CL2012003641A1 - Compuesto analogo de glucagon que comprende sustituciones de los residuos aminoacidos en las posiciones 3 y/o 4 del glucagón nativo y que tiene actividad en el receptor de glucagon y/o el receptor de glp-1; composicion farmaceutica que comprende el compuesto; uso del compuesto para prevenir aumento de peso o promover perdida de peso en un sujeto que lo necesita. - Google Patents
Compuesto analogo de glucagon que comprende sustituciones de los residuos aminoacidos en las posiciones 3 y/o 4 del glucagón nativo y que tiene actividad en el receptor de glucagon y/o el receptor de glp-1; composicion farmaceutica que comprende el compuesto; uso del compuesto para prevenir aumento de peso o promover perdida de peso en un sujeto que lo necesita.Info
- Publication number
- CL2012003641A1 CL2012003641A1 CL2012003641A CL2012003641A CL2012003641A1 CL 2012003641 A1 CL2012003641 A1 CL 2012003641A1 CL 2012003641 A CL2012003641 A CL 2012003641A CL 2012003641 A CL2012003641 A CL 2012003641A CL 2012003641 A1 CL2012003641 A1 CL 2012003641A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- glucagon
- receptor
- glp
- substitutions
- Prior art date
Links
- 102000051325 Glucagon Human genes 0.000 title 2
- 108060003199 Glucagon Proteins 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 2
- 229960004666 glucagon Drugs 0.000 title 2
- 108010063919 Glucagon Receptors Proteins 0.000 title 1
- 102100040890 Glucagon receptor Human genes 0.000 title 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 title 1
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 title 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
- -1 glucagon compound Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 title 1
- 230000004584 weight gain Effects 0.000 title 1
- 235000019786 weight gain Nutrition 0.000 title 1
- 230000004580 weight loss Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201000558 | 2010-06-24 | ||
| US35861410P | 2010-06-25 | 2010-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012003641A1 true CL2012003641A1 (es) | 2013-09-06 |
Family
ID=44630046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012003641A CL2012003641A1 (es) | 2010-06-24 | 2012-12-21 | Compuesto analogo de glucagon que comprende sustituciones de los residuos aminoacidos en las posiciones 3 y/o 4 del glucagón nativo y que tiene actividad en el receptor de glucagon y/o el receptor de glp-1; composicion farmaceutica que comprende el compuesto; uso del compuesto para prevenir aumento de peso o promover perdida de peso en un sujeto que lo necesita. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9169310B2 (es) |
| EP (1) | EP2585482B1 (es) |
| JP (1) | JP6023048B2 (es) |
| KR (1) | KR20130086343A (es) |
| CN (1) | CN103068841A (es) |
| AP (1) | AP2013006671A0 (es) |
| AU (1) | AU2011269430A1 (es) |
| BR (1) | BR112012033225A2 (es) |
| CA (1) | CA2802897A1 (es) |
| CL (1) | CL2012003641A1 (es) |
| CO (1) | CO6660483A2 (es) |
| EA (1) | EA201291234A1 (es) |
| EC (1) | ECSP12012357A (es) |
| MA (1) | MA34383B1 (es) |
| MX (1) | MX2012014961A (es) |
| NZ (1) | NZ604208A (es) |
| PE (1) | PE20130338A1 (es) |
| PH (1) | PH12012502472A1 (es) |
| SG (1) | SG186764A1 (es) |
| TN (1) | TN2012000560A1 (es) |
| WO (1) | WO2011160633A1 (es) |
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| WO2010070251A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070255A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070253A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| AU2008365556A1 (en) | 2008-12-15 | 2011-07-21 | Zealand Pharma A/S | Glucagon analogues |
