ZA977475B - N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action. - Google Patents

N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action.

Info

Publication number: ZA977475B
Authority: ZA; South Africa
Prior art keywords: glyoxylamides; asthmatic; antiallergic; immunosuppressant; immuno
Prior art date: 1996-09-06

Application number

ZA9707475A

Other languages

English (en)

Inventor

Guillaume Lebaut

Cecilia Menciu

Bernhard Kutscher

Peter Emig

Stefan Szelenyi

Kay Brune

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-06

Filing date

1997-08-20

Publication date

1998-02-19

1997-08-20 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1998-02-19 Publication of ZA977475B publication Critical patent/ZA977475B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA9707475A 1996-09-06 1997-08-20 N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action. ZA977475B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19636150A DE19636150A1 (de)	1996-09-06	1996-09-06	N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung

Publications (1)

Publication Number	Publication Date
ZA977475B true ZA977475B (en)	1998-02-19

Family

ID=7804772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9707475A ZA977475B (en)	1996-09-06	1997-08-20	N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action.

Country Status (26)

Country	Link
US (4)	US6008231A (xx)
EP (1)	EP0931063B3 (xx)
JP (1)	JP3296437B2 (xx)
KR (1)	KR100516321B1 (xx)
CN (3)	CN101219985B (xx)
AR (1)	AR008630A1 (xx)
AT (1)	ATE342889T1 (xx)
AU (1)	AU726521B2 (xx)
BR (1)	BR9712808B1 (xx)
CA (1)	CA2215013C (xx)
CZ (1)	CZ302301B6 (xx)
DE (2)	DE19636150A1 (xx)
DK (1)	DK0931063T5 (xx)
ES (1)	ES2276433T7 (xx)
HU (1)	HU227797B1 (xx)
IL (1)	IL127798A (xx)
NO (2)	NO314725B3 (xx)
NZ (1)	NZ334476A (xx)
PT (1)	PT931063E (xx)
RU (1)	RU2237661C2 (xx)
SK (1)	SK285618B6 (xx)
TR (1)	TR199900469T2 (xx)
TW (1)	TW550256B (xx)
UA (1)	UA60312C2 (xx)
WO (1)	WO1998009946A1 (xx)
ZA (1)	ZA977475B (xx)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19636150A1 (de) *	1996-09-06	1998-03-12	Asta Medica Ag	N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
US6214991B1 (en) *	1998-03-31	2001-04-10	The Institute For Pharmaceutical Discovery, Inc.	Substituted indolealkanoic acids
DE19814838C2 (de) *	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) *	1998-04-02	2001-04-19	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
CZ302588B6 (cs) *	1998-04-02	2011-07-27	Ziopharm Oncology, Inc.	Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva
DE19818964A1 (de) *	1998-04-28	1999-11-04	Dresden Arzneimittel	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE19917504A1 (de) *	1999-04-17	2000-10-19	Dresden Arzneimittel	Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
ATE330955T1 (de)	1998-04-28	2006-07-15	Elbion Ag	Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4.
AU777012B2 (en)	1999-08-21	2004-09-30	Takeda Gmbh	Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
TWI269654B (en) *	1999-09-28	2007-01-01	Baxter Healthcare Sa	N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (de) *	1999-12-23	2001-06-28	Asta Medica Ag	Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
DE10022925A1 (de) *	2000-05-11	2001-11-15	Basf Ag	Substituierte Indole als PARP-Inhibitoren
DE10037310A1 (de)	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
EP1427416A2 (en) *	2001-09-13	2004-06-16	Synta Pharmaceuticals Corporation	3-glyoxlylamideindoles for treating cancer
RU2337906C2 (ru) *	2001-12-03	2008-11-10	Уайт	Ингибиторы цитозольной фосфолипазы а2
US6903104B2 (en) *	2001-12-06	2005-06-07	National Health Research Institutes	Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
US20060100255A1 (en) *	2002-07-26	2006-05-11	Van Zandt Michael C	Substituted indolealkanoic acids derivative and formulations containing same for use in the treatment of diabetic complications
RU2315046C2 (ru) *	2002-08-01	2008-01-20	Элбион Аг	Способ получения гидроксииндолилглиоксиламидов высокой чистоты
DE10253426B4 (de) *	2002-11-15	2005-09-22	Elbion Ag	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
JP2006522151A (ja)	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
DE10318609A1 (de) *	2003-04-24	2004-11-11	Elbion Ag	5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318610A1 (de)	2003-04-24	2004-11-11	Elbion Ag	7-Azaindole und deren Verwendung als Therapeutika
