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WO1996039391B1 - Derives de styryl benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses - Google Patents

Derives de styryl benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses

Info

Publication number
WO1996039391B1
WO1996039391B1 PCT/US1996/008375 US9608375W WO9639391B1 WO 1996039391 B1 WO1996039391 B1 WO 1996039391B1 US 9608375 W US9608375 W US 9608375W WO 9639391 B1 WO9639391 B1 WO 9639391B1
Authority
WO
WIPO (PCT)
Prior art keywords
carbon atoms
compound
hydrogen
alkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/008375
Other languages
English (en)
Other versions
WO1996039391A1 (fr
Filing date
Publication date
Priority claimed from US08/468,271 external-priority patent/US6444694B1/en
Priority to AT96916978T priority Critical patent/ATE205196T1/de
Priority to DE69615023T priority patent/DE69615023T2/de
Priority to DK96916978T priority patent/DK0830345T3/da
Priority to EP96916978A priority patent/EP0830345B1/fr
Priority to NZ309499A priority patent/NZ309499A/xx
Application filed filed Critical
Priority to JP9500994A priority patent/JPH11506753A/ja
Priority to BR9609153A priority patent/BR9609153A/pt
Priority to AU59684/96A priority patent/AU711965B2/en
Publication of WO1996039391A1 publication Critical patent/WO1996039391A1/fr
Publication of WO1996039391B1 publication Critical patent/WO1996039391B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Composés de formule (I) ou (II), dans lesquelles R est phényle ou phényle substitué; ou R est furyle, pyridyle ou quinolinyle; R1 et R2 sont hydrogène, halogène, alkyle, alcoxy, nitro, carboxyle, alcoxy-carbonyle ou aryloxycarbonyle; R3 est hydrogène, alkyle, aryle ou arylalkyle; R4 et R5 sont hydrogène ou alkyle; ou leur sel pharmaceutiquement acceptable, servant d'inhibiteurs de la prolifération des cellules musculaires lisses.
PCT/US1996/008375 1995-06-06 1996-06-03 Derives de styryl benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses Ceased WO1996039391A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU59684/96A AU711965B2 (en) 1995-06-06 1996-06-03 Styryl benzimidazole derivatives as inhibitors of smooth muscle cell proliferation
DE69615023T DE69615023T2 (de) 1995-06-06 1996-06-03 Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation
DK96916978T DK0830345T3 (da) 1995-06-06 1996-06-03 Styryl-benzimidazol-derivater som inhibitorer af glatmuskel-celleproliferation
EP96916978A EP0830345B1 (fr) 1995-06-06 1996-06-03 Derives de styryl benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses
NZ309499A NZ309499A (en) 1995-06-06 1996-06-03 Styryl benzimidazole derivatives useful as inhibitors of smooth muscle cell proliferation
AT96916978T ATE205196T1 (de) 1995-06-06 1996-06-03 Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation
JP9500994A JPH11506753A (ja) 1995-06-06 1996-06-03 平滑筋細胞増殖の阻害薬としてのスチリルベンゾイミダゾール誘導体
BR9609153A BR9609153A (pt) 1995-06-06 1996-06-03 Derivados de estiril-benzimidazol como inibidores da proliferação de celula de musculo liso

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/468,271 US6444694B1 (en) 1995-06-06 1995-06-06 Styryl benzimidazole derivatives
US08/468,271 1995-06-06

Publications (2)

Publication Number Publication Date
WO1996039391A1 WO1996039391A1 (fr) 1996-12-12
WO1996039391B1 true WO1996039391B1 (fr) 1997-01-09

Family

ID=23859136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008375 Ceased WO1996039391A1 (fr) 1995-06-06 1996-06-03 Derives de styryl benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses

Country Status (19)

Country Link
US (1) US6444694B1 (fr)
EP (1) EP0830345B1 (fr)
JP (1) JPH11506753A (fr)
KR (1) KR19990022266A (fr)
CN (1) CN1192206A (fr)
AR (1) AR002749A1 (fr)
AT (1) ATE205196T1 (fr)
AU (1) AU711965B2 (fr)
BR (1) BR9609153A (fr)
CA (1) CA2223585A1 (fr)
DE (1) DE69615023T2 (fr)
DK (1) DK0830345T3 (fr)
ES (1) ES2162063T3 (fr)
HU (2) HUP9900679A3 (fr)
IL (1) IL118385A0 (fr)
NZ (1) NZ309499A (fr)
PT (1) PT830345E (fr)
WO (1) WO1996039391A1 (fr)
ZA (1) ZA964693B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (fr) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de la polymerase du virus hepatitis C avec une structure heterobicylic
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CN102911161A (zh) 2004-02-20 2013-02-06 贝林格尔.英格海姆国际有限公司 病毒聚合酶抑制剂
EP1915378A4 (fr) 2005-08-12 2009-07-22 Boehringer Ingelheim Int Inhibiteurs de polymerase virale
HUE039815T2 (hu) 2006-07-05 2019-02-28 Fibrotech Therapeutics Pty Ltd Gyógyhatású vegyületek
CN102574843B (zh) 2009-10-22 2015-06-17 法博太科制药有限公司 抗纤维化剂的稠环类似物
KR20190115451A (ko) 2017-02-03 2019-10-11 세르타 테라퓨틱스 피티와이 엘티디. 항-섬유성 화합물
KR102853258B1 (ko) * 2023-06-20 2025-09-01 이원다이애그노믹스(주) 암의 예방, 치료 또는 개선에 유효한 효과를 나타내는 신규한 화합물, 이의 제조방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575956A (en) * 1967-07-24 1971-04-20 Sterling Drug Inc 2-substituted-benz-x-azol-6-ylazo-aminonaphthalene compounds
DE1670908A1 (de) * 1967-08-16 1971-04-29 Hoechst Ag Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel
FR2104717A1 (en) * 1970-09-28 1972-04-21 Dynachim Sarl Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals
DE3505609A1 (de) 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
JPH05507072A (ja) 1990-04-16 1993-10-14 イッスム　リサーチ　ディヴェロプメント　カンパニー　オブ　ザ　ヒーブルー　ユニヴァーシティ　オブ　エルサレム Ｅｇｆレセプタチロシンキナーゼを阻害する複素環式エテンジイル化合物
US5196446A (en) 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
DE4212748A1 (de) 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions

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