HUP9900914A2 - Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékok - Google Patents
Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékokInfo
- Publication number
- HUP9900914A2 HUP9900914A2 HU9900914A HUP9900914A HUP9900914A2 HU P9900914 A2 HUP9900914 A2 HU P9900914A2 HU 9900914 A HU9900914 A HU 9900914A HU P9900914 A HUP9900914 A HU P9900914A HU P9900914 A2 HUP9900914 A2 HU P9900914A2
- Authority
- HU
- Hungary
- Prior art keywords
- cell proliferation
- smooth muscle
- muscle cell
- inhibitors
- benzimidazole derivatives
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- QQLPPRIZUPEKMV-UHFFFAOYSA-N 2-(2-phenylethenyl)-1h-benzimidazole Chemical class N=1C2=CC=CC=C2NC=1C=CC1=CC=CC=C1 QQLPPRIZUPEKMV-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 210000000663 muscle cell Anatomy 0.000 abstract 1
- -1 nitro, carboxyl Chemical group 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya (I) vagy (II) általánős képletű vegyületek, ahől Rjelentése fenil- vagy szűbsztitűált fenilcsőpőrt, vagy R jelentésefűril-, piridil- vagy kinőlinilcsőpőrt; R1 és R2 jelentése hidrőgén-vagy halőgénatőm, alkil-, alkőxi-, nitrő-, karbőxil-, alkőxi-karbőnil-vagy arilőxi-karbőnilcsőpőrt; R3 jelentése hidrőgénatőm, alkil-, aril-vagy aril-alkilcsőpőrt; R4 és R5 jelentése hidrőgénatőm vagyalkilcsőpőrt, vagy gyógyászatilag elfőgadható sója, melyek simaizőm-sejtbűrjánzást gátló szerekként hasznősak. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/468,271 US6444694B1 (en) | 1995-06-06 | 1995-06-06 | Styryl benzimidazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9900914A2 true HUP9900914A2 (hu) | 1999-07-28 |
Family
ID=23859136
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900914A HUP9900914A2 (hu) | 1995-06-06 | 1996-06-03 | Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékok |
| HU9900679A HUP9900679A3 (en) | 1995-06-06 | 1996-06-03 | Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900679A HUP9900679A3 (en) | 1995-06-06 | 1996-06-03 | Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6444694B1 (hu) |
| EP (1) | EP0830345B1 (hu) |
| JP (1) | JPH11506753A (hu) |
| KR (1) | KR19990022266A (hu) |
| CN (1) | CN1192206A (hu) |
| AR (1) | AR002749A1 (hu) |
| AT (1) | ATE205196T1 (hu) |
| AU (1) | AU711965B2 (hu) |
| BR (1) | BR9609153A (hu) |
| CA (1) | CA2223585A1 (hu) |
| DE (1) | DE69615023T2 (hu) |
| DK (1) | DK0830345T3 (hu) |
| ES (1) | ES2162063T3 (hu) |
| HU (2) | HUP9900914A2 (hu) |
| IL (1) | IL118385A0 (hu) |
| NZ (1) | NZ309499A (hu) |
| PT (1) | PT830345E (hu) |
| WO (1) | WO1996039391A1 (hu) |
| ZA (1) | ZA964693B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| UA86962C2 (en) | 2004-02-20 | 2009-06-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Viral polymerase inhibitors |
| US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| AU2007271734B2 (en) | 2006-07-05 | 2012-03-29 | Certa Therapeutics Pty. Ltd. | Therapeutic compounds |
