ZA200303435B - Benzodiazepine derivatives as GABA A receptor modulators. - Google Patents

Benzodiazepine derivatives as GABA A receptor modulators. Download PDF

Info

Publication number: ZA200303435B
Authority: ZA; South Africa
Prior art keywords: benzodiazepine; triazolo; imidazo; ethyl; carboxylate
Prior art date: 2000-11-16

Application number

ZA200303435A

Other languages

English (en)

Inventor

Raffaello Masciadri

Andrew William Thomas

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-16

Filing date

2003-05-05

Publication date

2004-08-05

2003-05-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-08-05 Publication of ZA200303435B publication Critical patent/ZA200303435B/en

Links

102000004300 GABA-A Receptors Human genes 0.000 title description 14
108090000839 GABA-A Receptors Proteins 0.000 title description 14
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BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 29
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229960003692 gamma aminobutyric acid Drugs 0.000 claims description 16
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200303435A 2000-11-16 2003-05-05 Benzodiazepine derivatives as GABA A receptor modulators. ZA200303435B (en)

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JP (1)	JP4088151B2 (es)
KR (1)	KR100504300B1 (es)
CN (1)	CN1191255C (es)
AR (1)	AR031345A1 (es)
AT (1)	ATE268776T1 (es)
AU (2)	AU2002217007B2 (es)
BG (1)	BG107817A (es)
BR (1)	BR0115393A (es)
CA (1)	CA2427576C (es)
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DE (1)	DE60103776T2 (es)
DK (1)	DK1337535T3 (es)
EC (1)	ECSP034607A (es)
ES (1)	ES2220831T3 (es)
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WO (1)	WO2002040487A2 (es)
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Publication number	Publication date
EP1337535B1 (en)	2004-06-09
NZ525413A (en)	2005-02-25
TR200402073T4 (tr)	2004-10-21
US6743789B2 (en)	2004-06-01
RU2278865C2 (ru)	2006-06-27
MY141675A (en)	2010-06-15
WO2002040487A2 (en)	2002-05-23
CA2427576C (en)	2007-11-06
UY27026A1 (es)	2002-06-20
NO324706B1 (no)	2007-12-03
DE60103776T2 (de)	2005-07-14
KR100504300B1 (ko)	2005-07-28
BG107817A (bg)	2004-07-30
EP1337535A2 (en)	2003-08-27
JP4088151B2 (ja)	2008-05-21
MXPA03004251A (es)	2003-09-22
NO20032208D0 (no)	2003-05-15
DE60103776D1 (de)	2004-07-15
GC0000375A (en)	2007-03-31
AU1700702A (en)	2002-05-27
CN1474820A (zh)	2004-02-11
IL155813A0 (en)	2003-12-23
KR20030045192A (ko)	2003-06-09
RU2003116895A (ru)	2005-02-20
HUP0303281A2 (hu)	2004-01-28
PE20020583A1 (es)	2002-07-06
BR0115393A (pt)	2004-07-06
TWI239333B (en)	2005-09-11
GT200100230A (es)	2002-07-04
CA2427576A1 (en)	2002-05-23
PT1337535E (pt)	2004-09-30
US20020103371A1 (en)	2002-08-01
PL362925A1 (en)	2004-11-02
CZ20031597A3 (cs)	2003-11-12
SI1337535T1 (en)	2004-10-31
HUP0303281A3 (en)	2005-05-30
ES2220831T3 (es)	2004-12-16
PA8532401A1 (es)	2002-08-26
AU2002217007B2 (en)	2006-11-30
WO2002040487A3 (en)	2002-09-26
NO20032208L (no)	2003-05-15
ATE268776T1 (de)	2004-06-15
JP2004517070A (ja)	2004-06-10
YU35603A (sh)	2006-05-25
CZ295256B6 (cs)	2005-06-15
HRP20030360A2 (en)	2005-04-30
HK1062442A1 (en)	2004-11-05
MA26962A1 (fr)	2004-12-20
ECSP034607A (es)	2003-06-25
JO2359B1 (en)	2006-12-12
CN1191255C (zh)	2005-03-02
AR031345A1 (es)	2003-09-17
DK1337535T3 (da)	2004-10-25
SK7232003A3 (en)	2004-03-02

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