UY26918A1 - 7 - PIRIDOPIRIMIDIN OXY (II) - Google Patents
7 - PIRIDOPIRIMIDIN OXY (II)Info
- Publication number
- UY26918A1 UY26918A1 UY26918A UY26918A UY26918A1 UY 26918 A1 UY26918 A1 UY 26918A1 UY 26918 A UY26918 A UY 26918A UY 26918 A UY26918 A UY 26918A UY 26918 A1 UY26918 A1 UY 26918A1
- Authority
- UY
- Uruguay
- Prior art keywords
- disease
- piridopirimidin
- oxy
- crohn
- alzheimer
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a compuestos de la fórmula: 1 en la que R1, R2, R3 y Ar1 tienen los significados definidos en la invención, y a métodos de obtención y a su utilización para el tratamiento de trastornos causados por p38, p.ej. el método de la reivindicación 26 o 27, en el que dicho trastorno causado por p38 se selecciona entre la artritis, la enfermedad de Crohn, la enfermedad de Alzheimer, el síndrome de intestino irritable, el síndrome de la deficiencia respiratoria adulta y la enfermedad pulmonar obstructiva crónica.The present invention relates to compounds of the formula: 1 in which R1, R2, R3 and Ar1 have the meanings defined in the invention, and methods of obtaining them and their use for the treatment of disorders caused by p38, e.g. the method of claim 26 or 27, wherein said disorder caused by p38 is selected from arthritis, Crohn's disease, Alzheimer's disease, irritable bowel syndrome, adult respiratory deficiency syndrome and lung disease chronic obstructive
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22958400P | 2000-08-31 | 2000-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY26918A1 true UY26918A1 (en) | 2002-02-28 |
Family
ID=22861859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY26918A UY26918A1 (en) | 2000-08-31 | 2001-08-30 | 7 - PIRIDOPIRIMIDIN OXY (II) |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1315726A1 (en) |
| JP (1) | JP4141830B2 (en) |
| KR (1) | KR100571339B1 (en) |
| CN (1) | CN1275964C (en) |
| AR (1) | AR033681A1 (en) |
| AU (2) | AU2001293784B2 (en) |
| BR (1) | BR0113628A (en) |
| CA (1) | CA2420286A1 (en) |
| GT (1) | GT200100191A (en) |
| MX (1) | MXPA03001821A (en) |
| PA (1) | PA8527301A1 (en) |
| PE (1) | PE20020406A1 (en) |
| UY (1) | UY26918A1 (en) |
| WO (1) | WO2002018380A1 (en) |
| ZA (1) | ZA200301079B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2243568T3 (en) * | 2000-08-31 | 2005-12-01 | F. Hoffmann-La Roche Ag | 7-OXO-PYRIDOPIRIMIDINAS. |
| US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| CA2479644A1 (en) * | 2002-04-03 | 2003-10-09 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
| EP1499320B1 (en) * | 2002-04-19 | 2007-08-22 | Smithkline Beecham Corporation | Novel compounds |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| UY27939A1 (en) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | COMPOUNDS |
| US7129351B2 (en) | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| JP2006514624A (en) | 2002-11-18 | 2006-05-11 | エフ．ホフマン−ラ ロシュ アーゲー | Diazinopyrimidines |
| US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| KR20050111636A (en) | 2003-04-10 | 2005-11-25 | 에프. 호프만-라 로슈 아게 | Pyrimido compounds |
| EP1648493B1 (en) * | 2003-07-07 | 2009-12-09 | Van Andel Research Institute | Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor |
| JP4616839B2 (en) * | 2003-11-13 | 2011-01-19 | エフ．ホフマン−ラ ロシュ アーゲー | Hydroxyalkyl-substituted pyrido-7-pyrimidin-7-ones |
| WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| EP1831215A1 (en) * | 2004-11-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Pyrido[2,3-d]pyrimidines as anti-inflamatory agents |
| WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| EP1931667A1 (en) * | 2005-09-28 | 2008-06-18 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| EP1981886B1 (en) | 2006-01-31 | 2009-08-12 | F.Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| KR100661523B1 (en) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | Improved torsion correction device mounted on carton manufacturing equipment |
| EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
| CA2668731A1 (en) | 2006-11-09 | 2008-05-15 | Tobias Gabriel | Kinase inhibitors and methods for using the same |
| WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| KR101106162B1 (en) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | Unloading guide support unit in stitching device for packing box manufacturing equipment |
| ES2694223T3 (en) * | 2012-03-22 | 2018-12-19 | Oscotec, Inc. | Pyridopyrimidine compounds and their use as FLT3 inhibitors |
| KR102350704B1 (en) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | Heteroaryl compounds and uses thereof |
| CN111793068A (en) | 2013-03-15 | 2020-10-20 | 西建卡尔有限责任公司 | Heteroaryl compounds and uses thereof |
| TWI647220B (en) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | Heteroaryl compound and its use |
| CN114751905A (en) | 2014-09-12 | 2022-07-15 | 生物实验萨纽斯药物有限公司 | Novel pyridopyrimidine derivative compound, pharmaceutical composition thereof and use thereof |
| KR20200067170A (en) | 2017-10-05 | 2020-06-11 | 풀크럼 쎄러퓨틱스, 인코포레이티드 | P38 kinase inhibitors that reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| TWI831829B (en) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | Phenoxy-pyridyl-pyrimidine compounds and methods of use |
| IL284326B2 (en) | 2018-12-27 | 2024-08-01 | Servier Lab | Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer |
| TWI748317B (en) | 2019-01-03 | 2021-12-01 | 美商建南德克公司 | Pyrido-pyrimidinone and pteridinone compounds and methods of use |
| CA3142340A1 (en) * | 2019-05-31 | 2020-12-03 | Les Laboratoires Servier | Heterobicyclic inhibitors of mat2a and methods of use for treating cancer |
| CN115960098A (en) * | 2020-09-11 | 2023-04-14 | 上海凌达生物医药有限公司 | Preparation method and application of a class of nitrogen-containing condensed ring compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK281724B6 (en) * | 1994-11-14 | 2001-07-10 | Warner-Lambert Company | 6-ARYLPYRIDO [2,3-D] PYRIMIDINS, THEIR USE AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASE |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| KR20010043829A (en) * | 1998-05-26 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Bicyclic Pyrimidines and Bicyclic 3,4-Dihydropyrimidines as Inhibitors of Cellular Proliferation |
-
2001
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/en not_active Expired - Fee Related
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/en active IP Right Grant
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/en not_active Expired - Fee Related
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 AU AU9378401A patent/AU9378401A/en active Pending
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/en not_active Application Discontinuation
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Ceased
- 2001-08-22 CN CNB018150306A patent/CN1275964C/en not_active Expired - Fee Related
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/en unknown
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/en not_active Application Discontinuation
- 2001-08-30 UY UY26918A patent/UY26918A1/en not_active Application Discontinuation
- 2001-08-30 AR ARP010104132A patent/AR033681A1/en unknown
- 2001-09-18 GT GT200100191A patent/GT200100191A/en unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20020406A1 (en) | 2002-05-17 |
| KR20030022422A (en) | 2003-03-15 |
| CN1451005A (en) | 2003-10-22 |
| CA2420286A1 (en) | 2002-03-07 |
| BR0113628A (en) | 2003-07-01 |
| KR100571339B1 (en) | 2006-04-17 |
| AU2001293784B2 (en) | 2007-08-30 |
| ZA200301079B (en) | 2004-05-07 |
| AR033681A1 (en) | 2004-01-07 |
| WO2002018380A1 (en) | 2002-03-07 |
| JP2004507541A (en) | 2004-03-11 |
| AU9378401A (en) | 2002-03-13 |
| CN1275964C (en) | 2006-09-20 |
| GT200100191A (en) | 2002-05-16 |
| EP1315726A1 (en) | 2003-06-04 |
| JP4141830B2 (en) | 2008-08-27 |
| PA8527301A1 (en) | 2002-07-30 |
| MXPA03001821A (en) | 2003-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20141001 |