| CN104961822A (zh) | 2009-07-13 | 2015-10-07 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| AU2011269430A1 (en) | 2010-06-24 | 2013-01-10 | Zealand Pharma A/S | Glucagon analogues |
| EP2585462B1 (en) | 2010-06-24 | 2020-02-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors |
| EP2758426B1 (en) * | 2011-09-23 | 2019-08-07 | Novo Nordisk A/S | Novel glucagon analogues |
| EA028665B1 (ru) | 2012-05-03 | 2017-12-29 | Зилэнд Фарма А/С | Соединения - двойные агонисты gip-glp-1 и способы |
| JP6534927B2 (ja) | 2012-07-23 | 2019-06-26 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| WO2014170496A1 (en) | 2013-04-18 | 2014-10-23 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
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| CN119119233A (zh) | 2013-10-17 | 2024-12-13 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| KR102310392B1 (ko) | 2013-11-06 | 2021-10-13 | 질랜드 파마 에이/에스 | 글루카곤-glp-1-gip 삼원 효능제 화합물 |
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| WO2015185640A1 (en) | 2014-06-04 | 2015-12-10 | Novo Nordisk A/S | Glp-1/glucagon receptor co-agonists for medical use |
| WO2015193378A1 (en) * | 2014-06-18 | 2015-12-23 | Novo Nordisk A/S | Novel glp-1 receptor agonists with cholesterol efflux activity |
| JP2017536343A (ja) * | 2014-10-10 | 2017-12-07 | ノヴォ ノルディスク アー/エス | 安定したglp−1ベースのglp−1/グルカゴン受容体コアゴニスト |
| KR102620911B1 (ko) | 2014-10-29 | 2024-01-05 | 질랜드 파마 에이/에스 | Gip 효능제 화합물 및 방법 |
| WO2016133863A1 (en) | 2015-02-17 | 2016-08-25 | Eli Lilly And Company | Nasal powder formulation for treatment of hypoglycemia |
| KR20170126504A (ko) | 2015-03-18 | 2017-11-17 | 질랜드 파마 에이/에스 | 아밀린 유사체 |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AU2016247499B2 (en) * | 2015-04-16 | 2020-09-03 | Zealand Pharma A/S | Acylated glucagon analogue |
| LT3494120T (lt) | 2016-08-05 | 2021-05-25 | Boehringer Ingelheim International Gmbh | Oksadiazolopiridino dariniai, skirti naudoti kaip grelino o-aciltransferazės (goat) inhibitoriai |
| AR109514A1 (es) | 2016-09-09 | 2018-12-19 | Zealand Pharma As | Análogos de amilina |
| JP6563614B1 (ja) * | 2016-12-09 | 2019-08-21 | ジーランド・ファーマ・ア/エス | アシル化glp−1/glp−2二重アゴニスト |
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| EA202091804A1 (ru) | 2018-02-02 | 2020-12-24 | Бёрингер Ингельхайм Интернациональ Гмбх | Гетероциклил-замещенные оксадиазолопиридиновые производные для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) |
| TWI771669B (zh) | 2019-04-26 | 2022-07-21 | 美商美國禮來大藥廠 | 製備穩定胜肽調配物之方法 |
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| EP2307037A4 (en) | 2008-06-17 | 2011-08-03 | Univ Indiana Res & Tech Corp | GLUCAGON ANALOGUE WITH IMPROVED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS |
| TWI474832B (zh) | 2008-06-17 | 2015-03-01 | Univ Indiana Res & Tech Corp | 胰高血糖素/glp-1受體共同激動劑 |
| PL219335B1 (pl) | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| ES2552636T3 (es) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulina estabilizada por halógenos |
| WO2010070255A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070251A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070253A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| AU2008365556A1 (en) | 2008-12-15 | 2011-07-21 | Zealand Pharma A/S | Glucagon analogues |
