BR0113628A - 7-oxopyridopyrimidines as inhibitors of cell proliferation - Google Patents
7-oxopyridopyrimidines as inhibitors of cell proliferationInfo
- Publication number
- BR0113628A BR0113628A BR0113628-3A BR0113628A BR0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- heterocyclyl
- aryl
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- UWABAWGNHPXGBQ-UHFFFAOYSA-N 6h-pyrido[3,2-d]pyrimidin-7-one Chemical class C1=NC=NC2=CC(=O)CN=C21 UWABAWGNHPXGBQ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000004367 cycloalkylaryl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- -1 monoalkylamino Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"7-OXO-PIRIDOPIRIMIDINAS COMO INIBIDORES DE UMA PROLIFERAçãO CELULAR". Compostos de fórmula (I) nos quais R^ 1^ é hidrogênio ou alquila; R^ 2^ é cicloalquila substituída, cicloalquila heterossubstituída, cicloalquila heteroalquilsubstituída, cicloalquil-arila heterossubstituída, heterociclila, heterociclil espiro cicloalquila, aralcóxi, alcóxi, -alquileno-S(O)~ n~-alquila (onde n é 1 ou 2) ou -SO~ 2~Ar^ 2^; R^ 3^ é hidrogênio, amino, monoalquilamino, dialquilamino, acilamino, -NR^ a^-C(=O)-R^ b^ (onde R^ a^ é hidrogênio ou alquila e R^ b^ heterociclila ou heteroalquila), alquila, cicloalquila, arila, aralquila, haloalquila, heteroalquila, cianoalquila, -alquileno-C(O)-R (onde R é hidrogênio, alquila, hidróxi, alcóxi, amino, monoalquilamino ou dialquilamino), acila, ou ftalimidoalquila; e cada um dentre Ar^ 1^ e Ar^ 2^ é independentemente arila, e seu emprego para o tratamento de distúrbios selecionados do grupo consistindo em artrite, doença de Crohn, doença de Alzheimer, síndrome do intestino irritável, síndrome da dificuldade respiratória do adulto, e doença pulmonar obstrutiva crónica."7-OXYPYROPYPYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION". Compounds of formula (I) wherein R2 is hydrogen or alkyl; R 2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkyl aryl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, S (O) n -alkyl (where n is 1 or 2) -SO-2-Ar ^ 2 ^; R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, -NR4 a4 -C (= O) -R4b4 (where R4a4 is hydrogen or alkyl and R4b4 heterocyclyl or heteroalkyl) alkyl, cycloalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -C (O) alkylene -R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), acyl, or phthalimidoalkyl; and each of Ar ^ 1 ^ and Ar ^ 2 ^ is independently aryl, and its use for the treatment of disorders selected from the group consisting of arthritis, Crohn's disease, Alzheimer's disease, irritable bowel syndrome, respiratory distress syndrome. adult, and chronic obstructive pulmonary disease.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22958400P | 2000-08-31 | 2000-08-31 | |
| PCT/EP2001/009689 WO2002018380A1 (en) | 2000-08-31 | 2001-08-22 | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0113628A true BR0113628A (en) | 2003-07-01 |
Family
ID=22861859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0113628-3A BR0113628A (en) | 2000-08-31 | 2001-08-22 | 7-oxopyridopyrimidines as inhibitors of cell proliferation |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1315726A1 (en) |
| JP (1) | JP4141830B2 (en) |
| KR (1) | KR100571339B1 (en) |
| CN (1) | CN1275964C (en) |
| AR (1) | AR033681A1 (en) |
| AU (2) | AU2001293784B2 (en) |
| BR (1) | BR0113628A (en) |
| CA (1) | CA2420286A1 (en) |
| GT (1) | GT200100191A (en) |
| MX (1) | MXPA03001821A (en) |
| PA (1) | PA8527301A1 (en) |
| PE (1) | PE20020406A1 (en) |
| UY (1) | UY26918A1 (en) |
| WO (1) | WO2002018380A1 (en) |
| ZA (1) | ZA200301079B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2243568T3 (en) * | 2000-08-31 | 2005-12-01 | F. Hoffmann-La Roche Ag | 7-OXO-PYRIDOPIRIMIDINAS. |
| US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| CA2479644A1 (en) * | 2002-04-03 | 2003-10-09 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
| EP1499320B1 (en) * | 2002-04-19 | 2007-08-22 | Smithkline Beecham Corporation | Novel compounds |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| UY27939A1 (en) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | COMPOUNDS |
| US7129351B2 (en) | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| JP2006514624A (en) | 2002-11-18 | 2006-05-11 | エフ．ホフマン−ラ ロシュ アーゲー | Diazinopyrimidines |
| US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| KR20050111636A (en) | 2003-04-10 | 2005-11-25 | 에프. 호프만-라 로슈 아게 | Pyrimido compounds |
| EP1648493B1 (en) * | 2003-07-07 | 2009-12-09 | Van Andel Research Institute | Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor |
| JP4616839B2 (en) * | 2003-11-13 | 2011-01-19 | エフ．ホフマン−ラ ロシュ アーゲー | Hydroxyalkyl-substituted pyrido-7-pyrimidin-7-ones |
| WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| EP1831215A1 (en) * | 2004-11-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Pyrido[2,3-d]pyrimidines as anti-inflamatory agents |
| WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| EP1931667A1 (en) * | 2005-09-28 | 2008-06-18 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| EP1981886B1 (en) | 2006-01-31 | 2009-08-12 | F.Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| KR100661523B1 (en) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | Improved torsion correction device mounted on carton manufacturing equipment |
| EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
| CA2668731A1 (en) | 2006-11-09 | 2008-05-15 | Tobias Gabriel | Kinase inhibitors and methods for using the same |
| WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| KR101106162B1 (en) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | Unloading guide support unit in stitching device for packing box manufacturing equipment |
| ES2694223T3 (en) * | 2012-03-22 | 2018-12-19 | Oscotec, Inc. | Pyridopyrimidine compounds and their use as FLT3 inhibitors |
| KR102350704B1 (en) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | Heteroaryl compounds and uses thereof |
| CN111793068A (en) | 2013-03-15 | 2020-10-20 | 西建卡尔有限责任公司 | Heteroaryl compounds and uses thereof |
| TWI647220B (en) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | Heteroaryl compound and its use |
| CN114751905A (en) | 2014-09-12 | 2022-07-15 | 生物实验萨纽斯药物有限公司 | Novel pyridopyrimidine derivative compound, pharmaceutical composition thereof and use thereof |
| KR20200067170A (en) | 2017-10-05 | 2020-06-11 | 풀크럼 쎄러퓨틱스, 인코포레이티드 | P38 kinase inhibitors that reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| TWI831829B (en) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | Phenoxy-pyridyl-pyrimidine compounds and methods of use |
| IL284326B2 (en) | 2018-12-27 | 2024-08-01 | Servier Lab | Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer |
| TWI748317B (en) | 2019-01-03 | 2021-12-01 | 美商建南德克公司 | Pyrido-pyrimidinone and pteridinone compounds and methods of use |
| CA3142340A1 (en) * | 2019-05-31 | 2020-12-03 | Les Laboratoires Servier | Heterobicyclic inhibitors of mat2a and methods of use for treating cancer |
| CN115960098A (en) * | 2020-09-11 | 2023-04-14 | 上海凌达生物医药有限公司 | Preparation method and application of a class of nitrogen-containing condensed ring compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK281724B6 (en) * | 1994-11-14 | 2001-07-10 | Warner-Lambert Company | 6-ARYLPYRIDO [2,3-D] PYRIMIDINS, THEIR USE AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASE |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| KR20010043829A (en) * | 1998-05-26 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Bicyclic Pyrimidines and Bicyclic 3,4-Dihydropyrimidines as Inhibitors of Cellular Proliferation |
-
2001
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/en not_active Expired - Fee Related
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/en active IP Right Grant
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/en not_active Expired - Fee Related
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 AU AU9378401A patent/AU9378401A/en active Pending
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/en not_active Application Discontinuation
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Ceased
- 2001-08-22 CN CNB018150306A patent/CN1275964C/en not_active Expired - Fee Related
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/en unknown
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/en not_active Application Discontinuation
- 2001-08-30 UY UY26918A patent/UY26918A1/en not_active Application Discontinuation
- 2001-08-30 AR ARP010104132A patent/AR033681A1/en unknown
- 2001-09-18 GT GT200100191A patent/GT200100191A/en unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20020406A1 (en) | 2002-05-17 |
| KR20030022422A (en) | 2003-03-15 |
| CN1451005A (en) | 2003-10-22 |
| CA2420286A1 (en) | 2002-03-07 |
| UY26918A1 (en) | 2002-02-28 |
| KR100571339B1 (en) | 2006-04-17 |
| AU2001293784B2 (en) | 2007-08-30 |
| ZA200301079B (en) | 2004-05-07 |
| AR033681A1 (en) | 2004-01-07 |
| WO2002018380A1 (en) | 2002-03-07 |
| JP2004507541A (en) | 2004-03-11 |
| AU9378401A (en) | 2002-03-13 |
| CN1275964C (en) | 2006-09-20 |
| GT200100191A (en) | 2002-05-16 |
| EP1315726A1 (en) | 2003-06-04 |
| JP4141830B2 (en) | 2008-08-27 |
| PA8527301A1 (en) | 2002-07-30 |
| MXPA03001821A (en) | 2003-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |