UY30925A1 - Proteinas de fusion de inmunoglobulina y metodos de elaboracion - Google Patents
Proteinas de fusion de inmunoglobulina y metodos de elaboracionInfo
- Publication number
- UY30925A1 UY30925A1 UY30925A UY30925A UY30925A1 UY 30925 A1 UY30925 A1 UY 30925A1 UY 30925 A UY30925 A UY 30925A UY 30925 A UY30925 A UY 30925A UY 30925 A1 UY30925 A1 UY 30925A1
- Authority
- UY
- Uruguay
- Prior art keywords
- fusion proteins
- immunoglobulin fusion
- immunoglobulin
- elaboration
- methods
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 5
- 102000018358 immunoglobulin Human genes 0.000 title abstract 5
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000012745 Immunoglobulin Subunits Human genes 0.000 abstract 1
- 108010079585 Immunoglobulin Subunits Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
Abstract
En ciertas materializaciones, la proteína de fusion puede incluir un polipéptido no inmunoglobulina unido a un polipéptido inmunoglobulina. En ciertas materializaciones, el polipéptido no inmunoglobulina puede incluir una region bisagra Fc de inmunoglobulina, pero que permite la union correcta de las cadenas de inmunoglobulina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90154007P | 2007-02-15 | 2007-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY30925A1 true UY30925A1 (es) | 2008-09-30 |
Family
ID=39690682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY30925A UY30925A1 (es) | 2007-02-15 | 2008-02-15 | Proteinas de fusion de inmunoglobulina y metodos de elaboracion |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20080199467A1 (es) |
| AR (1) | AR065373A1 (es) |
| CL (1) | CL2008000460A1 (es) |
| TW (1) | TW200848071A (es) |
| UY (1) | UY30925A1 (es) |
| WO (1) | WO2008100470A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005019434A2 (en) | 2003-08-26 | 2005-03-03 | The Regents Of The University Of Colorado, A Body Corporate | Serine protease inhibitors for treatment of bacterial infections |
| US20090060925A1 (en) * | 2004-08-03 | 2009-03-05 | The Trustees Of Columbia University In The City Of | Rage Fusion Proteins and Methods of Use |
| US7901688B2 (en) | 2004-08-03 | 2011-03-08 | Transtech Pharma, Inc. | Rage fusion proteins |
| EP1963786B1 (en) * | 2005-12-23 | 2013-07-24 | GCoder Systems AB | Positioning pattern |
| EA015657B1 (ru) * | 2006-02-09 | 2011-10-31 | Транстек Фарма, Инк. | Слитые белки rage и способы применения |
| EA017291B1 (ru) | 2006-05-05 | 2012-11-30 | Транстек Фарма, Инк. | Белки слияния на основе rage, их композиции и способы их применения |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| AU2008265983B2 (en) | 2007-06-14 | 2013-06-20 | Galactica Pharmaceuticals, Inc. | RAGE fusion proteins |
| CA2713281C (en) | 2008-01-31 | 2019-10-15 | Dimiter S. Dimitrov | Engineered antibody constant domain molecules |
| EP2421892A1 (en) | 2009-04-20 | 2012-02-29 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| KR102103476B1 (ko) | 2011-06-24 | 2020-04-23 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| CA2896951A1 (en) * | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| JP2019515904A (ja) * | 2016-04-14 | 2019-06-13 | アイコニック セラピューティクス,インコーポレイテッド | 新血管新生に関連する障害を治療するための組成物および方法 |
| EP3483180A1 (en) | 2017-11-14 | 2019-05-15 | Affilogic | Multi specific molecules |
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| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| IE922437A1 (en) * | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| US5891341A (en) * | 1995-04-05 | 1999-04-06 | The Picower Institute For Medical Research | Compositions and devices for partitioning advanced glycosylation endproducts, and methods of their use |
| FI119756B (fi) * | 1995-01-18 | 2009-03-13 | Alteon Inc | Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa |
| US5656261A (en) * | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
| CN1142778C (zh) * | 1995-01-18 | 2004-03-24 | 奥尔顿有限公司 | 噻唑鎓化合物用于预防和逆转高级糖基化终产物形成的用途 |
| US5747035A (en) * | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US6555651B2 (en) * | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
| US7081241B1 (en) * | 1998-10-06 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Extracellular rage binding protein (EN-RAGE) and uses thereof |
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US7101838B2 (en) * | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| MY131805A (en) * | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| US6380165B1 (en) * | 1997-09-19 | 2002-04-30 | The Picower Institute For Medical Research | Immunological advanced glycation endproduct crosslink |
| US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6465422B1 (en) * | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| US6753150B2 (en) * | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
| HK1039749B (zh) * | 1998-10-05 | 2007-10-05 | 法麦克萨有限公司 | Ctl表位和t辅助淋巴细胞表位在免疫接种中的应用 |
