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WO2008099913A1 - ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 - Google Patents

ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 Download PDF

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Publication number
WO2008099913A1
WO2008099913A1 PCT/JP2008/052500 JP2008052500W WO2008099913A1 WO 2008099913 A1 WO2008099913 A1 WO 2008099913A1 JP 2008052500 W JP2008052500 W JP 2008052500W WO 2008099913 A1 WO2008099913 A1 WO 2008099913A1
Authority
WO
WIPO (PCT)
Prior art keywords
hmgb
antibody
active ingredient
therapeutic agent
antibody capable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/052500
Other languages
English (en)
French (fr)
Inventor
Yukio Ando
Ikuro Maruyama
Shingo Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kagoshima University NUC
Kumamoto University NUC
Shino Test Corp
Original Assignee
Kagoshima University NUC
Kumamoto University NUC
Shino Test Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kagoshima University NUC, Kumamoto University NUC, Shino Test Corp filed Critical Kagoshima University NUC
Priority to EP08711330A priority Critical patent/EP2123297A4/en
Priority to US12/449,543 priority patent/US8470325B2/en
Priority to JP2008558144A priority patent/JP5225109B2/ja
Publication of WO2008099913A1 publication Critical patent/WO2008099913A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　従来、HMGB-2に結合することなくHMGB-1に特異的に結合し、かつ親和性の高い抗体を得ることは容易ではなかった。このような中、本発明者らは、特定のペプチドを抗原として用いることによって、HMGB-2よりもHMGB-1に強く反応する抗体を取得することに成功した。また本発明者らは、上記抗体がHMGB-1に対して中和活性を有することを見出した。本発明者らは、上記抗体をアミロイドシスの疾患モデル動物に投与した結果、顕著な治療効果が得られることを実証することに成功した。
PCT/JP2008/052500 2007-02-15 2008-02-15 ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 Ceased WO2008099913A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08711330A EP2123297A4 (en) 2007-02-15 2008-02-15 THERAPEUTIC AGENT WITH AN ANTIBODY FOR SPECIFIC BINDING TO HUMAN HMGB-1 AS AN ACTIVE SUBSTANCE
US12/449,543 US8470325B2 (en) 2007-02-15 2008-02-15 Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody
JP2008558144A JP5225109B2 (ja) 2007-02-15 2008-02-15 ヒトｈｍｇｂ−１に特異的に結合する抗体を有効成分として含有する治療剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007034325 2007-02-15
JP2007-034325 2007-02-15

Publications (1)

Publication Number Publication Date
WO2008099913A1 true WO2008099913A1 (ja) 2008-08-21

Family

ID=39690138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052500 Ceased WO2008099913A1 (ja) 2007-02-15 2008-02-15 ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤

Country Status (5)

Country Link
US (1) US8470325B2 (ja)
EP (1) EP2123297A4 (ja)
JP (1) JP5225109B2 (ja)
TW (1) TW200902063A (ja)
WO (1) WO2008099913A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020059847A1 (ja) 2018-09-21 2020-03-26 国立大学法人 東京医科歯科大学 ヒトｈｍｇｂ１に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物
US10730937B2 (en) 2016-08-09 2020-08-04 National University Corporation Tokyo Medical And Dental University Antibodies against HMB1, and composition comprising same for treating or preventing alzheimer's disease

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200846366A (en) * 2007-02-15 2008-12-01 Univ Fukuoka Agent for suppressing rejection in organ transplantation comprising anti-hmgb-1 antibody
EP2123299A4 (en) * 2007-02-15 2011-10-05 Univ Kyushu Nat Univ Corp THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY
FI20105715A0 (fi) 2010-06-18 2010-06-18 Helsingin Yliopisto Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine
US20150335763A1 (en) * 2013-01-09 2015-11-26 The Feinstein Institute For Medical Research Hmgb1-binding beads and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003534351A (ja) * 2000-05-22 2003-11-18 ニュー・ヨーク・ユニヴァーシティー アミロイドβ及びアミロイド沈着物に対する免疫応答誘導のための、アミロイドβと相同的な、合成の、免疫原性だが非アミロイド原性ペプチド
JP2004107260A (ja) * 2002-09-18 2004-04-08 Takeda Chem Ind Ltd 脳アミロイドーシス予防・治療薬のスクリーニング方法

