|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
AU5006993A
(en)
*
|
1992-08-21 |
1994-03-15 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
NZ250375A
(en)
*
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
|
US5359030A
(en)
*
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US5478860A
(en)
*
|
1993-06-04 |
1995-12-26 |
Inex Pharmaceuticals Corp. |
Stable microemulsions for hydrophobic compound delivery
|
|
KR100361933B1
(ko)
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
|
US5965566A
(en)
*
|
1993-10-20 |
1999-10-12 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
EP0727992A4
(en)
*
|
1993-10-20 |
2001-01-31 |
Enzon Inc |
SUBSTITUTED TAXOID SUBSTANCES IN 2 'AND / OR 7' POSITION
|
|
US5880131A
(en)
*
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5643575A
(en)
*
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
*
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
KR960705579A
(ko)
*
|
1993-11-10 |
1996-11-08 |
에릭에스. 딕커 |
개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates)
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US5730990A
(en)
*
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US7008624B1
(en)
*
|
1995-02-22 |
2006-03-07 |
Immunex Corporation |
Antagonists of interleukin-15
|
|
DE19512484A1
(de)
*
|
1995-04-04 |
1996-10-17 |
Bayer Ag |
Kohlenhydratmodifizierte Cytostatika
|
|
DE19514087A1
(de)
*
|
1995-04-13 |
1996-10-17 |
Deutsches Krebsforsch |
Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
|
|
EP0741187A2
(en)
*
|
1995-05-05 |
1996-11-06 |
F. Hoffmann-La Roche Ag |
Recombinant obese (Ob) proteins
|
|
ZA963530B
(en)
*
|
1995-05-05 |
1996-11-05 |
Hoffmann La Roche |
Recombinant obese (ob) proteins
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
CA2329474C
(en)
|
1995-11-02 |
2002-02-26 |
Schering Corporation |
Continuous low-dose cytokine infusion therapy
|
|
US6025324A
(en)
*
|
1996-05-15 |
2000-02-15 |
Hoffmann-La Roche Inc. |
Pegylated obese (ob) protein compositions
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
WO1998032466A1
(en)
*
|
1997-01-29 |
1998-07-30 |
Polymasc Pharmaceuticals Plc |
Pegylation process
|
|
AU6326198A
(en)
|
1997-02-13 |
1998-09-08 |
Lxr Biotechnology Inc. |
Organ preservation solution
|
|
WO1998037200A2
(en)
|
1997-02-21 |
1998-08-27 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
US5981709A
(en)
*
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
US5985263A
(en)
*
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US7005504B2
(en)
*
|
1998-01-22 |
2006-02-28 |
Genentech, Inc. |
Antibody fragment-peg conjugates
|
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
|
US6468532B1
(en)
|
1998-01-22 |
2002-10-22 |
Genentech, Inc. |
Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
|
|
FR2774687B1
(fr)
*
|
1998-02-06 |
2002-03-22 |
Inst Nat Sante Rech Med |
Lipopeptides contenant un fragment de l'interferon gamma, et leur utilisation dans des compositions pharmaceutiques
|
|
US6180096B1
(en)
*
|
1998-03-26 |
2001-01-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
|
KR100622796B1
(ko)
*
|
1998-04-28 |
2006-09-13 |
어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. |
폴리올-ifn-베타 공액체
|
|
SK288038B6
(en)
|
1998-05-15 |
2013-01-02 |
Merck Sharp & Dohme |
Use of ribavirin and interferon alpha for manufacture pharmaceutical compositions for treating chronic hepatitis C infection
|
|
KR20050055053A
(ko)
*
|
1998-06-08 |
2005-06-10 |
에프. 호프만-라 로슈 아게 |
만성 C형 간염을 치료하기 위한 폴리에틸렌글리콜-인터페론-α 및 리바비린의 용도
|
|
US6703381B1
(en)
*
|
1998-08-14 |
2004-03-09 |
Nobex Corporation |
Methods for delivery therapeutic compounds across the blood-brain barrier
|
|
HK1042098B
(zh)
|
1998-10-16 |
2009-10-30 |
拜奥根Idec马萨诸塞公司 |
干扰素-β融合蛋白及用途
|
|
TR200101086T2
(tr)
*
|
1998-10-16 |
2001-08-21 |
Biogen, Inc. |
Interferon beta-1A'nın polimer birleşikleri ve kullanımları.