DE10318611A1 (de) *	2003-04-24	2004-11-11	Elbion Ag	4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
US20050075364A1 (en) *	2003-07-01	2005-04-07	Kap-Sun Yeung	Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
DE10334040A1 (de) *	2003-07-25	2005-03-10	Zentaris Gmbh	Neue N-substituierte Indolyl-3-glyoxylsäureamide, deren Verwendung als Arzneimittel und Verfahren zu deren Herstellung
BRPI0414313A (pt)	2003-09-11	2006-11-07	Kemia Inc	inibidores de citocinas
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
DE102004031538A1 (de) *	2004-06-29	2006-02-09	Baxter International Inc., Deerfield	Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
ES2424255T3 (es) *	2004-11-08	2013-09-30	Baxter International Inc.	Composiciones particuladas de inhibidores de tubulina
US20060100432A1 (en) *	2004-11-09	2006-05-11	Matiskella John D	Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100209A1 (en) *	2004-11-09	2006-05-11	Chong-Hui Gu	Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US8604055B2 (en)	2004-12-31	2013-12-10	Dr. Reddy's Laboratories Ltd.	Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
CN103102303B (zh)	2004-12-31	2015-10-28	雷迪博士实验室有限公司	作为cetp抑制剂的苄胺衍生物
JP2006247963A (ja) *	2005-03-09	2006-09-21	Oji Paper Co Ltd	インクジェット記録用シート
WO2006099256A2 (en) *	2005-03-11	2006-09-21	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US7392768B2 (en)	2005-04-29	2008-07-01	Tendix Development, Llc	Radial impulse engine, pump, and compressor systems, and associated methods of operation
US20060280787A1 (en) *	2005-06-14	2006-12-14	Baxter International Inc.	Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US7598380B2 (en) *	2005-08-03	2009-10-06	Bristol-Myers Squibb Company	Method of preparation of azaindole derivatives
ITMI20051999A1 (it) *	2005-10-21	2007-04-22	Eratech S R L	Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
US7851476B2 (en) *	2005-12-14	2010-12-14	Bristol-Myers Squibb Company	Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en)	2006-04-25	2010-10-05	Bristol-Myers Squibb Company	Diketo-piperazine and piperidine derivatives as antiviral agents
ES2378281T3 (es)	2006-07-05	2012-04-10	Nycomed Gmbh	Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
EP2049520A4 (en) *	2006-08-07	2011-01-05	Ironwood Pharmaceuticals Inc	indole compounds
WO2008073623A2 (en) *	2006-11-02	2008-06-19	Arete Therapeutics, Inc.	Soluble epoxide hydrolase inhibitors
CA2670778A1 (en) *	2006-11-28	2008-06-05	Ziopharm Oncology, Inc.	Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
WO2010127099A2 (en)	2009-04-29	2010-11-04	Amarin Corporation Plc	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es)	2010-12-22	2013-05-15	Ironwood Pharmaceuticals Inc	Inhibidores de la faah y composiciones farmaceuticas que los contienen
JP5964965B2 (ja)	2011-08-18	2016-08-03	ドクターレディズラボラトリーズリミテッド	コレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての置換複素環式アミン化合物
CN103958511A (zh)	2011-09-27	2014-07-30	雷迪博士实验室有限公司	作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
EP3165224A1 (en)	2015-11-09	2017-05-10	Albert-Ludwigs-Universität Freiburg	Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
CN109000634B (zh) *	2018-06-04	2022-06-03	上海智蕙林医疗科技有限公司	一种导航对象行进路线的提醒方法和系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB797258A (en) *	1955-04-11	1958-06-25	Upjohn Co	3-substituted indoles
GB944443A (xx) *	1959-09-25	1900-01-01
GB1028812A (en) *	1962-08-28	1966-05-11	Ici Ltd	Indole derivatives
GB1089071A (en) *	1964-02-28	1967-11-01	Merck & Co Inc	Indole derivatives
US3686213A (en) *	1970-08-28	1972-08-22	American Cyanamid Co	Substituted aminoethyl indoles
SU457698A1 (ru) *	1972-10-20	1975-01-25	Всесоюзный научно-исследовательский химико-фармацевтический институт им. Серго Орджоникидзе	Способ получени производных индолил-2-уксусной кислоты
FR2689888B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
PT675110E (pt) *	1994-04-01	2002-11-29	Lilly Co Eli	1h-indole-3-glioxilamidas inibidoras da spla2
DE19636150A1 (de) *	1996-09-06	1998-03-12	Asta Medica Ag	N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DE19946301A1 (de) *	1998-04-02	2001-04-19	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
US7205299B2 (en) *	2003-06-05	2007-04-17	Zentaris Gmbh	Indole derivatives having an apoptosis-inducing effect

