AR045914A1 - Compuesto alcoholico terciario del 8-azoniabiciclo [3.2.1] octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultima - Google Patents
Compuesto alcoholico terciario del 8-azoniabiciclo [3.2.1] octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultimaInfo
- Publication number
- AR045914A1 AR045914A1 ARP040102499A ARP040102499A AR045914A1 AR 045914 A1 AR045914 A1 AR 045914A1 AR P040102499 A ARP040102499 A AR P040102499A AR P040102499 A ARP040102499 A AR P040102499A AR 045914 A1 AR045914 A1 AR 045914A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- pharmaceutical composition
- formula
- prepare
- acetylcholine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000001476 alcoholic effect Effects 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 2
- 229960004373 acetylcholine Drugs 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical compound C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000018569 Respiratory Tract disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto alcohólico terciario del 8-azoniabiciclo[3.2.1]octano representado por la fórmula (1), en la que: R2 y R3 se seleccionan, independientemente, del grupo constituido por grupos alquilo inferiores de cadena lineal o ramificada (que tienen preferiblemente C1-6), grupos cicloalquilos (C1-6), cicloalquil-alquilo(C6-10), 2-tienilo, 2-piridilo, fenilo, fenilo sustituido con un grupo alquilo que no tiene más de 4 átomos de carbono y fenilo sustituido con un grupo alcoxi que no tiene más de 4 átomos de carbono; y X- representa un anión asociado con la carga positiva del átomo de N; de tal modo que el compuesto es una sal cuaternaria. Composición farmacéutica para el tratamiento de enfermedades mediadas por los receptores muscarínicos de la acetilcolina, que comprende el compuesto de la fórmula (1) y un vehículo del mismo farmacéuticamente aceptable. Uso del compuesto de la fórmula (1) para preparar una composición farmacéutica útil para inhibir la unión de la acetilcolina a sus receptores en un mamífero que lo necesite, mediante la administración de una cantidad segura y eficaz de dicho compuesto. De esta forma se puede tratar una enfermedad mediada por un receptor muscarínico de la acetilcolina, en el que la acetilcolina se une a dicho receptor, tales como las enfermedades del tracto respiratorio.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48798203P | 2003-07-17 | 2003-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045914A1 true AR045914A1 (es) | 2005-11-16 |
Family
ID=34102736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102499A AR045914A1 (es) | 2003-07-17 | 2004-07-15 | Compuesto alcoholico terciario del 8-azoniabiciclo [3.2.1] octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultima |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7495010B2 (es) |
| EP (1) | EP1648461A4 (es) |
| JP (1) | JP2007525478A (es) |
| KR (1) | KR20060054316A (es) |
| CN (1) | CN1822839A (es) |
| AR (1) | AR045914A1 (es) |
| AU (1) | AU2004259238A1 (es) |
| BR (1) | BRPI0412537A (es) |
| CA (1) | CA2532433A1 (es) |
| IL (1) | IL172912A0 (es) |
| IS (1) | IS8296A (es) |
| MA (1) | MA27901A1 (es) |
| MX (1) | MXPA06000663A (es) |
| NO (1) | NO20060777L (es) |
| PE (1) | PE20050250A1 (es) |
| RU (1) | RU2006104851A (es) |
| TW (1) | TW200519108A (es) |
| WO (1) | WO2005009362A2 (es) |
| ZA (1) | ZA200600167B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1677795T1 (sl) * | 2003-10-14 | 2011-04-29 | Glaxo Group Ltd | Antagonisti muskarinskega acetilholinskega receptorja |
| BRPI0415281A (pt) * | 2003-10-17 | 2006-12-19 | Glaxo Group Ltd | antagonistas de receptor de acetilcolina muscarìnico |
| AR046225A1 (es) * | 2003-11-04 | 2005-11-30 | Glaxo Group Ltd | Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion |
| WO2005087236A1 (en) * | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
| US20070185148A1 (en) * | 2004-03-17 | 2007-08-09 | Glaxo Group Limited | M3 muscarinic acetylchoine receptor antagonists |