|
|
DK2319928T3
(da)
|
1998-10-23 |
2013-06-24 |
Kirin Amgen Inc |
Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
|
|
US6362162B1
(en)
|
1999-04-08 |
2002-03-26 |
Schering Corporation |
CML Therapy
|
|
US6923966B2
(en)
|
1999-04-08 |
2005-08-02 |
Schering Corporation |
Melanoma therapy
|
|
US6605273B2
(en)
|
1999-04-08 |
2003-08-12 |
Schering Corporation |
Renal cell carcinoma treatment
|
|
EP1043026B1
(en)
|
1999-04-08 |
2005-06-01 |
Schering Corporation |
Melanoma therapy
|
|
US7169889B1
(en)
|
1999-06-19 |
2007-01-30 |
Biocon Limited |
Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
|
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
AU4934299A
(en)
*
|
1999-07-15 |
2001-02-05 |
Kuhnil Pharm. Co., Ltd. |
Novel water soluble-cyclosporine conjugated compounds
|
|
YU32402A
(sh)
|
1999-11-12 |
2005-03-15 |
Maxygen Holdings Ltd. |
Konjugati gama interferona
|
|
BR0015506A
(pt)
|
1999-11-12 |
2002-07-23 |
Maxygen Holdings Ltd |
Conjugados de interferon gama, métodos para sua preparação, composições farmacêuticas que compreendem ás moléculas e seu uso no tratamento de doenças
|
|
AU782580B2
(en)
|
2000-01-10 |
2005-08-11 |
Maxygen, Inc. |
G-CSF conjugates
|
|
ATE428445T1
(de)
|
2000-02-11 |
2009-05-15 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
|
IT1317835B1
(it)
*
|
2000-02-15 |
2003-07-15 |
San Raffaele Centro Fond |
Citochine modificate per uso nella terapia del cancro.
|
|
US7109303B2
(en)
*
|
2000-02-15 |
2006-09-19 |
Fondazione Centro San Raffaele Del Monte Tabor |
Modified cytokines for use in cancer therapy
|
|
US7309694B2
(en)
*
|
2000-02-15 |
2007-12-18 |
Fondazione Centro San Raffaele Del Monte Tabor |
Modified cytokines for use in cancer therapy
|
|
US6586398B1
(en)
*
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
SG98393A1
(en)
|
2000-05-19 |
2003-09-19 |
Inst Materials Research & Eng |
Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
|
|
EP1292337A2
(en)
|
2000-06-08 |
2003-03-19 |
La Jolla Pharmaceutical |
Multivalent platform molecules comprising high molecular weight polyethylene oxide
|
|
US7208167B2
(en)
*
|
2000-08-07 |
2007-04-24 |
Sciclone Pharmaceuticals, Inc. |
Treatment of hepatitis C with thymosin and peptide combination therapy
|
|
JP2004508338A
(ja)
*
|
2000-09-08 |
2004-03-18 |
グリフォン セラピューティクス,インコーポレーテッド |
ポリマー修飾合成タンパク質
|
|
US7118737B2
(en)
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
US20020065397A1
(en)
*
|
2000-10-12 |
2002-05-30 |
Joseph Roberts |
Protecting therapeutic compositions from host-mediated inactivation
|
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
US6867183B2
(en)
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
BR0207576A
(pt)
|
2001-02-27 |
2004-04-27 |
Maxygen Aps |
Variante glicosilada de um polipeptìdeo de interferon beta precursor (ifnb), processos de aumentar a glicosilação in vivo de uma molécula de ifnb precursora, de produzir uma molécula de ifnb glicosilada, para preparar uma variante conjugada e de tratar um mamìfero com esclerose múltiplam composição farmacêutica, molécula de ifnb variante, sequência de nucleotìdeo, vetor de expressão, célula hospedeira de glicosilação conjugado, e, uso de um conjugado
