ZA200600167B - Muscarinic acetylcholine receptor antagonists - Google Patents

Muscarinic acetylcholine receptor antagonists Download PDF

Info

Publication number: ZA200600167B
Authority: ZA; South Africa
Prior art keywords: compound according; endo; compound; use according; duration
Prior art date: 2003-07-17

Application number

ZA200600167A

Other languages

English (en)

Inventor

Kristen E Belmonte

Busch-Petersen Jakob

Laine Dramane

Michael R Palovich

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-17

Filing date

2006-01-06

Publication date

2007-01-31

2006-01-06 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2007-01-31 Publication of ZA200600167B publication Critical patent/ZA200600167B/en

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230000005802 health problem Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
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229910052739 hydrogen Inorganic materials 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
LHLMOSXCXGLMMN-VVQPYUEFSA-M ipratropium bromide Chemical compound [Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 LHLMOSXCXGLMMN-VVQPYUEFSA-M 0.000 description 1
229960001361 ipratropium bromide Drugs 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
238000012417 linear regression Methods 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
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238000012986 modification Methods 0.000 description 1
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210000003097 mucus Anatomy 0.000 description 1
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230000004118 muscle contraction Effects 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
238000010422 painting Methods 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
230000001991 pathophysiological effect Effects 0.000 description 1
210000001428 peripheral nervous system Anatomy 0.000 description 1
239000008024 pharmaceutical diluent Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
210000004879 pulmonary tissue Anatomy 0.000 description 1
239000002287 radioligand Substances 0.000 description 1
238000003653 radioligand binding assay Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
229960002646 scopolamine Drugs 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000000779 smoke Substances 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
241000894007 species Species 0.000 description 1
229940046810 spiriva Drugs 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000005062 synaptic transmission Effects 0.000 description 1
238000012385 systemic delivery Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000006068 taste-masking agent Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229960000257 tiotropium bromide Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
230000007384 vagal nerve stimulation Effects 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000004804 winding Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200600167A 2003-07-17 2006-01-06 Muscarinic acetylcholine receptor antagonists ZA200600167B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48798203P	2003-07-17	2003-07-17

Publications (1)

Publication Number	Publication Date
ZA200600167B true ZA200600167B (en)	2007-01-31

Family

ID=34102736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200600167A ZA200600167B (en)	2003-07-17	2006-01-06	Muscarinic acetylcholine receptor antagonists

Country Status (19)

Country	Link
US (1)	US7495010B2 (fr)
EP (1)	EP1648461A4 (fr)
JP (1)	JP2007525478A (fr)
KR (1)	KR20060054316A (fr)
CN (1)	CN1822839A (fr)
AR (1)	AR045914A1 (fr)
AU (1)	AU2004259238A1 (fr)
BR (1)	BRPI0412537A (fr)
CA (1)	CA2532433A1 (fr)
IL (1)	IL172912A0 (fr)
IS (1)	IS8296A (fr)
MA (1)	MA27901A1 (fr)
MX (1)	MXPA06000663A (fr)
NO (1)	NO20060777L (fr)
PE (1)	PE20050250A1 (fr)
RU (1)	RU2006104851A (fr)
TW (1)	TW200519108A (fr)
WO (1)	WO2005009362A2 (fr)
ZA (1)	ZA200600167B (fr)

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AU2012202307B2 (en) *	2004-04-27	2015-05-07	Glaxo Group Limited	Muscarinic acetylcholine receptor antagonists
PE20060259A1 (es)	2004-04-27	2006-03-25	Glaxo Group Ltd	Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico
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JP2007537261A (ja) *	2004-05-13	2007-12-20	グラクソ　グループ　リミテッド	ムスカリン性アセチルコリン受容体アンタゴニスト
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US20090258858A1 (en)	2004-10-29	2009-10-15	Jakob Busch-Petersen	Muscarinic acetylcholine receptor antagonists
US20090142279A1 (en)	2004-11-15	2009-06-04	Budzik Brian W	Novel m3 muscarinic acetylcholine receptor antagonists
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PE20060826A1 (es)	2004-12-06	2006-10-08	Smithkline Beecham Corp	Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende
WO2006065755A2 (fr)	2004-12-13	2006-06-22	Glaxo Group Limited	Sels d'ammonium quaternaire d'amines heteroaromatiques fusionnees utilises comme nouveaux antagonistes du recepteur de l'acetylcholine muscarinique
WO2006065788A2 (fr)	2004-12-13	2006-06-22	Glaxo Group Limited	Nouveaux antagonistes du recepteur muscarinique de l'acetylcholine
WO2007018508A1 (fr)	2005-07-28	2007-02-15	Glaxo Group Limited	Nouveaux antagonistes du récepteur muscarinique m3 de l’acétylcholine
WO2007018514A1 (fr)	2005-07-28	2007-02-15	Glaxo Group Limited	Nouveaux antagonistes récepteurs d’acétylcholine muscarinique m3
EP1937230A4 (fr)	2005-08-02	2009-08-26	Glaxo Group Ltd	Antagonistes du recepteur d'acetylcholine muscarinique m3
WO2007016639A2 (fr)	2005-08-02	2007-02-08	Glaxo Group Limited	Antagonistes des recepteurs de l' acetylcholine muscarinique m3
EP1937068A4 (fr)	2005-08-18	2010-08-04	Glaxo Group Ltd	Antagonistes de recepteurs d'acetylcholine muscarinique

