WO2002038541A9 - Cyanopyrrolidine derivatives - Google Patents

Cyanopyrrolidine derivatives

Info

Publication number: WO2002038541A9
Authority: WO; WIPO (PCT)
Prior art keywords: halogeno; alternatively; hydrogen; hydroxyimino; united
Prior art date: 2000-11-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

PCT/JP2001/009818

Other languages

English (en)

French (fr)

Other versions

WO2002038541A1 (en

Inventor

Hiroshi Fukushima

Akira Hiratate

Masato Takahashi

Kazuya Kameo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Taisho Pharmaceutical Co Ltd

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-10

Filing date

2001-11-09

Publication date

2002-08-08

2001-09-11 Priority to UA2003065269A priority Critical patent/UA74023C2/uk

2001-11-09 Priority to HR20030366A priority patent/HRP20030366A2/hr

2001-11-09 Priority to IL15577601A priority patent/IL155776A0/xx

2001-11-09 Priority to BR0114851-6A priority patent/BR0114851A/pt

2001-11-09 Priority to AU1274502A priority patent/AU1274502A/xx

2001-11-09 Priority to HR20070116A priority patent/HRP20070116A2/xx

2001-11-09 Priority to MXPA03004114A priority patent/MXPA03004114A/es

2001-11-09 Priority to JP2002541077A priority patent/JP3987890B2/ja

2001-11-09 Priority to AU2002212745A priority patent/AU2002212745B2/en

2001-11-09 Priority to CA002428271A priority patent/CA2428271C/en

2001-11-09 Priority to US10/416,370 priority patent/US20040072892A1/en

2001-11-09 Priority to HU0302248A priority patent/HUP0302248A2/hu

2001-11-09 Priority to SK563-2003A priority patent/SK5632003A3/sk

2001-11-09 Priority to NZ525705A priority patent/NZ525705A/en

2001-11-09 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

2001-11-09 Priority to EEP200300175A priority patent/EE200300175A/xx

2001-11-09 Priority to EP01981047A priority patent/EP1333025A4/en

2001-11-09 Priority to HK04104700.9A priority patent/HK1061688B/xx

2001-11-09 Priority to EA200300559A priority patent/EA006204B1/ru

2001-11-09 Priority to KR1020037006310A priority patent/KR100680079B1/ko

2002-05-16 Publication of WO2002038541A1 publication Critical patent/WO2002038541A1/ja

2002-08-08 Publication of WO2002038541A9 publication Critical patent/WO2002038541A9/ja

2003-04-29 Priority to NO20031949A priority patent/NO20031949L/no

2003-05-10 Priority to BG107799A priority patent/BG107799A/bg

2003-05-10 Anticipated expiration legal-status Critical

2005-09-23 Priority to NO20054429A priority patent/NO20054429L/no

2006-11-02 Priority to US11/556,096 priority patent/US20070112059A1/en

2006-11-02 Priority to US11/556,064 priority patent/US20070112205A1/en

2007-03-19 Priority to IL182030A priority patent/IL182030A0/en

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PCT/JP2001/009818 2000-11-10 2001-11-09 Cyanopyrrolidine derivatives Ceased WO2002038541A1 (en)

Priority Applications (25)

Application Number	Priority Date	Filing Date	Title
UA2003065269A UA74023C2 (en)	2000-11-10	2001-09-11	Cyanopyrrolidine derivatives
EEP200300175A EE200300175A (et)	2000-11-10	2001-11-09	Tsüanopürrolidiini derivaadid
BR0114851-6A BR0114851A (pt)	2000-11-10	2001-11-09	Derivados de cianopirrolidina
AU1274502A AU1274502A (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
HR20070116A HRP20070116A2 (hr)	2000-11-10	2001-11-09	Derivati cijanopirolidina
MXPA03004114A MXPA03004114A (es)	2000-11-10	2001-11-09	Derivados de cianopirrolidina.
JP2002541077A JP3987890B2 (ja)	2000-11-10	2001-11-09	シアノピロリジン誘導体
AU2002212745A AU2002212745B2 (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
CA002428271A CA2428271C (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives as inhibitors of dpp-iv
US10/416,370 US20040072892A1 (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
HU0302248A HUP0302248A2 (hu)	2000-11-10	2001-11-09	Cianopirrolidin-származékok és az ezeket tartalmazó gyógyászati készítmények
IL15577601A IL155776A0 (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
NZ525705A NZ525705A (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
HR20030366A HRP20030366A2 (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
HK04104700.9A HK1061688B (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
SK563-2003A SK5632003A3 (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives
EP01981047A EP1333025A4 (en)	2000-11-10	2001-11-09	CYANOPYRROLIDINE DERIVATIVES
EA200300559A EA006204B1 (ru)	2000-11-10	2001-11-09	Производные цианопирролидина
KR1020037006310A KR100680079B1 (ko)	2000-11-10	2001-11-09	시아노피롤리딘 유도체
NO20031949A NO20031949L (no)	2000-11-10	2003-04-29	Cyanopyrrolidinderivater
BG107799A BG107799A (bg)	2000-11-10	2003-05-10	-ианопиролидинови производни
NO20054429A NO20054429L (no)	2000-11-10	2005-09-23	Forbindelser
US11/556,096 US20070112059A1 (en)	2000-11-10	2006-11-02	Cyanopyrrolidine derivatives
US11/556,064 US20070112205A1 (en)	2000-11-10	2006-11-02	Cyanopyrrolidine derivatives
IL182030A IL182030A0 (en)	2000-11-10	2007-03-19	Cyanopyrrolidine derivatives

