BR9609153A - Derivados de estiril-benzimidazol como inibidores da proliferação de celula de musculo liso - Google Patents
Derivados de estiril-benzimidazol como inibidores da proliferação de celula de musculo lisoInfo
- Publication number
- BR9609153A BR9609153A BR9609153A BR9609153A BR9609153A BR 9609153 A BR9609153 A BR 9609153A BR 9609153 A BR9609153 A BR 9609153A BR 9609153 A BR9609153 A BR 9609153A BR 9609153 A BR9609153 A BR 9609153A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- styrene
- cell proliferation
- smooth muscle
- muscle cell
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/468,271 US6444694B1 (en) | 1995-06-06 | 1995-06-06 | Styryl benzimidazole derivatives |
| PCT/US1996/008375 WO1996039391A1 (en) | 1995-06-06 | 1996-06-03 | Styryl benzimidazole derivatives as inhibitors of smooth muscle cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9609153A true BR9609153A (pt) | 1999-05-04 |
Family
ID=23859136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9609153A BR9609153A (pt) | 1995-06-06 | 1996-06-03 | Derivados de estiril-benzimidazol como inibidores da proliferação de celula de musculo liso |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6444694B1 (pt) |
| EP (1) | EP0830345B1 (pt) |
| JP (1) | JPH11506753A (pt) |
| KR (1) | KR19990022266A (pt) |
| CN (1) | CN1192206A (pt) |
| AR (1) | AR002749A1 (pt) |
| AT (1) | ATE205196T1 (pt) |
| AU (1) | AU711965B2 (pt) |
| BR (1) | BR9609153A (pt) |
| CA (1) | CA2223585A1 (pt) |
| DE (1) | DE69615023T2 (pt) |
| DK (1) | DK0830345T3 (pt) |
| ES (1) | ES2162063T3 (pt) |
| HU (2) | HUP9900914A2 (pt) |
| IL (1) | IL118385A0 (pt) |
| NZ (1) | NZ309499A (pt) |
| PT (1) | PT830345E (pt) |
| WO (1) | WO1996039391A1 (pt) |
| ZA (1) | ZA964693B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| UA86962C2 (en) | 2004-02-20 | 2009-06-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Viral polymerase inhibitors |
| US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| AU2007271734B2 (en) | 2006-07-05 | 2012-03-29 | Certa Therapeutics Pty. Ltd. | Therapeutic compounds |
| CN105153188B (zh) * | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| EP3577103A1 (en) | 2017-02-03 | 2019-12-11 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| KR102853258B1 (ko) * | 2023-06-20 | 2025-09-01 | 이원다이애그노믹스(주) | 암의 예방, 치료 또는 개선에 유효한 효과를 나타내는 신규한 화합물, 이의 제조방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3575956A (en) * | 1967-07-24 | 1971-04-20 | Sterling Drug Inc | 2-substituted-benz-x-azol-6-ylazo-aminonaphthalene compounds |
| DE1670908A1 (de) * | 1967-08-16 | 1971-04-29 | Hoechst Ag | Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel |
| FR2104717A1 (en) * | 1970-09-28 | 1972-04-21 | Dynachim Sarl | Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals |
| DE3505609A1 (de) | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Benzimidazolyl-pyridazinone |
| JPH05507072A (ja) | 1990-04-16 | 1993-10-14 | イッスム リサーチ ディヴェロプメント カンパニー オブ ザ ヒーブルー ユニヴァーシティ オブ エルサレム | Ｅｇｆレセプタチロシンキナーゼを阻害する複素環式エテンジイル化合物 |
| US5196446A (en) | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
| DE4212748A1 (de) | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
-
1995
- 1995-06-06 US US08/468,271 patent/US6444694B1/en not_active Expired - Fee Related
-
1996
- 1996-05-22 IL IL11838596A patent/IL118385A0/xx unknown
- 1996-05-30 AR ARP960102799A patent/AR002749A1/es unknown
- 1996-06-03 PT PT96916978T patent/PT830345E/pt unknown
- 1996-06-03 KR KR1019970708745A patent/KR19990022266A/ko not_active Withdrawn
- 1996-06-03 WO PCT/US1996/008375 patent/WO1996039391A1/en not_active Ceased
- 1996-06-03 NZ NZ309499A patent/NZ309499A/xx unknown
- 1996-06-03 EP EP96916978A patent/EP0830345B1/en not_active Expired - Lifetime
- 1996-06-03 CN CN96195860A patent/CN1192206A/zh active Pending
- 1996-06-03 DK DK96916978T patent/DK0830345T3/da active
- 1996-06-03 AU AU59684/96A patent/AU711965B2/en not_active Ceased
- 1996-06-03 BR BR9609153A patent/BR9609153A/pt unknown
- 1996-06-03 ES ES96916978T patent/ES2162063T3/es not_active Expired - Lifetime
- 1996-06-03 DE DE69615023T patent/DE69615023T2/de not_active Expired - Fee Related
- 1996-06-03 AT AT96916978T patent/ATE205196T1/de not_active IP Right Cessation
- 1996-06-03 CA CA002223585A patent/CA2223585A1/en not_active Abandoned
- 1996-06-03 HU HU9900914A patent/HUP9900914A2/hu unknown
- 1996-06-03 HU HU9900679A patent/HUP9900679A3/hu unknown
- 1996-06-03 JP JP9500994A patent/JPH11506753A/ja active Pending
- 1996-06-05 ZA ZA9604693A patent/ZA964693B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1192206A (zh) | 1998-09-02 |
| HUP9900679A2 (hu) | 1999-09-28 |
| DE69615023D1 (de) | 2001-10-11 |
| ATE205196T1 (de) | 2001-09-15 |
| PT830345E (pt) | 2002-01-30 |
| KR19990022266A (ko) | 1999-03-25 |
| ES2162063T3 (es) | 2001-12-16 |
| US6444694B1 (en) | 2002-09-03 |
| JPH11506753A (ja) | 1999-06-15 |
| HUP9900914A2 (hu) | 1999-07-28 |
| NZ309499A (en) | 2000-08-25 |
| IL118385A0 (en) | 1996-09-12 |
| AU711965B2 (en) | 1999-10-28 |
| CA2223585A1 (en) | 1996-12-12 |
| DE69615023T2 (de) | 2002-06-06 |
| EP0830345B1 (en) | 2001-09-05 |
| DK0830345T3 (da) | 2001-11-19 |
| ZA964693B (en) | 1997-12-05 |
| MX9709647A (es) | 1998-07-31 |
| EP0830345A1 (en) | 1998-03-25 |
| HUP9900679A3 (en) | 2001-07-30 |
| AU5968496A (en) | 1996-12-24 |
| WO1996039391A1 (en) | 1996-12-12 |
| AR002749A1 (es) | 1998-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |