PE20130338A1 - Analogos del glucagon - Google Patents
Analogos del glucagonInfo
- Publication number
- PE20130338A1 PE20130338A1 PE2012002452A PE2012002452A PE20130338A1 PE 20130338 A1 PE20130338 A1 PE 20130338A1 PE 2012002452 A PE2012002452 A PE 2012002452A PE 2012002452 A PE2012002452 A PE 2012002452A PE 20130338 A1 PE20130338 A1 PE 20130338A1
- Authority
- PE
- Peru
- Prior art keywords
- leu
- ala
- ser
- aib
- glu
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 abstract 1
- -1 Leu Chemical compound 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A PEPTIDOS ANALOGOS DE GLUCAGON DE FORMULA R1-Z-R2 DONDE R1 ES H, ALQUILO(C1-C4), ACETILO, BENZOILO, ENTRE OTROS; R2 ES OH O NH2; Z ES UN PEPTIDO DE FORMULA His-X2-X3-X4-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-X15-Ser-X17-Ala-Ala-X20-X21-Phe-Val-X24-Trp-Leu-X27-X28-Ala EN DONDE X2 ES Aib, Ser O Gly; X3 ES Gln, Glu, Gly, His, Phe, Leu, Trp, Tyr, ENTRE OTROS; X4 ES Gly, Ala, D-Ala, Val, Aib, Leu, D-Leu, Pro, ENTRE OTROS; X15 ES Asp O Glu; X17 ES Arg O X; X20 ES Arg, His O X; X21 ES Asp O Glu; X24 ES Ala O X; X27 ES Leu O X; X28 ES Arg O X, EN DONDE X ES Glu, Lys, Ser, Cys, Dbu, Dpr O Orn; EN DONDE LA CADENA LATERAL DE UN RESIDUO DE AMINOACIDO X ESTA CONJUGADO CON UN SUSTITUYENTE LIPOFILO. DICHO PEPTIDO TIENE UNA SECUENCIA DE AMINOACIDOS TAL COMO H-Aib-EGTFTSDYSKYLDSKAAHDFVEWLLSA; H-Aib-HGTFTSDYSKYLDSKAAHDFVEWLLSA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE OBESIDAD, SINDROME METABOLICO, INTOLERANCIA A LA GLUCOSA, DIABETES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201000558 | 2010-06-24 | ||
| US35861410P | 2010-06-25 | 2010-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20130338A1 true PE20130338A1 (es) | 2013-03-16 |
Family
ID=44630046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012002452A PE20130338A1 (es) | 2010-06-24 | 2011-06-24 | Analogos del glucagon |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9169310B2 (es) |
| EP (1) | EP2585482B1 (es) |
| JP (1) | JP6023048B2 (es) |
| KR (1) | KR20130086343A (es) |
| CN (1) | CN103068841A (es) |
| AP (1) | AP2013006671A0 (es) |
| AU (1) | AU2011269430A1 (es) |
| BR (1) | BR112012033225A2 (es) |
| CA (1) | CA2802897A1 (es) |
| CL (1) | CL2012003641A1 (es) |
| CO (1) | CO6660483A2 (es) |
| EA (1) | EA201291234A1 (es) |
| EC (1) | ECSP12012357A (es) |
| MA (1) | MA34383B1 (es) |
| MX (1) | MX2012014961A (es) |
| NZ (1) | NZ604208A (es) |
| PE (1) | PE20130338A1 (es) |
| PH (1) | PH12012502472A1 (es) |
| SG (1) | SG186764A1 (es) |
| TN (1) | TN2012000560A1 (es) |
| WO (1) | WO2011160633A1 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010070251A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070255A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070253A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| AU2008365556A1 (en) | 2008-12-15 | 2011-07-21 | Zealand Pharma A/S | Glucagon analogues |
| CN104961822A (zh) | 2009-07-13 | 2015-10-07 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| AU2011269430A1 (en) | 2010-06-24 | 2013-01-10 | Zealand Pharma A/S | Glucagon analogues |
| EP2585462B1 (en) | 2010-06-24 | 2020-02-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors |
| EP2758426B1 (en) * | 2011-09-23 | 2019-08-07 | Novo Nordisk A/S | Novel glucagon analogues |
| EA028665B1 (ru) | 2012-05-03 | 2017-12-29 | Зилэнд Фарма А/С | Соединения - двойные агонисты gip-glp-1 и способы |
| JP6534927B2 (ja) | 2012-07-23 | 2019-06-26 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| WO2014170496A1 (en) | 2013-04-18 | 2014-10-23 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| CN119119233A (zh) | 2013-10-17 | 2024-12-13 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| KR102310392B1 (ko) | 2013-11-06 | 2021-10-13 | 질랜드 파마 에이/에스 | 글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물 |