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2000-344036		2000-11-10
JP2000344036		2000-11-10
JP2001215766		2001-07-16
JP2001-215766		2001-07-16

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
US11/556,064 Division US20070112205A1 (en)	2000-11-10	2006-11-02	Cyanopyrrolidine derivatives
US11/556,096 Division US20070112059A1 (en)	2000-11-10	2006-11-02	Cyanopyrrolidine derivatives

Publications (2)

Publication Number	Publication Date
WO2002038541A1 WO2002038541A1 (en)	2002-05-16
WO2002038541A9 true WO2002038541A9 (en)	2002-08-08

Family

ID=26603777

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2001/009818 Ceased WO2002038541A1 (en)	2000-11-10	2001-11-09	Cyanopyrrolidine derivatives

Country Status (22)

Country	Link
US (3)	US20040072892A1 (ja)
EP (2)	EP1746086A1 (ja)
JP (1)	JP3987890B2 (ja)
KR (3)	KR100680081B1 (ja)
CN (1)	CN1298703C (ja)
AU (2)	AU2002212745B2 (ja)
BG (1)	BG107799A (ja)
BR (1)	BR0114851A (ja)
CA (1)	CA2428271C (ja)
CZ (1)	CZ20031250A3 (ja)
EA (2)	EA008226B1 (ja)
EE (1)	EE200300175A (ja)
HR (2)	HRP20030366A2 (ja)
HU (1)	HUP0302248A2 (ja)
IL (2)	IL155776A0 (ja)
MX (1)	MXPA03004114A (ja)
NO (2)	NO20031949L (ja)
NZ (1)	NZ525705A (ja)
PL (1)	PL361463A1 (ja)
SK (1)	SK5632003A3 (ja)
TW (1)	TWI243162B (ja)
WO (1)	WO2002038541A1 (ja)

Cited By (5)

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US7470700B2 (en)	2003-08-13	2008-12-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7550590B2 (en)	2003-03-25	2009-06-23	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7897633B2 (en)	2004-02-05	2011-03-01	Probiodrug Ag	Inhibitors of glutaminyl cyclase
US8883714B2 (en)	2008-04-07	2014-11-11	Arena Pharmaceuticals, Inc.	Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues
US8906901B2 (en)	2005-09-14	2014-12-09	Takeda Pharmaceutical Company Limited	Administration of dipeptidyl peptidase inhibitors

Families Citing this family (111)