| EP1121454B1 (en) * | 1998-10-06 | 2007-11-14 | The Trustees of Columbia University in the City of New York | Extracellular novel rage binding protein (en-rage) and uses thereof |
| US6197294B1 (en) * | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
| US6787566B2 (en) * | 1999-04-05 | 2004-09-07 | City Of Hope | Breakers of advanced glycation endproducts |
| US6605642B2 (en) * | 1999-04-05 | 2003-08-12 | City Of Hope | Inhibitors of formation of advanced glycation endproducts (AGES) |
| US6939545B2 (en) * | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| EP1307219A4 (en) * | 1999-08-13 | 2005-04-06 | Univ Columbia | METHODS OF INHIBITING BETA FIBRILLE BINDING BETA TO RAGE RECEPTOR, AND CONSEQUENCES THEREOF |
| US20050170382A1 (en) * | 1999-10-06 | 2005-08-04 | The Trustees Of Columbia University In The City Of New York. | RAGE-related compositions |
| CA2382165A1 (en) * | 1999-12-08 | 2001-06-14 | Genset S.A. | Full-length human cdnas encoding potentially secreted proteins |
| MXPA02010194A (es) * | 2000-04-14 | 2004-08-19 | Niadyne Corp | Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age). |
| US6908741B1 (en) * | 2000-05-30 | 2005-06-21 | Transtech Pharma, Inc. | Methods to identify compounds that modulate RAGE |
| US6825164B1 (en) * | 2000-08-14 | 2004-11-30 | The Trustees Of Columbia University In The City Of New York | Method to increase cerebral blood flow in amyloid angiopathy |
| US6563015B1 (en) * | 2000-08-14 | 2003-05-13 | The Trustees Of Columbia University In The City Of New York | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) and mutant APP in brain and uses thereof |
| US6900041B2 (en) * | 2000-10-02 | 2005-05-31 | Reddy Us Therapeutics Inc. | Methods and compositions for the treatment of inflammatory diseases |
| AU2002213192A1 (en) * | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| US20050244849A1 (en) * | 2000-12-15 | 2005-11-03 | Genetics Institute, Llc | Screening assays for rheumatoid arthritis |
| WO2002066978A2 (en) * | 2000-12-29 | 2002-08-29 | Reddy Us Therapeutics, Inc. | Detection of compounds that modulate inflammatory responses |
| CN100522242C (zh) * | 2001-02-19 | 2009-08-05 | 默克专利有限公司 | 具有降低的免疫原性的人工蛋白质 |
| JP3837494B2 (ja) * | 2001-03-19 | 2006-10-25 | 国立大学法人金沢大学 | 可溶型rageタンパク質 |
| US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US20060140933A1 (en) * | 2002-08-16 | 2006-06-29 | Wyeth And Imperial College Innovations Limited | Compositions and methods for treating rage-associated disorders |
| WO2004100890A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of Columbia University In The City Of New York | Rage g82s-related methods and compositions for treating inflammatory disorders |
| ZA200508300B (en) * | 2003-05-20 | 2007-03-28 | Transtech Pharma Inc | RAGE antagonists as agents to reverse amyloidosis and diseases associated therewith |
| US20050008649A1 (en) * | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| EP1660014A4 (en) * | 2003-09-05 | 2009-07-22 | Univ Columbia | RAGE-RELATED METHODS AND COMPOSITIONS FOR TREATING GLOMERULAR DAMAGE |
| US20070167360A1 (en) * | 2003-10-31 | 2007-07-19 | Yan Shi D | Methods for treating multiple sclerosis |
| US7151400B2 (en) * | 2004-07-13 | 2006-12-19 | Taiwan Semiconductor Manufacturing Company, Ltd. | Boost-biased level shifter |
| EP1771565B1 (en) * | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| US20090060925A1 (en) * | 2004-08-03 | 2009-03-05 | The Trustees Of Columbia University In The City Of | Rage Fusion Proteins and Methods of Use |
| US7901688B2 (en) * | 2004-08-03 | 2011-03-08 | Transtech Pharma, Inc. | Rage fusion proteins |
| JP2008537874A (ja) * | 2004-09-27 | 2008-10-02 | セントカー・インコーポレーテツド | sRAGEミメティボディ、組成物、方法および使用 |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| EA015657B1 (ru) * | 2006-02-09 | 2011-10-31 | Транстек Фарма, Инк. | Слитые белки rage и способы применения |
| EA017291B1 (ru) * | 2006-05-05 | 2012-11-30 | Транстек Фарма, Инк. | Белки слияния на основе rage, их композиции и способы их применения |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
-
2008
- 2008-02-11 WO PCT/US2008/001786 patent/WO2008100470A2/en not_active Ceased
- 2008-02-11 US US12/069,499 patent/US20080199467A1/en not_active Abandoned
- 2008-02-13 CL CL200800460A patent/CL2008000460A1/es unknown
- 2008-02-15 TW TW097105462A patent/TW200848071A/zh unknown
- 2008-02-15 AR ARP080100659A patent/AR065373A1/es unknown
- 2008-02-15 UY UY30925A patent/UY30925A1/es not_active Application Discontinuation
-
2010
- 2010-10-06 US US12/899,073 patent/US20110110945A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CL2008000460A1 (es) | 2008-08-22 |
| AR065373A1 (es) | 2009-06-03 |
| US20110110945A1 (en) | 2011-05-12 |
| WO2008100470A2 (en) | 2008-08-21 |
| WO2008100470A3 (en) | 2008-12-24 |
| TW200848071A (en) | 2008-12-16 |
| US20080199467A1 (en) | 2008-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20170912 |