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WO2007039781A3 - Nouveaux composes - Google Patents

Nouveaux composes Download PDF

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Publication number
WO2007039781A3
WO2007039781A3 PCT/HU2006/000087 HU2006000087W WO2007039781A3 WO 2007039781 A3 WO2007039781 A3 WO 2007039781A3 HU 2006000087 W HU2006000087 W HU 2006000087W WO 2007039781 A3 WO2007039781 A3 WO 2007039781A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
alkyl
compounds
oxadioi
clutamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2006/000087
Other languages
English (en)
Other versions
WO2007039781A2 (fr
Inventor
Krisztina GÁL
Csaba WÉBER
Gábor András WÁGNER
Attila HORVÁTH
Györgyné NYÉKI
Mónika VASTAG
György KESERÜ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of WO2007039781A2 publication Critical patent/WO2007039781A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007039781A3 publication Critical patent/WO2007039781A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de formule (I) dans laquelle Y1 et Y2 sont sélectionnés dans le groupe constitué par hydrogène, atome halogène; C1-4 alkyle, C1-4 alkoxy, cyano et un groupe trifluorométhyle, Q représente le groupe -CH- ou N; X1 et X2 sont différents et sont sélectionnés indépendamment dans le groupe N et O; Z désigne le groupe -(CH2)n- ou S; n est égal à 1 ou à 2; R est sélectionné dans le groupe constitué par C1-7 alkyle, C1-4 haloalkyle, C1-4 hydroxyalkyle, C1-4 cyanoalkyle, C1-3 OC1-3 alkyle, C2-7 alcényle, C2-7 alkynyle, C0-2(NR1R2)alkyle éventuellement substitués; par un cycloalkyle éventuellement substitué en C3-7, aryle, hétéroaryle ou hétérocyclyle saturés; R1 et R2 sont sélectionnés indépendamment dans le groupe constitué par hydrogène, C1-7 alkyle ou C1-6 alkanoyle; par des énantiomères et/ou des racémates et/ou des diastéréoisomères et/ou des isomères géométriques et/ou des sels pharmaceutiquement acceptables formés d'acides et de bases; l'invention concerne également des procédés de production desdits composés, des compositions pharmaceutiques renfermant lesdits composés et leur utilisation dans la prévention et/ou le traitement de troubles induits par le récepteur de mGluR5.
PCT/HU2006/000087 2005-10-05 2006-10-05 Nouveaux composes Ceased WO2007039781A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0500920A HUP0500920A2 (en) 2005-10-05 2005-10-05 Oxadiazole derivatives, process for their preparation and their use
HUP0500920 2005-10-05

Publications (2)

Publication Number Publication Date
WO2007039781A2 WO2007039781A2 (fr) 2007-04-12
WO2007039781A3 true WO2007039781A3 (fr) 2010-08-26

Family

ID=89986317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2006/000087 Ceased WO2007039781A2 (fr) 2005-10-05 2006-10-05 Nouveaux composes

Country Status (2)

Country Link
HU (1) HUP0500920A2 (fr)
WO (1) WO2007039781A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0720043A2 (pt) 2006-12-15 2014-01-07 Abbott Lab Composto oxadiazol
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US20120040998A1 (en) * 2009-04-23 2012-02-16 Mercer Swati P 2-alkyl piperidine mglur5 receptor modulators
US9421177B2 (en) 2009-08-14 2016-08-23 University Of Virginia Patent Foundation Imidamide sphingosine kinase inhibitors
WO2011082010A1 (fr) * 2009-12-29 2011-07-07 Eli Lilly And Company Composés de tétrahydrotriazolopyridine en tant que potentialisateurs sélectifs de récepteur mglu5 utiles pour le traitement de la schizophrénie
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
WO2011092293A2 (fr) 2010-02-01 2011-08-04 Novartis Ag Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf
WO2011095450A1 (fr) 2010-02-02 2011-08-11 Novartis Ag Dérivés de cyclohexylamide à titre d'antagonistes du récepteur crf
US9545105B2 (en) 2010-10-21 2017-01-17 Bayer Intellectual Property Gmbh 1-(heterocyclic carbonyl) piperidines
PT2855453T (pt) 2012-06-04 2017-03-09 Actelion Pharmaceuticals Ltd Derivados de benzimidazol-prolina
AU2013328301A1 (en) * 2012-10-10 2015-05-28 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
MX366642B (es) 2013-12-04 2019-07-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina.
WO2020154431A1 (fr) * 2019-01-25 2020-07-30 Lynch Kevin R Inhibiteurs de l'homologue 2 de spinster (spns2) destinés à être utilisés en thérapie
KR20220085798A (ko) * 2019-10-17 2022-06-22 지보당 에스아 Trmp8 조절제로서의 치환된 아자사이클
GB202012170D0 (en) * 2020-08-05 2020-09-16 Givaudan Sa Organic compounds
US20230373937A1 (en) * 2020-09-09 2023-11-23 University Of Virginia Patent Foundation Inhibitors of spinster homolog 2 (spns2) for use in therapy
CN119317620A (zh) 2022-06-13 2025-01-14 亚力维克希斯股份有限公司 氮杂环烷基羰基环状胺化合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017652A1 (fr) * 1996-10-18 1998-04-30 Boehringer Ingelheim Pharma Kg Oxadiazoles, procedes permettant de les preparer et leur utilisation comme medicaments
WO2000039125A1 (fr) * 1998-12-23 2000-07-06 Pfizer Limited Piperidines utilises comme modulateurs de ccr5
WO2002092086A1 (fr) * 2001-03-27 2002-11-21 F. Hoffmann-La Roche Ag Derives d'imidazo (1,2-a)-pyridine tenant lieu d'antagonistes mglur5
WO2004014902A2 (fr) * 2002-08-09 2004-02-19 Astrazeneca Ab Nouveaux composes
WO2005044797A1 (fr) * 2003-11-06 2005-05-19 Addex Pharmaceuticals Sa Modulateurs allosteriques de recepteurs glutamate metabotropiques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017652A1 (fr) * 1996-10-18 1998-04-30 Boehringer Ingelheim Pharma Kg Oxadiazoles, procedes permettant de les preparer et leur utilisation comme medicaments
WO2000039125A1 (fr) * 1998-12-23 2000-07-06 Pfizer Limited Piperidines utilises comme modulateurs de ccr5
WO2002092086A1 (fr) * 2001-03-27 2002-11-21 F. Hoffmann-La Roche Ag Derives d'imidazo (1,2-a)-pyridine tenant lieu d'antagonistes mglur5
WO2004014902A2 (fr) * 2002-08-09 2004-02-19 Astrazeneca Ab Nouveaux composes
WO2005044797A1 (fr) * 2003-11-06 2005-05-19 Addex Pharmaceuticals Sa Modulateurs allosteriques de recepteurs glutamate metabotropiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BING YAN ET AL.: "Quality control on combinatorial chemistry:", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 5, no. 5, 2003, pages 547 - 559, XP002413033 *

Also Published As

Publication number Publication date
WO2007039781A2 (fr) 2007-04-12
HU0500920D0 (en) 2005-12-28
HUP0500920A2 (en) 2007-07-30

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