UY30324A1 - Proteinas de fusion del rage, formulaciones y métodos de uso - Google Patents
Proteinas de fusion del rage, formulaciones y métodos de usoInfo
- Publication number
- UY30324A1 UY30324A1 UY30324A UY30324A UY30324A1 UY 30324 A1 UY30324 A1 UY 30324A1 UY 30324 A UY30324 A UY 30324A UY 30324 A UY30324 A UY 30324A UY 30324 A1 UY30324 A1 UY 30324A1
- Authority
- UY
- Uruguay
- Prior art keywords
- rage
- fusion proteins
- rage fusion
- formulations
- methods
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 6
- 108020001507 fusion proteins Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
Se revelan proteínas de fusion del RAGE que comprenden secuencias de polipéptidos RAGE unidos a un segundo polipéptido no RAGE. La proteína de fusion del RAGE puede usar un dominio de polipéptido RAGE que comprende un sitio de union de ligando del RAGE y un fragmento de union interdominio unido directamente al extremo N del dominio CH2 de una inmunoglobulina. También se revelan formulaciones de proteínas de fusion del RAGE y el uso de las proteínas de fusion del RAGE y las formulaciones de las proteínas de fusion del RAGE como medicamentos para patologías mediadas por el RAGE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79845506P | 2006-05-05 | 2006-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY30324A1 true UY30324A1 (es) | 2008-01-02 |
Family
ID=38521887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY30324A UY30324A1 (es) | 2006-05-05 | 2007-05-04 | Proteinas de fusion del rage, formulaciones y métodos de uso |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7981424B2 (es) |
| EP (2) | EP2380983A3 (es) |
| JP (1) | JP5558810B2 (es) |
| KR (1) | KR20090008459A (es) |
| CN (1) | CN101548012A (es) |
| AR (1) | AR060862A1 (es) |
| AU (1) | AU2007248784B2 (es) |
| BR (1) | BRPI0711193A2 (es) |
| CA (1) | CA2651348A1 (es) |
| DO (1) | DOP2007000089A (es) |
| EA (1) | EA017291B1 (es) |
| IL (1) | IL194482A0 (es) |
| MX (1) | MX2008013863A (es) |
| NL (1) | NL2000626A1 (es) |
| NZ (1) | NZ571692A (es) |
| PE (1) | PE20080397A1 (es) |
| SG (1) | SG171670A1 (es) |
| TW (1) | TW200801036A (es) |
| UY (1) | UY30324A1 (es) |
| WO (1) | WO2007130302A2 (es) |
| ZA (1) | ZA200809394B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7901688B2 (en) | 2004-08-03 | 2011-03-08 | Transtech Pharma, Inc. | Rage fusion proteins |
| US20090060925A1 (en) * | 2004-08-03 | 2009-03-05 | The Trustees Of Columbia University In The City Of | Rage Fusion Proteins and Methods of Use |
| EP1963786B1 (en) * | 2005-12-23 | 2013-07-24 | GCoder Systems AB | Positioning pattern |
| EA015657B1 (ru) * | 2006-02-09 | 2011-10-31 | Транстек Фарма, Инк. | Слитые белки rage и способы применения |
| EA017291B1 (ru) | 2006-05-05 | 2012-11-30 | Транстек Фарма, Инк. | Белки слияния на основе rage, их композиции и способы их применения |
| WO2008099913A1 (ja) | 2007-02-15 | 2008-08-21 | Kumamoto University | ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| TW200846366A (en) * | 2007-02-15 | 2008-12-01 | Univ Fukuoka | Agent for suppressing rejection in organ transplantation comprising anti-hmgb-1 antibody |
| EP2123299A4 (en) * | 2007-02-15 | 2011-10-05 | Univ Kyushu Nat Univ Corp | THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY |
| AU2008265983B2 (en) | 2007-06-14 | 2013-06-20 | Galactica Pharmaceuticals, Inc. | RAGE fusion proteins |
| EP2421892A1 (en) * | 2009-04-20 | 2012-02-29 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| WO2011102845A1 (en) * | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| WO2013074820A1 (en) | 2011-11-16 | 2013-05-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Immunogenic tumor associated stromal cell antigen peptides and methods of their use |
| PT2925338T (pt) * | 2012-11-28 | 2019-05-31 | Nono Inc | Formulação liofilizada de tat-nr2b9c |
| US10251935B2 (en) * | 2012-11-28 | 2019-04-09 | Nono Inc. | Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose |
| EP3077823B1 (en) | 2013-12-05 | 2019-09-04 | The Broad Institute, Inc. | Compositions and methods for identifying and treating cachexia or pre-cachexia |
| WO2016051808A1 (ja) * | 2014-10-01 | 2016-04-07 | 国立研究開発法人農業・食品産業技術総合研究機構 | 遺伝子組換えカイコにより生産したビオチン化酸化ｌｄｌ受容体・終末糖化産物受容体 |
| EP3822291A1 (en) | 2015-06-10 | 2021-05-19 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| US11111296B2 (en) | 2015-12-14 | 2021-09-07 | The Broad Institute, Inc. | Compositions and methods for treating cardiac dysfunction |
| CN112699601B (zh) * | 2020-12-28 | 2022-05-31 | 电子科技大学 | 一种传感器网络数据的空时重构方法 |
| US20230246158A1 (en) * | 2022-02-02 | 2023-08-03 | Enevate Corporation | Cycle life in si/li batteries using high temperature deep discharge cycling |
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| WO2004100890A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of Columbia University In The City Of New York | Rage g82s-related methods and compositions for treating inflammatory disorders |
| US20050008649A1 (en) * | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| EP1660014A4 (en) * | 2003-09-05 | 2009-07-22 | Univ Columbia | RAGE-RELATED METHODS AND COMPOSITIONS FOR TREATING GLOMERULAR DAMAGE |
| US20070167360A1 (en) * | 2003-10-31 | 2007-07-19 | Yan Shi D | Methods for treating multiple sclerosis |
| US20060012414A1 (en) * | 2004-07-15 | 2006-01-19 | Texas Instruments Incorporated | Circuit and method for generating a polyphase clock signal and system incorporating the same |
| US20060040354A1 (en) | 2004-07-20 | 2006-02-23 | O'keefe Theresa L | Novel polyadenylation signal for use in expression vectors |
| EP1771565B1 (en) * | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| US20090060925A1 (en) * | 2004-08-03 | 2009-03-05 | The Trustees Of Columbia University In The City Of | Rage Fusion Proteins and Methods of Use |
| US7901688B2 (en) * | 2004-08-03 | 2011-03-08 | Transtech Pharma, Inc. | Rage fusion proteins |
| JP2008537874A (ja) * | 2004-09-27 | 2008-10-02 | セントカー・インコーポレーテツド | ｓＲＡＧＥミメティボディ、組成物、方法および使用 |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| EA015657B1 (ru) * | 2006-02-09 | 2011-10-31 | Транстек Фарма, Инк. | Слитые белки rage и способы применения |
| EA017291B1 (ru) | 2006-05-05 | 2012-11-30 | Транстек Фарма, Инк. | Белки слияния на основе rage, их композиции и способы их применения |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
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2007
- 2007-04-25 EA EA200870502A patent/EA017291B1/ru not_active IP Right Cessation
- 2007-04-25 CN CNA200780018207XA patent/CN101548012A/zh active Pending
- 2007-04-25 EP EP11167432A patent/EP2380983A3/en not_active Withdrawn
- 2007-04-25 AU AU2007248784A patent/AU2007248784B2/en not_active Ceased
- 2007-04-25 SG SG201103296-8A patent/SG171670A1/en unknown
- 2007-04-25 CA CA002651348A patent/CA2651348A1/en not_active Abandoned
- 2007-04-25 WO PCT/US2007/010125 patent/WO2007130302A2/en not_active Ceased
- 2007-04-25 MX MX2008013863A patent/MX2008013863A/es active IP Right Grant
- 2007-04-25 NZ NZ571692A patent/NZ571692A/en not_active IP Right Cessation
- 2007-04-25 US US11/789,637 patent/US7981424B2/en not_active Expired - Fee Related
- 2007-04-25 JP JP2009509615A patent/JP5558810B2/ja not_active Expired - Fee Related
- 2007-04-25 EP EP07794379A patent/EP2021474A2/en not_active Withdrawn
- 2007-04-25 BR BRPI0711193-2A patent/BRPI0711193A2/pt not_active IP Right Cessation
- 2007-04-25 KR KR1020087029731A patent/KR20090008459A/ko not_active Withdrawn
- 2007-05-04 AR ARP070101949A patent/AR060862A1/es not_active Application Discontinuation
- 2007-05-04 DO DO2007000089A patent/DOP2007000089A/es unknown
- 2007-05-04 TW TW096115905A patent/TW200801036A/zh unknown
- 2007-05-04 UY UY30324A patent/UY30324A1/es not_active Application Discontinuation
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- 2007-05-04 PE PE2007000550A patent/PE20080397A1/es not_active Application Discontinuation
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2011
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Also Published As
| Publication number | Publication date |
|---|---|
| US7981424B2 (en) | 2011-07-19 |
| JP5558810B2 (ja) | 2014-07-23 |
| MX2008013863A (es) | 2008-11-14 |
| US8344120B2 (en) | 2013-01-01 |
| TW200801036A (en) | 2008-01-01 |
| SG171670A1 (en) | 2011-06-29 |
| BRPI0711193A2 (pt) | 2013-06-18 |
| AU2007248784B2 (en) | 2013-11-21 |
| EA200870502A1 (ru) | 2009-06-30 |
| EP2380983A2 (en) | 2011-10-26 |
| CA2651348A1 (en) | 2007-11-15 |
| KR20090008459A (ko) | 2009-01-21 |
| PE20080397A1 (es) | 2008-04-28 |
| JP2009536201A (ja) | 2009-10-08 |
| NL2000626A1 (nl) | 2007-11-06 |
| ZA200809394B (en) | 2009-07-29 |
| DOP2007000089A (es) | 2007-11-15 |
| IL194482A0 (en) | 2011-08-01 |
| US20080045455A1 (en) | 2008-02-21 |
| US20110282035A1 (en) | 2011-11-17 |
| WO2007130302A2 (en) | 2007-11-15 |
| EP2021474A2 (en) | 2009-02-11 |
| EP2380983A3 (en) | 2012-12-05 |
| EA017291B1 (ru) | 2012-11-30 |
| NZ571692A (en) | 2012-01-12 |
| CN101548012A (zh) | 2009-09-30 |
| AR060862A1 (es) | 2008-07-16 |
| WO2007130302A3 (en) | 2008-04-03 |
| AU2007248784A1 (en) | 2007-11-15 |
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