1996
- 1996-09-06 DE DE19636150A patent/DE19636150A1/de not_active Ceased
1997
- 1997-08-16 DK DK97937586T patent/DK0931063T5/da active
- 1997-08-16 DE DE59712752T patent/DE59712752D1/de not_active Expired - Lifetime
- 1997-08-16 IL IL12779897A patent/IL127798A/xx not_active IP Right Cessation
- 1997-08-16 KR KR10-1999-7001909A patent/KR100516321B1/ko not_active Expired - Fee Related
- 1997-08-16 BR BRPI9712808-2A patent/BR9712808B1/pt not_active IP Right Cessation
- 1997-08-16 WO PCT/EP1997/004474 patent/WO1998009946A1/de not_active Ceased
- 1997-08-16 RU RU99106782A patent/RU2237661C2/ru not_active IP Right Cessation
- 1997-08-16 CZ CZ0061699A patent/CZ302301B6/cs not_active IP Right Cessation
- 1997-08-16 CN CN2008100087226A patent/CN101219985B/zh not_active Expired - Fee Related
- 1997-08-16 SK SK271-99A patent/SK285618B6/sk not_active IP Right Cessation
- 1997-08-16 TR TR1999/00469T patent/TR199900469T2/xx unknown
- 1997-08-16 AT AT97937586T patent/ATE342889T1/de active
- 1997-08-16 AU AU40158/97A patent/AU726521B2/en not_active Ceased
- 1997-08-16 CN CNB971971285A patent/CN100376554C/zh not_active Expired - Fee Related
- 1997-08-16 HU HU9903741A patent/HU227797B1/hu not_active IP Right Cessation
- 1997-08-16 ES ES97937586T patent/ES2276433T7/es active Active
- 1997-08-16 EP EP97937586A patent/EP0931063B3/de not_active Expired - Lifetime
- 1997-08-16 JP JP51216798A patent/JP3296437B2/ja not_active Expired - Fee Related
- 1997-08-16 PT PT97937586T patent/PT931063E/pt unknown
- 1997-08-16 UA UA99041907A patent/UA60312C2/uk unknown
- 1997-08-16 NZ NZ334476A patent/NZ334476A/xx not_active IP Right Cessation
- 1997-08-16 CN CNB021320616A patent/CN100488948C/zh not_active Expired - Fee Related
- 1997-08-20 ZA ZA9707475A patent/ZA977475B/xx unknown
- 1997-09-04 CA CA002215013A patent/CA2215013C/en not_active Expired - Fee Related
- 1997-09-05 AR ARP970104064A patent/AR008630A1/es active IP Right Grant
- 1997-09-08 US US08/925,326 patent/US6008231A/en not_active Expired - Lifetime
- 1997-09-30 TW TW086112985A patent/TW550256B/zh not_active IP Right Cessation
1999
- 1999-03-04 NO NO19991071A patent/NO314725B3/no not_active IP Right Cessation
- 1999-09-30 US US09/409,263 patent/US6344467B1/en not_active Expired - Lifetime
2002
- 2002-01-30 US US10/058,836 patent/US20020161025A1/en not_active Abandoned
2003
- 2003-01-30 NO NO20030481A patent/NO20030481D0/no not_active Application Discontinuation
- 2003-04-01 US US10/402,931 patent/US6919344B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2276433T7 (es)	2009-11-05
UA60312C2 (uk)	2003-10-15
DE59712752D1 (de)	2006-11-30
HK1123280A1 (en)	2009-06-12
CN1227542A (zh)	1999-09-01
CN1496980A (zh)	2004-05-19
CN100376554C (zh)	2008-03-26
AR008630A1 (es)	2000-02-09
SK27199A3 (en)	1999-08-06
EP0931063B1 (de)	2006-10-18
CN101219985B (zh)	2011-04-27
HK1021641A1 (zh)	2000-06-23
IL127798A0 (en)	1999-10-28
IL127798A (en)	2003-07-31
CN100488948C (zh)	2009-05-20
NO314725B1 (no)	2003-05-12
DK0931063T3 (da)	2007-02-19
KR100516321B1 (ko)	2005-09-23
US20030207892A1 (en)	2003-11-06
US6919344B2 (en)	2005-07-19
DK0931063T5 (da)	2010-01-11
EP0931063A1 (de)	1999-07-28
CZ61699A3 (cs)	1999-06-16
TW550256B (en)	2003-09-01
HUP9903741A3 (en)	2001-01-29
JP3296437B2 (ja)	2002-07-02
ATE342889T1 (de)	2006-11-15
EP0931063B3 (de)	2009-04-08
CZ302301B6 (cs)	2011-02-09
NZ334476A (en)	2000-05-26
NO314725B3 (no)	2009-03-09
HUP9903741A2 (hu)	2000-04-28
DE19636150A1 (de)	1998-03-12
NO20030481L (no)	1999-03-04
US6344467B1 (en)	2002-02-05
WO1998009946A1 (de)	1998-03-12
TR199900469T2 (xx)	1999-05-21
NO991071L (no)	1999-03-04
SK285618B6 (sk)	2007-05-03
AU726521B2 (en)	2000-11-09
JP2000505098A (ja)	2000-04-25
CA2215013A1 (en)	1998-03-06
HK1064379A1 (zh)	2005-01-28
AU726521C (en)	1998-03-26
RU2237661C2 (ru)	2004-10-10
CN101219985A (zh)	2008-07-16
PT931063E (pt)	2007-02-28
NO20030481D0 (no)	2003-01-30
ES2276433T3 (es)	2007-06-16
BR9712808A (pt)	1999-11-23
US6008231A (en)	1999-12-28
US20020161025A1 (en)	2002-10-31
NO991071D0 (no)	1999-03-04
BR9712808B1 (pt)	2009-05-05
AU4015897A (en)	1998-03-26
KR20000068495A (ko)	2000-11-25
CA2215013C (en)	2002-03-05
HU227797B1 (en)	2012-03-28