| WO2005095407A1 (en) * | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| TWI363759B (en) | 2004-04-27 | 2012-05-11 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| AU2012202307B2 (en) * | 2004-04-27 | 2015-05-07 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| US7598267B2 (en) * | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| JP2008520579A (ja) * | 2004-11-15 | 2008-06-19 | グラクソ グループ リミテッド | 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト |
| EP1937267A4 (en) * | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| EP1937068A4 (en) * | 2005-08-18 | 2010-08-04 | Glaxo Group Ltd | ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS |
| UY31636A1 (es) | 2008-02-06 | 2009-08-03 | Farmacoforos duales-antagonistas muscarinicos de pde4 | |
| UY31637A1 (es) | 2008-02-06 | 2009-08-03 | Farmacoforos duales-antagonistas muscarinicos de pde4 | |
| TW200946526A (en) | 2008-02-06 | 2009-11-16 | Glaxo Group Ltd | Dual pharmacophores-PDE4-muscarinic antagonistics |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| EP3248970A1 (en) | 2016-05-27 | 2017-11-29 | Zentiva K.S. | Forms of umeclidinium bromide |
| CN118987229A (zh) * | 2024-09-10 | 2024-11-22 | 北京大学 | 一种Chrm4特异性拮抗剂在制备治疗肺部2型免疫炎症性疾病的药物中的应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800478A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| US2800481A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | Tertiary alcohol derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| US2800482A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | Olefinic derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| AT298118B (de) | 1967-06-08 | 1972-04-25 | Siemens Ag | Verfahren zur Umsetzung von Spannungen in digitale Werte und Vorrichtung zur Durchführung des Verfahrens |
| CY1308A (en) | 1979-12-06 | 1985-12-06 | Glaxo Group Ltd | Device for dispensing medicaments |
| EP0069715B1 (en) | 1981-07-08 | 1986-11-05 | Aktiebolaget Draco | Powder inhalator |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| IE56059B1 (en) | 1982-10-08 | 1991-04-10 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| BE905189A (fr) | 1985-07-30 | 1987-01-29 | Glaxo Group Ltd | Dispositif pour administrer des medicaments a des patients. |
| IT1204826B (it) | 1986-03-04 | 1989-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche per inalazione |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US5780466A (en) | 1995-01-30 | 1998-07-14 | Sanofi | Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present |
| JP2001505576A (ja) | 1996-12-02 | 2001-04-24 | ジョージタウン ユニバーシティ | トロパン誘導体類及びそれらの合成方法 |
| US6248752B1 (en) | 1998-02-27 | 2001-06-19 | Charles Duane Smith | Azabicyclooctane compositions and methods for enhancing chemotherapy |
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| AU2001271027B2 (en) * | 2000-07-11 | 2005-07-07 | Msd K.K. | Ester derivatives |
| RU2004110717A (ru) | 2001-10-17 | 2005-10-20 | Юсиби, С.А. (Be) | Производные хинуклидина, способы их получения и их применение в качестве и нгибиторов м2- и/или м3- мускариновых рецепторов |
| UY27927A1 (es) | 2002-08-06 | 2003-12-31 | Glaxo Group Ltd | Antagonistas del receptor muscarínico m3 de acetilcolina |
| WO2004091482A2 (en) | 2003-04-07 | 2004-10-28 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| UY28417A1 (es) | 2003-07-17 | 2005-02-28 | Glaxo Group Ltd | Antagonistas de los receptores muscarinicos de la acetilcolina |
| TW200519109A (en) | 2003-07-17 | 2005-06-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| SI1677795T1 (sl) | 2003-10-14 | 2011-04-29 | Glaxo Group Ltd | Antagonisti muskarinskega acetilholinskega receptorja |
| BRPI0415281A (pt) | 2003-10-17 | 2006-12-19 | Glaxo Group Ltd | antagonistas de receptor de acetilcolina muscarìnico |
| AR046225A1 (es) | 2003-11-04 | 2005-11-30 | Glaxo Group Ltd | Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion |
| CA2543858C (en) | 2003-11-21 | 2014-04-15 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| AR046783A1 (es) | 2003-12-03 | 2005-12-21 | Glaxo Group Ltd | Compuesto de sal ciclica de amonio cuaternario composicion farmaceutica que lo comprende y su uso para preparar esta ultima |
| PE20050897A1 (es) | 2003-12-03 | 2005-11-06 | Glaxo Group Ltd | Nuevos antagonistas del receptor muscarinico m3 de acetilcolina |