| CA2929459C (en) | 2013-11-06 | 2022-05-03 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| AR098616A1 (es) | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Péptido para el tratamiento de hipoglicemia severa |
| WO2015185640A1 (en) | 2014-06-04 | 2015-12-10 | Novo Nordisk A/S | Glp-1/glucagon receptor co-agonists for medical use |
| WO2015193378A1 (en) * | 2014-06-18 | 2015-12-23 | Novo Nordisk A/S | Novel glp-1 receptor agonists with cholesterol efflux activity |
| JP2017536343A (ja) * | 2014-10-10 | 2017-12-07 | ノヴォ ノルディスク アー／エス | 安定したｇｌｐ−１ベースのｇｌｐ−１／グルカゴン受容体コアゴニスト |
| KR102620911B1 (ko) | 2014-10-29 | 2024-01-05 | 질랜드 파마 에이/에스 | Gip 효능제 화합물 및 방법 |
| WO2016133863A1 (en) | 2015-02-17 | 2016-08-25 | Eli Lilly And Company | Nasal powder formulation for treatment of hypoglycemia |
| KR20170126504A (ko) | 2015-03-18 | 2017-11-17 | 질랜드 파마 에이/에스 | 아밀린 유사체 |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AU2016247499B2 (en) * | 2015-04-16 | 2020-09-03 | Zealand Pharma A/S | Acylated glucagon analogue |
| LT3494120T (lt) | 2016-08-05 | 2021-05-25 | Boehringer Ingelheim International Gmbh | Oksadiazolopiridino dariniai, skirti naudoti kaip grelino o-aciltransferazės (goat) inhibitoriai |
| AR109514A1 (es) | 2016-09-09 | 2018-12-19 | Zealand Pharma As | Análogos de amilina |
| JP6563614B1 (ja) * | 2016-12-09 | 2019-08-21 | ジーランド・ファーマ・ア／エス | アシル化ｇｌｐ−１／ｇｌｐ−２二重アゴニスト |
| BR112020003319A2 (pt) * | 2017-08-16 | 2020-08-25 | Dong-A St Co., Ltd. | análogo de peptídeo de oxintomodulina acilada |
| WO2019149657A1 (en) | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors |
| US11136337B2 (en) | 2018-02-02 | 2021-10-05 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| EA202091803A1 (ru) | 2018-02-02 | 2020-12-16 | Бёрингер Ингельхайм Интернациональ Гмбх | Производные триазолопиримидина для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) |
| EA202091804A1 (ru) | 2018-02-02 | 2020-12-24 | Бёрингер Ингельхайм Интернациональ Гмбх | Гетероциклил-замещенные оксадиазолопиридиновые производные для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) |
| TWI771669B (zh) | 2019-04-26 | 2022-07-21 | 美商美國禮來大藥廠 | 製備穩定胜肽調配物之方法 |
| MX2022005661A (es) | 2019-11-11 | 2022-09-07 | Boehringer Ingelheim Int | Agonistas del receptor npy2. |
| CN115916789B (zh) | 2020-05-22 | 2025-06-27 | 勃林格殷格翰国际有限公司 | 制备烷基7-氨基-5-甲基-[1,2,5]噁二唑并[3,4-b]吡啶羧酸酯的连续方法 |
| HUE066997T2 (hu) | 2020-05-22 | 2024-09-28 | Boehringer Ingelheim Int | Eljárás alkil-7-amino-5-metil-[1,2,5]oxidiazol[3,4-B]piridin-karboxilát elõállítására |
| AU2021322137A1 (en) | 2020-08-07 | 2023-01-19 | Boehringer Ingelheim International Gmbh | Soluble NPY2 receptor agonists |
| WO2023016346A1 (zh) * | 2021-08-10 | 2023-02-16 | 南京明德新药研发有限公司 | 含内酰胺桥的多肽化合物 |
| CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
| WO2025219590A1 (en) | 2024-04-19 | 2025-10-23 | Actimed Therapeutics Ltd | Beta-blockers for preserving muscle mass, bone density, and cardiac function in weight loss treatments |
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| WO2009087082A2 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil |
| WO2009087081A2 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue insulinderivate mit extrem verzögertem zeit-/wirkungsprofil |
| DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| NZ588857A (en) | 2008-04-22 | 2012-07-27 | Univ Case Western Reserve | Isoform-specific insulin analogue for control blood sugar levels |
| TWI451876B (zh) | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
| EP2307037A4 (en) | 2008-06-17 | 2011-08-03 | Univ Indiana Res & Tech Corp | GLUCAGON ANALOGUE WITH IMPROVED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS |
| TWI474832B (zh) | 2008-06-17 | 2015-03-01 | Univ Indiana Res & Tech Corp | 胰高血糖素／ｇｌｐ-１受體共同激動劑 |
| PL219335B1 (pl) | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| ES2552636T3 (es) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulina estabilizada por halógenos |