Publication	Publication Date	Title
ZA977475B (en)	1998-02-19	N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action.
ZA979985B (en)	1998-05-07	N-substituted 2-cyanopyrrolidines.
ZA9710429B (en)	1998-06-10	Broad-spectrumδ-endotoxins.
PL331585A1 (en)	1999-07-19	2- 2,5-substituted phenylketoneoles
ZA979199B (en)	1998-05-11	Aminothiophenecarboxamides.
ZA973901B (en)	1997-12-08	Alternative fuel.
ZA976168B (en)	1998-02-02	3-Ureido-pyridofurans and -pyridothiophenes.
ZA97521B (en)	1997-08-04	19-Nor-pregnene derivatives.
ZA977206B (en)	1999-11-12	Arylalkanoylpyridazines.
ZA977944B (en)	1998-03-02	Anti-mine protection.
ZA978045B (en)	1998-03-10	New benzamidine derivatives.
ZA978304B (en)	1998-03-24	3-alkyl-3-phenyl-piperidines.
ZA976733B (en)	1998-03-03	Hydrotreating process.
DE69723848D1 (en)	2003-09-04	3-descladinose-2,3-anhydroerythromycin-derivate
ZA972328B (en)	1997-09-19	Fluoroalkyl- and fluoroalkoxy-substituted heterocyclic bradykinin antagonists, process for their preparation, and their use.
ZA959630B (en)	1997-08-21	Diaminocyclobutene-3, 4-diones.
ZA97572B (en)	1997-08-04	1-pyrazol-3-ylethyl-4-indol-3-ylpiperidines.
ZA971466B (en)	1997-08-28	Endothelin-receptor-antagonists.
ZA976022B (en)	1998-02-02	Cycloalkano-pyridines.
ZA9710318B (en)	1998-06-10	Safe re-locker.
ZA977791B (en)	1998-03-02	GLP-1 derivatives.
CY2322B1 (en)	2003-11-14	Benzoaeguequinoline derivatives.
ZA975754B (en)	1998-03-20	Explosive.
ZA971124B (en)	1997-08-25	In chamber system protectors.
ZA971474B (en)	1997-08-28	Endothelin-receptor-antagonists.