|
|
US7038015B2
(en)
*
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
|
US6958388B2
(en)
|
2001-04-06 |
2005-10-25 |
Maxygen, Aps |
Interferon gamma polypeptide variants
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6835802B2
(en)
*
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US6858580B2
(en)
*
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6713452B2
(en)
*
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828305B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
CA2457876C
(en)
|
2001-08-22 |
2011-10-11 |
Bioartificial Gel Technologies Inc. |
Process for the preparation of activated polyethylene glycols
|
|
US7196059B2
(en)
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7166571B2
(en)
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6913903B2
(en)
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7312192B2
(en)
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
UA78726C2
(en)
*
|
2001-11-01 |
2007-04-25 |
Sciclone Pharmaceuticals Inc |
Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
|
|
US20040058865A1
(en)
*
|
2001-11-26 |
2004-03-25 |
Danishefsky Samuel J |
Homing peptide multimers, their preparation and uses
|
|
US7041855B2
(en)
*
|
2001-12-11 |
2006-05-09 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
|
US6916962B2
(en)
*
|
2001-12-11 |
2005-07-12 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
|
US6956135B2
(en)
*
|
2001-12-11 |
2005-10-18 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
|
KR100488351B1
(ko)
*
|
2001-12-11 |
2005-05-11 |
선바이오(주) |
신규한 폴리에틸렌글리콜-프로피온알데히드 유도체
|
|
KR100888371B1
(ko)
|
2002-01-17 |
2009-03-13 |
동아제약주식회사 |
가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제
|
|
NZ534708A
(en)
|
2002-01-18 |
2007-05-31 |
Biogen Idec Inc |
Polyalkylene glycol with moiety for conjugating biologically active compound
|
|
US20030191056A1
(en)
*
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
|
GB0209896D0
(en)
*
|
2002-04-30 |
2002-06-05 |
Molmed Spa |
Conjugate
|
|
GB0209893D0
(en)
*
|
2002-04-30 |
2002-06-05 |
Molmed Spa |
Conjugate
|
|
WO2003105768A2
(en)
|
2002-06-13 |
2003-12-24 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
US20040002451A1
(en)
*
|
2002-06-20 |
2004-01-01 |
Bruce Kerwin |
Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing
|
|
PT1517710E
(pt)
|
2002-06-21 |
2011-07-08 |
Novo Nordisk Healthcare Ag |
Glicoformas do factor vii peguilado
|
|
MY140819A
(en)
|
2002-06-28 |
2010-01-29 |
Idenix Caymans Ltd |
Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
|
|
WO2004005341A2
(en)
*
|
2002-07-03 |
2004-01-15 |
Maxygen Holdings Ltd. |
Full-length interferon gamma polypeptide variants
|
|
KR101101261B1
(ko)
|
2002-07-19 |
2012-01-04 |
인스티튜트 오브 머티어리얼스 리서치 & 엔지니어링 |
생체분해성 삼블럭 공중합체, 이의 합성 방법, 및이로부터 제조된 하이드로겔 및 생체물질
|
|
EP1382352A1
(de)
|
2002-07-19 |
2004-01-21 |
GBF Gesellschaft für Biotechnologische Forschung mbH |
Bisacyloxypropylcystein-Konjugate und deren Verwendung
|
|
MXPA05000796A
(es)
|
2002-07-24 |
2005-04-19 |
Hoffmann La Roche |
Aditivos de acidos polialquilenglicolicos.
