MA34383B1 - Analogues de glucagon - Google Patents
Analogues de glucagonInfo
- Publication number
- MA34383B1 MA34383B1 MA35571A MA35571A MA34383B1 MA 34383 B1 MA34383 B1 MA 34383B1 MA 35571 A MA35571 A MA 35571A MA 35571 A MA35571 A MA 35571A MA 34383 B1 MA34383 B1 MA 34383B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- relates
- glucagon
- compounds
- glucagon analogues
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 abstract 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 abstract 1
- 101500028775 Homo sapiens Glucagon Proteins 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000004584 weight gain Effects 0.000 abstract 1
- 235000019786 weight gain Nutrition 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des substances et des procédés pour favoriser la perte de poids ou prévenir le gain de poids et pour traiter le diabète ou des troubles associés. En particulier, l'invention concerne de nouveaux composés peptidiques d'analogues de glucagon efficaces dans de tels procédés. Les composés peuvent procurer leur effet en ayant, par exemple, une sélectivité accrue pour le récepteur GLP-1 comparée au glucagon humain.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201000558 | 2010-06-24 | ||
| US35861410P | 2010-06-25 | 2010-06-25 | |
| PCT/DK2011/000072 WO2011160633A1 (fr) | 2010-06-24 | 2011-06-24 | Analogues de glucagon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34383B1 true MA34383B1 (fr) | 2013-07-03 |
Family
ID=44630046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35571A MA34383B1 (fr) | 2010-06-24 | 2011-06-24 | Analogues de glucagon |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9169310B2 (fr) |
| EP (1) | EP2585482B1 (fr) |
| JP (1) | JP6023048B2 (fr) |
| KR (1) | KR20130086343A (fr) |
| CN (1) | CN103068841A (fr) |
| AP (1) | AP2013006671A0 (fr) |
| AU (1) | AU2011269430A1 (fr) |
| BR (1) | BR112012033225A2 (fr) |
| CA (1) | CA2802897A1 (fr) |
| CL (1) | CL2012003641A1 (fr) |
| CO (1) | CO6660483A2 (fr) |
| EA (1) | EA201291234A1 (fr) |
| EC (1) | ECSP12012357A (fr) |
| MA (1) | MA34383B1 (fr) |
| MX (1) | MX2012014961A (fr) |
| NZ (1) | NZ604208A (fr) |
| PE (1) | PE20130338A1 (fr) |
| PH (1) | PH12012502472A1 (fr) |
| SG (1) | SG186764A1 (fr) |
| TN (1) | TN2012000560A1 (fr) |
| WO (1) | WO2011160633A1 (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA104605C2 (uk) | 2008-12-15 | 2014-02-25 | Зіленд Фарма А/С | Аналоги глюкагону |
| ES2477880T3 (es) | 2008-12-15 | 2014-07-18 | Zealand Pharma A/S | Análogos del glucagón |
| CA2747155A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
| CN102292348B (zh) | 2008-12-15 | 2015-07-08 | 西兰制药公司 | 胰高血糖素类似物 |
| EA022816B1 (ru) | 2009-07-13 | 2016-03-31 | Зилэнд Фарма А/С | Ацилированные аналоги глюкагона |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| EP2585462B1 (fr) | 2010-06-24 | 2020-02-26 | Takeda Pharmaceutical Company Limited | Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes) |
| JP6023048B2 (ja) | 2010-06-24 | 2016-11-09 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| CN104093735B (zh) * | 2011-09-23 | 2018-07-06 | 诺沃—诺迪斯克有限公司 | 新的胰高血糖素类似物 |
| EA028665B1 (ru) | 2012-05-03 | 2017-12-29 | Зилэнд Фарма А/С | Соединения - двойные агонисты gip-glp-1 и способы |
| NZ704043A (en) * | 2012-07-23 | 2017-07-28 | Zealand Pharma As | Glucagon analogues |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| BR112015025464A2 (pt) | 2013-04-18 | 2017-10-10 | Novo Nordisk As | coagonistas do receptor de glp-1/glucagon estáveis, prolongados para uso médico |
| GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| HRP20181505T1 (hr) | 2013-10-17 | 2018-11-02 | Zealand Pharma A/S | Acilirani analozi glukagona |
| US10093713B2 (en) | 2013-11-06 | 2018-10-09 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
| MX369770B (es) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Compuestos agonistas triples de glucagón-glp-1-gip. |
| AR098616A1 (es) | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Péptido para el tratamiento de hipoglicemia severa |
| JP2017525656A (ja) | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー/エス | 医療用のglp−1/グルカゴン受容体コアゴニスト |
| WO2015193378A1 (fr) * | 2014-06-18 | 2015-12-23 | Novo Nordisk A/S | Nouveaux agonistes des récepteurs au glp-1 à activité d'efflux de cholestérol |
| EP3204408B1 (fr) * | 2014-10-10 | 2020-05-06 | Novo Nordisk A/S | Co-agonistes du récepteur glp-1/glucagon à base de glp-1 stable |
| MX381640B (es) | 2014-10-29 | 2025-03-04 | Zealand Pharma As | Metodos y compuestos agonistas de gip. |
| UA121874C2 (uk) | 2015-02-17 | 2020-08-10 | Елі Ліллі Енд Компані | Порошкова назальна композиція для лікування гіпоглікемії |
| AR103954A1 (es) | 2015-03-18 | 2017-06-14 | Zealand Pharma As | Análogos de amilina |
| WO2016168388A2 (fr) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Thérapies pour l'obésité, le diabète et indications associées |
| KR20170137198A (ko) * | 2015-04-16 | 2017-12-12 | 질랜드 파마 에이/에스 | 아실화된 글루카곤 유사체 |
| AU2017307033B2 (en) | 2016-08-05 | 2020-11-26 | Boehringer Ingelheim International Gmbh | Oxadiazolopyridine derivates for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| TWI784968B (zh) | 2016-09-09 | 2022-12-01 | 丹麥商西蘭製藥公司 | 澱粉素類似物 |
| JP6563614B1 (ja) * | 2016-12-09 | 2019-08-21 | ジーランド・ファーマ・ア/エス | アシル化glp−1/glp−2二重アゴニスト |
| CN116854804A (zh) * | 2017-08-16 | 2023-10-10 | 东亚St株式会社 | 酰化胃泌酸调节素肽类似物 |
| CA3087827A1 (fr) | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Derives d'oxadiazolopyridine a substitution heterocyclyle utilises en tant qu'inhibiteurs de la ghreline o-acyltransferase (goat) |
| CN111630055B (zh) | 2018-02-02 | 2023-07-14 | 勃林格殷格翰国际有限公司 | 用作饥饿素o-酰基转移酶(goat)抑制剂的吡唑取代的和吲唑取代的噁二唑并吡啶衍生物 |
| EA202091803A1 (ru) | 2018-02-02 | 2020-12-16 | Бёрингер Ингельхайм Интернациональ Гмбх | Производные триазолопиримидина для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) |
| KR20200116978A (ko) | 2018-02-02 | 2020-10-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로서의 벤질-치환된, (피리딘-3-일)메틸-치환된 또는 (피리딘-4-일)메틸-치환된 옥사디아졸로피리딘 유도체 |
| TWI771669B (zh) | 2019-04-26 | 2022-07-21 | 美商美國禮來大藥廠 | 製備穩定胜肽調配物之方法 |
| MX2022005661A (es) | 2019-11-11 | 2022-09-07 | Boehringer Ingelheim Int | Agonistas del receptor npy2. |
| JP7702969B2 (ja) | 2020-05-22 | 2025-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルキル7-アミノ-5-メチル-[1,2,5]オキサジアゾロ[3,4-b]ピリジンカルボキシレートの連続製造方法 |
| EP4153599B1 (fr) | 2020-05-22 | 2024-03-13 | Boehringer Ingelheim International GmbH | Procédé de fabrication de 7-amino-5-méthyl- [1,2,5] oxadiazolo [3,4-b] pyridine-carboxylate d'alkyle |
| WO2022029231A1 (fr) | 2020-08-07 | 2022-02-10 | Boehringer Ingelheim International Gmbh | Agonistes du récepteur npy2 solubles |
| WO2023016346A1 (fr) * | 2021-08-10 | 2023-02-16 | 南京明德新药研发有限公司 | Composé polypeptidique contenant un pont lactame |
| CN115490760B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物 |