| WO2010070255A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070251A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070253A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| AU2008365556A1 (en) | 2008-12-15 | 2011-07-21 | Zealand Pharma A/S | Glucagon analogues |
| JP5755566B2 (ja) | 2008-12-19 | 2015-07-29 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | アミド系インスリンプロドラッグ |
| JP5789515B2 (ja) | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン類似体 |
| CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
| CN104961822A (zh) * | 2009-07-13 | 2015-10-07 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| EA026384B1 (ru) | 2010-01-20 | 2017-04-28 | Зилэнд Фарма А/С | Лечение заболеваний сердца |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| AU2011269430A1 (en) | 2010-06-24 | 2013-01-10 | Zealand Pharma A/S | Glucagon analogues |
| PH12013501495A1 (en) | 2011-01-20 | 2013-09-16 | Zealand Pharma As | Combination of acylated glucagon analogues with insulin analogues |
| BR112014015681A2 (pt) | 2011-12-23 | 2019-09-24 | Boehringer Ingelheim Int | análogos de glucagon |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| CN119119233A (zh) | 2013-10-17 | 2024-12-13 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
-
2011
- 2011-06-24 AU AU2011269430A patent/AU2011269430A1/en not_active Abandoned
- 2011-06-24 PH PH1/2012/502472A patent/PH12012502472A1/en unknown
- 2011-06-24 EP EP11741514.1A patent/EP2585482B1/en active Active
- 2011-06-24 SG SG2012093522A patent/SG186764A1/en unknown
- 2011-06-24 AP AP2013006671A patent/AP2013006671A0/xx unknown
- 2011-06-24 EA EA201291234A patent/EA201291234A1/ru unknown
- 2011-06-24 PE PE2012002452A patent/PE20130338A1/es not_active Application Discontinuation
- 2011-06-24 WO PCT/DK2011/000072 patent/WO2011160633A1/en not_active Ceased
- 2011-06-24 CA CA2802897A patent/CA2802897A1/en not_active Abandoned
- 2011-06-24 MA MA35571A patent/MA34383B1/fr unknown
- 2011-06-24 US US13/704,299 patent/US9169310B2/en not_active Expired - Fee Related
- 2011-06-24 JP JP2013515699A patent/JP6023048B2/ja not_active Expired - Fee Related
- 2011-06-24 MX MX2012014961A patent/MX2012014961A/es not_active Application Discontinuation
- 2011-06-24 KR KR1020137001877A patent/KR20130086343A/ko not_active Withdrawn
- 2011-06-24 CN CN2011800305165A patent/CN103068841A/zh active Pending
- 2011-06-24 BR BR112012033225A patent/BR112012033225A2/pt not_active IP Right Cessation
- 2011-06-24 NZ NZ604208A patent/NZ604208A/en not_active IP Right Cessation
-
2012
- 2012-11-29 TN TNP2012000560A patent/TN2012000560A1/en unknown
- 2012-12-21 CO CO12232544A patent/CO6660483A2/es unknown
- 2012-12-21 CL CL2012003641A patent/CL2012003641A1/es unknown
- 2012-12-26 EC ECSP12012357 patent/ECSP12012357A/es unknown
-
2015
- 2015-09-14 US US14/853,335 patent/US20150376257A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150376257A1 (en) | 2015-12-31 |
| US9169310B2 (en) | 2015-10-27 |
| JP6023048B2 (ja) | 2016-11-09 |
| CA2802897A1 (en) | 2011-12-29 |
| KR20130086343A (ko) | 2013-08-01 |
| WO2011160633A1 (en) | 2011-12-29 |
| SG186764A1 (en) | 2013-02-28 |
| AP2013006671A0 (en) | 2013-01-31 |
| ECSP12012357A (es) | 2013-01-31 |
| MA34383B1 (fr) | 2013-07-03 |
| BR112012033225A2 (pt) | 2017-06-20 |
| CN103068841A (zh) | 2013-04-24 |
| PH12012502472A1 (en) | 2013-03-25 |
| JP2013530969A (ja) | 2013-08-01 |
| EA201291234A1 (ru) | 2013-07-30 |
| NZ604208A (en) | 2014-10-31 |
| CL2012003641A1 (es) | 2013-09-06 |
| US20130157929A1 (en) | 2013-06-20 |
| TN2012000560A1 (en) | 2014-04-01 |
| MX2012014961A (es) | 2013-02-26 |
| EP2585482B1 (en) | 2019-03-27 |
| CO6660483A2 (es) | 2013-04-30 |
| EP2585482A1 (en) | 2013-05-01 |
| AU2011269430A1 (en) | 2013-01-10 |
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