|
|
US7563507B2
(en)
*
|
2002-08-16 |
2009-07-21 |
University Of Massachusetts |
Pyridine and related ligand compounds, functionalized nanoparticulate composites and methods of preparation
|
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
US7217845B2
(en)
*
|
2002-11-25 |
2007-05-15 |
Sun Bio, Inc. |
Bifunctional polyethylene glycol derivatives
|
|
CN102319437B
(zh)
*
|
2002-12-26 |
2017-10-13 |
山景医药公司 |
具有增强的生物学效用的干扰素‑β的聚合物缀合物
|
|
GEP20084487B
(en)
*
|
2002-12-26 |
2008-09-25 |
Mountain View Pharmaceuticals |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof
|
|
US20040176655A1
(en)
*
|
2003-02-05 |
2004-09-09 |
Ayoub Paul Marie |
Methods of preparing branched alkyl aromatic hydrocarbons
|
|
WO2004084949A2
(en)
*
|
2003-03-20 |
2004-10-07 |
Xencor |
Generating protein pro-drugs using reversible ppg linkages
|
|
CA2458085A1
(en)
|
2003-03-21 |
2004-09-21 |
F. Hoffmann-La Roche Ag |
Transcriptional activity assay
|
|
PL3521297T3
(pl)
|
2003-05-30 |
2022-04-04 |
Gilead Pharmasset Llc |
Zmodyfikowane fluorowane analogi nukleozydów
|
|
GB0320638D0
(en)
|
2003-09-03 |
2003-10-01 |
Novartis Ag |
Organic compounds
|
|
EP2322569B1
(en)
*
|
2003-10-09 |
2020-08-26 |
Ambrx, Inc. |
Polymer derivatives for the selective modification of proteins
|
|
CN102516386A
(zh)
|
2003-10-10 |
2012-06-27 |
诺沃挪第克公司 |
Il-21衍生物
|
|
ES2428358T3
(es)
|
2003-10-17 |
2013-11-07 |
Novo Nordisk A/S |
Terapia de combinación
|
|
ZA200606224B
(en)
*
|
2004-02-02 |
2007-11-28 |
Ambrx Inc |
Modified human growth hormone polypeptides and their uses
|
|
CA2553035A1
(en)
|
2004-02-02 |
2005-08-18 |
Ambrx, Inc. |
Modified human growth hormone polypeptides and their uses
|
|
US7351787B2
(en)
*
|
2004-03-05 |
2008-04-01 |
Bioartificial Gel Technologies, Inc. |
Process for the preparation of activated polyethylene glycols
|
|
CA2566247A1
(en)
|
2004-05-19 |
2005-12-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
US20060194726A1
(en)
*
|
2004-05-25 |
2006-08-31 |
Rueger David C |
Methods of treating cartilage defects
|
|
WO2005123113A2
(en)
*
|
2004-06-14 |
2005-12-29 |
Intermune, Inc. |
Interferon compositions and methods of use thereof
|
|
JP2008503217A
(ja)
|
2004-06-18 |
2008-02-07 |
アンブレツクス・インコーポレイテツド |
新規抗原結合ポリペプチド及びそれらの使用
|
|
AU2005260763B2
(en)
|
2004-06-30 |
2011-12-22 |
Nektar Therapeutics |
Polymer-factor IX moiety conjugates
|
|
US8143380B2
(en)
*
|
2004-07-08 |
2012-03-27 |
Amgen Inc. |
Therapeutic peptides
|
|
PL2626368T3
(pl)
|
2004-07-19 |
2017-06-30 |
Biocon Limited |
Koniugaty insulina-oligomer, ich formulacje i zastosowania
|
|
EP1771573A4
(en)
|
2004-07-21 |
2009-02-18 |
Ambrx Inc |
BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS
|
|
CN101023094B
(zh)
*
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
US7632491B2
(en)
*
|
2004-08-12 |
2009-12-15 |
Schering Corporation |
Stable pegylated interferon formulation
|
|
PT3109244T
(pt)
|
2004-09-14 |
2019-06-04 |
Gilead Pharmasset Llc |
¿preparação de ribofuranosil pirimidinas e purinas 2¿-fluoro-2¿-alquil substituídas ou outras opcionalmente substituídas e os seus derivados
|
|
BRPI0519170A8
(pt)
|
2004-12-22 |
2018-05-08 |
Ambrx Inc |
formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado
|
|
CN102732588B
(zh)
|
2004-12-22 |
2015-01-07 |
Ambrx公司 |
氨酰基-tRNA合成酶的组合物及其用途
|
|
BRPI0518661A2
(pt)
|
2004-12-22 |
2008-12-02 |
Ambrx Inc |
mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante
|
|
ATE542920T1
(de)
|
2004-12-22 |
2012-02-15 |
Ambrx Inc |
Modifiziertes menschliches wachstumshormon
|
|
PT1835938E
(pt)
*
|
2004-12-27 |
2013-11-06 |
Baxter Int |
Conjugados de polímero-factor de von willebrand
|
|
CN101119743B
(zh)
|
2005-01-31 |
2012-09-26 |
株式会社Eci |
免疫增强剂
|
|
MX2007014524A
(es)
|
2005-05-18 |
2008-02-07 |
Maxygen Inc |
Polipeptidos desarrollados de interferon-alfa.