| WO2025219590A1 (fr) | 2024-04-19 | 2025-10-23 | Actimed Therapeutics Ltd | Bêta-bloquants pour préserver la masse musculaire, la densité osseuse et la fonction cardiaque lors de traitements de perte de poids |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ202757A (en) | 1981-12-23 | 1985-11-08 | Novo Industri As | Peptides and medicaments |
| BRPI9711437B8 (pt) | 1996-08-30 | 2021-05-25 | Novo Nordisk As | derivados de glp-1 |
| ES2239364T3 (es) | 1996-09-09 | 2005-09-16 | Zealand Pharma A/S | Sintesis de peptidos en fase solida. |
| CA2265454A1 (fr) | 1996-09-09 | 1998-03-19 | Zealand Pharmaceuticals A/S | Promedicaments peptidiques contenant une sequence de liaison alpha-hydroxyacide |
| UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| CA2310097C (fr) | 1997-11-14 | 2014-07-29 | Amylin Pharmaceuticals, Inc. | Nouveaux composes agonistes de l'exendine |
| IL138214A0 (en) | 1998-03-09 | 2001-10-31 | Zealand Pharmaceuticals As | Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
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| RU2485135C2 (ru) | 2005-06-13 | 2013-06-20 | Импиэриэл Инноувейшнс Лимитид | Соединения оксинтомодулина (варианты), фармацевтическая композиция на их основе, способы лечения и профилактики ожирения и сопутствующих заболеваний (варианты) и лекарственное средство (варианты) |
| US20090202497A1 (en) | 2005-08-23 | 2009-08-13 | The General Hospital Corporation | Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes |
| CN101534846B (zh) | 2005-11-07 | 2014-11-05 | 印第安纳大学研究及科技有限公司 | 显示生理学溶解性和稳定性的胰高血糖素类似物 |
| WO2007081824A2 (fr) | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Protéines résistantes à la fibrillation |
| US7928058B2 (en) | 2006-02-22 | 2011-04-19 | Merck Sharp & Dohme Corp. | Pharmaceutical composition comprising oxyntomodulin derivatives and a method for reducing body weight using the composition |
| CA2658276A1 (fr) | 2006-07-18 | 2008-01-24 | Sanofi-Aventis | Anticorps antagoniste destine au traitement du cancer |
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| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| AU2008216265B2 (en) | 2007-02-15 | 2014-04-03 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
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| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| KR20100111682A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| KR20100111683A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| WO2009129250A2 (fr) | 2008-04-14 | 2009-10-22 | Case Western Reserve University | Analogues de l'insuline à prendre au moment des repas de stabilité améliorée |
| RU2010147076A (ru) | 2008-04-22 | 2012-05-27 | Кейз Вестерн Ризев Юнивесити (Us) | Аналоги инсулина специфичные к изоформам |
| TWI451876B (zh) | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
| PA8830501A1 (es) | 2008-06-17 | 2010-07-27 | Univ Indiana Res & Tech Corp | Co-agonistas del receptor de glucagon/glp-1 |
| CN102088989B (zh) | 2008-06-17 | 2014-11-26 | 印第安纳大学研究及科技有限公司 | 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物 |
| PL219335B1 (pl) | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| WO2010014946A2 (fr) | 2008-07-31 | 2010-02-04 | Case Western Reserve University | Insuline stabilisée par de l'halogène |
| CN102292348B (zh) | 2008-12-15 | 2015-07-08 | 西兰制药公司 | 胰高血糖素类似物 |
| ES2477880T3 (es) | 2008-12-15 | 2014-07-18 | Zealand Pharma A/S | Análogos del glucagón |
| CA2747155A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
| UA104605C2 (uk) * | 2008-12-15 | 2014-02-25 | Зіленд Фарма А/С | Аналоги глюкагону |
| CA2747490C (fr) | 2008-12-19 | 2017-02-14 | Indiana University Research And Technology Corporation | Analogues d'insuline |