| CN105153188B (zh) * | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| EP3577103A1 (en) | 2017-02-03 | 2019-12-11 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| KR102853258B1 (ko) * | 2023-06-20 | 2025-09-01 | 이원다이애그노믹스(주) | 암의 예방, 치료 또는 개선에 유효한 효과를 나타내는 신규한 화합물, 이의 제조방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3575956A (en) * | 1967-07-24 | 1971-04-20 | Sterling Drug Inc | 2-substituted-benz-x-azol-6-ylazo-aminonaphthalene compounds |
| DE1670908A1 (de) * | 1967-08-16 | 1971-04-29 | Hoechst Ag | Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel |
| FR2104717A1 (en) * | 1970-09-28 | 1972-04-21 | Dynachim Sarl | Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals |
| DE3505609A1 (de) | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Benzimidazolyl-pyridazinone |
| JPH05507072A (ja) | 1990-04-16 | 1993-10-14 | イッスム リサーチ ディヴェロプメント カンパニー オブ ザ ヒーブルー ユニヴァーシティ オブ エルサレム | Ｅｇｆレセプタチロシンキナーゼを阻害する複素環式エテンジイル化合物 |
| US5196446A (en) | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
| DE4212748A1 (de) | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
-
1995
- 1995-06-06 US US08/468,271 patent/US6444694B1/en not_active Expired - Fee Related
-
1996
- 1996-05-22 IL IL11838596A patent/IL118385A0/xx unknown
- 1996-05-30 AR ARP960102799A patent/AR002749A1/es unknown
- 1996-06-03 PT PT96916978T patent/PT830345E/pt unknown
- 1996-06-03 KR KR1019970708745A patent/KR19990022266A/ko not_active Withdrawn
- 1996-06-03 WO PCT/US1996/008375 patent/WO1996039391A1/en not_active Ceased
- 1996-06-03 NZ NZ309499A patent/NZ309499A/xx unknown
- 1996-06-03 EP EP96916978A patent/EP0830345B1/en not_active Expired - Lifetime
- 1996-06-03 CN CN96195860A patent/CN1192206A/zh active Pending
- 1996-06-03 DK DK96916978T patent/DK0830345T3/da active
- 1996-06-03 AU AU59684/96A patent/AU711965B2/en not_active Ceased
- 1996-06-03 BR BR9609153A patent/BR9609153A/pt unknown
- 1996-06-03 ES ES96916978T patent/ES2162063T3/es not_active Expired - Lifetime
- 1996-06-03 DE DE69615023T patent/DE69615023T2/de not_active Expired - Fee Related
- 1996-06-03 AT AT96916978T patent/ATE205196T1/de not_active IP Right Cessation
- 1996-06-03 CA CA002223585A patent/CA2223585A1/en not_active Abandoned
- 1996-06-03 HU HU9900914A patent/HUP9900914A2/hu unknown
- 1996-06-03 HU HU9900679A patent/HUP9900679A3/hu unknown
- 1996-06-03 JP JP9500994A patent/JPH11506753A/ja active Pending
- 1996-06-05 ZA ZA9604693A patent/ZA964693B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1192206A (zh) | 1998-09-02 |
| HUP9900679A2 (hu) | 1999-09-28 |
| DE69615023D1 (de) | 2001-10-11 |
| ATE205196T1 (de) | 2001-09-15 |
| PT830345E (pt) | 2002-01-30 |
| KR19990022266A (ko) | 1999-03-25 |
| ES2162063T3 (es) | 2001-12-16 |
| US6444694B1 (en) | 2002-09-03 |
| JPH11506753A (ja) | 1999-06-15 |
| NZ309499A (en) | 2000-08-25 |
| IL118385A0 (en) | 1996-09-12 |
| AU711965B2 (en) | 1999-10-28 |
| CA2223585A1 (en) | 1996-12-12 |
| DE69615023T2 (de) | 2002-06-06 |
| EP0830345B1 (en) | 2001-09-05 |
| DK0830345T3 (da) | 2001-11-19 |
| ZA964693B (en) | 1997-12-05 |
| MX9709647A (es) | 1998-07-31 |
| EP0830345A1 (en) | 1998-03-25 |
| HUP9900679A3 (en) | 2001-07-30 |
| BR9609153A (pt) | 1999-05-04 |
| AU5968496A (en) | 1996-12-24 |
| WO1996039391A1 (en) | 1996-12-12 |
| AR002749A1 (es) | 1998-04-29 |
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