| EP1725241A4 (en) | 2004-03-17 | 2009-03-25 | Glaxo Group Ltd | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC M3 RECEPTOR |
| WO2005095407A1 (en) | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| US20070185148A1 (en) | 2004-03-17 | 2007-08-09 | Glaxo Group Limited | M3 muscarinic acetylchoine receptor antagonists |
| EP1725240A4 (en) | 2004-03-17 | 2009-03-25 | Glaxo Group Ltd | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR |
| TWI363759B (en) | 2004-04-27 | 2012-05-11 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| US7598267B2 (en) | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| TW200606161A (en) | 2004-05-28 | 2006-02-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| WO2006050239A2 (en) | 2004-10-29 | 2006-05-11 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| US20090142279A1 (en) | 2004-11-15 | 2009-06-04 | Budzik Brian W | Novel m3 muscarinic acetylcholine receptor antagonists |
| JP2008520579A (ja) | 2004-11-15 | 2008-06-19 | グラクソ グループ リミテッド | 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト |
| PE20061162A1 (es) | 2004-12-06 | 2006-10-14 | Smithkline Beecham Corp | Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos |
| PE20060826A1 (es) | 2004-12-06 | 2006-10-08 | Smithkline Beecham Corp | Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende |
| WO2006065788A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Novel muscarinic acetylcholine receptor antagonists |
| WO2006065755A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists |
| WO2007018514A1 (en) | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
| WO2007018508A1 (en) | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetycholine receptor antagonists |
| EP1937267A4 (en) | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| EP1937230A4 (en) | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| EP1937068A4 (en) | 2005-08-18 | 2010-08-04 | Glaxo Group Ltd | ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS |
-
2004
- 2004-07-15 AR ARP040102499A patent/AR045914A1/es unknown
- 2004-07-15 PE PE2004000674A patent/PE20050250A1/es not_active Application Discontinuation
- 2004-07-15 TW TW093121063A patent/TW200519108A/zh unknown
- 2004-07-16 RU RU2006104851/04A patent/RU2006104851A/ru not_active Application Discontinuation
- 2004-07-16 US US10/565,048 patent/US7495010B2/en not_active Expired - Fee Related
- 2004-07-16 CN CNA2004800206526A patent/CN1822839A/zh active Pending
- 2004-07-16 KR KR1020067001001A patent/KR20060054316A/ko not_active Withdrawn
- 2004-07-16 WO PCT/US2004/023041 patent/WO2005009362A2/en not_active Ceased
- 2004-07-16 CA CA002532433A patent/CA2532433A1/en not_active Abandoned
- 2004-07-16 BR BRPI0412537-1A patent/BRPI0412537A/pt not_active IP Right Cessation
- 2004-07-16 MX MXPA06000663A patent/MXPA06000663A/es unknown
- 2004-07-16 JP JP2006520387A patent/JP2007525478A/ja active Pending
- 2004-07-16 EP EP04778509A patent/EP1648461A4/en not_active Withdrawn
- 2004-07-16 AU AU2004259238A patent/AU2004259238A1/en not_active Abandoned
-
2005
- 2005-12-29 IL IL172912A patent/IL172912A0/en unknown
-
2006
- 2006-01-06 ZA ZA200600167A patent/ZA200600167B/en unknown
- 2006-01-06 MA MA28705A patent/MA27901A1/fr unknown
- 2006-02-13 IS IS8296A patent/IS8296A/is unknown
- 2006-02-17 NO NO20060777A patent/NO20060777L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006104851A (ru) | 2006-06-27 |
| CA2532433A1 (en) | 2005-02-03 |
| JP2007525478A (ja) | 2007-09-06 |
| EP1648461A4 (en) | 2009-04-01 |
| KR20060054316A (ko) | 2006-05-22 |
| BRPI0412537A (pt) | 2006-09-19 |
| MA27901A1 (fr) | 2006-05-02 |
| US7495010B2 (en) | 2009-02-24 |
| WO2005009362A3 (en) | 2005-04-07 |
| CN1822839A (zh) | 2006-08-23 |
| AU2004259238A1 (en) | 2005-02-03 |
| ZA200600167B (en) | 2007-01-31 |
| IL172912A0 (en) | 2006-06-11 |
| MXPA06000663A (es) | 2006-03-30 |
| WO2005009362A2 (en) | 2005-02-03 |
| EP1648461A2 (en) | 2006-04-26 |
| IS8296A (is) | 2006-02-13 |
| NO20060777L (no) | 2006-04-11 |
| PE20050250A1 (es) | 2005-04-08 |
| TW200519108A (en) | 2005-06-16 |
| US20060178396A1 (en) | 2006-08-10 |
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