| WO2010080609A1 (fr) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Promédicaments insuliniques à base d'amide |
| CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
| EA022816B1 (ru) * | 2009-07-13 | 2016-03-31 | Зилэнд Фарма А/С | Ацилированные аналоги глюкагона |
| CA2786934A1 (fr) | 2010-01-20 | 2011-07-28 | Zealand Pharma A/S | Traitement d'etats pathologiques cardiaques |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| JP6023048B2 (ja) | 2010-06-24 | 2016-11-09 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| PH12013501495A1 (en) | 2011-01-20 | 2013-09-16 | Zealand Pharma As | Combination of acylated glucagon analogues with insulin analogues |
| AP2014007797A0 (en) | 2011-12-23 | 2014-07-31 | Boehringer Ingelheim Int | Glucagon analogues |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| HRP20181505T1 (hr) | 2013-10-17 | 2018-11-02 | Zealand Pharma A/S | Acilirani analozi glukagona |
-
2011
- 2011-06-24 JP JP2013515699A patent/JP6023048B2/ja not_active Expired - Fee Related
- 2011-06-24 WO PCT/DK2011/000072 patent/WO2011160633A1/fr not_active Ceased
- 2011-06-24 MX MX2012014961A patent/MX2012014961A/es not_active Application Discontinuation
- 2011-06-24 CA CA2802897A patent/CA2802897A1/fr not_active Abandoned
- 2011-06-24 KR KR1020137001877A patent/KR20130086343A/ko not_active Withdrawn
- 2011-06-24 US US13/704,299 patent/US9169310B2/en not_active Expired - Fee Related
- 2011-06-24 BR BR112012033225A patent/BR112012033225A2/pt not_active IP Right Cessation
- 2011-06-24 PH PH1/2012/502472A patent/PH12012502472A1/en unknown
- 2011-06-24 EA EA201291234A patent/EA201291234A1/ru unknown
- 2011-06-24 NZ NZ604208A patent/NZ604208A/en not_active IP Right Cessation
- 2011-06-24 MA MA35571A patent/MA34383B1/fr unknown
- 2011-06-24 AP AP2013006671A patent/AP2013006671A0/xx unknown
- 2011-06-24 AU AU2011269430A patent/AU2011269430A1/en not_active Abandoned
- 2011-06-24 CN CN2011800305165A patent/CN103068841A/zh active Pending
- 2011-06-24 SG SG2012093522A patent/SG186764A1/en unknown
- 2011-06-24 EP EP11741514.1A patent/EP2585482B1/fr active Active
- 2011-06-24 PE PE2012002452A patent/PE20130338A1/es not_active Application Discontinuation
-
2012
- 2012-11-29 TN TNP2012000560A patent/TN2012000560A1/en unknown
- 2012-12-21 CL CL2012003641A patent/CL2012003641A1/es unknown
- 2012-12-21 CO CO12232544A patent/CO6660483A2/es unknown
- 2012-12-26 EC ECSP12012357 patent/ECSP12012357A/es unknown
-
2015
- 2015-09-14 US US14/853,335 patent/US20150376257A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2585482A1 (fr) | 2013-05-01 |
| PH12012502472A1 (en) | 2013-03-25 |
| US20150376257A1 (en) | 2015-12-31 |
| ECSP12012357A (es) | 2013-01-31 |
| CA2802897A1 (fr) | 2011-12-29 |
| AU2011269430A1 (en) | 2013-01-10 |
| NZ604208A (en) | 2014-10-31 |
| EP2585482B1 (fr) | 2019-03-27 |
| MX2012014961A (es) | 2013-02-26 |
| PE20130338A1 (es) | 2013-03-16 |
| CN103068841A (zh) | 2013-04-24 |
| JP2013530969A (ja) | 2013-08-01 |
| BR112012033225A2 (pt) | 2017-06-20 |
| AP2013006671A0 (en) | 2013-01-31 |
| KR20130086343A (ko) | 2013-08-01 |
| CL2012003641A1 (es) | 2013-09-06 |
| TN2012000560A1 (en) | 2014-04-01 |
| CO6660483A2 (es) | 2013-04-30 |
| US20130157929A1 (en) | 2013-06-20 |
| US9169310B2 (en) | 2015-10-27 |
| WO2011160633A1 (fr) | 2011-12-29 |
| EA201291234A1 (ru) | 2013-07-30 |
| SG186764A1 (en) | 2013-02-28 |
| JP6023048B2 (ja) | 2016-11-09 |
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