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MA26962A1 - Derives de benzodiazepine tels que gaba en tant que modulateurs de reception. - Google Patents

Derives de benzodiazepine tels que gaba en tant que modulateurs de reception.

Info

Publication number
MA26962A1
MA26962A1 MA27163A MA27163A MA26962A1 MA 26962 A1 MA26962 A1 MA 26962A1 MA 27163 A MA27163 A MA 27163A MA 27163 A MA27163 A MA 27163A MA 26962 A1 MA26962 A1 MA 26962A1
Authority
MA
Morocco
Prior art keywords
gaba
benzodiazepine derivatives
modulators
reception
reception modulators
Prior art date
Application number
MA27163A
Other languages
English (en)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26962A1 publication Critical patent/MA26962A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA27163A 2000-11-16 2003-05-16 Derives de benzodiazepine tels que gaba en tant que modulateurs de reception. MA26962A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16

Publications (1)

Publication Number Publication Date
MA26962A1 true MA26962A1 (fr) 2004-12-20

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27163A MA26962A1 (fr) 2000-11-16 2003-05-16 Derives de benzodiazepine tels que gaba en tant que modulateurs de reception.

Country Status (40)

Country Link
US (1) US6743789B2 (fr)
EP (1) EP1337535B1 (fr)
JP (1) JP4088151B2 (fr)
KR (1) KR100504300B1 (fr)
CN (1) CN1191255C (fr)
AR (1) AR031345A1 (fr)
AT (1) ATE268776T1 (fr)
AU (2) AU1700702A (fr)
BG (1) BG107817A (fr)
BR (1) BR0115393A (fr)
CA (1) CA2427576C (fr)
CZ (1) CZ295256B6 (fr)
DE (1) DE60103776T2 (fr)
DK (1) DK1337535T3 (fr)
EC (1) ECSP034607A (fr)
ES (1) ES2220831T3 (fr)
GC (1) GC0000375A (fr)
GT (1) GT200100230A (fr)
HR (1) HRP20030360A2 (fr)
HU (1) HUP0303281A3 (fr)
IL (1) IL155813A0 (fr)
JO (1) JO2359B1 (fr)
MA (1) MA26962A1 (fr)
MX (1) MXPA03004251A (fr)
MY (1) MY141675A (fr)
NO (1) NO324706B1 (fr)
NZ (1) NZ525413A (fr)
PA (1) PA8532401A1 (fr)
PE (1) PE20020583A1 (fr)
PL (1) PL362925A1 (fr)
PT (1) PT1337535E (fr)
RU (1) RU2278865C2 (fr)
SI (1) SI1337535T1 (fr)
SK (1) SK7232003A3 (fr)
TR (1) TR200402073T4 (fr)
TW (1) TWI239333B (fr)
UY (1) UY27026A1 (fr)
WO (1) WO2002040487A2 (fr)
YU (1) YU35603A (fr)
ZA (1) ZA200303435B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
WO2004113321A1 (fr) * 2003-06-19 2004-12-29 Daiichi Pharmaceutical Co., Ltd. Procede d'introduction selective de composants amino
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
AU2005272627A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
KR100869388B1 (ko) 2004-10-12 2008-11-21 에프. 호프만-라 로슈 아게 인지 장애를 치료하기 위한이미다조[1,5-ａ]트라이아졸로[1,5-ｄ]벤조다이아제핀유도체
WO2006045429A1 (fr) * 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Dérivés de benzodiazépine à substitution halogène
MX2007004639A (es) * 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de imidazo-benzodiazepina.
CA2590333C (fr) 2004-12-14 2013-01-08 F. Hoffmann-La Roche Ag Imidazo-benzodiazepines tetracycliques en tant que modulateurs des recepteurs gaba
EP2682481A3 (fr) * 2005-08-03 2014-09-17 The Johns-Hopkins University Procédés de caractérisation et de traitement de la déficience cognitive lors du vieillissement et de la maladie
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
ES2348356T3 (es) * 2005-10-11 2010-12-03 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina.
WO2007053596A1 (fr) * 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
EP2358714B1 (fr) 2008-11-18 2012-08-01 F. Hoffmann-La Roche AG Alkylcyclohexyléthers de dihydrotétrazabenzoazulènes
MY150837A (en) * 2008-11-28 2014-02-28 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
NO3034079T3 (fr) 2010-11-15 2018-06-09
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (fr) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Nouveaux agonistes gabaa et leurs procedes d'utilisation pour lutter contre l'hyperexcitabilite et l'inflammation bronchiques au cours de l'asthme
NZ722077A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN113264939A (zh) * 2015-06-19 2021-08-17 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
US20240132513A1 (en) 2022-08-19 2024-04-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (fr) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
RU2278865C2 (ru) 2006-06-27
HUP0303281A2 (hu) 2004-01-28
AU2002217007B2 (en) 2006-11-30
JP4088151B2 (ja) 2008-05-21
SK7232003A3 (en) 2004-03-02
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
ECSP034607A (es) 2003-06-25
MY141675A (en) 2010-06-15
BG107817A (bg) 2004-07-30
KR20030045192A (ko) 2003-06-09
CN1474820A (zh) 2004-02-11
IL155813A0 (en) 2003-12-23
WO2002040487A2 (fr) 2002-05-23
GC0000375A (en) 2007-03-31
CA2427576A1 (fr) 2002-05-23
ZA200303435B (en) 2004-08-05
CZ20031597A3 (cs) 2003-11-12
MXPA03004251A (es) 2003-09-22
CA2427576C (fr) 2007-11-06
DE60103776D1 (de) 2004-07-15
HRP20030360A2 (en) 2005-04-30
YU35603A (sh) 2006-05-25
BR0115393A (pt) 2004-07-06
JO2359B1 (en) 2006-12-12
DE60103776T2 (de) 2005-07-14
CN1191255C (zh) 2005-03-02
US20020103371A1 (en) 2002-08-01
KR100504300B1 (ko) 2005-07-28
EP1337535A2 (fr) 2003-08-27
NO20032208L (no) 2003-05-15
AU1700702A (en) 2002-05-27
PL362925A1 (en) 2004-11-02
ATE268776T1 (de) 2004-06-15
CZ295256B6 (cs) 2005-06-15
WO2002040487A3 (fr) 2002-09-26
SI1337535T1 (en) 2004-10-31
HK1062442A1 (en) 2004-11-05
PA8532401A1 (es) 2002-08-26
EP1337535B1 (fr) 2004-06-09
HUP0303281A3 (en) 2005-05-30
TWI239333B (en) 2005-09-11
PE20020583A1 (es) 2002-07-06
DK1337535T3 (da) 2004-10-25
GT200100230A (es) 2002-07-04
UY27026A1 (es) 2002-06-20
RU2003116895A (ru) 2005-02-20
PT1337535E (pt) 2004-09-30
NO20032208D0 (no) 2003-05-15
JP2004517070A (ja) 2004-06-10
NO324706B1 (no) 2007-12-03
US6743789B2 (en) 2004-06-01
ES2220831T3 (es) 2004-12-16
AR031345A1 (es) 2003-09-17

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