| JP5755566B2 (ja) | 2008-12-19 | 2015-07-29 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | アミド系インスリンプロドラッグ |
| JP5789515B2 (ja) | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | インスリン類似体 |
| CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
| CN104961822A (zh) * | 2009-07-13 | 2015-10-07 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| EA026384B1 (ru) | 2010-01-20 | 2017-04-28 | Зилэнд Фарма А/С | Лечение заболеваний сердца |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| AU2011269430A1 (en) | 2010-06-24 | 2013-01-10 | Zealand Pharma A/S | Glucagon analogues |
| PH12013501495A1 (en) | 2011-01-20 | 2013-09-16 | Zealand Pharma As | Combination of acylated glucagon analogues with insulin analogues |
| BR112014015681A2 (pt) | 2011-12-23 | 2019-09-24 | Boehringer Ingelheim Int | análogos de glucagon |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| CN119119233A (zh) | 2013-10-17 | 2024-12-13 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
-
2011
- 2011-06-24 AU AU2011269430A patent/AU2011269430A1/en not_active Abandoned
- 2011-06-24 PH PH1/2012/502472A patent/PH12012502472A1/en unknown
- 2011-06-24 EP EP11741514.1A patent/EP2585482B1/en active Active
- 2011-06-24 SG SG2012093522A patent/SG186764A1/en unknown
- 2011-06-24 AP AP2013006671A patent/AP2013006671A0/xx unknown
- 2011-06-24 EA EA201291234A patent/EA201291234A1/ru unknown
- 2011-06-24 PE PE2012002452A patent/PE20130338A1/es not_active Application Discontinuation
- 2011-06-24 WO PCT/DK2011/000072 patent/WO2011160633A1/en not_active Ceased
- 2011-06-24 CA CA2802897A patent/CA2802897A1/en not_active Abandoned
- 2011-06-24 MA MA35571A patent/MA34383B1/fr unknown
- 2011-06-24 US US13/704,299 patent/US9169310B2/en not_active Expired - Fee Related
- 2011-06-24 JP JP2013515699A patent/JP6023048B2/ja not_active Expired - Fee Related
- 2011-06-24 MX MX2012014961A patent/MX2012014961A/es not_active Application Discontinuation
- 2011-06-24 KR KR1020137001877A patent/KR20130086343A/ko not_active Withdrawn
- 2011-06-24 CN CN2011800305165A patent/CN103068841A/zh active Pending
- 2011-06-24 BR BR112012033225A patent/BR112012033225A2/pt not_active IP Right Cessation
- 2011-06-24 NZ NZ604208A patent/NZ604208A/en not_active IP Right Cessation
-
2012
- 2012-11-29 TN TNP2012000560A patent/TN2012000560A1/en unknown
- 2012-12-21 CO CO12232544A patent/CO6660483A2/es unknown
- 2012-12-21 CL CL2012003641A patent/CL2012003641A1/es unknown
- 2012-12-26 EC ECSP12012357 patent/ECSP12012357A/es unknown
-
2015
- 2015-09-14 US US14/853,335 patent/US20150376257A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150376257A1 (en) | 2015-12-31 |
| US9169310B2 (en) | 2015-10-27 |
| JP6023048B2 (ja) | 2016-11-09 |
| CA2802897A1 (en) | 2011-12-29 |
| KR20130086343A (ko) | 2013-08-01 |
| WO2011160633A1 (en) | 2011-12-29 |
| SG186764A1 (en) | 2013-02-28 |
| AP2013006671A0 (en) | 2013-01-31 |
| ECSP12012357A (es) | 2013-01-31 |
| MA34383B1 (fr) | 2013-07-03 |
| BR112012033225A2 (pt) | 2017-06-20 |
| PE20130338A1 (es) | 2013-03-16 |
| CN103068841A (zh) | 2013-04-24 |
| PH12012502472A1 (en) | 2013-03-25 |
| JP2013530969A (ja) | 2013-08-01 |
| EA201291234A1 (ru) | 2013-07-30 |
| NZ604208A (en) | 2014-10-31 |
| US20130157929A1 (en) | 2013-06-20 |
| TN2012000560A1 (en) | 2014-04-01 |
| MX2012014961A (es) | 2013-02-26 |
| EP2585482B1 (en) | 2019-03-27 |
| CO6660483A2 (es) | 2013-04-30 |
| EP2585482A1 (en) | 2013-05-01 |
| AU2011269430A1 (en) | 2013-01-10 |
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