|
|
US20070015701A1
(en)
*
|
2005-06-01 |
2007-01-18 |
Samuel Zalipsky |
Macromolecular conjugates of bone morphogenetic protein-7
|
|
WO2006133089A2
(en)
*
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
EP1893632B1
(en)
|
2005-06-17 |
2015-08-12 |
Novo Nordisk Health Care AG |
Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
|
|
CA2611151A1
(en)
|
2005-06-17 |
2006-12-28 |
Novartis Ag |
Use of sanglifehrin in hcv
|
|
EP1896072A4
(en)
*
|
2005-06-24 |
2013-01-09 |
Univ Duke |
SYSTEM FOR DIRECT HEALTH MANAGEMENT BASED ON HEAT-CONTROLLED BIOPOLYMERS
|
|
MX2008002149A
(es)
*
|
2005-08-18 |
2008-04-22 |
Ambrx Inc |
Composiciones de arnt y sus usos.
|
|
US20070123646A1
(en)
*
|
2005-09-13 |
2007-05-31 |
Lele Bhalchandra S |
Protein-polymer conjugates and synthesis thereof
|
|
EP1776963A1
(en)
*
|
2005-10-19 |
2007-04-25 |
Gbf-Gesellschaft Für Biotechnologische Forschung Mbh |
Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
|
|
PT1954710E
(pt)
*
|
2005-11-08 |
2011-06-07 |
Ambrx Inc |
Aceleradores para a modificação de aminoácidos nãonaturais e polipeptídeos de aminoácidos não-naturais
|
|
CN101454461A
(zh)
|
2005-11-16 |
2009-06-10 |
Ambrx公司 |
包括非天然氨基酸的方法和组合物
|
|
CA2882445A1
(en)
*
|
2005-12-14 |
2007-06-21 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
CA2634034A1
(en)
|
2005-12-20 |
2007-06-28 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8841255B2
(en)
*
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
US8992905B2
(en)
|
2006-01-12 |
2015-03-31 |
Hokusan Co. Ltd. |
Oral composition containing interferon-α
|
|
AR059193A1
(es)
|
2006-01-31 |
2008-03-12 |
Bayer Schering Pharma Ag |
Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
|
|
EP1818392B1
(en)
*
|
2006-02-14 |
2010-08-25 |
Genetix Limited |
Cell culture medium
|
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
BRPI0708832A2
(pt)
*
|
2006-03-31 |
2011-06-14 |
Baxter Int |
construÇço proteinÁcea
|
|
EP2007789B1
(en)
|
2006-04-11 |
2015-05-20 |
Novartis AG |
Spirocyclic HCV/HIV inhibitors and their uses
|
|
US9283260B2
(en)
|
2006-04-21 |
2016-03-15 |
Amgen Inc. |
Lyophilized therapeutic peptibody formulations
|
|
EP2213733A3
(en)
|
2006-05-24 |
2010-12-29 |
Novo Nordisk Health Care AG |
Factor IX analogues having prolonged in vivo half life
|
|
EP1897557A1
(en)
*
|
2006-09-07 |
2008-03-12 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Use of glycolipids as adjuvants
|
|
US9133495B2
(en)
*
|
2006-09-08 |
2015-09-15 |
Ambrx, Inc. |
Hybrid suppressor tRNA for vertebrate cells
|
|
WO2008030614A2
(en)
*
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
|
EP2615108B1
(en)
*
|
2006-09-08 |
2016-10-26 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and thier uses
|
|
CN104163864B
(zh)
|
2007-03-30 |
2017-08-01 |
Ambrx公司 |
经修饰fgf‑21多肽和其用途
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
WO2008137471A2
(en)
|
2007-05-02 |
2008-11-13 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
|
DK2203181T3
(en)
|
2007-10-16 |
2018-05-28 |
Biocon Ltd |
An orally administrable solid composition and a method thereof
|
|
US8946148B2
(en)
|
2007-11-20 |
2015-02-03 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
SG188143A1
(en)
|
2008-02-08 |
2013-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
TW200946541A
(en)
*
|
2008-03-27 |
2009-11-16 |
Idenix Pharmaceuticals Inc |
