Date
MA28980B1 true MA28980B1 (fr) 2007-11-01

Family

ID=35613661

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29689A MA28980B1 (fr) 2004-07-29 2007-02-21 1, 1, 2, 2-tetra (hetero) arylethanes ou 1, 1, 2-tri (hetero) aryle-2-heterocyclylethanes comme inhibiteurs des canaux potassiques

Country Status (15)

Country Link
KR (1) KR20070043985A (fr)
AR (1) AR049847A1 (fr)
BR (1) BRPI0513793A (fr)
CR (1) CR8876A (fr)
EC (1) ECSP077208A (fr)
IL (1) IL180846A0 (fr)
MA (1) MA28980B1 (fr)
MX (1) MX2007001188A (fr)
NO (1) NO20071107L (fr)
PE (1) PE20060382A1 (fr)
RU (1) RU2344134C2 (fr)
TW (1) TW200607493A (fr)
UA (1) UA88018C2 (fr)
WO (1) WO2006028590A1 (fr)
ZA (1) ZA200700477B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102427806B (zh) * 2009-03-18 2015-11-25 麦迪库瑞国际公司 替罗非班的透皮药物制剂和给药
NZ703632A (en) 2012-06-11 2016-01-29 Bristol Myers Squibb Co Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2140865B2 (de) * 1971-08-14 1979-10-11 Bayer Ag, 5090 Leverkusen 1 -Imidazolyl-methanphosphonsäureester, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE19951701A1 (de) * 1999-10-27 2001-05-03 Aventis Pharma Gmbh Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten
ATE400551T1 (de) * 2002-01-04 2008-07-15 Neurosearch As Kaliumkanal-modulatoren

Also Published As

Publication number Publication date
MX2007001188A (es) 2007-03-21
BRPI0513793A (pt) 2008-05-13
PE20060382A1 (es) 2006-05-15
ZA200700477B (en) 2009-08-26
RU2344134C2 (ru) 2009-01-20
RU2007107408A (ru) 2008-09-10
IL180846A0 (en) 2007-06-03
CR8876A (es) 2007-08-28
UA88018C2 (ru) 2009-09-10
ECSP077208A (es) 2007-02-28
WO2006028590A1 (fr) 2006-03-16
KR20070043985A (ko) 2007-04-26
TW200607493A (en) 2006-03-01
NO20071107L (no) 2007-04-19
AR049847A1 (es) 2006-09-06

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