ZA200302008B - Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target-specific prodrug. - Google Patents
Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target-specific prodrug. Download PDFInfo
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- ZA200302008B ZA200302008B ZA200302008A ZA200302008A ZA200302008B ZA 200302008 B ZA200302008 B ZA 200302008B ZA 200302008 A ZA200302008 A ZA 200302008A ZA 200302008 A ZA200302008 A ZA 200302008A ZA 200302008 B ZA200302008 B ZA 200302008B
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10045592A DE10045592A1 (de) | 2000-09-15 | 2000-09-15 | Ein Antikörper-TNF-TNF Inhibitor Fusionsprotein (TNF-Selektokin) als zielspezifisches Prozytokin zur Tumortherapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200302008B true ZA200302008B (en) | 2004-06-25 |
Family
ID=7656260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200302008A ZA200302008B (en) | 2000-09-15 | 2003-03-12 | Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target-specific prodrug. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20040053829A1 (et) |
| EP (1) | EP1317556A1 (et) |
| JP (1) | JP2004508828A (et) |
| KR (1) | KR20030048041A (et) |
| CN (1) | CN1214115C (et) |
| AU (1) | AU2001293819A1 (et) |
| BG (1) | BG107613A (et) |
| BR (1) | BR0113928A (et) |
| CA (1) | CA2422759A1 (et) |
| DE (1) | DE10045592A1 (et) |
| EE (1) | EE200300100A (et) |
| HR (1) | HRP20030192A2 (et) |
| HU (1) | HUP0301693A3 (et) |
| IL (1) | IL154185A0 (et) |
| MX (1) | MXPA03002229A (et) |
| NO (1) | NO20031185L (et) |
| PL (1) | PL360540A1 (et) |
| RU (1) | RU2003106429A (et) |
| SK (1) | SK2812003A3 (et) |
| WO (1) | WO2002022833A1 (et) |
| YU (1) | YU18903A (et) |
| ZA (1) | ZA200302008B (et) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7468354B2 (en) | 2000-12-01 | 2008-12-23 | Genspera, Inc. | Tissue specific prodrugs |
| PE20021080A1 (es) * | 2001-04-12 | 2003-02-12 | Boehringer Ingelheim Int | Un anticuerpo especifico fapo bibh1 en el tratamiento del cancer |
| DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| DE10247755B4 (de) * | 2002-10-14 | 2006-01-19 | Pfizenmaier, Klaus, Prof. Dr. | Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine |
| AU2004210088A1 (en) * | 2003-02-06 | 2004-08-19 | Micromet Ag | Trimeric polypeptide construct to induce an enduring T cell response |
| US7374898B2 (en) * | 2004-10-12 | 2008-05-20 | The Research Foundation Of State University Of New York | Peptide inhibitors against seprase |
| US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
| EP1736482A1 (en) * | 2005-06-20 | 2006-12-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Recombinant trimeric 4-1BBL |
| DE102005036542A1 (de) * | 2005-08-03 | 2007-02-08 | Universität Stuttgart | CTL-Prodrug |
| EP1972350A1 (en) * | 2007-03-20 | 2008-09-24 | Rijksuniversiteit Groningen | Dual targeting system |
| EP2009022A1 (en) * | 2007-06-26 | 2008-12-31 | Apogenix GmbH | Trimeric death ligands with enhanced activity (tenascin) |
| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| CN106995495A (zh) | 2009-01-12 | 2017-08-01 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
| CN102481341B (zh) * | 2009-02-23 | 2017-05-17 | 希托马克斯医疗有限公司 | 蛋白原及其使用方法 |
| CA3115461A1 (en) * | 2018-03-09 | 2019-09-12 | AskGene Pharma, Inc. | Novel cytokine prodrugs |
| WO2019222294A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CN113840832A (zh) | 2018-05-14 | 2021-12-24 | 狼人治疗公司 | 可活化白介素-2多肽及其使用方法 |
| CN112534052B (zh) | 2018-07-25 | 2024-09-20 | 奥美药业有限公司 | 全新il-21前药及使用方法 |
| EP3856764A4 (en) | 2018-09-27 | 2022-11-02 | Xilio Development, Inc. | MASKED CYTOKINE POLYPEPTIDES |
| SG11202112541RA (en) | 2019-05-14 | 2021-12-30 | Werewolf Therapeutics Inc | Separation moieties and methods and use thereof |