Solid forms of an anti-HIV phosphoindole compound
|
|
TWI573806B
(zh)
|
2008-04-17 |
2017-03-11 |
巴克斯歐塔公司 |
生物活性胜肽
|
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
EP4074327A1
(en)
|
2008-06-27 |
2022-10-19 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
|
NZ600382A
(en)
|
2008-07-23 |
2013-11-29 |
Ambrx Inc |
Modified bovine G-CSF polypeptides and their uses
|
|
CN101671390B
(zh)
*
|
2008-09-10 |
2012-10-03 |
海南四环心脑血管药物研究院有限公司 |
人干扰素α衍生物及其聚乙二醇化修饰物的制备和用途
|
|
EA201170493A1
(ru)
|
2008-09-26 |
2011-10-31 |
Амбркс, Инк. |
Микроорганизмы и вакцины, зависимые от репликации неприродных аминокислот
|
|
HUE035168T2
(en)
|
2008-09-26 |
2018-05-02 |
Ambrx Inc |
Modified animal erythropoietin polypeptides and their applications
|
|
NZ593648A
(en)
|
2008-12-23 |
2013-09-27 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
NZ617066A
(en)
|
2008-12-23 |
2015-02-27 |
Gilead Pharmasset Llc |
Nucleoside analogs
|
|
AU2009329872B2
(en)
|
2008-12-23 |
2016-07-07 |
Gilead Pharmasset Llc |
Synthesis of purine nucleosides
|
|
US8512690B2
(en)
|
2009-04-10 |
2013-08-20 |
Novartis Ag |
Derivatised proline containing peptide compounds as protease inhibitors
|
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
|
CN101870728A
(zh)
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
TWI576352B
(zh)
|
2009-05-20 |
2017-04-01 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
JP5906183B2
(ja)
*
|
2009-06-04 |
2016-04-20 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
骨障害を治療するための、および、体重を管理するための化合物および方法
|
|
WO2011009047A2
(en)
*
|
2009-07-16 |
2011-01-20 |
Ta Tung Yuan |
Il-1ra-polymer conjugates
|
|
EP2459211A1
(en)
|
2009-07-31 |
2012-06-06 |
Medtronic, Inc. |
Continuous subcutaneous administration of interferon- to hepatitis c infected patients
|
|
KR101887009B1
(ko)
|
2009-08-14 |
2018-08-09 |
파세비오 파마수티컬스 인코포레이티드 |
변형된 혈관활성 장 펩티드
|
|
US8475652B2
(en)
|
2009-10-19 |
2013-07-02 |
Jan A. K. Paul |
Method for purification of uncatalyzed natural fuels from metal ions by means of at least one hemeprotein and use of the at least on hemeprotein
|
|
US8822496B2
(en)
|
2009-10-30 |
2014-09-02 |
Boehringer Ingelheim International Gmbh |
Dosage regimens for HCV combination therapy
|
|
EP2805965A1
(en)
|
2009-12-21 |
2014-11-26 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
|
CN102753573A
(zh)
|
2009-12-21 |
2012-10-24 |
Ambrx公司 |
经过修饰的牛促生长素多肽和其用途
|
|
CA2791841C
(en)
|
2010-03-05 |
2023-01-03 |
Rigshospitalet |
Chimeric inhibitor molecules of complement activation
|
|
ES2644990T3
(es)
|
2010-03-31 |
2017-12-01 |
Gilead Pharmasset Llc |
Síntesis estereoselectiva de principios activos que contienen fósforo
|
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
|
|
WO2011143274A1
(en)
|
2010-05-10 |
2011-11-17 |
Perseid Therapeutics |
Polypeptide inhibitors of vla4
|
|
WO2011161644A1
(en)
|
2010-06-24 |
2011-12-29 |
Panmed Ltd. |
Treatment of hepatitis c virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
SI3572091T1
(sl)
|
2010-08-17 |
2024-07-31 |
Ambrx, Inc., |
Modificirani polipeptidi relaksina in njihova uporaba
|
|
US9150655B2
(en)
|
2010-09-03 |
2015-10-06 |
Academia Sinica |
Anti-C-met antibody and methods of use thereof
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
MX2013003903A
(es)
|
2010-10-05 |
2013-05-20 |
Novartis Ag |
Nuevos tratamientos de infeccion por el virus de hepatitis c.