2004
- 2004-07-15 PE PE2004000674A patent/PE20050250A1/es not_active Application Discontinuation
- 2004-07-15 TW TW093121063A patent/TW200519108A/zh unknown
- 2004-07-15 AR ARP040102499A patent/AR045914A1/es unknown
- 2004-07-16 WO PCT/US2004/023041 patent/WO2005009362A2/fr not_active Ceased
- 2004-07-16 RU RU2006104851/04A patent/RU2006104851A/ru not_active Application Discontinuation
- 2004-07-16 CN CNA2004800206526A patent/CN1822839A/zh active Pending
- 2004-07-16 US US10/565,048 patent/US7495010B2/en not_active Expired - Fee Related
- 2004-07-16 JP JP2006520387A patent/JP2007525478A/ja active Pending
- 2004-07-16 EP EP04778509A patent/EP1648461A4/fr not_active Withdrawn
- 2004-07-16 BR BRPI0412537-1A patent/BRPI0412537A/pt not_active IP Right Cessation
- 2004-07-16 CA CA002532433A patent/CA2532433A1/fr not_active Abandoned
- 2004-07-16 AU AU2004259238A patent/AU2004259238A1/en not_active Abandoned
- 2004-07-16 MX MXPA06000663A patent/MXPA06000663A/es unknown
- 2004-07-16 KR KR1020067001001A patent/KR20060054316A/ko not_active Withdrawn
2005
- 2005-12-29 IL IL172912A patent/IL172912A0/en unknown
2006
- 2006-01-06 MA MA28705A patent/MA27901A1/fr unknown
- 2006-01-06 ZA ZA200600167A patent/ZA200600167B/en unknown
- 2006-02-13 IS IS8296A patent/IS8296A/is unknown
- 2006-02-17 NO NO20060777A patent/NO20060777L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BRPI0412537A (pt)	2006-09-19
JP2007525478A (ja)	2007-09-06
EP1648461A2 (fr)	2006-04-26
WO2005009362A3 (fr)	2005-04-07
EP1648461A4 (fr)	2009-04-01
IS8296A (is)	2006-02-13
WO2005009362A2 (fr)	2005-02-03
MA27901A1 (fr)	2006-05-02
MXPA06000663A (es)	2006-03-30
NO20060777L (no)	2006-04-11
PE20050250A1 (es)	2005-04-08
IL172912A0 (en)	2006-06-11
US20060178396A1 (en)	2006-08-10
US7495010B2 (en)	2009-02-24
TW200519108A (en)	2005-06-16
AR045914A1 (es)	2005-11-16
CN1822839A (zh)	2006-08-23
AU2004259238A1 (en)	2005-02-03
KR20060054316A (ko)	2006-05-22
RU2006104851A (ru)	2006-06-27
CA2532433A1 (fr)	2005-02-03

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EP1740177B1 (fr)	2012-08-08	Antagonistes des recepteurs muscariniques de l'acetylcholine
US7495010B2 (en)	2009-02-24	Muscarinic acetylcholine receptor antagonists
US20060178395A1 (en)	2006-08-10	Muscarinic acetylcholine receptor antagonists
US20060160844A1 (en)	2006-07-20	Muscarinic acetylcholine receptor antagonists
WO2006062931A2 (fr)	2006-06-15	Combinaisons medicales
US7579345B2 (en)	2009-08-25	Muscarinic acetylcholine receptor antagonists
WO2006062883A2 (fr)	2006-06-15	Combinaisons medicales
US20070293531A1 (en)	2007-12-20	Muscarinic Acetycholine Receptor Antagonists
US20090076061A1 (en)	2009-03-19	Muscarinic acetycholine receptor antagonists
HK1102423B (en)	2013-01-04	Muscarinic acetylcholine receptor antagonists