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WO2007039781A3 - 1,2,4-oxadioi.e derivatives with activity at the metabotropic clutamate receptors - Google Patents

1,2,4-oxadioi.e derivatives with activity at the metabotropic clutamate receptors Download PDF

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Publication number
WO2007039781A3
WO2007039781A3 PCT/HU2006/000087 HU2006000087W WO2007039781A3 WO 2007039781 A3 WO2007039781 A3 WO 2007039781A3 HU 2006000087 W HU2006000087 W HU 2006000087W WO 2007039781 A3 WO2007039781 A3 WO 2007039781A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
alkyl
compounds
oxadioi
clutamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2006/000087
Other languages
French (fr)
Other versions
WO2007039781A2 (en
Inventor
Krisztina GÁL
Csaba WÉBER
Gábor András WÁGNER
Attila HORVÁTH
Györgyné NYÉKI
Mónika VASTAG
György KESERÜ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of WO2007039781A2 publication Critical patent/WO2007039781A2/en
Anticipated expiration legal-status Critical
Publication of WO2007039781A3 publication Critical patent/WO2007039781A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to new compounds of formula (I) wherein Y1 and Y2 selected from the group consisting of hydrogen, halogen atom; C1-4 alkyl, C1-4 alkoxy, cyano and trifluoromethyl group, Q is -CH- group or N; X1 and X2 are different and are independently selected from N and O; Z is -(CH2)n- group or S; n is 1 or 2; R is selected from the group consisting of optionally substituted C1-7 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 cyanoalkyl, C1-3 OC1-3 alkyl, C2-7 alkenyl, C2-7 alkynyl, C0-2(NR1R2)alkyl; an optionally substituted C3-7 cycloalkyl, aryl, heteroaryl or saturated heterocyclyl; R1 and R2 are independently selected from hydrogen, C1-7 alkyl or C1-6 alkanoyl group - and/or enentiomers and/or racemates and/or diastereomers and/or geometric isomers and/or pharmaceutically acceptable salts thereof formed with acids and bases, to the processes for producing said compounds, to pharmaceutical compositions containing said compounds and to their use in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
PCT/HU2006/000087 2005-10-05 2006-10-05 New compounds Ceased WO2007039781A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0500920A HUP0500920A2 (en) 2005-10-05 2005-10-05 Oxadiazole derivatives, process for their preparation and their use
HUP0500920 2005-10-05

Publications (2)

Publication Number Publication Date
WO2007039781A2 WO2007039781A2 (en) 2007-04-12
WO2007039781A3 true WO2007039781A3 (en) 2010-08-26

Family

ID=89986317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2006/000087 Ceased WO2007039781A2 (en) 2005-10-05 2006-10-05 New compounds

Country Status (2)

Country Link
HU (1) HUP0500920A2 (en)
WO (1) WO2007039781A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2009127095A (en) 2006-12-15 2011-01-20 Эбботт Лэборетриз (Us) NEW OXADIAZOLE COMPOUNDS
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
EP2421370A4 (en) * 2009-04-23 2012-12-12 Merck Sharp & Dohme MGLUR5 RECEPTOR MODULATORS FILLED WITH 2-ALKYL PIPERIDINES
CA2808582A1 (en) 2009-08-14 2011-02-17 University Of Virginia Patent Foundation Imidamide sphingosine kinase inhibitors
CA2784768C (en) * 2009-12-29 2015-02-03 Eli Lilly And Company Tetrahydrotriazolopyridine compounds as selective mglu5 receptor potentiators useful for the treatment of schizophrenia
CN102762572A (en) 2010-02-01 2012-10-31 诺瓦提斯公司 Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN102753527B (en) 2010-02-02 2014-12-24 诺华股份有限公司 Cyclohexyl amide derivatives as crf receptor antagonists
WO2012052489A1 (en) 2010-10-21 2012-04-26 Bayer Cropscience Ag 1-(heterocyclic carbonyl) piperidines
SG10201702540UA (en) 2012-06-04 2017-05-30 Actelion Pharmaceuticals Ltd Benzimidazole-proline derivatives
CA2885180C (en) 2012-10-10 2021-03-02 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
JP2016510810A (en) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Azetidine amide derivatives as orexin receptor antagonists
UA116053C2 (en) 2013-12-04 2018-01-25 Ідорсія Фармасьютікалз Лтд Use of benzimidazole-proline derivatives
US20220089581A1 (en) * 2019-01-25 2022-03-24 University Of Virginia Patent Foundation Inhibitors of spinster homolog 2 (spns2) for use in therapy
EP4045491A1 (en) * 2019-10-17 2022-08-24 Givaudan SA Substituted azacyles as trmp8 modulators
GB202012170D0 (en) * 2020-08-05 2020-09-16 Givaudan Sa Organic compounds
EP4210824A1 (en) * 2020-09-09 2023-07-19 University of Virginia Patent Foundation Inhibitors of spinster homolog 2 (spns2) for use in therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017652A1 (en) * 1996-10-18 1998-04-30 Boehringer Ingelheim Pharma Kg Oxadiazoles, processes for their preparation and their use as medicaments
WO2000039125A1 (en) * 1998-12-23 2000-07-06 Pfizer Limited Piperidines as ccr5 modulators
WO2002092086A1 (en) * 2001-03-27 2002-11-21 F. Hoffmann-La Roche Ag Imidazo (1,2-a)-pyridine derivatives as mglur5 antagonists
WO2004014902A2 (en) * 2002-08-09 2004-02-19 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
WO2005044797A1 (en) * 2003-11-06 2005-05-19 Addex Pharmaceuticals Sa Allosteric modulators of metabotropic glutamate receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017652A1 (en) * 1996-10-18 1998-04-30 Boehringer Ingelheim Pharma Kg Oxadiazoles, processes for their preparation and their use as medicaments
WO2000039125A1 (en) * 1998-12-23 2000-07-06 Pfizer Limited Piperidines as ccr5 modulators
WO2002092086A1 (en) * 2001-03-27 2002-11-21 F. Hoffmann-La Roche Ag Imidazo (1,2-a)-pyridine derivatives as mglur5 antagonists
WO2004014902A2 (en) * 2002-08-09 2004-02-19 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
WO2005044797A1 (en) * 2003-11-06 2005-05-19 Addex Pharmaceuticals Sa Allosteric modulators of metabotropic glutamate receptors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BING YAN ET AL.: "Quality control on combinatorial chemistry:", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 5, no. 5, 2003, pages 547 - 559, XP002413033 *

Also Published As

Publication number Publication date
HUP0500920A2 (en) 2007-07-30
HU0500920D0 (en) 2005-12-28
WO2007039781A2 (en) 2007-04-12

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