|
|
KR20130120481A
(ko)
|
2010-10-08 |
2013-11-04 |
노파르티스 아게 |
술파미드 ns3 억제제의 비타민 e 제제
|
|
DK2637694T3
(da)
*
|
2010-11-12 |
2021-06-07 |
Nektar Therapeutics |
KONJUGATER AF EN Il-2-ENHED OG EN POLYMER
|
|
CN105381450A
(zh)
|
2010-11-30 |
2016-03-09 |
诺华有限公司 |
丙型肝炎病毒感染的新疗法
|
|
PT3042910T
(pt)
|
2010-11-30 |
2019-04-16 |
Gilead Pharmasset Llc |
2'-espiro-nucleósidos para utilização na terapia da hepatite c
|
|
US8440309B2
(en)
|
2011-01-31 |
2013-05-14 |
Confluent Surgical, Inc. |
Crosslinked polymers with the crosslinker as therapeutic for sustained release
|
|
JP2014509628A
(ja)
|
2011-03-31 |
2014-04-21 |
ノバルティス アーゲー |
C型肝炎ウイルス感染症を治療するためのアリスポリビル
|
|
CN103458913A
(zh)
|
2011-04-01 |
2013-12-18 |
诺华股份有限公司 |
对乙型肝炎病毒感染或其与丁型肝炎病毒感染及相关肝脏疾病结合的治疗
|
|
SG193908A1
(en)
|
2011-04-13 |
2013-11-29 |
Novartis Ag |
Treatment of hepatitis c virus infection with alisporivir
|
|
WO2012170524A1
(en)
|
2011-06-06 |
2012-12-13 |
Phasebio Pharmaceuticals, Inc. |
Use of modified vasoactive intestinal peptides in the treatment of hypertension
|
|
WO2012170969A2
(en)
|
2011-06-10 |
2012-12-13 |
Biogen Idec Ma Inc. |
Pro-coagulant compounds and methods of use thereof
|
|
CN103930440A
(zh)
|
2011-07-01 |
2014-07-16 |
拜耳知识产权有限责任公司 |
松弛素融合多肽及其用途
|
|
RU2014116988A
(ru)
|
2011-09-27 |
2015-11-10 |
Новартис Аг |
Алиспоривир для лечения инфекции, вызванной вирусом гепатита с
|
|
US8767214B2
(en)
|
2011-10-06 |
2014-07-01 |
Nordson Corporation |
Powder flow detection
|
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
|
JP2015509980A
(ja)
|
2012-03-14 |
2015-04-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Hcv−hiv同時感染患者集団のhcv感染症を治療するための併用療法
|
|
JP2015512900A
(ja)
|
2012-03-28 |
2015-04-30 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法
|
|
CN104379171A
(zh)
*
|
2012-04-25 |
2015-02-25 |
第一三共株式会社 |
骨修复促进剂
|
|
US9738724B2
(en)
|
2012-06-08 |
2017-08-22 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
ES2611788T3
(es)
|
2012-06-26 |
2017-05-10 |
Sutro Biopharma, Inc. |
Proteínas de Fc modificadas que comprenden residuos de aminoácidos no naturales específicos del sitio, conjugados de las mismas, métodos para su preparación y métodos para su uso
|
|
EP3539563A1
(en)
|
2012-07-19 |
2019-09-18 |
Redwood Bioscience, Inc. |
Antibody specific for cd22 and methods of use thereof
|
|
CA2882034C
(en)
|
2012-08-16 |
2019-10-29 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
HRP20190878T1
(hr)
|
2012-08-31 |
2019-07-26 |
Sutro Biopharma, Inc. |
Modificirane aminokiseline koje sadrže azidnu grupu
|
|
JP6538561B2
(ja)
|
2012-10-25 |
2019-07-03 |
バイオベラティブ・ユーエスエイ・インコーポレイテッド |
抗補体C1s抗体とそれらの用途
|
|
WO2014071206A1
(en)
|
2012-11-02 |
2014-05-08 |
True North Therapeutics, Inc. |
Anti-complement c1s antibodies and uses thereof
|
|
EP2922870B1
(en)
|
2012-11-21 |
2019-08-07 |
The Governors of the University of Alberta |
Immunomodulatory peptides and methods of use thereof
|
|
US20140205566A1
(en)
|
2012-11-30 |
2014-07-24 |
Novartis Ag |
Cyclic nucleuoside derivatives and uses thereof
|
|