| US11845801B2 (en) | 2019-06-12 | 2023-12-19 | AskGene Pharma, Inc. | IL-15 prodrugs and methods of use thereof |
| JP2022545439A (ja) * | 2019-08-21 | 2022-10-27 | アスクジーン・ファーマ・インコーポレイテッド | 新規ｉｌ－２１プロドラッグおよびその使用方法 |
| EP4034551A1 (en) * | 2019-09-28 | 2022-08-03 | AskGene Pharma, Inc. | Cytokine prodrugs and dual-prodrugs |
| JP2023503258A (ja) | 2019-11-14 | 2023-01-27 | ウェアウルフ セラピューティクス， インコーポレイテッド | 活性化可能サイトカインポリペプチド及びその使用方法 |
| JP2023553323A (ja) | 2020-11-25 | 2023-12-21 | エクシリオ デベロップメント， インコーポレイテッド | 腫瘍特異的に切断可能なリンカー |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981001145A1 (en) * | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US5502037A (en) * | 1993-07-09 | 1996-03-26 | Neuromed Technologies, Inc. | Pro-cytotoxic drug conjugates for anticancer therapy |
| US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
| US5614191A (en) * | 1995-03-15 | 1997-03-25 | The United States Of America As Represented By The Department Of Health And Human Services | IL-13 receptor specific chimeric proteins and uses thereof |
| DE19900709A1 (de) * | 1999-01-11 | 2000-07-13 | Falkenberg Frank W | Eine neue Applikationsform für biologisch wirksame Substanzen zur Anwendung bei Menschen und Tieren |
-
2000
- 2000-09-15 DE DE10045592A patent/DE10045592A1/de not_active Withdrawn
-
2001
- 2001-09-17 PL PL36054001A patent/PL360540A1/xx not_active Application Discontinuation
- 2001-09-17 JP JP2002527275A patent/JP2004508828A/ja active Pending
- 2001-09-17 MX MXPA03002229A patent/MXPA03002229A/es unknown
- 2001-09-17 US US10/380,438 patent/US20040053829A1/en not_active Abandoned
- 2001-09-17 YU YU18903A patent/YU18903A/sh unknown
- 2001-09-17 AU AU2001293819A patent/AU2001293819A1/en not_active Abandoned
- 2001-09-17 WO PCT/EP2001/010730 patent/WO2002022833A1/de not_active Ceased
- 2001-09-17 CN CNB018157645A patent/CN1214115C/zh not_active Expired - Fee Related
- 2001-09-17 IL IL15418501A patent/IL154185A0/xx unknown
- 2001-09-17 HR HR20030192A patent/HRP20030192A2/hr not_active Application Discontinuation
- 2001-09-17 EP EP01974261A patent/EP1317556A1/de not_active Withdrawn
- 2001-09-17 BR BR0113928-2A patent/BR0113928A/pt not_active IP Right Cessation
- 2001-09-17 SK SK281-2003A patent/SK2812003A3/sk unknown
- 2001-09-17 KR KR10-2003-7003738A patent/KR20030048041A/ko not_active Withdrawn
- 2001-09-17 HU HU0301693A patent/HUP0301693A3/hu unknown
- 2001-09-17 EE EEP200300100A patent/EE200300100A/et unknown
- 2001-09-17 CA CA002422759A patent/CA2422759A1/en not_active Abandoned
- 2001-09-17 RU RU2003106429/13A patent/RU2003106429A/ru not_active Application Discontinuation
-
2003
- 2003-03-06 BG BG107613A patent/BG107613A/bg unknown
- 2003-03-12 ZA ZA200302008A patent/ZA200302008B/en unknown
- 2003-03-14 NO NO20031185A patent/NO20031185L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20031185L (no) | 2003-05-05 |
| SK2812003A3 (en) | 2003-11-04 |
| DE10045592A1 (de) | 2002-03-28 |
| AU2001293819A1 (en) | 2002-03-26 |
| PL360540A1 (en) | 2004-09-06 |
| MXPA03002229A (es) | 2005-06-20 |
| BG107613A (bg) | 2003-12-31 |
| US20040053829A1 (en) | 2004-03-18 |
| CN1458977A (zh) | 2003-11-26 |
| HUP0301693A2 (hu) | 2003-08-28 |
| EP1317556A1 (de) | 2003-06-11 |
| HRP20030192A2 (en) | 2005-10-31 |
| CA2422759A1 (en) | 2003-03-17 |
| KR20030048041A (ko) | 2003-06-18 |
| IL154185A0 (en) | 2003-07-31 |
| HUP0301693A3 (en) | 2005-11-28 |
| WO2002022833A1 (de) | 2002-03-21 |
| JP2004508828A (ja) | 2004-03-25 |
| CN1214115C (zh) | 2005-08-10 |
| RU2003106429A (ru) | 2004-08-27 |
| EE200300100A (et) | 2005-02-15 |
| YU18903A (sh) | 2006-05-25 |
| NO20031185D0 (no) | 2003-03-14 |
| BR0113928A (pt) | 2003-07-22 |
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