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MXPA02010194A - Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age). - Google Patents

Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age).

Info

Publication number
MXPA02010194A
MXPA02010194A MXPA02010194A MXPA02010194A MXPA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A
Authority
MX
Mexico
Prior art keywords
protein
formation
end product
age
advanced glycation
Prior art date
Application number
MXPA02010194A
Other languages
English (en)
Inventor
Georg Thomas Wondrak
Original Assignee
Niadyne Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22730907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA02010194(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Niadyne Corp filed Critical Niadyne Corp
Publication of MXPA02010194A publication Critical patent/MXPA02010194A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invencion se refiere a metodos para identificar compuestos que afectan la tension celular; en particular, el metodo se refiere a identificar compuestos que inhiben la formacion de proteina-producto final de glicacion avanzada, en que los compuestos son barredores de carbonilo que inhiben la formacion; el ensayo implica combinar la sustancia de interes con histona H1 y ADP-ribosa, y medir luego la fluorescencia y el entrelazamiento de proteina; se han identificado varios inhibidores de la glicacion de proteina-AGE, usando este ensayo.
MXPA02010194A 2000-04-14 2001-04-16 Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age). MXPA02010194A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19782900P 2000-04-14 2000-04-14
PCT/US2001/012368 WO2001079842A2 (en) 2000-04-14 2001-04-16 Method for identifying regulators of protein-age formation

Publications (1)

Publication Number Publication Date
MXPA02010194A true MXPA02010194A (es) 2004-08-19

Family

ID=22730907

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02010194A MXPA02010194A (es) 2000-04-14 2001-04-16 Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age).

Country Status (13)

Country Link
US (1) US6716635B2 (es)
EP (1) EP1272843B1 (es)
JP (1) JP3920641B2 (es)
CN (1) CN1205480C (es)
AT (1) ATE365319T1 (es)
AU (2) AU5355501A (es)
CY (1) CY1106852T1 (es)
DE (1) DE60129008T2 (es)
DK (1) DK1272843T3 (es)
ES (1) ES2286117T3 (es)
MX (1) MXPA02010194A (es)
PT (1) PT1272843E (es)
WO (1) WO2001079842A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452664B2 (en) 1999-12-15 2008-11-18 Massachusetts Institute Of Technology Methods for identifying agents which alter histone protein acetylation
US8642284B1 (en) 1999-12-15 2014-02-04 Massachusetts Institute Of Technology Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
WO2001078718A1 (en) * 2000-04-14 2001-10-25 Niadyne Corporation Methods of use of penicillamines for the treatment of conditions resulting from dna damage
US6751792B1 (en) * 2000-10-04 2004-06-15 Sun Microsystems, Inc. Using value-expression graphs for data-flow optimizations
US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
JP2006512900A (ja) * 2002-08-16 2006-04-20 ワイス Ｒａｇｅ関連疾患の治療用組成物及び方法
US20070287166A1 (en) * 2003-10-29 2007-12-13 Eisai Co., Ltd Diagnostic Method for Alzheimier's Disease
FR2863620B1 (fr) * 2003-12-16 2007-05-25 Roquette Freres Utilisation d'au moins un cetose de 3 a 5 atomes de carbone comme substitut d'agents reticulants de proteines
PT1720538E (pt) * 2004-03-02 2008-12-26 Univ Arizona Método para indução de morte celular com sequestrantes de carbonilo
AP2007003869A0 (en) * 2004-08-03 2007-02-28 Transtech Pharma Inc Rage fusion proteins and methods of use
US20090060925A1 (en) * 2004-08-03 2009-03-05 The Trustees Of Columbia University In The City Of Rage Fusion Proteins and Methods of Use
US20070099830A1 (en) 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
US7957931B2 (en) * 2005-12-23 2011-06-07 Gcoder Systems Ab Positioning pattern
EP1989227A2 (en) * 2006-02-09 2008-11-12 Transtech Pharma, Inc. Rage fusion proteins and methods of use
MX2008013863A (es) * 2006-05-05 2008-11-14 Transtech Pharma Inc Proteinas de fusion de rage y sus metodos de uso.
US20080199467A1 (en) * 2007-02-15 2008-08-21 Mjalli Adnan M M Immunoglobulin fusion proteins and methods of making
WO2008157378A2 (en) 2007-06-14 2008-12-24 Galactica Pharmaceuticals Page fusion proteins
WO2010122460A1 (en) 2009-04-20 2010-10-28 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
US9309304B2 (en) * 2012-05-16 2016-04-12 Cornell University Glycation cross-link breakers to increase resistance to enzymatic degradation
CN108776131B (zh) * 2018-03-19 2020-06-09 深圳市南山区疾病预防控制中心 一种食品中AGEs含量的检测方法
CN109970730B (zh) * 2019-04-30 2022-06-17 华东理工大学 一种双功能荧光探针及其制备方法和应用
JP7411205B2 (ja) * 2019-09-30 2024-01-11 丸善製薬株式会社 ＡＧＥｓ形成抑制剤及びその製造方法
CN111007135B (zh) * 2019-12-25 2022-08-02 广东食品药品职业学院 一种植物提取物抗糖化效果的评估方法
CN118020929A (zh) * 2023-12-26 2024-05-14 仙乐健康科技股份有限公司 一种抗蛋白质羰基化的组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2711990B1 (fr) 1993-11-05 1995-12-08 Exsymol Sa Produit pseudodipeptide possédant un groupement imidazole, et applications thérapeutiques, cosmétologiques et agroalimentaires.
FR2776188B1 (fr) 1998-03-20 2000-06-16 Fabre Pierre Dermo Cosmetique Oleamide de glycylglycine en dermo-cosmetologie

Also Published As

Publication number Publication date
ATE365319T1 (de) 2007-07-15
WO2001079842A2 (en) 2001-10-25
CN1451096A (zh) 2003-10-22
JP3920641B2 (ja) 2007-05-30
DE60129008T2 (de) 2007-10-11
EP1272843A2 (en) 2003-01-08
CN1205480C (zh) 2005-06-08
AU5355501A (en) 2001-10-30
JP2003531376A (ja) 2003-10-21
US20020037496A1 (en) 2002-03-28
DE60129008D1 (de) 2007-08-02
ES2286117T3 (es) 2007-12-01
WO2001079842A3 (en) 2002-10-24
HK1059117A1 (en) 2004-06-18
PT1272843E (pt) 2007-10-01
US6716635B2 (en) 2004-04-06
DK1272843T3 (da) 2007-10-08
CY1106852T1 (el) 2012-05-23
EP1272843B1 (en) 2007-06-20
AU2001253555B2 (en) 2005-01-06

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