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DE60226723D1 (de)	2001-03-27	2008-07-03	Merck & Co Inc	Dipeptidylpeptidase-hemmer für die behandlung oder prävention von diabetes
DE60221983T2 (de)	2001-06-27	2008-05-15	Smithkline Beecham Corp.	Fluorpyrrolidine als dipeptidyl-peptidase inhibitoren
WO2003002531A2 (en) *	2001-06-27	2003-01-09	Smithkline Beecham Corporation	Fluoropyrrolidines as dipeptidyl peptidase inhibitors
ES2296962T3 (es)	2001-06-27	2008-05-01	Smithkline Beecham Corporation	Pirrolidinas como inhibidores de dipeptidil peptidasa.
GB0125445D0 (en) *	2001-10-23	2001-12-12	Ferring Bv	Protease Inhibitors
WO2003057144A2 (en) *	2001-12-26	2003-07-17	Guilford Pharmaceuticals	Change inhibitors of dipeptidyl peptidase iv
EP1338595B1 (en)	2002-02-25	2006-05-03	Eisai Co., Ltd.	Xanthine derivatives as DPP-IV inhibitors
HUP0200849A2 (hu) *	2002-03-06	2004-08-30	Sanofi-Synthelabo	N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
AU2003235913A1 (en) *	2002-05-09	2003-11-11	Taisho Pharmaceutical Co., Ltd.	Cyanopyrrolidine derivatives
BR0311608A (pt) *	2002-06-04	2005-02-22	Pfizer Prod Inc	Amidas cìclicas fluoradas como inibidores da dipeptidil-peptidase iv
JPWO2004007446A1 (ja) *	2002-07-10	2005-11-10	アステラス製薬株式会社	新規なアゼチジン誘導体又はその塩
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PL374664A1 (en) *	2002-08-29	2005-10-31	Taisho Pharmaceutical Co, Ltd.	Benzenesulfonate of 4-fluoro-2-cyanopyrrolidine derivative
MXPA05005260A (es) *	2002-11-18	2005-07-25	Pfizer Prod Inc	Amidas ciclicas fluoradas que inhiben la dipeptidil peptidasa iv.
JP2005170792A (ja) *	2002-11-22	2005-06-30	Mitsubishi Pharma Corp	Ｌ−プロリン誘導体およびその医薬としての用途。
DE10308355A1 (de)	2003-02-27	2004-12-23	Aventis Pharma Deutschland Gmbh	Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
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US7148246B2 (en)	2003-02-27	2006-12-12	Sanofi-Aventis Deutschland Gmbh	Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
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WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
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US7678909B1 (en)	2003-08-13	2010-03-16	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
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IL155776A0 (en)	2003-12-23
US20040072892A1 (en)	2004-04-15
HRP20030366A2 (en)	2004-08-31
HK1061688A1 (zh)	2004-09-30
EP1333025A1 (en)	2003-08-06
CN1474809A (zh)	2004-02-11
BR0114851A (pt)	2003-09-16
IL182030A0 (en)	2007-07-24
BG107799A (bg)	2004-08-31
KR20030059232A (ko)	2003-07-07
CA2428271A1 (en)	2002-05-16
EA006204B1 (ru)	2005-10-27
EA008226B1 (ru)	2007-04-27
KR20060061410A (ko)	2006-06-07
NO20031949L (no)	2003-07-08
PL361463A1 (en)	2004-10-04
HUP0302248A2 (hu)	2003-10-28
EP1333025A4 (en)	2004-03-24
CZ20031250A3 (cs)	2003-08-13
SK5632003A3 (en)	2003-12-02
KR100620944B1 (ko)	2006-09-19
NO20054429L (no)	2003-07-08
AU2002212745B2 (en)	2007-01-04
TWI243162B (en)	2005-11-11
KR100680079B1 (ko)	2007-02-09
JPWO2002038541A1 (ja)	2004-03-18
WO2002038541A1 (en)	2002-05-16
US20070112205A1 (en)	2007-05-17
CN1298703C (zh)	2007-02-07
US20070112059A1 (en)	2007-05-17
JP3987890B2 (ja)	2007-10-10
KR20050096206A (ko)	2005-10-05
AU1274502A (en)	2002-05-21
EA200300559A1 (ru)	2003-10-30
MXPA03004114A (es)	2003-08-19
EE200300175A (et)	2003-06-16
NZ525705A (en)	2004-04-30
HRP20070116A2 (hr)	2007-07-31
EP1746086A1 (en)	2007-01-24
CA2428271C (en)	2005-12-27
KR100680081B1 (ko)	2007-02-09
NO20031949D0 (no)	2003-04-29
EA200500852A1 (ru)	2006-02-24

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DE69725696D1 (de)	2003-11-27	Carbapenem-antibiotikum, zusammensetzung und ihre herstellung
EP1057813A4 (en)	2001-11-21	INDOLE DERIVATIVES AND MEDICAL COMPOSITIONS CONTAINING THEM
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AU2124992A (en)	1993-02-25	Pharmaceutically useful indole derivatives
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WO2001002380A8 (fr)	2001-06-28	N-aralkyl amines cycliques antipsychotiques
AU7546794A (en)	1995-03-27	Depression remedy

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