JP6446443B2
(ja)
|
2013-06-10 |
2018-12-26 |
アイピエリアン,インコーポレイティド |
タウオパチーの処置方法
|
|
ES2658039T3
(es)
|
2013-07-10 |
2018-03-08 |
Sutro Biopharma, Inc. |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
|
NZ716840A
(en)
|
2013-08-27 |
2017-06-30 |
Gilead Pharmasset Llc |
Combination formulation of two antiviral compounds
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
WO2015070014A1
(en)
|
2013-11-08 |
2015-05-14 |
Biogen Idec Ma Inc. |
Procoagulant fusion compound
|
|
US20160289309A1
(en)
|
2013-11-27 |
2016-10-06 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
ES2818824T3
(es)
|
2014-05-08 |
2021-04-14 |
Phasebio Pharmaceuticals Inc |
Composiciones que comprenden una proteína de fusión de VIP-ELP para su uso en el tratamiento de fibrosis quística
|
|
RS61128B1
(sr)
|
2014-08-19 |
2020-12-31 |
Biogen Ma Inc |
Postupak pegilacije
|
|
SMT202100388T1
(it)
|
2014-10-24 |
2021-09-14 |
Bristol Myers Squibb Co |
Polipeptidi fgf-21 modificati e loro usi
|
|
AU2016219513B2
(en)
|
2015-02-09 |
2021-09-30 |
Immunoforge Co., Ltd. |
Methods and compositions for treating muscle disease and disorders
|
|
CN108699145A
(zh)
|
2015-09-02 |
2018-10-23 |
伊缪泰普有限公司 |
抗lag-3抗体
|
|
CN108135978A
(zh)
|
2015-10-08 |
2018-06-08 |
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IL-2Rβ选择性激动剂和长效IL-15激动剂的组合
|
|
MX377531B
(es)
|
2015-11-03 |
2025-03-10 |
Hoffmann La Roche |
Terapia de combinación de un inhibidor del ensamble de la cápside del hbv y un interferón.
|
|
SG11201808525UA
(en)
|
2016-04-04 |
2018-10-30 |
Bioverativ Usa Inc |
Anti-complement factor bb antibodies and uses thereof
|
|
WO2018087345A1
(en)
|
2016-11-14 |
2018-05-17 |
F. Hoffmann-La Roche Ag |
COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
|
|
BR112019016139A2
(pt)
|
2017-02-08 |
2020-04-07 |
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polipeptídio de relaxina modificada compreendendo um melhorador farmacocinético e usos do mesmo
|
|
KR20250171416A
(ko)
|
2017-07-11 |
2025-12-08 |
신톡스, 인크. |
비천연 뉴클레오티드의 도입 및 그의 방법
|
|
BR112020002272A2
(pt)
|
2017-08-03 |
2020-07-28 |
Synthorx, Inc. |
conjugados de citocina para o tratamento de doenças autoimunes
|
|
PL3849614T3
(pl)
|
2018-09-11 |
2024-04-22 |
Ambrx, Inc. |
Koniugaty polipeptydu interleukiny-2 i ich zastosowania
|
|
CN113366015A
(zh)
|
2018-10-19 |
2021-09-07 |
Ambrx公司 |
白细胞介素-10多肽缀合物、其二聚体及其用途
|
|
US20200246467A1
(en)
|
2019-02-06 |
2020-08-06 |
Synthorx, Inc. |
Il-2 conjugates and methods of use thereof
|
|
WO2020168017A1
(en)
|
2019-02-12 |
2020-08-20 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
|
AU2021233909A1
(en)
|
2020-03-11 |
2022-09-29 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
EP4199968A1
(en)
|
2020-08-20 |
2023-06-28 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
|
MX2023011480A
(es)
|
2021-04-03 |
2023-12-06 |
Ambrx Inc |
Conjugados anticuerpo anti-her2-fármaco y usos de estos.
|
|
CN119431229A
(zh)
*
|
2023-08-04 |
2025-02-14 |
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缩合剂及其在制备异硫氰酸酯中的用途
|