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WO2008126732A1 - 縮合二環式ヘテロアリール誘導体 - Google Patents

縮合二環式ヘテロアリール誘導体 Download PDF

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Publication number
WO2008126732A1
WO2008126732A1 PCT/JP2008/056541 JP2008056541W WO2008126732A1 WO 2008126732 A1 WO2008126732 A1 WO 2008126732A1 JP 2008056541 W JP2008056541 W JP 2008056541W WO 2008126732 A1 WO2008126732 A1 WO 2008126732A1
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WIPO (PCT)
Prior art keywords
group
bicyclic heteroaryl
alkyl group
fused bicyclic
optionally substituted
Prior art date
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Ceased
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PCT/JP2008/056541
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English (en)
French (fr)
Inventor
Kousei Shimada
Yoshiyuki Onishi
Makoto Mori
Eri Tokumaru
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Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES08739652.9T priority Critical patent/ES2550479T3/es
Priority to MX2009010790A priority patent/MX2009010790A/es
Priority to BRPI0809643-0A2A priority patent/BRPI0809643A2/pt
Priority to AU2008239179A priority patent/AU2008239179B2/en
Priority to NZ580588A priority patent/NZ580588A/en
Priority to JP2009509273A priority patent/JP5294419B2/ja
Priority to CN2008800189675A priority patent/CN101679298B/zh
Priority to CA002683089A priority patent/CA2683089A1/en
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Priority to EP08739652.9A priority patent/EP2138484B1/en
Publication of WO2008126732A1 publication Critical patent/WO2008126732A1/ja
Priority to IL201326A priority patent/IL201326A0/en
Priority to US12/573,625 priority patent/US20100048564A1/en
Anticipated expiration legal-status Critical
Priority to US13/418,796 priority patent/US20130035337A1/en
Ceased legal-status Critical Current

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Abstract

　本発明は、良好な血糖低下作用を有し、糖および脂質代謝疾患、もしくはペルオキシソーム活性化受容体（ＰＰＡＲ）γが介在する疾病の治療及び/又は発症を予防する新規縮合二環式ヘテロアリール誘導体又はその薬理上許容される塩に関する。　一般式（Ｉ） 【化１】　［式中、Ｒ１は、Ｃ１－Ｃ６アルキル基、置換基群ａから選択される基で独立に１乃至５個置換されていてもよいＣ６－Ｃ１０アリール基等；Ｒ２は、Ｃ１－Ｃ６アルキル基；Ｒ３は、置換基群ａから選択される基で独立に１乃至５個置換されていてもよいＣ６－Ｃ１０アリール基等；Ｑは、式＝ＣＨ－で表わされる基又は窒素原子；置換基群ａは、ハロゲン原子、Ｃ１－Ｃ６アルキル基、Ｃ１－Ｃ６ヒドロキシアルキル基等］を有する化合物又はその薬理上許容される塩。
PCT/JP2008/056541 2007-04-05 2008-04-02 縮合二環式ヘテロアリール誘導体 Ceased WO2008126732A1 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN2008800189675A CN101679298B (zh) 2007-04-05 2008-04-02 稠合二环杂芳基衍生物
BRPI0809643-0A2A BRPI0809643A2 (pt) 2007-04-05 2008-04-02 Derivados de heteroarila bicíclica fundida
AU2008239179A AU2008239179B2 (en) 2007-04-05 2008-04-02 Fused bicyclic heteroaryl derivatives
NZ580588A NZ580588A (en) 2007-04-05 2008-04-02 Fused bicyclic heteroaryl derivatives
JP2009509273A JP5294419B2 (ja) 2007-04-05 2008-04-02 縮合二環式ヘテロアリール誘導体
CA002683089A CA2683089A1 (en) 2007-04-05 2008-04-02 Benzimidazole derivatives and imidazopyridine derivatives with glucose lowering effect
EP08739652.9A EP2138484B1 (en) 2007-04-05 2008-04-02 Fused bicyclic heteroaryl derivatives
ES08739652.9T ES2550479T3 (es) 2007-04-05 2008-04-02 Derivados de heteroarilo bicíclico condensado
MX2009010790A MX2009010790A (es) 2007-04-05 2008-04-02 Derivados de heteroarilo biciclico fusionados.
IL201326A IL201326A0 (en) 2007-04-05 2009-10-01 Fused bicyclic heteroaryl derivatives
US12/573,625 US20100048564A1 (en) 2007-04-05 2009-10-05 Fused bicyclic heteroaryl derivative
US13/418,796 US20130035337A1 (en) 2007-04-05 2012-03-13 Fused bicyclic heteroaryl derivative

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
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WO2012033091A1 (ja) 2010-09-07 2012-03-15 第一三共株式会社 安息香酸エステル類の製造法
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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CN108822103A (zh) * 2018-07-28 2018-11-16 刘凤娟 一种咪唑并[4,5-b]吡啶化合物及其制备方法和应用
WO2024183807A1 (zh) * 2023-03-09 2024-09-12 哈尔滨三联药业股份有限公司 芳基并咪唑类化合物及其医药用途

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WO2010101164A1 (ja) 2009-03-05 2010-09-10 第一三共株式会社 ピリジン誘導体
US8946264B2 (en) 2009-03-05 2015-02-03 Daiichi Sankyo Company, Limited Pyridine derivative
JPWO2010101164A1 (ja) * 2009-03-05 2012-09-10 第一三共株式会社 ピリジン誘導体
WO2011065420A1 (ja) * 2009-11-26 2011-06-03 第一三共株式会社 ６－置換－１－メチル－１ｈ－ベンズイミダゾール誘導体の製造法及びその製造中間体
CN102725288A (zh) * 2009-11-26 2012-10-10 第一三共株式会社 用于制造6-取代的1-甲基-1h-苯并咪唑衍生物的方法和所述方法的中间体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012033091A1 (ja) 2010-09-07 2012-03-15 第一三共株式会社 安息香酸エステル類の製造法
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility

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CA2683089A1 (en) 2008-10-23
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EP2138484A4 (en) 2012-01-11
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MY148434A (en) 2013-04-30
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NZ580588A (en) 2011-12-22
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