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JPS62166897A (ja) 1986-01-20 1987-07-23 Toyo Soda Mfg Co Ltd 核内非ヒストン蛋白質に対するモノクロ−ナル抗体
EP0727487A1 (en) 1995-02-17 1996-08-21 K.U. Leuven Research & Development Multiple-tumor aberrant growth genes
AU719555B2 (en) 1996-07-17 2000-05-11 Kaneka Corporation Diagnostic drugs for autoimmune diseases
JP3267893B2 (ja) 1997-05-15 2002-03-25 鐘淵化学工業株式会社 自己免疫疾患の診断薬
US6303321B1 (en) * 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US6794132B2 (en) * 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
ITMI20010562A1 (it) 2001-03-16 2002-09-16 Marco E Bianchi Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari
US20030060410A1 (en) 2001-05-15 2003-03-27 North Shore Long Island Jewish Research Institute Use of HMG fragments as anti-inflammatory agents
US7304034B2 (en) * 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7220723B2 (en) * 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
JP4823465B2 (ja) 2001-07-13 2011-11-24 株式会社シノテスト ヒトｈｍｇ−１に特異的に結合する抗体並びにこの抗体を用いるヒトｈｍｇ−１の免疫学的測定方法及び免疫学的測定試薬
ITMI20011986A1 (it) * 2001-09-25 2003-03-25 San Raffaele Centro Fond Metodo e composizione per l'attivazione di cellule presentanti l'antigene
EP1453531B1 (de) 2001-12-19 2008-05-14 Alcedo Biotech GmbH Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren
DE60326453D1 (de) 2002-07-03 2009-04-16 Ct Cardiologico Monzino S P A Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung
GB0226251D0 (en) 2002-11-11 2002-12-18 San Raffaele Centro Fond Acetylated protein
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ITRM20040058A1 (it) 2004-02-03 2004-05-03 Marco E Bianchi Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali.
CN102731654A (zh) 2004-10-22 2012-10-17 米迪缪尼有限公司 抗hmgb1的高亲和力抗体及其用法
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EA017291B1 (ru) 2006-05-05 2012-11-30 Транстек Фарма, Инк. Белки слияния на основе rage, их композиции и способы их применения
EP2123299A4 (en) * 2007-02-15 2011-10-05 Univ Kyushu Nat Univ Corp THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY
TW200846366A (en) * 2007-02-15 2008-12-01 Univ Fukuoka Agent for suppressing rejection in organ transplantation comprising anti-hmgb-1 antibody

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003534351A (ja) * 2000-05-22 2003-11-18 ニュー・ヨーク・ユニヴァーシティー アミロイドβ及びアミロイド沈着物に対する免疫応答誘導のための、アミロイドβと相同的な、合成の、免疫原性だが非アミロイド原性ペプチド
JP2004107260A (ja) * 2002-09-18 2004-04-08 Takeda Chem Ind Ltd 脳アミロイドーシス予防・治療薬のスクリーニング方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2123297A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10730937B2 (en) 2016-08-09 2020-08-04 National University Corporation Tokyo Medical And Dental University Antibodies against HMB1, and composition comprising same for treating or preventing alzheimer's disease
WO2020059847A1 (ja) 2018-09-21 2020-03-26 国立大学法人 東京医科歯科大学 ヒトｈｍｇｂ１に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物
US12319731B2 (en) 2018-09-21 2025-06-03 Institute Of Science Tokyo Human monoclonal antibody binding specifically to human HMGB1, and pharmaceutical composition for treating or preventing Alzheimer's disease containing said human monoclonal antibody

Also Published As

Publication number Publication date
EP2123297A1 (en) 2009-11-25
US20110229487A1 (en) 2011-09-22
EP2123297A4 (en) 2011-10-12
US8470325B2 (en) 2013-06-25
JPWO2008099913A1 (ja) 2010-05-27
JP5225109B2 (ja) 2013-07-03
TW200902063A (en) 2009-01-16

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