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HUP9903741A2 - Asztmaellenes, allergiaellenes, immunvisszaszorító és/vagy immunmoduláló hatású N-helyettesített indol-3-glioxilamidok - Google Patents

Asztmaellenes, allergiaellenes, immunvisszaszorító és/vagy immunmoduláló hatású N-helyettesített indol-3-glioxilamidok

Info

Publication number
HUP9903741A2
HUP9903741A2 HU9903741A HUP9903741A HUP9903741A2 HU P9903741 A2 HUP9903741 A2 HU P9903741A2 HU 9903741 A HU9903741 A HU 9903741A HU P9903741 A HUP9903741 A HU P9903741A HU P9903741 A2 HUP9903741 A2 HU P9903741A2
Authority
HU
Hungary
Prior art keywords
antiallergic
immunosuppressive
glyoxylamid
antiasthmatic
immunomodulating effect
Prior art date
Application number
HU9903741A
Other languages
English (en)
Inventor
Kay Brune
Peter Emig
Bernhard Kutscher
Guillaume Lebaut
Cécilia Menciu
Stefan Szelenyi
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of HUP9903741A2 publication Critical patent/HUP9903741A2/hu
Publication of HUP9903741A3 publication Critical patent/HUP9903741A3/hu
Publication of HU227797B1 publication Critical patent/HU227797B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány (I) általánős képletű N-helyettesített indől-3-gliőxőlamidőkra, ezek előállítására és gyógyszerészeti alkalmazásűkravőnatkőzik. A vegyületek hisztamingátló, allergiaellenes ésimműngátló/imműnmődűláló hatással rendelkeznek. (I) ŕ
HU9903741A 1996-09-06 1997-08-16 N-substituted indol-3-glyoxylamid with antiasthmatic, antiallergic and immunosuppressive/immunomodulating effect HU227797B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19636150A DE19636150A1 (de) 1996-09-06 1996-09-06 N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
PCT/EP1997/004474 WO1998009946A1 (de) 1996-09-06 1997-08-16 N-substituierte indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender wirkung

Publications (3)

Publication Number Publication Date
HUP9903741A2 true HUP9903741A2 (hu) 2000-04-28
HUP9903741A3 HUP9903741A3 (en) 2001-01-29
HU227797B1 HU227797B1 (en) 2012-03-28

Family

ID=7804772

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903741A HU227797B1 (en) 1996-09-06 1997-08-16 N-substituted indol-3-glyoxylamid with antiasthmatic, antiallergic and immunosuppressive/immunomodulating effect

Country Status (26)

Country Link
US (4) US6008231A (hu)
EP (1) EP0931063B3 (hu)
JP (1) JP3296437B2 (hu)
KR (1) KR100516321B1 (hu)
CN (3) CN101219985B (hu)
AR (1) AR008630A1 (hu)
AT (1) ATE342889T1 (hu)
AU (1) AU726521B2 (hu)
BR (1) BR9712808B1 (hu)
CA (1) CA2215013C (hu)
CZ (1) CZ302301B6 (hu)
DE (2) DE19636150A1 (hu)
DK (1) DK0931063T5 (hu)
ES (1) ES2276433T7 (hu)
HU (1) HU227797B1 (hu)
IL (1) IL127798A (hu)
NO (2) NO314725B3 (hu)
NZ (1) NZ334476A (hu)
PT (1) PT931063E (hu)
RU (1) RU2237661C2 (hu)
SK (1) SK285618B6 (hu)
TR (1) TR199900469T2 (hu)
TW (1) TW550256B (hu)
UA (1) UA60312C2 (hu)
WO (1) WO1998009946A1 (hu)
ZA (1) ZA977475B (hu)

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Also Published As

Publication number Publication date
ES2276433T7 (es) 2009-11-05
UA60312C2 (uk) 2003-10-15
DE59712752D1 (de) 2006-11-30
HK1123280A1 (en) 2009-06-12
CN1227542A (zh) 1999-09-01
CN1496980A (zh) 2004-05-19
CN100376554C (zh) 2008-03-26
AR008630A1 (es) 2000-02-09
SK27199A3 (en) 1999-08-06
EP0931063B1 (de) 2006-10-18
CN101219985B (zh) 2011-04-27
HK1021641A1 (zh) 2000-06-23
IL127798A0 (en) 1999-10-28
IL127798A (en) 2003-07-31
ZA977475B (en) 1998-02-19
CN100488948C (zh) 2009-05-20
NO314725B1 (no) 2003-05-12
DK0931063T3 (da) 2007-02-19
KR100516321B1 (ko) 2005-09-23
US20030207892A1 (en) 2003-11-06
US6919344B2 (en) 2005-07-19
DK0931063T5 (da) 2010-01-11
EP0931063A1 (de) 1999-07-28
CZ61699A3 (cs) 1999-06-16
TW550256B (en) 2003-09-01
HUP9903741A3 (en) 2001-01-29
JP3296437B2 (ja) 2002-07-02
ATE342889T1 (de) 2006-11-15
EP0931063B3 (de) 2009-04-08
CZ302301B6 (cs) 2011-02-09
NZ334476A (en) 2000-05-26
NO314725B3 (no) 2009-03-09
DE19636150A1 (de) 1998-03-12
NO20030481L (no) 1999-03-04
US6344467B1 (en) 2002-02-05
WO1998009946A1 (de) 1998-03-12
TR199900469T2 (xx) 1999-05-21
NO991071L (no) 1999-03-04
SK285618B6 (sk) 2007-05-03
AU726521B2 (en) 2000-11-09
JP2000505098A (ja) 2000-04-25
CA2215013A1 (en) 1998-03-06
HK1064379A1 (zh) 2005-01-28
AU726521C (en) 1998-03-26
RU2237661C2 (ru) 2004-10-10
CN101219985A (zh) 2008-07-16
PT931063E (pt) 2007-02-28
NO20030481D0 (no) 2003-01-30
ES2276433T3 (es) 2007-06-16
BR9712808A (pt) 1999-11-23
US6008231A (en) 1999-12-28
US20020161025A1 (en) 2002-10-31
NO991071D0 (no) 1999-03-04
BR9712808B1 (pt) 2009-05-05
AU4015897A (en) 1998-03-26
KR20000068495A (ko) 2000-11-25
CA2215013C (en) 2002-03-05
HU227797B1 (en) 2012-03-28

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